Temperature-sensitive mutants of rabies virus: Behaviour following inoculation into mouse and fox
Identifieur interne : 000C55 ( Istex/Corpus ); précédent : 000C54; suivant : 000C56Temperature-sensitive mutants of rabies virus: Behaviour following inoculation into mouse and fox
Auteurs : F. Bussereau ; M. Aubert ; J. BlancouSource :
- Annales de l'Institut Pasteur / Virologie [ 0769-2617 ] ; 1983.
English descriptors
Abstract
Summary: Twenty-nine temperature sensitive (ts) mutants of the rabies challenge virus standard strain (CVS) were administered intramuscularly and intracerebrally to adult mice. All led to either rapid death or protection, with the response being dose-dependent. In mice, nine ts mutants (tsO 6, 31, 52, 55, 96, 103, 106, 116 and 117) exhibited a high level of protection for the lowest level of pathogenicity. This could not be correlated with (1) the type of mutagen which induced it, (2), inhibition of multiplication at the host temperature, (3) a weak ability to multiply in nervous cells in vitro, or (4) a specific viral function affected by the mutation. Since the tsO 55 showed the highest level of protection while at the same time remaining apathogenic in mice, it was chosen for testing in foxes. No difference in reaction was observed either intramuscularly or orally between this strain and the original CVS strain. The reasons for this lack of correlation in the response of mice and foxes are discussed.
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DOI: 10.1016/S0769-2617(83)80005-7
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ISTEX:1F0030DE4D97FF06320D6AAB01D3C0AAC6E5C009Le document en format XML
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Aubert</name><affiliation><mods:affiliation>Ministère de l'Agriculture, Direction de la Qualité, Services Vétérinaires, Centre National d'Études sur la Rage, B.P. 9, 54220 Malzeville (France)</mods:affiliation></affiliation></author><author><name sortKey="Blancou, J" sort="Blancou, J" uniqKey="Blancou J" first="J." last="Blancou">J. Blancou</name><affiliation><mods:affiliation>Ministère de l'Agriculture, Direction de la Qualité, Services Vétérinaires, Centre National d'Études sur la Rage, B.P. 9, 54220 Malzeville (France)</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:1F0030DE4D97FF06320D6AAB01D3C0AAC6E5C009</idno><date when="1983" year="1983">1983</date><idno type="doi">10.1016/S0769-2617(83)80005-7</idno><idno type="url">https://api.istex.fr/document/1F0030DE4D97FF06320D6AAB01D3C0AAC6E5C009/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000C55</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000C55</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Temperature-sensitive mutants of rabies virus: Behaviour following inoculation into mouse and fox</title><author><name sortKey="Bussereau, F" sort="Bussereau, F" uniqKey="Bussereau F" first="F." last="Bussereau">F. Bussereau</name><affiliation><mods:affiliation>Laboratoire de Génétique II (Bât. 400) Université de Paris-Sud, 9405 Orsay Cedex (France)</mods:affiliation></affiliation><affiliation><mods:affiliation>The whom reprint requests should be addressed at: Unité Rage, Institut Pasteur, 75724 Paris Cedex 15</mods:affiliation></affiliation></author><author><name sortKey="Aubert, M" sort="Aubert, M" uniqKey="Aubert M" first="M." last="Aubert">M. Aubert</name><affiliation><mods:affiliation>Ministère de l'Agriculture, Direction de la Qualité, Services Vétérinaires, Centre National d'Études sur la Rage, B.P. 9, 54220 Malzeville (France)</mods:affiliation></affiliation></author><author><name sortKey="Blancou, J" sort="Blancou, J" uniqKey="Blancou J" first="J." last="Blancou">J. Blancou</name><affiliation><mods:affiliation>Ministère de l'Agriculture, Direction de la Qualité, Services Vétérinaires, Centre National d'Études sur la Rage, B.P. 9, 54220 Malzeville (France)</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Annales de l'Institut Pasteur / Virologie</title><title level="j" type="abbrev">AIPV</title><idno type="ISSN">0769-2617</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1983">1983</date><biblScope unit="volume">134</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="315">315</biblScope><biblScope unit="page" to="325">325</biblScope></imprint><idno type="ISSN">0769-2617</idno></series><idno type="istex">1F0030DE4D97FF06320D6AAB01D3C0AAC6E5C009</idno><idno type="DOI">10.1016/S0769-2617(83)80005-7</idno><idno type="PII">S0769-2617(83)80005-7</idno><idno type="ArticleID">83800057</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0769-2617</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Mouse, Fox</term><term>Rabies virus, Temperature-sensitive mutant, Immunoprotection</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Summary: Twenty-nine temperature sensitive (ts) mutants of the rabies challenge virus standard strain (CVS) were administered intramuscularly and intracerebrally to adult mice. All led to either rapid death or protection, with the response being dose-dependent. In mice, nine ts mutants (tsO 6, 31, 52, 55, 96, 103, 106, 116 and 117) exhibited a high level of protection for the lowest level of pathogenicity. This could not be correlated with (1) the type of mutagen which induced it, (2), inhibition of multiplication at the host temperature, (3) a weak ability to multiply in nervous cells in vitro, or (4) a specific viral function affected by the mutation. Since the tsO 55 showed the highest level of protection while at the same time remaining apathogenic in mice, it was chosen for testing in foxes. No difference in reaction was observed either intramuscularly or orally between this strain and the original CVS strain. The reasons for this lack of correlation in the response of mice and foxes are discussed.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>F. Bussereau</name><affiliations><json:string>Laboratoire de Génétique II (Bât. 400) Université de Paris-Sud, 9405 Orsay Cedex (France)</json:string><json:string>The whom reprint requests should be addressed at: Unité Rage, Institut Pasteur, 75724 Paris Cedex 15</json:string></affiliations></json:item><json:item><name>M. Aubert</name><affiliations><json:string>Ministère de l'Agriculture, Direction de la Qualité, Services Vétérinaires, Centre National d'Études sur la Rage, B.P. 9, 54220 Malzeville (France)</json:string></affiliations></json:item><json:item><name>J. Blancou</name><affiliations><json:string>Ministère de l'Agriculture, Direction de la Qualité, Services Vétérinaires, Centre National d'Études sur la Rage, B.P. 9, 54220 Malzeville (France)</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Rabies virus, Temperature-sensitive mutant, Immunoprotection</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Mouse, Fox</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Virus rabique, Mutant thermosensible, Immunoprotection</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Souris, Renard</value></json:item></subject><articleId><json:string>83800057</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>Summary: Twenty-nine temperature sensitive (ts) mutants of the rabies challenge virus standard strain (CVS) were administered intramuscularly and intracerebrally to adult mice. All led to either rapid death or protection, with the response being dose-dependent. In mice, nine ts mutants (tsO 6, 31, 52, 55, 96, 103, 106, 116 and 117) exhibited a high level of protection for the lowest level of pathogenicity. This could not be correlated with (1) the type of mutagen which induced it, (2), inhibition of multiplication at the host temperature, (3) a weak ability to multiply in nervous cells in vitro, or (4) a specific viral function affected by the mutation. Since the tsO 55 showed the highest level of protection while at the same time remaining apathogenic in mice, it was chosen for testing in foxes. No difference in reaction was observed either intramuscularly or orally between this strain and the original CVS strain. The reasons for this lack of correlation in the response of mice and foxes are discussed.</abstract><qualityIndicators><score>6.846</score><pdfVersion>1.3</pdfVersion><pdfPageSize>486 x 702 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>4</keywordCount><abstractCharCount>1018</abstractCharCount><pdfWordCount>4854</pdfWordCount><pdfCharCount>20994</pdfCharCount><pdfPageCount>11</pdfPageCount><abstractWordCount>166</abstractWordCount></qualityIndicators><title>Temperature-sensitive mutants of rabies virus: Behaviour following inoculation into mouse and fox</title><pii><json:string>S0769-2617(83)80005-7</json:string></pii><genre><json:string>research-article</json:string></genre><host><volume>134</volume><pii><json:string>S0769-2617(83)X8001-4</json:string></pii><pages><last>325</last><first>315</first></pages><issn><json:string>0769-2617</json:string></issn><issue>3</issue><genre><json:string>journal</json:string></genre><language><json:string>unknown</json:string></language><title>Annales de l'Institut Pasteur / Virologie</title><publicationDate>1983</publicationDate></host><publicationDate>1983</publicationDate><copyrightDate>1983</copyrightDate><doi><json:string>10.1016/S0769-2617(83)80005-7</json:string></doi><id>1F0030DE4D97FF06320D6AAB01D3C0AAC6E5C009</id><score>0.18632233</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/1F0030DE4D97FF06320D6AAB01D3C0AAC6E5C009/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/1F0030DE4D97FF06320D6AAB01D3C0AAC6E5C009/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/1F0030DE4D97FF06320D6AAB01D3C0AAC6E5C009/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Temperature-sensitive mutants of rabies virus: Behaviour following inoculation into mouse and fox</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>ELSEVIER</publisher><availability><p>ELSEVIER</p></availability><date>1983</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Temperature-sensitive mutants of rabies virus: Behaviour following inoculation into mouse and fox</title><author xml:id="author-1"><persName><forename type="first">F.</forename><surname>Bussereau</surname></persName><affiliation>Laboratoire de Génétique II (Bât. 400) Université de Paris-Sud, 9405 Orsay Cedex (France)</affiliation><affiliation>The whom reprint requests should be addressed at: Unité Rage, Institut Pasteur, 75724 Paris Cedex 15</affiliation></author><author xml:id="author-2"><persName><forename type="first">M.</forename><surname>Aubert</surname></persName><affiliation>Ministère de l'Agriculture, Direction de la Qualité, Services Vétérinaires, Centre National d'Études sur la Rage, B.P. 9, 54220 Malzeville (France)</affiliation></author><author xml:id="author-3"><persName><forename type="first">J.</forename><surname>Blancou</surname></persName><affiliation>Ministère de l'Agriculture, Direction de la Qualité, Services Vétérinaires, Centre National d'Études sur la Rage, B.P. 9, 54220 Malzeville (France)</affiliation></author></analytic><monogr><title level="j">Annales de l'Institut Pasteur / Virologie</title><title level="j" type="abbrev">AIPV</title><idno type="pISSN">0769-2617</idno><idno type="PII">S0769-2617(83)X8001-4</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1983"></date><biblScope unit="volume">134</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="315">315</biblScope><biblScope unit="page" to="325">325</biblScope></imprint></monogr><idno type="istex">1F0030DE4D97FF06320D6AAB01D3C0AAC6E5C009</idno><idno type="DOI">10.1016/S0769-2617(83)80005-7</idno><idno type="PII">S0769-2617(83)80005-7</idno><idno type="ArticleID">83800057</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1983</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Summary: Twenty-nine temperature sensitive (ts) mutants of the rabies challenge virus standard strain (CVS) were administered intramuscularly and intracerebrally to adult mice. All led to either rapid death or protection, with the response being dose-dependent. In mice, nine ts mutants (tsO 6, 31, 52, 55, 96, 103, 106, 116 and 117) exhibited a high level of protection for the lowest level of pathogenicity. This could not be correlated with (1) the type of mutagen which induced it, (2), inhibition of multiplication at the host temperature, (3) a weak ability to multiply in nervous cells in vitro, or (4) a specific viral function affected by the mutation. Since the tsO 55 showed the highest level of protection while at the same time remaining apathogenic in mice, it was chosen for testing in foxes. No difference in reaction was observed either intramuscularly or orally between this strain and the original CVS strain. The reasons for this lack of correlation in the response of mice and foxes are discussed.</p></abstract><abstract xml:lang="fr"><p>Résumé: Vingt-neuf mutants thermosensibles (ts) du virus rabique, isolés à partir de la souche «challenge virus standard (CVS), ont été inoculés à des souris adultes par les voies intramusculaire et cérébrale. Tous les mutants provoquent une mort rapide ou induisent une protection; ces deux résultats étant fonction de la dose utilisée. Neuf mutants ts (tsO 6, 31, 52, 55, 96, 103, 106 et 117) induisent un haut niveau de protection pour un faible pouvoir pathogène. Ces propriétés n'ont pu être corrélées ni au type du mutagène qui les a induites, ni à une inhibition de la multiplication due à la température interne de l'hôte ni à un faible taux de multiplication dans des cellules nerveuses in vitro, ni à une fonction virale spécifique affectée lors de la mutation. Comme le mutant tsO 55 produit un haut niveau de protection en l'absence totale de pouvoir pathogène, ce mutant a été choisi pour être testé chez le renard ainsi que la souche CVS dont il est issu. Aucune différence de réaction n'a été observée entre les deux souches ni par voie musculaire ni par voie orale. Les raisons de ce manque de corrélation de la réponse du mutant ts chez la souris et le renard sont discutées.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Key-words</head><item><term>Rabies virus, Temperature-sensitive mutant, Immunoprotection</term></item><item><term>Mouse, Fox</term></item></list></keywords></textClass><textClass xml:lang="fr"><keywords scheme="keyword"><list><head>Mots-Clés</head><item><term>Virus rabique, Mutant thermosensible, Immunoprotection</term></item><item><term>Souris, Renard</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1983">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/1F0030DE4D97FF06320D6AAB01D3C0AAC6E5C009/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier doc found" wicri:toSee="Elsevier, no converted or simple article"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 5.0.1//EN//XML" URI="art501.dtd" name="istex:docType"></istex:docType><istex:document><article version="5.0" xml:lang="en" docsubtype="fla"><item-info><jid>AIPV</jid><aid>83800057</aid><ce:pii>S0769-2617(83)80005-7</ce:pii><ce:doi>10.1016/S0769-2617(83)80005-7</ce:doi><ce:copyright type="unknown" year="1983"></ce:copyright></item-info><head><ce:title>Temperature-sensitive mutants of rabies virus: Behaviour following inoculation into mouse and fox</ce:title><ce:author-group><ce:author><ce:given-name>F.</ce:given-name><ce:surname>Bussereau</ce:surname><ce:cross-ref refid="aff1"><ce:sup>(1)</ce:sup></ce:cross-ref><ce:cross-ref refid="cor1"><ce:sup>*</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>M.</ce:given-name><ce:surname>Aubert</ce:surname><ce:cross-ref refid="aff2"><ce:sup>(2)</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>J.</ce:given-name><ce:surname>Blancou</ce:surname><ce:cross-ref refid="aff2"><ce:sup>(2)</ce:sup></ce:cross-ref></ce:author><ce:affiliation id="aff1"><ce:label>(1)</ce:label><ce:textfn>Laboratoire de Génétique II (Bât. 400) Université de Paris-Sud, 9405 Orsay Cedex (France)</ce:textfn></ce:affiliation><ce:affiliation id="aff2"><ce:label>(2)</ce:label><ce:textfn>Ministère de l'Agriculture, Direction de la Qualité, Services Vétérinaires, Centre National d'Études sur la Rage, B.P. 9, 54220 Malzeville (France)</ce:textfn></ce:affiliation><ce:correspondence id="cor1"><ce:label>*</ce:label><ce:text>The whom reprint requests should be addressed at: Unité Rage, Institut Pasteur, 75724 Paris Cedex 15</ce:text></ce:correspondence></ce:author-group><ce:date-received day="24" month="12" year="1982"></ce:date-received><ce:date-accepted day="19" month="5" year="1983"></ce:date-accepted><ce:abstract id="ab1" class="author" xml:lang="en"><ce:section-title>Summary</ce:section-title><ce:abstract-sec><ce:simple-para>Twenty-nine temperature sensitive (ts) mutants of the rabies challenge virus standard strain (CVS) were administered intramuscularly and intracerebrally to adult mice. All led to either rapid death or protection, with the response being dose-dependent. In mice, nine ts mutants (tsO 6, 31, 52, 55, 96, 103, 106, 116 and 117) exhibited a high level of protection for the lowest level of pathogenicity. This could not be correlated with (1) the type of mutagen which induced it, (2), inhibition of multiplication at the host temperature, (3) a weak ability to multiply in nervous cells <ce:italic>in vitro</ce:italic>, or (4) a specific viral function affected by the mutation. Since the tsO 55 showed the highest level of protection while at the same time remaining apathogenic in mice, it was chosen for testing in foxes. No difference in reaction was observed either intramuscularly or orally between this strain and the original CVS strain. The reasons for this lack of correlation in the response of mice and foxes are discussed.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:abstract id="ab2" class="author" xml:lang="fr"><ce:section-title>Résumé</ce:section-title><ce:abstract-sec><ce:simple-para>Vingt-neuf mutants thermosensibles (ts) du virus rabique, isolés à partir de la souche «challenge virus standard (CVS), ont été inoculés à des souris adultes par les voies intramusculaire et cérébrale. Tous les mutants provoquent une mort rapide ou induisent une protection; ces deux résultats étant fonction de la dose utilisée. Neuf mutants ts (tsO 6, 31, 52, 55, 96, 103, 106 et 117) induisent un haut niveau de protection pour un faible pouvoir pathogène. Ces propriétés n'ont pu être corrélées ni au type du mutagène qui les a induites, ni à une inhibition de la multiplication due à la température interne de l'hôte ni à un faible taux de multiplication dans des cellules nerveuses <ce:italic>in vitro</ce:italic>, ni à une fonction virale spécifique affectée lors de la mutation. Comme le mutant tsO 55 produit un haut niveau de protection en l'absence totale de pouvoir pathogène, ce mutant a été choisi pour être testé chez le renard ainsi que la souche CVS dont il est issu. Aucune différence de réaction n'a été observée entre les deux souches ni par voie musculaire ni par voie orale. Les raisons de ce manque de corrélation de la réponse du mutant ts chez la souris et le renard sont discutées.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords class="keyword" xml:lang="en"><ce:section-title>Key-words</ce:section-title><ce:keyword><ce:text>Rabies virus, Temperature-sensitive mutant, Immunoprotection</ce:text></ce:keyword><ce:keyword><ce:text>Mouse, Fox</ce:text></ce:keyword></ce:keywords><ce:keywords class="keyword" xml:lang="fr"><ce:section-title>Mots-Clés</ce:section-title><ce:keyword><ce:text>Virus rabique, Mutant thermosensible, Immunoprotection</ce:text></ce:keyword><ce:keyword><ce:text>Souris, Renard</ce:text></ce:keyword></ce:keywords></head><tail><ce:bibliography><ce:section-title>References</ce:section-title><ce:bibliography-sec><ce:bib-reference id="bib1"><ce:label>[1]</ce:label><sb:reference><sb:comment>(Inst. Pasteur)</sb:comment><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Aubert</ce:surname><ce:given-name>M.F.A.</ce:given-name></sb:author><sb:author><ce:surname>Bussereau</ce:surname><ce:given-name>F.</ce:given-name></sb:author><sb:author><ce:surname>Blancou</ce:surname><ce:given-name>J.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Pathogenic, immunogenic and protective powers of ten temperature-sensitive mutants of rabies in mice</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Ann. 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Dis.</sb:maintitle></sb:title><sb:volume-nr>5</sb:volume-nr></sb:series><sb:date>1982</sb:date></sb:issue><sb:pages><sb:first-page>173</sb:first-page><sb:last-page>176</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference></ce:bibliography-sec></ce:bibliography></tail></article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Temperature-sensitive mutants of rabies virus: Behaviour following inoculation into mouse and fox</title></titleInfo><titleInfo type="alternative" lang="en" contentType="CDATA"><title>Temperature-sensitive mutants of rabies virus: Behaviour following inoculation into mouse and fox</title></titleInfo><name type="personal"><namePart type="given">F.</namePart><namePart type="family">Bussereau</namePart><affiliation>Laboratoire de Génétique II (Bât. 400) Université de Paris-Sud, 9405 Orsay Cedex (France)</affiliation><affiliation>The whom reprint requests should be addressed at: Unité Rage, Institut Pasteur, 75724 Paris Cedex 15</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Aubert</namePart><affiliation>Ministère de l'Agriculture, Direction de la Qualité, Services Vétérinaires, Centre National d'Études sur la Rage, B.P. 9, 54220 Malzeville (France)</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Blancou</namePart><affiliation>Ministère de l'Agriculture, Direction de la Qualité, Services Vétérinaires, Centre National d'Études sur la Rage, B.P. 9, 54220 Malzeville (France)</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1983</dateIssued><copyrightDate encoding="w3cdtf">1983</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">Summary: Twenty-nine temperature sensitive (ts) mutants of the rabies challenge virus standard strain (CVS) were administered intramuscularly and intracerebrally to adult mice. All led to either rapid death or protection, with the response being dose-dependent. In mice, nine ts mutants (tsO 6, 31, 52, 55, 96, 103, 106, 116 and 117) exhibited a high level of protection for the lowest level of pathogenicity. This could not be correlated with (1) the type of mutagen which induced it, (2), inhibition of multiplication at the host temperature, (3) a weak ability to multiply in nervous cells in vitro, or (4) a specific viral function affected by the mutation. Since the tsO 55 showed the highest level of protection while at the same time remaining apathogenic in mice, it was chosen for testing in foxes. No difference in reaction was observed either intramuscularly or orally between this strain and the original CVS strain. The reasons for this lack of correlation in the response of mice and foxes are discussed.</abstract><abstract lang="fr">Résumé: Vingt-neuf mutants thermosensibles (ts) du virus rabique, isolés à partir de la souche «challenge virus standard (CVS), ont été inoculés à des souris adultes par les voies intramusculaire et cérébrale. Tous les mutants provoquent une mort rapide ou induisent une protection; ces deux résultats étant fonction de la dose utilisée. Neuf mutants ts (tsO 6, 31, 52, 55, 96, 103, 106 et 117) induisent un haut niveau de protection pour un faible pouvoir pathogène. Ces propriétés n'ont pu être corrélées ni au type du mutagène qui les a induites, ni à une inhibition de la multiplication due à la température interne de l'hôte ni à un faible taux de multiplication dans des cellules nerveuses in vitro, ni à une fonction virale spécifique affectée lors de la mutation. Comme le mutant tsO 55 produit un haut niveau de protection en l'absence totale de pouvoir pathogène, ce mutant a été choisi pour être testé chez le renard ainsi que la souche CVS dont il est issu. Aucune différence de réaction n'a été observée entre les deux souches ni par voie musculaire ni par voie orale. Les raisons de ce manque de corrélation de la réponse du mutant ts chez la souris et le renard sont discutées.</abstract><subject lang="en"><genre>Key-words</genre><topic>Rabies virus, Temperature-sensitive mutant, Immunoprotection</topic><topic>Mouse, Fox</topic></subject><subject lang="fr"><genre>Mots-Clés</genre><topic>Virus rabique, Mutant thermosensible, Immunoprotection</topic><topic>Souris, Renard</topic></subject><relatedItem type="host"><titleInfo><title>Annales de l'Institut Pasteur / Virologie</title></titleInfo><titleInfo type="abbreviated"><title>AIPV</title></titleInfo><genre type="journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">198307</dateIssued></originInfo><identifier type="ISSN">0769-2617</identifier><identifier type="PII">S0769-2617(83)X8001-4</identifier><part><date>198307</date><detail type="volume"><number>134</number><caption>vol.</caption></detail><detail type="issue"><number>3</number><caption>no.</caption></detail><extent unit="issue pages"><start>285</start><end>433</end></extent><extent unit="issue pages"><start>1</start><end>3</end></extent><extent unit="pages"><start>315</start><end>325</end></extent></part></relatedItem><identifier type="istex">1F0030DE4D97FF06320D6AAB01D3C0AAC6E5C009</identifier><identifier type="DOI">10.1016/S0769-2617(83)80005-7</identifier><identifier type="PII">S0769-2617(83)80005-7</identifier><identifier type="ArticleID">83800057</identifier><recordInfo><recordContentSource>ELSEVIER</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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