Nontypeable Haemophilus influenzae (NTHi) directly interfere with the regulation of E-cadherin in lung epithelial cells.
Identifieur interne : 000752 ( Main/Corpus ); précédent : 000751; suivant : 000753Nontypeable Haemophilus influenzae (NTHi) directly interfere with the regulation of E-cadherin in lung epithelial cells.
Auteurs : Inga Kaufhold ; Sünja Osbahr ; Kensuke Shima ; Sebastian Marwitz ; Kristina Rohmann ; Daniel Drömann ; Torsten Goldmann ; Klaus Dalhoff ; Jan RuppSource :
- Microbes and infection [ 1769-714X ] ; 2017.
English descriptors
- KwdEn :
- A549 Cells (microbiology), Blotting, Western (MeSH), Cadherins (metabolism), Fibroblast Growth Factor 2 (metabolism), Haemophilus Infections (metabolism), Haemophilus Infections (microbiology), Haemophilus influenzae (MeSH), Humans (MeSH), Lung (microbiology), Microscopy, Fluorescence (MeSH), Real-Time Polymerase Chain Reaction (MeSH), Respiratory Mucosa (microbiology), Zonula Occludens-1 Protein (metabolism).
- MESH :
- chemical , metabolism : Cadherins, Fibroblast Growth Factor 2, Zonula Occludens-1 Protein.
- metabolism : Haemophilus Infections.
- microbiology : A549 Cells, Haemophilus Infections, Lung, Respiratory Mucosa.
- Blotting, Western, Haemophilus influenzae, Humans, Microscopy, Fluorescence, Real-Time Polymerase Chain Reaction.
Abstract
Loss of epithelial barriers characterized by reduction of E-cadherin is a hallmark of chronic obstructive pulmonary disease (COPD). We investigated the effects of nontypeable Haemophilus influenzae (NTHi) infections, associated with acute exacerbations of chronic bronchitis, on the regulation of E-cadherin in host cells. NTHi infection decreased E-cadherin mRNA and protein-levels in lung epithelial cells. E-cadherin reduction was mediated by activation of the fibroblast growth factor 2 (FGF2), the mammalian target of rapamycin (mTOR) and Slug. These data indicate that epithelial integrity and barrier function is disturbed by NTHi infection. Mainly, the destruction of cell-cell contacts is a prominent feature in NTHi infection.
DOI: 10.1016/j.micinf.2017.07.002
PubMed: 28802586
Links to Exploration step
pubmed:28802586Le document en format XML
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Electronic address: inga.kaufhold@uksh.de.</nlm:affiliation></affiliation></author><author><name sortKey="Osbahr, Sunja" sort="Osbahr, Sunja" uniqKey="Osbahr S" first="Sünja" last="Osbahr">Sünja Osbahr</name><affiliation><nlm:affiliation>Department of Infectious Diseases and Microbiology, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Shima, Kensuke" sort="Shima, Kensuke" uniqKey="Shima K" first="Kensuke" last="Shima">Kensuke Shima</name><affiliation><nlm:affiliation>Department of Infectious Diseases and Microbiology, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Marwitz, Sebastian" sort="Marwitz, Sebastian" uniqKey="Marwitz S" first="Sebastian" last="Marwitz">Sebastian Marwitz</name><affiliation><nlm:affiliation>Clinical and Experimental Pathology, Research Center Borstel, Parkallee 1-40, 23845 Borstel, Germany; Airway Research Center North (ARCN), German Center for Lung Research, Wöhrendamm 80, 22927 Groβhansdorf, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Rohmann, Kristina" sort="Rohmann, Kristina" uniqKey="Rohmann K" first="Kristina" last="Rohmann">Kristina Rohmann</name><affiliation><nlm:affiliation>Medical Clinic III, University Hospital Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Dromann, Daniel" sort="Dromann, Daniel" uniqKey="Dromann D" first="Daniel" last="Drömann">Daniel Drömann</name><affiliation><nlm:affiliation>Medical Clinic III, University Hospital Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany; Airway Research Center North (ARCN), German Center for Lung Research, Wöhrendamm 80, 22927 Groβhansdorf, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Goldmann, Torsten" sort="Goldmann, Torsten" uniqKey="Goldmann T" first="Torsten" last="Goldmann">Torsten Goldmann</name><affiliation><nlm:affiliation>Clinical and Experimental Pathology, Research Center Borstel, Parkallee 1-40, 23845 Borstel, Germany; Airway Research Center North (ARCN), German Center for Lung Research, Wöhrendamm 80, 22927 Groβhansdorf, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Dalhoff, Klaus" sort="Dalhoff, Klaus" uniqKey="Dalhoff K" first="Klaus" last="Dalhoff">Klaus Dalhoff</name><affiliation><nlm:affiliation>Medical Clinic III, University Hospital Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany; Airway Research Center North (ARCN), German Center for Lung Research, Wöhrendamm 80, 22927 Groβhansdorf, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Rupp, Jan" sort="Rupp, Jan" uniqKey="Rupp J" first="Jan" last="Rupp">Jan Rupp</name><affiliation><nlm:affiliation>Department of Infectious Diseases and Microbiology, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28802586</idno><idno type="pmid">28802586</idno><idno type="doi">10.1016/j.micinf.2017.07.002</idno><idno type="wicri:Area/Main/Corpus">000752</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000752</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Nontypeable Haemophilus influenzae (NTHi) directly interfere with the regulation of E-cadherin in lung epithelial cells.</title><author><name sortKey="Kaufhold, Inga" sort="Kaufhold, Inga" uniqKey="Kaufhold I" first="Inga" last="Kaufhold">Inga Kaufhold</name><affiliation><nlm:affiliation>Department of Infectious Diseases and Microbiology, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany. Electronic address: inga.kaufhold@uksh.de.</nlm:affiliation></affiliation></author><author><name sortKey="Osbahr, Sunja" sort="Osbahr, Sunja" uniqKey="Osbahr S" first="Sünja" last="Osbahr">Sünja Osbahr</name><affiliation><nlm:affiliation>Department of Infectious Diseases and Microbiology, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Shima, Kensuke" sort="Shima, Kensuke" uniqKey="Shima K" first="Kensuke" last="Shima">Kensuke Shima</name><affiliation><nlm:affiliation>Department of Infectious Diseases and Microbiology, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Marwitz, Sebastian" sort="Marwitz, Sebastian" uniqKey="Marwitz S" first="Sebastian" last="Marwitz">Sebastian Marwitz</name><affiliation><nlm:affiliation>Clinical and Experimental Pathology, Research Center Borstel, Parkallee 1-40, 23845 Borstel, Germany; Airway Research Center North (ARCN), German Center for Lung Research, Wöhrendamm 80, 22927 Groβhansdorf, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Rohmann, Kristina" sort="Rohmann, Kristina" uniqKey="Rohmann K" first="Kristina" last="Rohmann">Kristina Rohmann</name><affiliation><nlm:affiliation>Medical Clinic III, University Hospital Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Dromann, Daniel" sort="Dromann, Daniel" uniqKey="Dromann D" first="Daniel" last="Drömann">Daniel Drömann</name><affiliation><nlm:affiliation>Medical Clinic III, University Hospital Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany; Airway Research Center North (ARCN), German Center for Lung Research, Wöhrendamm 80, 22927 Groβhansdorf, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Goldmann, Torsten" sort="Goldmann, Torsten" uniqKey="Goldmann T" first="Torsten" last="Goldmann">Torsten Goldmann</name><affiliation><nlm:affiliation>Clinical and Experimental Pathology, Research Center Borstel, Parkallee 1-40, 23845 Borstel, Germany; Airway Research Center North (ARCN), German Center for Lung Research, Wöhrendamm 80, 22927 Groβhansdorf, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Dalhoff, Klaus" sort="Dalhoff, Klaus" uniqKey="Dalhoff K" first="Klaus" last="Dalhoff">Klaus Dalhoff</name><affiliation><nlm:affiliation>Medical Clinic III, University Hospital Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany; Airway Research Center North (ARCN), German Center for Lung Research, Wöhrendamm 80, 22927 Groβhansdorf, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Rupp, Jan" sort="Rupp, Jan" uniqKey="Rupp J" first="Jan" last="Rupp">Jan Rupp</name><affiliation><nlm:affiliation>Department of Infectious Diseases and Microbiology, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Microbes and infection</title><idno type="eISSN">1769-714X</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>A549 Cells (microbiology)</term><term>Blotting, Western (MeSH)</term><term>Cadherins (metabolism)</term><term>Fibroblast Growth Factor 2 (metabolism)</term><term>Haemophilus Infections (metabolism)</term><term>Haemophilus Infections (microbiology)</term><term>Haemophilus influenzae (MeSH)</term><term>Humans (MeSH)</term><term>Lung (microbiology)</term><term>Microscopy, Fluorescence (MeSH)</term><term>Real-Time Polymerase Chain Reaction (MeSH)</term><term>Respiratory Mucosa (microbiology)</term><term>Zonula Occludens-1 Protein (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cadherins</term><term>Fibroblast Growth Factor 2</term><term>Zonula Occludens-1 Protein</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Haemophilus Infections</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>A549 Cells</term><term>Haemophilus Infections</term><term>Lung</term><term>Respiratory Mucosa</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Blotting, Western</term><term>Haemophilus influenzae</term><term>Humans</term><term>Microscopy, Fluorescence</term><term>Real-Time Polymerase Chain Reaction</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Loss of epithelial barriers characterized by reduction of E-cadherin is a hallmark of chronic obstructive pulmonary disease (COPD). We investigated the effects of nontypeable Haemophilus influenzae (NTHi) infections, associated with acute exacerbations of chronic bronchitis, on the regulation of E-cadherin in host cells. NTHi infection decreased E-cadherin mRNA and protein-levels in lung epithelial cells. E-cadherin reduction was mediated by activation of the fibroblast growth factor 2 (FGF2), the mammalian target of rapamycin (mTOR) and Slug. These data indicate that epithelial integrity and barrier function is disturbed by NTHi infection. Mainly, the destruction of cell-cell contacts is a prominent feature in NTHi infection.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">28802586</PMID><DateCompleted><Year>2018</Year><Month>06</Month><Day>14</Day></DateCompleted><DateRevised><Year>2018</Year><Month>08</Month><Day>08</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1769-714X</ISSN><JournalIssue CitedMedium="Internet"><Volume>19</Volume><Issue>11</Issue><PubDate><Year>2017</Year><Month>11</Month></PubDate></JournalIssue><Title>Microbes and infection</Title><ISOAbbreviation>Microbes Infect</ISOAbbreviation></Journal><ArticleTitle>Nontypeable Haemophilus influenzae (NTHi) directly interfere with the regulation of E-cadherin in lung epithelial cells.</ArticleTitle><Pagination><MedlinePgn>560-566</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S1286-4579(17)30116-8</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.micinf.2017.07.002</ELocationID><Abstract><AbstractText>Loss of epithelial barriers characterized by reduction of E-cadherin is a hallmark of chronic obstructive pulmonary disease (COPD). We investigated the effects of nontypeable Haemophilus influenzae (NTHi) infections, associated with acute exacerbations of chronic bronchitis, on the regulation of E-cadherin in host cells. NTHi infection decreased E-cadherin mRNA and protein-levels in lung epithelial cells. E-cadherin reduction was mediated by activation of the fibroblast growth factor 2 (FGF2), the mammalian target of rapamycin (mTOR) and Slug. These data indicate that epithelial integrity and barrier function is disturbed by NTHi infection. Mainly, the destruction of cell-cell contacts is a prominent feature in NTHi infection.</AbstractText><CopyrightInformation>Copyright © 2017 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kaufhold</LastName><ForeName>Inga</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Department of Infectious Diseases and Microbiology, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany. Electronic address: inga.kaufhold@uksh.de.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Osbahr</LastName><ForeName>Sünja</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Infectious Diseases and Microbiology, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shima</LastName><ForeName>Kensuke</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Infectious Diseases and Microbiology, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marwitz</LastName><ForeName>Sebastian</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Clinical and Experimental Pathology, Research Center Borstel, Parkallee 1-40, 23845 Borstel, Germany; Airway Research Center North (ARCN), German Center for Lung Research, Wöhrendamm 80, 22927 Groβhansdorf, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rohmann</LastName><ForeName>Kristina</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Medical Clinic III, University Hospital Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Drömann</LastName><ForeName>Daniel</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Medical Clinic III, University Hospital Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany; Airway Research Center North (ARCN), German Center for Lung Research, Wöhrendamm 80, 22927 Groβhansdorf, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Goldmann</LastName><ForeName>Torsten</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Clinical and Experimental Pathology, Research Center Borstel, Parkallee 1-40, 23845 Borstel, Germany; Airway Research Center North (ARCN), German Center for Lung Research, Wöhrendamm 80, 22927 Groβhansdorf, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dalhoff</LastName><ForeName>Klaus</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Medical Clinic III, University Hospital Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany; Airway Research Center North (ARCN), German Center for Lung Research, Wöhrendamm 80, 22927 Groβhansdorf, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rupp</LastName><ForeName>Jan</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Infectious Diseases and Microbiology, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>08</Month><Day>10</Day></ArticleDate></Article><MedlineJournalInfo><Country>France</Country><MedlineTA>Microbes Infect</MedlineTA><NlmUniqueID>100883508</NlmUniqueID><ISSNLinking>1286-4579</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015820">Cadherins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D062826">Zonula Occludens-1 Protein</NameOfSubstance></Chemical><Chemical><RegistryNumber>103107-01-3</RegistryNumber><NameOfSubstance UI="D016222">Fibroblast Growth Factor 2</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000072283" MajorTopicYN="N">A549 Cells</DescriptorName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015153" MajorTopicYN="N">Blotting, Western</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015820" MajorTopicYN="N">Cadherins</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016222" MajorTopicYN="N">Fibroblast Growth Factor 2</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006192" MajorTopicYN="N">Haemophilus Infections</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006193" MajorTopicYN="Y">Haemophilus influenzae</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008168" MajorTopicYN="N">Lung</DescriptorName><QualifierName UI="Q000382" MajorTopicYN="Y">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008856" MajorTopicYN="N">Microscopy, Fluorescence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D060888" MajorTopicYN="N">Real-Time Polymerase Chain Reaction</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020545" MajorTopicYN="N">Respiratory Mucosa</DescriptorName><QualifierName UI="Q000382" MajorTopicYN="Y">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D062826" MajorTopicYN="N">Zonula Occludens-1 Protein</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">COPD</Keyword><Keyword MajorTopicYN="Y">E-cadherin</Keyword><Keyword MajorTopicYN="Y">Nontypeable Haemophilus influenzae</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year><Month>05</Month><Day>08</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2017</Year><Month>07</Month><Day>28</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>07</Month><Day>31</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>8</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2018</Year><Month>6</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>8</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28802586</ArticleId><ArticleId IdType="pii">S1286-4579(17)30116-8</ArticleId><ArticleId IdType="doi">10.1016/j.micinf.2017.07.002</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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