Feroniellin A-induced autophagy causes apoptosis in multidrug-resistant human A549 lung cancer cells.
Identifieur interne : 000E92 ( Main/Corpus ); précédent : 000E91; suivant : 000E93Feroniellin A-induced autophagy causes apoptosis in multidrug-resistant human A549 lung cancer cells.
Auteurs : Chutima Kaewpiboon ; Serm Surapinit ; Waraporn Malilas ; Jeong Moon ; Preecha Phuwapraisirisan ; Santi Tip-Pyang ; Randal N. Johnston ; Sang Seok Koh ; Wanchai Assavalapsakul ; Young-Hwa ChungSource :
- International journal of oncology [ 1791-2423 ] ; 2014.
English descriptors
- KwdEn :
- ATP Binding Cassette Transporter, Subfamily B (biosynthesis), Antineoplastic Agents (pharmacology), Apoptosis (drug effects), Apoptosis (genetics), Apoptosis Regulatory Proteins (genetics), Autophagy (drug effects), Beclin-1 (MeSH), Cell Line, Tumor (MeSH), Coumarins (pharmacology), Drug Resistance, Neoplasm (drug effects), Etoposide (pharmacology), Furans (pharmacology), Glycosides (pharmacology), Humans (MeSH), Lung Neoplasms (drug therapy), Membrane Proteins (genetics), Microfilament Proteins (MeSH), Nitriles (pharmacology), Promoter Regions, Genetic (MeSH), RNA Interference (MeSH), RNA, Small Interfering (MeSH), Sirolimus (pharmacology), Sulfones (pharmacology), Transcription Factor RelA (antagonists & inhibitors), Transcription Factor RelA (biosynthesis), Transcription, Genetic (MeSH).
- MESH :
- chemical , antagonists & inhibitors : Transcription Factor RelA.
- chemical , biosynthesis : ATP Binding Cassette Transporter, Subfamily B, Transcription Factor RelA.
- chemical , genetics : Apoptosis Regulatory Proteins, Membrane Proteins.
- chemical , pharmacology : Antineoplastic Agents, Coumarins, Etoposide, Furans, Glycosides, Nitriles, Sirolimus, Sulfones.
- drug effects : Apoptosis, Autophagy, Drug Resistance, Neoplasm.
- drug therapy : Lung Neoplasms.
- genetics : Apoptosis.
- chemical : Beclin-1, Cell Line, Tumor, Humans, Microfilament Proteins, Promoter Regions, Genetic, RNA Interference, RNA, Small Interfering, Transcription, Genetic.
Abstract
During the screening of natural chemicals that can reverse multidrug resistance in human A549 lung cancer cells resistant to etoposide (A549RT-eto), we discovered that Feroniellin A (FERO), a novel furanocoumarin, shows toxicity toward A549RT-eto cells in a dose- and time-dependent manner. FERO reduced the expression of NF-κB, leading to downregulation of P-glycoprotein (P-gp), encoded by MDR1, which eventually sensitized A549RT-eto cells to apoptosis. FERO specifically diminished transcription and promoter activity of MDR1 but did not inhibit the expression of other multidrug resistance genes MRP2 and BCRP. Moreover, co-administration of FERO with Bay11-7802, an inhibitor of NF-κB, accelerated apoptosis of A549RT-eto cells through decreased expression of P-gp, indicating that NF-κB is involved in multidrug resistance. Conversely, addition of Z-VAD, a pan-caspase inhibitor, blocked FERO-induced apoptosis in A549RT-eto cells but did not block downregulation of P-gp, indicating that a decrease in P-gp expression is necessary but not sufficient for FERO-induced apoptosis. Interestingly, we found that FERO also induces autophagy, which is characterized by the conversion of LC3 I to LC3 II, induction of GFP-LC3 puncta, enhanced expression of Beclin-1 and ATG5, and inactivation of mTOR. Furthermore, suppression of Beclin-1 by siRNA reduced FERO-induced apoptosis in A549RT-eto cells and activation of autophagy by rapamycin accelerated FERO-induced apoptosis, suggesting that autophagy plays an active role in FERO-induced apoptosis. Herein, we report that FERO reverses multidrug resistance in A549RT-eto cells and exerts its cytotoxic effect by induction of both autophagy and apoptosis, which suggests that FERO can be a useful anticancer drug for multidrug-resistant lung cancer.
DOI: 10.3892/ijo.2014.2297
PubMed: 24535083
Links to Exploration step
pubmed:24535083Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Feroniellin A-induced autophagy causes apoptosis in multidrug-resistant human A549 lung cancer cells.</title><author><name sortKey="Kaewpiboon, Chutima" sort="Kaewpiboon, Chutima" uniqKey="Kaewpiboon C" first="Chutima" last="Kaewpiboon">Chutima Kaewpiboon</name><affiliation><nlm:affiliation>Program in Biotechnology, Chulalongkorn University, Bangkok 10330, Thailand.</nlm:affiliation></affiliation></author><author><name sortKey="Surapinit, Serm" sort="Surapinit, Serm" uniqKey="Surapinit S" first="Serm" last="Surapinit">Serm Surapinit</name><affiliation><nlm:affiliation>Program in Biotechnology, Chulalongkorn University, Bangkok 10330, Thailand.</nlm:affiliation></affiliation></author><author><name sortKey="Malilas, Waraporn" sort="Malilas, Waraporn" uniqKey="Malilas W" first="Waraporn" last="Malilas">Waraporn Malilas</name><affiliation><nlm:affiliation>BK21+, Department of Cogno-Mechatronics Engineering, Pusan National University, Busan 609-735, Republic of Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Moon, Jeong" sort="Moon, Jeong" uniqKey="Moon J" first="Jeong" last="Moon">Jeong Moon</name><affiliation><nlm:affiliation>BK21+, Department of Cogno-Mechatronics Engineering, Pusan National University, Busan 609-735, Republic of Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Phuwapraisirisan, Preecha" sort="Phuwapraisirisan, Preecha" uniqKey="Phuwapraisirisan P" first="Preecha" last="Phuwapraisirisan">Preecha Phuwapraisirisan</name><affiliation><nlm:affiliation>Natural Products Research Unit, Department of Chemistry, Chulalongkorn University, Bangkok 10330, Thailand.</nlm:affiliation></affiliation></author><author><name sortKey="Tip Pyang, Santi" sort="Tip Pyang, Santi" uniqKey="Tip Pyang S" first="Santi" last="Tip-Pyang">Santi Tip-Pyang</name><affiliation><nlm:affiliation>Natural Products Research Unit, Department of Chemistry, Chulalongkorn University, Bangkok 10330, Thailand.</nlm:affiliation></affiliation></author><author><name sortKey="Johnston, Randal N" sort="Johnston, Randal N" uniqKey="Johnston R" first="Randal N" last="Johnston">Randal N. Johnston</name><affiliation><nlm:affiliation>Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta T2N4N1, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Koh, Sang Seok" sort="Koh, Sang Seok" uniqKey="Koh S" first="Sang Seok" last="Koh">Sang Seok Koh</name><affiliation><nlm:affiliation>Immunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology, and Department of Functional Genomics, University of Science and Technology, Daejeon 305-333, Republic of Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Assavalapsakul, Wanchai" sort="Assavalapsakul, Wanchai" uniqKey="Assavalapsakul W" first="Wanchai" last="Assavalapsakul">Wanchai Assavalapsakul</name><affiliation><nlm:affiliation>Department of Microbiology, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.</nlm:affiliation></affiliation></author><author><name sortKey="Chung, Young Hwa" sort="Chung, Young Hwa" uniqKey="Chung Y" first="Young-Hwa" last="Chung">Young-Hwa Chung</name><affiliation><nlm:affiliation>BK21+, Department of Cogno-Mechatronics Engineering, Pusan National University, Busan 609-735, Republic of Korea.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24535083</idno><idno type="pmid">24535083</idno><idno type="doi">10.3892/ijo.2014.2297</idno><idno type="wicri:Area/Main/Corpus">000E92</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000E92</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Feroniellin A-induced autophagy causes apoptosis in multidrug-resistant human A549 lung cancer cells.</title><author><name sortKey="Kaewpiboon, Chutima" sort="Kaewpiboon, Chutima" uniqKey="Kaewpiboon C" first="Chutima" last="Kaewpiboon">Chutima Kaewpiboon</name><affiliation><nlm:affiliation>Program in Biotechnology, Chulalongkorn University, Bangkok 10330, Thailand.</nlm:affiliation></affiliation></author><author><name sortKey="Surapinit, Serm" sort="Surapinit, Serm" uniqKey="Surapinit S" first="Serm" last="Surapinit">Serm Surapinit</name><affiliation><nlm:affiliation>Program in Biotechnology, Chulalongkorn University, Bangkok 10330, Thailand.</nlm:affiliation></affiliation></author><author><name sortKey="Malilas, Waraporn" sort="Malilas, Waraporn" uniqKey="Malilas W" first="Waraporn" last="Malilas">Waraporn Malilas</name><affiliation><nlm:affiliation>BK21+, Department of Cogno-Mechatronics Engineering, Pusan National University, Busan 609-735, Republic of Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Moon, Jeong" sort="Moon, Jeong" uniqKey="Moon J" first="Jeong" last="Moon">Jeong Moon</name><affiliation><nlm:affiliation>BK21+, Department of Cogno-Mechatronics Engineering, Pusan National University, Busan 609-735, Republic of Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Phuwapraisirisan, Preecha" sort="Phuwapraisirisan, Preecha" uniqKey="Phuwapraisirisan P" first="Preecha" last="Phuwapraisirisan">Preecha Phuwapraisirisan</name><affiliation><nlm:affiliation>Natural Products Research Unit, Department of Chemistry, Chulalongkorn University, Bangkok 10330, Thailand.</nlm:affiliation></affiliation></author><author><name sortKey="Tip Pyang, Santi" sort="Tip Pyang, Santi" uniqKey="Tip Pyang S" first="Santi" last="Tip-Pyang">Santi Tip-Pyang</name><affiliation><nlm:affiliation>Natural Products Research Unit, Department of Chemistry, Chulalongkorn University, Bangkok 10330, Thailand.</nlm:affiliation></affiliation></author><author><name sortKey="Johnston, Randal N" sort="Johnston, Randal N" uniqKey="Johnston R" first="Randal N" last="Johnston">Randal N. Johnston</name><affiliation><nlm:affiliation>Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta T2N4N1, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Koh, Sang Seok" sort="Koh, Sang Seok" uniqKey="Koh S" first="Sang Seok" last="Koh">Sang Seok Koh</name><affiliation><nlm:affiliation>Immunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology, and Department of Functional Genomics, University of Science and Technology, Daejeon 305-333, Republic of Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Assavalapsakul, Wanchai" sort="Assavalapsakul, Wanchai" uniqKey="Assavalapsakul W" first="Wanchai" last="Assavalapsakul">Wanchai Assavalapsakul</name><affiliation><nlm:affiliation>Department of Microbiology, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.</nlm:affiliation></affiliation></author><author><name sortKey="Chung, Young Hwa" sort="Chung, Young Hwa" uniqKey="Chung Y" first="Young-Hwa" last="Chung">Young-Hwa Chung</name><affiliation><nlm:affiliation>BK21+, Department of Cogno-Mechatronics Engineering, Pusan National University, Busan 609-735, Republic of Korea.</nlm:affiliation></affiliation></author></analytic><series><title level="j">International journal of oncology</title><idno type="eISSN">1791-2423</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>ATP Binding Cassette Transporter, Subfamily B (biosynthesis)</term><term>Antineoplastic Agents (pharmacology)</term><term>Apoptosis (drug effects)</term><term>Apoptosis (genetics)</term><term>Apoptosis Regulatory Proteins (genetics)</term><term>Autophagy (drug effects)</term><term>Beclin-1 (MeSH)</term><term>Cell Line, Tumor (MeSH)</term><term>Coumarins (pharmacology)</term><term>Drug Resistance, Neoplasm (drug effects)</term><term>Etoposide (pharmacology)</term><term>Furans (pharmacology)</term><term>Glycosides (pharmacology)</term><term>Humans (MeSH)</term><term>Lung Neoplasms (drug therapy)</term><term>Membrane Proteins (genetics)</term><term>Microfilament Proteins (MeSH)</term><term>Nitriles (pharmacology)</term><term>Promoter Regions, Genetic (MeSH)</term><term>RNA Interference (MeSH)</term><term>RNA, Small Interfering (MeSH)</term><term>Sirolimus (pharmacology)</term><term>Sulfones (pharmacology)</term><term>Transcription Factor RelA (antagonists & inhibitors)</term><term>Transcription Factor RelA (biosynthesis)</term><term>Transcription, Genetic (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Transcription Factor RelA</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>ATP Binding Cassette Transporter, Subfamily B</term><term>Transcription Factor RelA</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Apoptosis Regulatory Proteins</term><term>Membrane Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antineoplastic Agents</term><term>Coumarins</term><term>Etoposide</term><term>Furans</term><term>Glycosides</term><term>Nitriles</term><term>Sirolimus</term><term>Sulfones</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Apoptosis</term><term>Autophagy</term><term>Drug Resistance, Neoplasm</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Lung Neoplasms</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Apoptosis</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Beclin-1</term><term>Cell Line, Tumor</term><term>Humans</term><term>Microfilament Proteins</term><term>Promoter Regions, Genetic</term><term>RNA Interference</term><term>RNA, Small Interfering</term><term>Transcription, Genetic</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">During the screening of natural chemicals that can reverse multidrug resistance in human A549 lung cancer cells resistant to etoposide (A549RT-eto), we discovered that Feroniellin A (FERO), a novel furanocoumarin, shows toxicity toward A549RT-eto cells in a dose- and time-dependent manner. FERO reduced the expression of NF-κB, leading to downregulation of P-glycoprotein (P-gp), encoded by MDR1, which eventually sensitized A549RT-eto cells to apoptosis. FERO specifically diminished transcription and promoter activity of MDR1 but did not inhibit the expression of other multidrug resistance genes MRP2 and BCRP. Moreover, co-administration of FERO with Bay11-7802, an inhibitor of NF-κB, accelerated apoptosis of A549RT-eto cells through decreased expression of P-gp, indicating that NF-κB is involved in multidrug resistance. Conversely, addition of Z-VAD, a pan-caspase inhibitor, blocked FERO-induced apoptosis in A549RT-eto cells but did not block downregulation of P-gp, indicating that a decrease in P-gp expression is necessary but not sufficient for FERO-induced apoptosis. Interestingly, we found that FERO also induces autophagy, which is characterized by the conversion of LC3 I to LC3 II, induction of GFP-LC3 puncta, enhanced expression of Beclin-1 and ATG5, and inactivation of mTOR. Furthermore, suppression of Beclin-1 by siRNA reduced FERO-induced apoptosis in A549RT-eto cells and activation of autophagy by rapamycin accelerated FERO-induced apoptosis, suggesting that autophagy plays an active role in FERO-induced apoptosis. Herein, we report that FERO reverses multidrug resistance in A549RT-eto cells and exerts its cytotoxic effect by induction of both autophagy and apoptosis, which suggests that FERO can be a useful anticancer drug for multidrug-resistant lung cancer.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24535083</PMID><DateCompleted><Year>2014</Year><Month>11</Month><Day>26</Day></DateCompleted><DateRevised><Year>2018</Year><Month>12</Month><Day>02</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1791-2423</ISSN><JournalIssue CitedMedium="Internet"><Volume>44</Volume><Issue>4</Issue><PubDate><Year>2014</Year><Month>Apr</Month></PubDate></JournalIssue><Title>International journal of oncology</Title><ISOAbbreviation>Int J Oncol</ISOAbbreviation></Journal><ArticleTitle>Feroniellin A-induced autophagy causes apoptosis in multidrug-resistant human A549 lung cancer cells.</ArticleTitle><Pagination><MedlinePgn>1233-42</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3892/ijo.2014.2297</ELocationID><Abstract><AbstractText>During the screening of natural chemicals that can reverse multidrug resistance in human A549 lung cancer cells resistant to etoposide (A549RT-eto), we discovered that Feroniellin A (FERO), a novel furanocoumarin, shows toxicity toward A549RT-eto cells in a dose- and time-dependent manner. FERO reduced the expression of NF-κB, leading to downregulation of P-glycoprotein (P-gp), encoded by MDR1, which eventually sensitized A549RT-eto cells to apoptosis. FERO specifically diminished transcription and promoter activity of MDR1 but did not inhibit the expression of other multidrug resistance genes MRP2 and BCRP. Moreover, co-administration of FERO with Bay11-7802, an inhibitor of NF-κB, accelerated apoptosis of A549RT-eto cells through decreased expression of P-gp, indicating that NF-κB is involved in multidrug resistance. Conversely, addition of Z-VAD, a pan-caspase inhibitor, blocked FERO-induced apoptosis in A549RT-eto cells but did not block downregulation of P-gp, indicating that a decrease in P-gp expression is necessary but not sufficient for FERO-induced apoptosis. Interestingly, we found that FERO also induces autophagy, which is characterized by the conversion of LC3 I to LC3 II, induction of GFP-LC3 puncta, enhanced expression of Beclin-1 and ATG5, and inactivation of mTOR. Furthermore, suppression of Beclin-1 by siRNA reduced FERO-induced apoptosis in A549RT-eto cells and activation of autophagy by rapamycin accelerated FERO-induced apoptosis, suggesting that autophagy plays an active role in FERO-induced apoptosis. Herein, we report that FERO reverses multidrug resistance in A549RT-eto cells and exerts its cytotoxic effect by induction of both autophagy and apoptosis, which suggests that FERO can be a useful anticancer drug for multidrug-resistant lung cancer.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kaewpiboon</LastName><ForeName>Chutima</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Program in Biotechnology, Chulalongkorn University, Bangkok 10330, Thailand.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Surapinit</LastName><ForeName>Serm</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Program in Biotechnology, Chulalongkorn University, Bangkok 10330, Thailand.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Malilas</LastName><ForeName>Waraporn</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>BK21+, Department of Cogno-Mechatronics Engineering, Pusan National University, Busan 609-735, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Moon</LastName><ForeName>Jeong</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>BK21+, Department of Cogno-Mechatronics Engineering, Pusan National University, Busan 609-735, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Phuwapraisirisan</LastName><ForeName>Preecha</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Natural Products Research Unit, Department of Chemistry, Chulalongkorn University, Bangkok 10330, Thailand.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tip-Pyang</LastName><ForeName>Santi</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Natural Products Research Unit, Department of Chemistry, Chulalongkorn University, Bangkok 10330, Thailand.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Johnston</LastName><ForeName>Randal N</ForeName><Initials>RN</Initials><AffiliationInfo><Affiliation>Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta T2N4N1, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Koh</LastName><ForeName>Sang Seok</ForeName><Initials>SS</Initials><AffiliationInfo><Affiliation>Immunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology, and Department of Functional Genomics, University of Science and Technology, Daejeon 305-333, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Assavalapsakul</LastName><ForeName>Wanchai</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Department of Microbiology, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chung</LastName><ForeName>Young-Hwa</ForeName><Initials>YH</Initials><AffiliationInfo><Affiliation>BK21+, Department of Cogno-Mechatronics Engineering, Pusan National University, Busan 609-735, Republic of Korea.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>02</Month><Day>11</Day></ArticleDate></Article><MedlineJournalInfo><Country>Greece</Country><MedlineTA>Int J Oncol</MedlineTA><NlmUniqueID>9306042</NlmUniqueID><ISSNLinking>1019-6439</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C434003">3-(4-methylphenylsulfonyl)-2-propenenitrile</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C513055">ABCB1 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018435">ATP Binding Cassette Transporter, Subfamily B</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000970">Antineoplastic Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D051017">Apoptosis Regulatory Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C491997">BECN1 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000071186">Beclin-1</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D003374">Coumarins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005663">Furans</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D006027">Glycosides</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C412617">KLHL1 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008565">Membrane Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008840">Microfilament Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D009570">Nitriles</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C498143">RELA protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D034741">RNA, Small Interfering</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D013450">Sulfones</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D051996">Transcription Factor RelA</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C533509">feronielloside</NameOfSubstance></Chemical><Chemical><RegistryNumber>6PLQ3CP4P3</RegistryNumber><NameOfSubstance UI="D005047">Etoposide</NameOfSubstance></Chemical><Chemical><RegistryNumber>W36ZG6FT64</RegistryNumber><NameOfSubstance UI="D020123">Sirolimus</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D018435" MajorTopicYN="N">ATP Binding Cassette Transporter, Subfamily B</DescriptorName><QualifierName UI="Q000096" MajorTopicYN="N">biosynthesis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000970" MajorTopicYN="N">Antineoplastic Agents</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017209" MajorTopicYN="N">Apoptosis</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000235" 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MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051996" MajorTopicYN="N">Transcription Factor RelA</DescriptorName><QualifierName UI="Q000037" MajorTopicYN="N">antagonists & inhibitors</QualifierName><QualifierName UI="Q000096" MajorTopicYN="Y">biosynthesis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014158" MajorTopicYN="N">Transcription, Genetic</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2013</Year><Month>11</Month><Day>27</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2014</Year><Month>01</Month><Day>30</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>2</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>2</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>12</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">24535083</ArticleId><ArticleId IdType="doi">10.3892/ijo.2014.2297</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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