Circadian rhythms, metabolic oscillators, and the target of rapamycin (TOR) pathway: the Neurospora connection.
Identifieur interne : 000418 ( Main/Corpus ); précédent : 000417; suivant : 000419Circadian rhythms, metabolic oscillators, and the target of rapamycin (TOR) pathway: the Neurospora connection.
Auteurs : Patricia Lakin-ThomasSource :
- Current genetics [ 1432-0983 ] ; 2019.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : TOR Serine-Threonine Kinases.
- physiology : Circadian Rhythm, Neurospora crassa.
- Circadian Clocks, Energy Metabolism, Signal Transduction.
Abstract
Circadian (24-h) rhythmicity is a fundamental property of eukaryotic cells, and it is not surprising that it intersects with fundamental metabolic processes. Many links between these two processes have been documented, and speculation has been growing that there may be circadian "metabolic oscillators" that interact with and exist independently of the well-known circadian transcription/translation feedback loops (TTFLs) that have been extensively studied. This review takes a critical look at the evidence for the existence of metabolic oscillators at the cellular level, attempting to answer these questions: does metabolism affect circadian rhythmicity, and vice versa? Is metabolism rhythmic, and if so, is that rhythmicity cell autonomous? Systems displaying "non-canonical rhythmicity" in the absence of functional TTFLs provide opportunities for identifying metabolic oscillators, and this review emphasizes the fungus Neurospora crassa as a model system. Recent papers describing links between the target of rapamycin (TOR) signaling pathway and circadian rhythmicity are highlighted, suggesting the potential for TOR signaling in generating rhythmicity independent of TTFLs.
DOI: 10.1007/s00294-018-0897-6
PubMed: 30367189
Links to Exploration step
pubmed:30367189Le document en format XML
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<author><name sortKey="Lakin Thomas, Patricia" sort="Lakin Thomas, Patricia" uniqKey="Lakin Thomas P" first="Patricia" last="Lakin-Thomas">Patricia Lakin-Thomas</name>
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<series><title level="j">Current genetics</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Circadian Clocks (MeSH)</term>
<term>Circadian Rhythm (physiology)</term>
<term>Energy Metabolism (MeSH)</term>
<term>Neurospora crassa (physiology)</term>
<term>Signal Transduction (MeSH)</term>
<term>TOR Serine-Threonine Kinases (metabolism)</term>
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<front><div type="abstract" xml:lang="en">Circadian (24-h) rhythmicity is a fundamental property of eukaryotic cells, and it is not surprising that it intersects with fundamental metabolic processes. Many links between these two processes have been documented, and speculation has been growing that there may be circadian "metabolic oscillators" that interact with and exist independently of the well-known circadian transcription/translation feedback loops (TTFLs) that have been extensively studied. This review takes a critical look at the evidence for the existence of metabolic oscillators at the cellular level, attempting to answer these questions: does metabolism affect circadian rhythmicity, and vice versa? Is metabolism rhythmic, and if so, is that rhythmicity cell autonomous? Systems displaying "non-canonical rhythmicity" in the absence of functional TTFLs provide opportunities for identifying metabolic oscillators, and this review emphasizes the fungus Neurospora crassa as a model system. Recent papers describing links between the target of rapamycin (TOR) signaling pathway and circadian rhythmicity are highlighted, suggesting the potential for TOR signaling in generating rhythmicity independent of TTFLs.</div>
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<Abstract><AbstractText>Circadian (24-h) rhythmicity is a fundamental property of eukaryotic cells, and it is not surprising that it intersects with fundamental metabolic processes. Many links between these two processes have been documented, and speculation has been growing that there may be circadian "metabolic oscillators" that interact with and exist independently of the well-known circadian transcription/translation feedback loops (TTFLs) that have been extensively studied. This review takes a critical look at the evidence for the existence of metabolic oscillators at the cellular level, attempting to answer these questions: does metabolism affect circadian rhythmicity, and vice versa? Is metabolism rhythmic, and if so, is that rhythmicity cell autonomous? Systems displaying "non-canonical rhythmicity" in the absence of functional TTFLs provide opportunities for identifying metabolic oscillators, and this review emphasizes the fungus Neurospora crassa as a model system. Recent papers describing links between the target of rapamycin (TOR) signaling pathway and circadian rhythmicity are highlighted, suggesting the potential for TOR signaling in generating rhythmicity independent of TTFLs.</AbstractText>
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