RenardV1, France, Analysis, bibRecord, 000460

Structure-activity relationship of stress-inducing odorants in the rat

Identifieur interne : 000460 ( France/Analysis ); précédent : 000459; suivant : 000461

Structure-activity relationship of stress-inducing odorants in the rat

Auteurs : E. Vernet-Maury [France] ; E. H. Polak [France] ; A. Demael [France]

Source :

Journal of Chemical Ecology [ 0098-0331 ] ; 1984-07-01.

RBID : ISTEX:075DBE43138CBDE04C42B8D9D36B525E7DF9DE31

Abstract

Abstract: The stress for 12 sulfur-containing synthetized volatiles was evaluated in male Wistar rats and compared to that for fox-dropping extract concentrate. Stress behavior was analyzed by quantifying various stress responses in a standard open field and measuring the increase in plasma corticosterone concentration. Nine compounds induced stress—a dihydrothiazole, two cyclic polysulfides, five mercaptoketones, and a mercaptan. For the mercaptoketones, the following structure-activity relationships were observed. Size can vary considerably; the mercapto group can be either alpha or beta and either secondary or tertiary. The keto group is not essential, since a structurally related mercaptan remains active. The mercapto group is essential for activity in mercaptoketones, since conversion to a methyl sulfide resulted in a neutral response. This type of odorant could function as an allomone and may have potential in rat control as an area repellent.

Url:

https://api.istex.fr/document/075DBE43138CBDE04C42B8D9D36B525E7DF9DE31/fulltext/pdf

DOI: 10.1007/BF00987509

Affiliations:

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ISTEX:075DBE43138CBDE04C42B8D9D36B525E7DF9DE31

Le document en format XML

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<front><div type="abstract" xml:lang="en">Abstract: The stress for 12 sulfur-containing synthetized volatiles was evaluated in male Wistar rats and compared to that for fox-dropping extract concentrate. Stress behavior was analyzed by quantifying various stress responses in a standard open field and measuring the increase in plasma corticosterone concentration. Nine compounds induced stress—a dihydrothiazole, two cyclic polysulfides, five mercaptoketones, and a mercaptan. For the mercaptoketones, the following structure-activity relationships were observed. Size can vary considerably; the mercapto group can be either alpha or beta and either secondary or tertiary. The keto group is not essential, since a structurally related mercaptan remains active. The mercapto group is essential for activity in mercaptoketones, since conversion to a methyl sulfide resulted in a neutral response. This type of odorant could function as an allomone and may have potential in rat control as an area repellent.</div>
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Structure-activity relationship of stress-inducing odorants in the rat

Structure-activity relationship of stress-inducing odorants in the rat

Source :

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri