MoSnt2-dependent deacetylation of histone H3 mediates MoTor-dependent autophagy and plant infection by the rice blast fungus Magnaporthe oryzae.
Identifieur interne : 000522 ( Main/Corpus ); précédent : 000521; suivant : 000523MoSnt2-dependent deacetylation of histone H3 mediates MoTor-dependent autophagy and plant infection by the rice blast fungus Magnaporthe oryzae.
Auteurs : Min He ; Youpin Xu ; Jinhua Chen ; Yuan Luo ; Yang Lv ; Jia Su ; Michael J. Kershaw ; Weitao Li ; Jing Wang ; Junjie Yin ; Xiaobo Zhu ; Xiaohong Liu ; Mawsheng Chern ; Bingtian Ma ; Jichun Wang ; Peng Qin ; Weilan Chen ; Yuping Wang ; Wenming Wang ; Zhenglong Ren ; Xianjun Wu ; Ping Li ; Shigui Li ; Youliang Peng ; Fucheng Lin ; Nicholas J. Talbot ; Xuewei ChenSource :
- Autophagy [ 1554-8635 ] ; 2018.
English descriptors
- KwdEn :
- Acetylation (MeSH), Autophagy (drug effects), Autophagy (genetics), Cell Wall (drug effects), Cell Wall (metabolism), Epigenesis, Genetic (drug effects), Fungal Proteins (genetics), Fungal Proteins (metabolism), Gene Deletion (MeSH), Gene Expression Regulation, Fungal (drug effects), Histone Deacetylases (metabolism), Histones (metabolism), Magnaporthe (drug effects), Magnaporthe (genetics), Magnaporthe (growth & development), Magnaporthe (pathogenicity), Models, Biological (MeSH), Oryza (microbiology), Oxidative Stress (drug effects), Oxidative Stress (genetics), Plant Diseases (microbiology), Protein Binding (drug effects), Signal Transduction (drug effects), Sirolimus (pharmacology).
- MESH :
- chemical , genetics : Fungal Proteins.
- drug effects : Autophagy, Cell Wall, Epigenesis, Genetic, Gene Expression Regulation, Fungal, Magnaporthe, Oxidative Stress, Protein Binding, Signal Transduction.
- genetics : Autophagy, Magnaporthe, Oxidative Stress.
- growth & development : Magnaporthe.
- metabolism : Cell Wall, Fungal Proteins, Histone Deacetylases, Histones.
- microbiology : Oryza, Plant Diseases.
- pathogenicity : Magnaporthe.
- chemical , pharmacology : Sirolimus.
- Acetylation, Gene Deletion, Models, Biological.
Abstract
Autophagy is essential for appressorium-mediated plant infection by Magnaporthe oryzae, the causal agent of rice blast disease and a major threat to global food security. The regulatory mechanism of pathogenicity-associated autophagy, however, remains largely unknown. Here, we report the identification and functional characterization of a plausible ortholog of yeast SNT2 in M. oryzae, which we term MoSNT2. Deletion mutants of MoSNT2 are compromised in autophagy homeostasis and display severe defects in autophagy-dependent fungal cell death and pathogenicity. These mutants are also impaired in infection structure development, conidiation, oxidative stress tolerance and cell wall integrity. MoSnt2 recognizes histone H3 acetylation through its PHD1 domain and thereby recruits the histone deacetylase complex, resulting in deacetylation of H3. MoSnt2 binds to promoters of autophagy genes MoATG6, 15, 16, and 22 to regulate their expression. In addition, MoTor controls MoSNT2 expression to regulate MoTor signaling which leads to autophagy and rice infection. Our study provides evidence of a direct link between MoSnt2 and MoTor signaling and defines a novel epigenetic mechanism by which MoSNT2 regulates infection-associated autophagy and plant infection by the rice blast fungus.
ABBREVIATIONS
M. oryzae: Magnaporthe oryzae; S. cerevisiae: Saccharomyces cerevisiae; F. oxysporum: Fusarium oxysporum; U. maydis: Ustilago maydis; Compl.: complemented strains of ΔMosnt2 expressing MoSNT2-GFP; ATG: autophagy-related; HDAC: histone deacetylase complex; Tor: target of rapamycin kinase; MTOR: mechanistic target of rapamycin kinase in mammals; MoSnt2: DNA binding SaNT domain protein in M. oryzae; MoTor: target of rapamycin kinase in M. oryzae; MoAtg8: autophagy-related protein 8 in M. oryzae; MoHos2: hda one similar protein in M. oryzae; MoeIf4G: eukaryotic translation initiation factor 4 G in M. oryzae; MoRs2: ribosomal protein S2 in M. oryzae; MoRs3: ribosomal protein S3 in M. oryzae; MoIcl1: isocitrate lyase in M. oryzae; MoSet1: histone H3K4 methyltransferase in M. oryzae; Asd4: ascus development 4; Abl1: AMP-activated protein kinase β subunit-like protein; Tig1: TBL1-like gene required for invasive growth; Rpd3: reduced potassium dependency; KAT8: lysine (K) acetyltransferase 8; PHD: plant homeodomain; ELM2: Egl-27 and MTA1 homology 2; GFP: green fluorescent protein; YFP: yellow fluorescent protein; YFP
DOI: 10.1080/15548627.2018.1458171
PubMed: 29929416
PubMed Central: PMC6135590
Links to Exploration step
pubmed:29929416Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">MoSnt2-dependent deacetylation of histone H3 mediates MoTor-dependent autophagy and plant infection by the rice blast fungus Magnaporthe oryzae.</title><author><name sortKey="He, Min" sort="He, Min" uniqKey="He M" first="Min" last="He">Min He</name><affiliation><nlm:affiliation>a State Key Laboratory of Hybrid Rice, Key Laboratory of Major Crop Diseases & Collaborative Innovation Center for Hybrid Rice in Yangtze River Basin, Rice Research Institute , Sichuan Agricultural University , Chengdu , China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>b School of Biosciences , University of Exeter , Exeter , UK.</nlm:affiliation></affiliation></author><author><name sortKey="Xu, Youpin" sort="Xu, Youpin" uniqKey="Xu Y" first="Youpin" last="Xu">Youpin Xu</name><affiliation><nlm:affiliation>a State Key Laboratory of Hybrid Rice, Key Laboratory of Major Crop Diseases & Collaborative Innovation Center for Hybrid Rice in Yangtze River Basin, Rice Research Institute , Sichuan Agricultural University , Chengdu , China.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, Jinhua" sort="Chen, Jinhua" uniqKey="Chen J" first="Jinhua" last="Chen">Jinhua Chen</name><affiliation><nlm:affiliation>a State Key Laboratory of Hybrid Rice, Key Laboratory of Major Crop Diseases & Collaborative Innovation Center for Hybrid Rice in Yangtze River Basin, Rice Research Institute , Sichuan Agricultural University , Chengdu , China.</nlm:affiliation></affiliation></author><author><name sortKey="Luo, Yuan" sort="Luo, Yuan" uniqKey="Luo Y" first="Yuan" last="Luo">Yuan Luo</name><affiliation><nlm:affiliation>a State Key Laboratory of Hybrid Rice, Key Laboratory of Major Crop Diseases & Collaborative Innovation Center for Hybrid Rice in Yangtze River Basin, Rice Research Institute , Sichuan Agricultural University , Chengdu , China.</nlm:affiliation></affiliation></author><author><name sortKey="Lv, Yang" sort="Lv, Yang" uniqKey="Lv Y" first="Yang" last="Lv">Yang Lv</name><affiliation><nlm:affiliation>a State Key Laboratory of Hybrid Rice, Key Laboratory of Major Crop Diseases & Collaborative Innovation Center for Hybrid Rice in Yangtze River Basin, Rice Research Institute , Sichuan Agricultural University , Chengdu , China.</nlm:affiliation></affiliation></author><author><name sortKey="Su, Jia" sort="Su, Jia" uniqKey="Su J" first="Jia" last="Su">Jia Su</name><affiliation><nlm:affiliation>a State Key Laboratory of Hybrid Rice, Key Laboratory of Major Crop Diseases & Collaborative Innovation Center for Hybrid Rice in Yangtze River Basin, Rice Research Institute , Sichuan Agricultural University , Chengdu , China.</nlm:affiliation></affiliation></author><author><name sortKey="Kershaw, Michael J" sort="Kershaw, Michael J" uniqKey="Kershaw M" first="Michael J" last="Kershaw">Michael J. Kershaw</name><affiliation><nlm:affiliation>b School of Biosciences , University of Exeter , Exeter , UK.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Weitao" sort="Li, Weitao" uniqKey="Li W" first="Weitao" last="Li">Weitao Li</name><affiliation><nlm:affiliation>a State Key Laboratory of Hybrid Rice, Key Laboratory of Major Crop Diseases & Collaborative Innovation Center for Hybrid Rice in Yangtze River Basin, Rice Research Institute , Sichuan Agricultural University , Chengdu , China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Jing" sort="Wang, Jing" uniqKey="Wang J" first="Jing" last="Wang">Jing Wang</name><affiliation><nlm:affiliation>a State Key Laboratory of Hybrid Rice, Key Laboratory of Major Crop Diseases & Collaborative Innovation Center for Hybrid Rice in Yangtze River Basin, Rice Research Institute , Sichuan Agricultural University , Chengdu , China.</nlm:affiliation></affiliation></author><author><name sortKey="Yin, Junjie" sort="Yin, Junjie" uniqKey="Yin J" first="Junjie" last="Yin">Junjie Yin</name><affiliation><nlm:affiliation>a State Key Laboratory of Hybrid Rice, Key Laboratory of Major Crop Diseases & Collaborative Innovation Center for Hybrid Rice in Yangtze River Basin, Rice Research Institute , Sichuan Agricultural University , Chengdu , China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhu, Xiaobo" sort="Zhu, Xiaobo" uniqKey="Zhu X" first="Xiaobo" last="Zhu">Xiaobo Zhu</name><affiliation><nlm:affiliation>a State Key Laboratory of Hybrid Rice, Key Laboratory of Major Crop Diseases & Collaborative Innovation Center for Hybrid Rice in Yangtze River Basin, Rice Research Institute , Sichuan Agricultural University , Chengdu , China.</nlm:affiliation></affiliation></author><author><name sortKey="Liu, Xiaohong" sort="Liu, Xiaohong" uniqKey="Liu X" first="Xiaohong" last="Liu">Xiaohong Liu</name><affiliation><nlm:affiliation>c State Key Laboratory for Rice Biology, Biotechnology Institute , Zhejiang University , Hangzhou , China.</nlm:affiliation></affiliation></author><author><name sortKey="Chern, Mawsheng" sort="Chern, Mawsheng" uniqKey="Chern M" first="Mawsheng" last="Chern">Mawsheng Chern</name><affiliation><nlm:affiliation>d Department of Plant Pathology , University of California , Davis , CA , USA.</nlm:affiliation></affiliation></author><author><name sortKey="Ma, Bingtian" sort="Ma, Bingtian" uniqKey="Ma B" first="Bingtian" last="Ma">Bingtian Ma</name><affiliation><nlm:affiliation>a State Key Laboratory of Hybrid Rice, Key Laboratory of Major Crop Diseases & Collaborative Innovation Center for Hybrid Rice in Yangtze River Basin, Rice Research Institute , Sichuan Agricultural University , Chengdu , China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Jichun" sort="Wang, Jichun" uniqKey="Wang J" first="Jichun" last="Wang">Jichun Wang</name><affiliation><nlm:affiliation>a State Key Laboratory of Hybrid Rice, Key Laboratory of Major Crop Diseases & Collaborative Innovation Center for Hybrid Rice in Yangtze River Basin, Rice Research Institute , Sichuan Agricultural University , Chengdu , China.</nlm:affiliation></affiliation></author><author><name sortKey="Qin, Peng" sort="Qin, Peng" uniqKey="Qin P" first="Peng" last="Qin">Peng Qin</name><affiliation><nlm:affiliation>a State Key Laboratory of Hybrid Rice, Key Laboratory of Major Crop Diseases & Collaborative Innovation Center for Hybrid Rice in Yangtze River Basin, Rice Research Institute , Sichuan Agricultural University , Chengdu , China.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, Weilan" sort="Chen, Weilan" uniqKey="Chen W" first="Weilan" last="Chen">Weilan Chen</name><affiliation><nlm:affiliation>a State Key Laboratory of Hybrid Rice, Key Laboratory of Major Crop Diseases & Collaborative Innovation Center for Hybrid Rice in Yangtze River Basin, Rice Research Institute , Sichuan Agricultural University , Chengdu , China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Yuping" sort="Wang, Yuping" uniqKey="Wang Y" first="Yuping" last="Wang">Yuping Wang</name><affiliation><nlm:affiliation>a State Key Laboratory of Hybrid Rice, Key Laboratory of Major Crop Diseases & Collaborative Innovation Center for Hybrid Rice in Yangtze River Basin, Rice Research Institute , Sichuan Agricultural University , Chengdu , China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Wenming" sort="Wang, Wenming" uniqKey="Wang W" first="Wenming" last="Wang">Wenming Wang</name><affiliation><nlm:affiliation>a State Key Laboratory of Hybrid Rice, Key Laboratory of Major Crop Diseases & Collaborative Innovation Center for Hybrid Rice in Yangtze River Basin, Rice Research Institute , Sichuan Agricultural University , Chengdu , China.</nlm:affiliation></affiliation></author><author><name sortKey="Ren, Zhenglong" sort="Ren, Zhenglong" uniqKey="Ren Z" first="Zhenglong" last="Ren">Zhenglong Ren</name><affiliation><nlm:affiliation>a State Key Laboratory of Hybrid Rice, Key Laboratory of Major Crop Diseases & Collaborative Innovation Center for Hybrid Rice in Yangtze River Basin, Rice Research Institute , Sichuan Agricultural University , Chengdu , China.</nlm:affiliation></affiliation></author><author><name sortKey="Wu, Xianjun" sort="Wu, Xianjun" uniqKey="Wu X" first="Xianjun" last="Wu">Xianjun Wu</name><affiliation><nlm:affiliation>a State Key Laboratory of Hybrid Rice, Key Laboratory of Major Crop Diseases & Collaborative Innovation Center for Hybrid Rice in Yangtze River Basin, Rice Research Institute , Sichuan Agricultural University , Chengdu , China.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Ping" sort="Li, Ping" uniqKey="Li P" first="Ping" last="Li">Ping Li</name><affiliation><nlm:affiliation>a State Key Laboratory of Hybrid Rice, Key Laboratory of Major Crop Diseases & Collaborative Innovation Center for Hybrid Rice in Yangtze River Basin, Rice Research Institute , Sichuan Agricultural University , Chengdu , China.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Shigui" sort="Li, Shigui" uniqKey="Li S" first="Shigui" last="Li">Shigui Li</name><affiliation><nlm:affiliation>a State Key Laboratory of Hybrid Rice, Key Laboratory of Major Crop Diseases & Collaborative Innovation Center for Hybrid Rice in Yangtze River Basin, Rice Research Institute , Sichuan Agricultural University , Chengdu , China.</nlm:affiliation></affiliation></author><author><name sortKey="Peng, Youliang" sort="Peng, Youliang" uniqKey="Peng Y" first="Youliang" last="Peng">Youliang Peng</name><affiliation><nlm:affiliation>e State Key Laboratory of Agrobiotechnology and MOA, Key Laboratory of Plant Pathology , China Agricultural University , Beijing , China.</nlm:affiliation></affiliation></author><author><name sortKey="Lin, Fucheng" sort="Lin, Fucheng" uniqKey="Lin F" first="Fucheng" last="Lin">Fucheng Lin</name><affiliation><nlm:affiliation>c State Key Laboratory for Rice Biology, Biotechnology Institute , Zhejiang University , Hangzhou , China.</nlm:affiliation></affiliation></author><author><name sortKey="Talbot, Nicholas J" sort="Talbot, Nicholas J" uniqKey="Talbot N" first="Nicholas J" last="Talbot">Nicholas J. Talbot</name><affiliation><nlm:affiliation>b School of Biosciences , University of Exeter , Exeter , UK.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, Xuewei" sort="Chen, Xuewei" uniqKey="Chen X" first="Xuewei" last="Chen">Xuewei Chen</name><affiliation><nlm:affiliation>a State Key Laboratory of Hybrid Rice, Key Laboratory of Major Crop Diseases & Collaborative Innovation Center for Hybrid Rice in Yangtze River Basin, Rice Research Institute , Sichuan Agricultural University , Chengdu , China.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2018">2018</date><idno type="RBID">pubmed:29929416</idno><idno type="pmid">29929416</idno><idno type="doi">10.1080/15548627.2018.1458171</idno><idno type="pmc">PMC6135590</idno><idno type="wicri:Area/Main/Corpus">000522</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000522</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">MoSnt2-dependent deacetylation of histone H3 mediates MoTor-dependent autophagy and plant infection by the rice blast fungus Magnaporthe oryzae.</title><author><name sortKey="He, Min" sort="He, Min" uniqKey="He M" first="Min" last="He">Min He</name><affiliation><nlm:affiliation>a State Key Laboratory of Hybrid Rice, Key Laboratory of Major Crop Diseases & Collaborative Innovation Center for Hybrid Rice in Yangtze River Basin, Rice Research Institute , Sichuan Agricultural University , Chengdu , China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>b School of Biosciences , University of Exeter , Exeter , UK.</nlm:affiliation></affiliation></author><author><name sortKey="Xu, Youpin" sort="Xu, Youpin" uniqKey="Xu Y" first="Youpin" last="Xu">Youpin Xu</name><affiliation><nlm:affiliation>a State Key Laboratory of Hybrid Rice, Key Laboratory of Major Crop Diseases & Collaborative Innovation Center for Hybrid Rice in Yangtze River Basin, Rice Research Institute , Sichuan Agricultural University , Chengdu , China.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, Jinhua" sort="Chen, Jinhua" uniqKey="Chen J" first="Jinhua" last="Chen">Jinhua Chen</name><affiliation><nlm:affiliation>a State Key Laboratory of Hybrid Rice, Key Laboratory of Major Crop Diseases & Collaborative Innovation Center for Hybrid Rice in Yangtze River Basin, Rice Research Institute , Sichuan Agricultural University , Chengdu , China.</nlm:affiliation></affiliation></author><author><name sortKey="Luo, Yuan" sort="Luo, Yuan" uniqKey="Luo Y" first="Yuan" last="Luo">Yuan Luo</name><affiliation><nlm:affiliation>a State Key Laboratory of Hybrid Rice, Key Laboratory of Major Crop Diseases & Collaborative Innovation Center for Hybrid Rice in Yangtze River Basin, Rice Research Institute , Sichuan Agricultural University , Chengdu , China.</nlm:affiliation></affiliation></author><author><name sortKey="Lv, Yang" sort="Lv, Yang" uniqKey="Lv Y" first="Yang" last="Lv">Yang Lv</name><affiliation><nlm:affiliation>a State Key Laboratory of Hybrid Rice, Key Laboratory of Major Crop Diseases & Collaborative Innovation Center for Hybrid Rice in Yangtze River Basin, Rice Research Institute , Sichuan Agricultural University , Chengdu , China.</nlm:affiliation></affiliation></author><author><name sortKey="Su, Jia" sort="Su, Jia" uniqKey="Su J" first="Jia" last="Su">Jia Su</name><affiliation><nlm:affiliation>a State Key Laboratory of Hybrid Rice, Key Laboratory of Major Crop Diseases & Collaborative Innovation Center for Hybrid Rice in Yangtze River Basin, Rice Research Institute , Sichuan Agricultural University , Chengdu , China.</nlm:affiliation></affiliation></author><author><name sortKey="Kershaw, Michael J" sort="Kershaw, Michael J" uniqKey="Kershaw M" first="Michael J" last="Kershaw">Michael J. Kershaw</name><affiliation><nlm:affiliation>b School of Biosciences , University of Exeter , Exeter , UK.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Weitao" sort="Li, Weitao" uniqKey="Li W" first="Weitao" last="Li">Weitao Li</name><affiliation><nlm:affiliation>a State Key Laboratory of Hybrid Rice, Key Laboratory of Major Crop Diseases & Collaborative Innovation Center for Hybrid Rice in Yangtze River Basin, Rice Research Institute , Sichuan Agricultural University , Chengdu , China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Jing" sort="Wang, Jing" uniqKey="Wang J" first="Jing" last="Wang">Jing Wang</name><affiliation><nlm:affiliation>a State Key Laboratory of Hybrid Rice, Key Laboratory of Major Crop Diseases & Collaborative Innovation Center for Hybrid Rice in Yangtze River Basin, Rice Research Institute , Sichuan Agricultural University , Chengdu , China.</nlm:affiliation></affiliation></author><author><name sortKey="Yin, Junjie" sort="Yin, Junjie" uniqKey="Yin J" first="Junjie" last="Yin">Junjie Yin</name><affiliation><nlm:affiliation>a State Key Laboratory of Hybrid Rice, Key Laboratory of Major Crop Diseases & Collaborative Innovation Center for Hybrid Rice in Yangtze River Basin, Rice Research Institute , Sichuan Agricultural University , Chengdu , China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhu, Xiaobo" sort="Zhu, Xiaobo" uniqKey="Zhu X" first="Xiaobo" last="Zhu">Xiaobo Zhu</name><affiliation><nlm:affiliation>a State Key Laboratory of Hybrid Rice, Key Laboratory of Major Crop Diseases & Collaborative Innovation Center for Hybrid Rice in Yangtze River Basin, Rice Research Institute , Sichuan Agricultural University , Chengdu , China.</nlm:affiliation></affiliation></author><author><name sortKey="Liu, Xiaohong" sort="Liu, Xiaohong" uniqKey="Liu X" first="Xiaohong" last="Liu">Xiaohong Liu</name><affiliation><nlm:affiliation>c State Key Laboratory for Rice Biology, Biotechnology Institute , Zhejiang University , Hangzhou , China.</nlm:affiliation></affiliation></author><author><name sortKey="Chern, Mawsheng" sort="Chern, Mawsheng" uniqKey="Chern M" first="Mawsheng" last="Chern">Mawsheng Chern</name><affiliation><nlm:affiliation>d Department of Plant Pathology , University of California , Davis , CA , USA.</nlm:affiliation></affiliation></author><author><name sortKey="Ma, Bingtian" sort="Ma, Bingtian" uniqKey="Ma B" first="Bingtian" last="Ma">Bingtian Ma</name><affiliation><nlm:affiliation>a State Key Laboratory of Hybrid Rice, Key Laboratory of Major Crop Diseases & Collaborative Innovation Center for Hybrid Rice in Yangtze River Basin, Rice Research Institute , Sichuan Agricultural University , Chengdu , China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Jichun" sort="Wang, Jichun" uniqKey="Wang J" first="Jichun" last="Wang">Jichun Wang</name><affiliation><nlm:affiliation>a State Key Laboratory of Hybrid Rice, Key Laboratory of Major Crop Diseases & Collaborative Innovation Center for Hybrid Rice in Yangtze River Basin, Rice Research Institute , Sichuan Agricultural University , Chengdu , China.</nlm:affiliation></affiliation></author><author><name sortKey="Qin, Peng" sort="Qin, Peng" uniqKey="Qin P" first="Peng" last="Qin">Peng Qin</name><affiliation><nlm:affiliation>a State Key Laboratory of Hybrid Rice, Key Laboratory of Major Crop Diseases & Collaborative Innovation Center for Hybrid Rice in Yangtze River Basin, Rice Research Institute , Sichuan Agricultural University , Chengdu , China.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, Weilan" sort="Chen, Weilan" uniqKey="Chen W" first="Weilan" last="Chen">Weilan Chen</name><affiliation><nlm:affiliation>a State Key Laboratory of Hybrid Rice, Key Laboratory of Major Crop Diseases & Collaborative Innovation Center for Hybrid Rice in Yangtze River Basin, Rice Research Institute , Sichuan Agricultural University , Chengdu , China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Yuping" sort="Wang, Yuping" uniqKey="Wang Y" first="Yuping" last="Wang">Yuping Wang</name><affiliation><nlm:affiliation>a State Key Laboratory of Hybrid Rice, Key Laboratory of Major Crop Diseases & Collaborative Innovation Center for Hybrid Rice in Yangtze River Basin, Rice Research Institute , Sichuan Agricultural University , Chengdu , China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Wenming" sort="Wang, Wenming" uniqKey="Wang W" first="Wenming" last="Wang">Wenming Wang</name><affiliation><nlm:affiliation>a State Key Laboratory of Hybrid Rice, Key Laboratory of Major Crop Diseases & Collaborative Innovation Center for Hybrid Rice in Yangtze River Basin, Rice Research Institute , Sichuan Agricultural University , Chengdu , China.</nlm:affiliation></affiliation></author><author><name sortKey="Ren, Zhenglong" sort="Ren, Zhenglong" uniqKey="Ren Z" first="Zhenglong" last="Ren">Zhenglong Ren</name><affiliation><nlm:affiliation>a State Key Laboratory of Hybrid Rice, Key Laboratory of Major Crop Diseases & Collaborative Innovation Center for Hybrid Rice in Yangtze River Basin, Rice Research Institute , Sichuan Agricultural University , Chengdu , China.</nlm:affiliation></affiliation></author><author><name sortKey="Wu, Xianjun" sort="Wu, Xianjun" uniqKey="Wu X" first="Xianjun" last="Wu">Xianjun Wu</name><affiliation><nlm:affiliation>a State Key Laboratory of Hybrid Rice, Key Laboratory of Major Crop Diseases & Collaborative Innovation Center for Hybrid Rice in Yangtze River Basin, Rice Research Institute , Sichuan Agricultural University , Chengdu , China.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Ping" sort="Li, Ping" uniqKey="Li P" first="Ping" last="Li">Ping Li</name><affiliation><nlm:affiliation>a State Key Laboratory of Hybrid Rice, Key Laboratory of Major Crop Diseases & Collaborative Innovation Center for Hybrid Rice in Yangtze River Basin, Rice Research Institute , Sichuan Agricultural University , Chengdu , China.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Shigui" sort="Li, Shigui" uniqKey="Li S" first="Shigui" last="Li">Shigui Li</name><affiliation><nlm:affiliation>a State Key Laboratory of Hybrid Rice, Key Laboratory of Major Crop Diseases & Collaborative Innovation Center for Hybrid Rice in Yangtze River Basin, Rice Research Institute , Sichuan Agricultural University , Chengdu , China.</nlm:affiliation></affiliation></author><author><name sortKey="Peng, Youliang" sort="Peng, Youliang" uniqKey="Peng Y" first="Youliang" last="Peng">Youliang Peng</name><affiliation><nlm:affiliation>e State Key Laboratory of Agrobiotechnology and MOA, Key Laboratory of Plant Pathology , China Agricultural University , Beijing , China.</nlm:affiliation></affiliation></author><author><name sortKey="Lin, Fucheng" sort="Lin, Fucheng" uniqKey="Lin F" first="Fucheng" last="Lin">Fucheng Lin</name><affiliation><nlm:affiliation>c State Key Laboratory for Rice Biology, Biotechnology Institute , Zhejiang University , Hangzhou , China.</nlm:affiliation></affiliation></author><author><name sortKey="Talbot, Nicholas J" sort="Talbot, Nicholas J" uniqKey="Talbot N" first="Nicholas J" last="Talbot">Nicholas J. Talbot</name><affiliation><nlm:affiliation>b School of Biosciences , University of Exeter , Exeter , UK.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, Xuewei" sort="Chen, Xuewei" uniqKey="Chen X" first="Xuewei" last="Chen">Xuewei Chen</name><affiliation><nlm:affiliation>a State Key Laboratory of Hybrid Rice, Key Laboratory of Major Crop Diseases & Collaborative Innovation Center for Hybrid Rice in Yangtze River Basin, Rice Research Institute , Sichuan Agricultural University , Chengdu , China.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Autophagy</title><idno type="eISSN">1554-8635</idno><imprint><date when="2018" type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acetylation (MeSH)</term><term>Autophagy (drug effects)</term><term>Autophagy (genetics)</term><term>Cell Wall (drug effects)</term><term>Cell Wall (metabolism)</term><term>Epigenesis, Genetic (drug effects)</term><term>Fungal Proteins (genetics)</term><term>Fungal Proteins (metabolism)</term><term>Gene Deletion (MeSH)</term><term>Gene Expression Regulation, Fungal (drug effects)</term><term>Histone Deacetylases (metabolism)</term><term>Histones (metabolism)</term><term>Magnaporthe (drug effects)</term><term>Magnaporthe (genetics)</term><term>Magnaporthe (growth & development)</term><term>Magnaporthe (pathogenicity)</term><term>Models, Biological (MeSH)</term><term>Oryza (microbiology)</term><term>Oxidative Stress (drug effects)</term><term>Oxidative Stress (genetics)</term><term>Plant Diseases (microbiology)</term><term>Protein Binding (drug effects)</term><term>Signal Transduction (drug effects)</term><term>Sirolimus (pharmacology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Fungal Proteins</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Autophagy</term><term>Cell Wall</term><term>Epigenesis, Genetic</term><term>Gene Expression Regulation, Fungal</term><term>Magnaporthe</term><term>Oxidative Stress</term><term>Protein Binding</term><term>Signal Transduction</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Autophagy</term><term>Magnaporthe</term><term>Oxidative Stress</term></keywords><keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Magnaporthe</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Cell Wall</term><term>Fungal Proteins</term><term>Histone Deacetylases</term><term>Histones</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Oryza</term><term>Plant Diseases</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Magnaporthe</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Sirolimus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Acetylation</term><term>Gene Deletion</term><term>Models, Biological</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Autophagy is essential for appressorium-mediated plant infection by Magnaporthe oryzae, the causal agent of rice blast disease and a major threat to global food security. The regulatory mechanism of pathogenicity-associated autophagy, however, remains largely unknown. Here, we report the identification and functional characterization of a plausible ortholog of yeast SNT2 in M. oryzae, which we term MoSNT2. Deletion mutants of MoSNT2 are compromised in autophagy homeostasis and display severe defects in autophagy-dependent fungal cell death and pathogenicity. These mutants are also impaired in infection structure development, conidiation, oxidative stress tolerance and cell wall integrity. MoSnt2 recognizes histone H3 acetylation through its PHD1 domain and thereby recruits the histone deacetylase complex, resulting in deacetylation of H3. MoSnt2 binds to promoters of autophagy genes MoATG6, 15, 16, and 22 to regulate their expression. In addition, MoTor controls MoSNT2 expression to regulate MoTor signaling which leads to autophagy and rice infection. Our study provides evidence of a direct link between MoSnt2 and MoTor signaling and defines a novel epigenetic mechanism by which MoSNT2 regulates infection-associated autophagy and plant infection by the rice blast fungus.</div><div type="abstract" xml:lang="en"><p><b>ABBREVIATIONS</b></p><p>M. oryzae: Magnaporthe oryzae; S. cerevisiae: Saccharomyces cerevisiae; F. oxysporum: Fusarium oxysporum; U. maydis: Ustilago maydis; Compl.: complemented strains of ΔMosnt2 expressing MoSNT2-GFP; ATG: autophagy-related; HDAC: histone deacetylase complex; Tor: target of rapamycin kinase; MTOR: mechanistic target of rapamycin kinase in mammals; MoSnt2: DNA binding SaNT domain protein in M. oryzae; MoTor: target of rapamycin kinase in M. oryzae; MoAtg8: autophagy-related protein 8 in M. oryzae; MoHos2: hda one similar protein in M. oryzae; MoeIf4G: eukaryotic translation initiation factor 4 G in M. oryzae; MoRs2: ribosomal protein S2 in M. oryzae; MoRs3: ribosomal protein S3 in M. oryzae; MoIcl1: isocitrate lyase in M. oryzae; MoSet1: histone H3K4 methyltransferase in M. oryzae; Asd4: ascus development 4; Abl1: AMP-activated protein kinase β subunit-like protein; Tig1: TBL1-like gene required for invasive growth; Rpd3: reduced potassium dependency; KAT8: lysine (K) acetyltransferase 8; PHD: plant homeodomain; ELM2: Egl-27 and MTA1 homology 2; GFP: green fluorescent protein; YFP: yellow fluorescent protein; YFP</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">29929416</PMID><DateCompleted><Year>2019</Year><Month>10</Month><Day>15</Day></DateCompleted><DateRevised><Year>2019</Year><Month>10</Month><Day>15</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1554-8635</ISSN><JournalIssue CitedMedium="Internet"><Volume>14</Volume><Issue>9</Issue><PubDate><Year>2018</Year></PubDate></JournalIssue><Title>Autophagy</Title><ISOAbbreviation>Autophagy</ISOAbbreviation></Journal><ArticleTitle>MoSnt2-dependent deacetylation of histone H3 mediates MoTor-dependent autophagy and plant infection by the rice blast fungus Magnaporthe oryzae.</ArticleTitle><Pagination><MedlinePgn>1543-1561</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1080/15548627.2018.1458171</ELocationID><Abstract><AbstractText>Autophagy is essential for appressorium-mediated plant infection by Magnaporthe oryzae, the causal agent of rice blast disease and a major threat to global food security. The regulatory mechanism of pathogenicity-associated autophagy, however, remains largely unknown. Here, we report the identification and functional characterization of a plausible ortholog of yeast SNT2 in M. oryzae, which we term MoSNT2. Deletion mutants of MoSNT2 are compromised in autophagy homeostasis and display severe defects in autophagy-dependent fungal cell death and pathogenicity. These mutants are also impaired in infection structure development, conidiation, oxidative stress tolerance and cell wall integrity. MoSnt2 recognizes histone H3 acetylation through its PHD1 domain and thereby recruits the histone deacetylase complex, resulting in deacetylation of H3. MoSnt2 binds to promoters of autophagy genes MoATG6, 15, 16, and 22 to regulate their expression. In addition, MoTor controls MoSNT2 expression to regulate MoTor signaling which leads to autophagy and rice infection. Our study provides evidence of a direct link between MoSnt2 and MoTor signaling and defines a novel epigenetic mechanism by which MoSNT2 regulates infection-associated autophagy and plant infection by the rice blast fungus.</AbstractText><AbstractText Label="ABBREVIATIONS">M. oryzae: Magnaporthe oryzae; S. cerevisiae: Saccharomyces cerevisiae; F. oxysporum: Fusarium oxysporum; U. maydis: Ustilago maydis; Compl.: complemented strains of ΔMosnt2 expressing MoSNT2-GFP; ATG: autophagy-related; HDAC: histone deacetylase complex; Tor: target of rapamycin kinase; MTOR: mechanistic target of rapamycin kinase in mammals; MoSnt2: DNA binding SaNT domain protein in M. oryzae; MoTor: target of rapamycin kinase in M. oryzae; MoAtg8: autophagy-related protein 8 in M. oryzae; MoHos2: hda one similar protein in M. oryzae; MoeIf4G: eukaryotic translation initiation factor 4 G in M. oryzae; MoRs2: ribosomal protein S2 in M. oryzae; MoRs3: ribosomal protein S3 in M. oryzae; MoIcl1: isocitrate lyase in M. oryzae; MoSet1: histone H3K4 methyltransferase in M. oryzae; Asd4: ascus development 4; Abl1: AMP-activated protein kinase β subunit-like protein; Tig1: TBL1-like gene required for invasive growth; Rpd3: reduced potassium dependency; KAT8: lysine (K) acetyltransferase 8; PHD: plant homeodomain; ELM2: Egl-27 and MTA1 homology 2; GFP: green fluorescent protein; YFP: yellow fluorescent protein; YFP<sup>CTF</sup>: C-terminal fragment of YFP; YFP<sup>NTF</sup>: N-terminal fragment of YFP; GST: glutathione S-transferase; bp: base pairs; DEGs: differentially expressed genes; CM: complete medium; MM-N: minimum medium minus nitrogen; CFW: calcofluor white; CR: congo red; DAPI: 4', 6-diamidino-2-phenylindole; BiFC: bimolecular fluorescence complementation; RT: reverse transcription; PCR: polymerase chain reaction; qPCR: quantitative polymerase chain reaction; RNAi: RNA interference; ChIP: chromatin immunoprecipitation.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>He</LastName><ForeName>Min</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>a State Key Laboratory of Hybrid Rice, Key Laboratory of Major Crop Diseases & Collaborative Innovation Center for Hybrid Rice in Yangtze River Basin, Rice Research Institute , Sichuan Agricultural University , Chengdu , China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>b School of Biosciences , University of Exeter , Exeter , UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xu</LastName><ForeName>Youpin</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>a State Key Laboratory of Hybrid Rice, Key Laboratory of Major Crop Diseases & Collaborative Innovation Center for Hybrid Rice in Yangtze River Basin, Rice Research Institute , Sichuan Agricultural University , Chengdu , China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Jinhua</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>a State Key Laboratory of Hybrid Rice, Key Laboratory of Major Crop Diseases & Collaborative Innovation Center for Hybrid Rice in Yangtze River Basin, Rice Research Institute , Sichuan Agricultural University , Chengdu , China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Luo</LastName><ForeName>Yuan</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>a State Key Laboratory of Hybrid Rice, Key Laboratory of Major Crop Diseases & Collaborative Innovation Center for Hybrid Rice in Yangtze River Basin, Rice Research Institute , Sichuan Agricultural University , Chengdu , China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lv</LastName><ForeName>Yang</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>a State Key Laboratory of Hybrid Rice, Key Laboratory of Major Crop Diseases & Collaborative Innovation Center for Hybrid Rice in Yangtze River Basin, Rice Research Institute , Sichuan Agricultural University , Chengdu , China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Su</LastName><ForeName>Jia</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>a State Key Laboratory of Hybrid Rice, Key Laboratory of Major Crop Diseases & Collaborative Innovation Center for Hybrid Rice in Yangtze River Basin, Rice Research Institute , Sichuan Agricultural University , Chengdu , China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kershaw</LastName><ForeName>Michael J</ForeName><Initials>MJ</Initials><AffiliationInfo><Affiliation>b School of Biosciences , University of Exeter , Exeter , UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Weitao</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>a State Key Laboratory of Hybrid Rice, Key Laboratory of Major Crop Diseases & Collaborative Innovation Center for Hybrid Rice in Yangtze River Basin, Rice Research Institute , Sichuan Agricultural University , Chengdu , China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Jing</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>a State Key Laboratory of Hybrid Rice, Key Laboratory of Major Crop Diseases & Collaborative Innovation Center for Hybrid Rice in Yangtze River Basin, Rice Research Institute , Sichuan Agricultural University , Chengdu , China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yin</LastName><ForeName>Junjie</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>a State Key Laboratory of Hybrid Rice, Key Laboratory of Major Crop Diseases & Collaborative Innovation Center for Hybrid Rice in Yangtze River Basin, Rice Research Institute , Sichuan Agricultural University , Chengdu , China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhu</LastName><ForeName>Xiaobo</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>a State Key Laboratory of Hybrid Rice, Key Laboratory of Major Crop Diseases & Collaborative Innovation Center for Hybrid Rice in Yangtze River Basin, Rice Research Institute , Sichuan Agricultural University , Chengdu , China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Xiaohong</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>c State Key Laboratory for Rice Biology, Biotechnology Institute , Zhejiang University , Hangzhou , China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chern</LastName><ForeName>Mawsheng</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>d Department of Plant Pathology , University of California , Davis , CA , USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ma</LastName><ForeName>Bingtian</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>a State Key Laboratory of Hybrid Rice, Key Laboratory of Major Crop Diseases & Collaborative Innovation Center for Hybrid Rice in Yangtze River Basin, Rice Research Institute , Sichuan Agricultural University , Chengdu , China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Jichun</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>a State Key Laboratory of Hybrid Rice, Key Laboratory of Major Crop Diseases & Collaborative Innovation Center for Hybrid Rice in Yangtze River Basin, Rice Research Institute , Sichuan Agricultural University , Chengdu , China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Qin</LastName><ForeName>Peng</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>a State Key Laboratory of Hybrid Rice, Key Laboratory of Major Crop Diseases & Collaborative Innovation Center for Hybrid Rice in Yangtze River Basin, Rice Research Institute , Sichuan Agricultural University , Chengdu , China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Weilan</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>a State Key Laboratory of Hybrid Rice, Key Laboratory of Major Crop Diseases & Collaborative Innovation Center for Hybrid Rice in Yangtze River Basin, Rice Research Institute , Sichuan Agricultural University , Chengdu , China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Yuping</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>a State Key Laboratory of Hybrid Rice, Key Laboratory of Major Crop Diseases & Collaborative Innovation Center for Hybrid Rice in Yangtze River Basin, Rice Research Institute , Sichuan Agricultural University , Chengdu , China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Wenming</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>a State Key Laboratory of Hybrid Rice, Key Laboratory of Major Crop Diseases & Collaborative Innovation Center for Hybrid Rice in Yangtze River Basin, Rice Research Institute , Sichuan Agricultural University , Chengdu , China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ren</LastName><ForeName>Zhenglong</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>a State Key Laboratory of Hybrid Rice, Key Laboratory of Major Crop Diseases & Collaborative Innovation Center for Hybrid Rice in Yangtze River Basin, Rice Research Institute , Sichuan Agricultural University , Chengdu , China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wu</LastName><ForeName>Xianjun</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>a State Key Laboratory of Hybrid Rice, Key Laboratory of Major Crop Diseases & Collaborative Innovation Center for Hybrid Rice in Yangtze River Basin, Rice Research Institute , Sichuan Agricultural University , Chengdu , China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Ping</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>a State Key Laboratory of Hybrid Rice, Key Laboratory of Major Crop Diseases & Collaborative Innovation Center for Hybrid Rice in Yangtze River Basin, Rice Research Institute , Sichuan Agricultural University , Chengdu , China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Shigui</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>a State Key Laboratory of Hybrid Rice, Key Laboratory of Major Crop Diseases & Collaborative Innovation Center for Hybrid Rice in Yangtze River Basin, Rice Research Institute , Sichuan Agricultural University , Chengdu , China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Peng</LastName><ForeName>Youliang</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>e State Key Laboratory of Agrobiotechnology and MOA, Key Laboratory of Plant Pathology , China Agricultural University , Beijing , China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lin</LastName><ForeName>Fucheng</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>c State Key Laboratory for Rice Biology, Biotechnology Institute , Zhejiang University , Hangzhou , China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Talbot</LastName><ForeName>Nicholas J</ForeName><Initials>NJ</Initials><AffiliationInfo><Affiliation>b School of Biosciences , University of Exeter , Exeter , UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Xuewei</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>a State Key Laboratory of Hybrid Rice, Key Laboratory of Major Crop Diseases & Collaborative Innovation Center for Hybrid Rice in Yangtze River Basin, Rice Research Institute , Sichuan Agricultural University , Chengdu , China.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2018</Year><Month>08</Month><Day>31</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Autophagy</MedlineTA><NlmUniqueID>101265188</NlmUniqueID><ISSNLinking>1554-8627</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005656">Fungal Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D006657">Histones</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.5.1.98</RegistryNumber><NameOfSubstance UI="D006655">Histone Deacetylases</NameOfSubstance></Chemical><Chemical><RegistryNumber>W36ZG6FT64</RegistryNumber><NameOfSubstance UI="D020123">Sirolimus</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000107" MajorTopicYN="N">Acetylation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001343" MajorTopicYN="Y">Autophagy</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002473" MajorTopicYN="N">Cell Wall</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D044127" MajorTopicYN="N">Epigenesis, Genetic</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005656" MajorTopicYN="N">Fungal Proteins</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017353" MajorTopicYN="N">Gene Deletion</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015966" MajorTopicYN="N">Gene Expression Regulation, Fungal</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006655" MajorTopicYN="N">Histone Deacetylases</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006657" MajorTopicYN="N">Histones</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020082" MajorTopicYN="N">Magnaporthe</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000254" MajorTopicYN="N">growth & development</QualifierName><QualifierName UI="Q000472" MajorTopicYN="Y">pathogenicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008954" MajorTopicYN="N">Models, Biological</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012275" MajorTopicYN="N">Oryza</DescriptorName><QualifierName UI="Q000382" MajorTopicYN="Y">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018384" MajorTopicYN="N">Oxidative Stress</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010935" MajorTopicYN="N">Plant Diseases</DescriptorName><QualifierName UI="Q000382" MajorTopicYN="Y">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011485" MajorTopicYN="N">Protein Binding</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020123" MajorTopicYN="N">Sirolimus</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Autophagy</Keyword><Keyword MajorTopicYN="Y">Magnaporthe oryzae</Keyword><Keyword MajorTopicYN="Y">MoSnt2</Keyword><Keyword MajorTopicYN="Y">MoTor signaling</Keyword><Keyword MajorTopicYN="Y">pathogenicity</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate 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