Antiaging effects of bioactive molecules isolated from plants and fungi.
Identifieur interne : 000375 ( Main/Corpus ); précédent : 000374; suivant : 000376Antiaging effects of bioactive molecules isolated from plants and fungi.
Auteurs : Jan Martel ; David M. Ojcius ; Yun-Fei Ko ; Chih-Jung Chang ; John D. YoungSource :
- Medicinal research reviews [ 1098-1128 ] ; 2019.
English descriptors
- KwdEn :
- MESH :
- chemical , isolation & purification : Biological Products.
- chemistry : Fungi, Plants.
- drug effects : Aging.
- chemical , pharmacology : Biological Products.
- chemical , physiology : TOR Serine-Threonine Kinases.
- Animals, Autophagy, Caloric Restriction, Humans, Longevity.
Abstract
Aging is influenced by many lifestyle choices that are under human control, including nutrition and exercise. The most effective known antiaging intervention consists of calorie restriction (CR), which increases lifespan in yeasts, worms, fruit flies, mice, and nonhuman primates. CR also improves healthspan by preventing the development of various aging-related diseases such as cancer, cardiovascular disease, diabetes, and neurodegeneration. Many compounds isolated from plants and fungi prolong lifespan and prevent age-related diseases in model organisms. These plant and fungal compounds modulate the same cellular and physiological pathways as CR, including those involving insulin and insulin-like growth factor-1, mammalian target of rapamycin, and sirtuins. Modulation of these aging-related pathways results in the activation of various cellular processes such as autophagy, DNA repair, and neutralization of reactive oxygen species. Together, these cellular processes are believed to delay aging and prevent chronic diseases by improving bodily functions and stress resistance. We review here the mechanisms of action of plant and fungal molecules possessing antiaging properties and discuss the possibilities and challenges associated with the development of antiaging compounds isolated from natural products.
DOI: 10.1002/med.21559
PubMed: 30648267
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pubmed:30648267Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Antiaging effects of bioactive molecules isolated from plants and fungi.</title><author><name sortKey="Martel, Jan" sort="Martel, Jan" uniqKey="Martel J" first="Jan" last="Martel">Jan Martel</name><affiliation><nlm:affiliation>Center for Molecular and Clinical Immunology, Chang Gung University, Taoyuan, Taiwan, Republic of China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Chang Gung Immunology Consortium, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan, Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Ojcius, David M" sort="Ojcius, David M" uniqKey="Ojcius D" first="David M" last="Ojcius">David M. Ojcius</name><affiliation><nlm:affiliation>Center for Molecular and Clinical Immunology, Chang Gung University, Taoyuan, Taiwan, Republic of China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Chang Gung Immunology Consortium, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan, Republic of China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Department of Biomedical Sciences, University of the Pacific, Arthur Dugoni School of Dentistry, San Francisco, California.</nlm:affiliation></affiliation></author><author><name sortKey="Ko, Yun Fei" sort="Ko, Yun Fei" uniqKey="Ko Y" first="Yun-Fei" last="Ko">Yun-Fei Ko</name><affiliation><nlm:affiliation>Chang Gung Immunology Consortium, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan, Republic of China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Chang Gung Biotechnology Corporation, Taipei, Taiwan, Republic of China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Biochemical Engineering Research Center, Ming Chi University of Technology, New Taipei City, Taiwan, Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Chang, Chih Jung" sort="Chang, Chih Jung" uniqKey="Chang C" first="Chih-Jung" last="Chang">Chih-Jung Chang</name><affiliation><nlm:affiliation>Center for Molecular and Clinical Immunology, Chang Gung University, Taoyuan, Taiwan, Republic of China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Chang Gung Immunology Consortium, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan, Republic of China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Taoyuan, Taiwan, Republic of China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Research Center of Bacterial Pathogenesis, Chang Gung University, Taoyuan, Taiwan, Republic of China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Department of Microbiology and Immunology, College of Medicine, Chang Gung University, Taoyuan, Taiwan, Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Young, John D" sort="Young, John D" uniqKey="Young J" first="John D" last="Young">John D. Young</name><affiliation><nlm:affiliation>Center for Molecular and Clinical Immunology, Chang Gung University, Taoyuan, Taiwan, Republic of China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Chang Gung Immunology Consortium, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan, Republic of China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Chang Gung Biotechnology Corporation, Taipei, Taiwan, Republic of China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Biochemical Engineering Research Center, Ming Chi University of Technology, New Taipei City, Taiwan, Republic of China.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2019">2019</date><idno type="RBID">pubmed:30648267</idno><idno type="pmid">30648267</idno><idno type="doi">10.1002/med.21559</idno><idno type="wicri:Area/Main/Corpus">000375</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000375</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Antiaging effects of bioactive molecules isolated from plants and fungi.</title><author><name sortKey="Martel, Jan" sort="Martel, Jan" uniqKey="Martel J" first="Jan" last="Martel">Jan Martel</name><affiliation><nlm:affiliation>Center for Molecular and Clinical Immunology, Chang Gung University, Taoyuan, Taiwan, Republic of China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Chang Gung Immunology Consortium, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan, Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Ojcius, David M" sort="Ojcius, David M" uniqKey="Ojcius D" first="David M" last="Ojcius">David M. Ojcius</name><affiliation><nlm:affiliation>Center for Molecular and Clinical Immunology, Chang Gung University, Taoyuan, Taiwan, Republic of China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Chang Gung Immunology Consortium, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan, Republic of China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Department of Biomedical Sciences, University of the Pacific, Arthur Dugoni School of Dentistry, San Francisco, California.</nlm:affiliation></affiliation></author><author><name sortKey="Ko, Yun Fei" sort="Ko, Yun Fei" uniqKey="Ko Y" first="Yun-Fei" last="Ko">Yun-Fei Ko</name><affiliation><nlm:affiliation>Chang Gung Immunology Consortium, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan, Republic of China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Chang Gung Biotechnology Corporation, Taipei, Taiwan, Republic of China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Biochemical Engineering Research Center, Ming Chi University of Technology, New Taipei City, Taiwan, Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Chang, Chih Jung" sort="Chang, Chih Jung" uniqKey="Chang C" first="Chih-Jung" last="Chang">Chih-Jung Chang</name><affiliation><nlm:affiliation>Center for Molecular and Clinical Immunology, Chang Gung University, Taoyuan, Taiwan, Republic of China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Chang Gung Immunology Consortium, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan, Republic of China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Taoyuan, Taiwan, Republic of China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Research Center of Bacterial Pathogenesis, Chang Gung University, Taoyuan, Taiwan, Republic of China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Department of Microbiology and Immunology, College of Medicine, Chang Gung University, Taoyuan, Taiwan, Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Young, John D" sort="Young, John D" uniqKey="Young J" first="John D" last="Young">John D. Young</name><affiliation><nlm:affiliation>Center for Molecular and Clinical Immunology, Chang Gung University, Taoyuan, Taiwan, Republic of China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Chang Gung Immunology Consortium, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan, Republic of China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Chang Gung Biotechnology Corporation, Taipei, Taiwan, Republic of China.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Biochemical Engineering Research Center, Ming Chi University of Technology, New Taipei City, Taiwan, Republic of China.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Medicinal research reviews</title><idno type="eISSN">1098-1128</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aging (drug effects)</term><term>Animals (MeSH)</term><term>Autophagy (MeSH)</term><term>Biological Products (isolation & purification)</term><term>Biological Products (pharmacology)</term><term>Caloric Restriction (MeSH)</term><term>Fungi (chemistry)</term><term>Humans (MeSH)</term><term>Longevity (MeSH)</term><term>Plants (chemistry)</term><term>TOR Serine-Threonine Kinases (physiology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>Biological Products</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Fungi</term><term>Plants</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Aging</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Biological Products</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>TOR Serine-Threonine Kinases</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Autophagy</term><term>Caloric Restriction</term><term>Humans</term><term>Longevity</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Aging is influenced by many lifestyle choices that are under human control, including nutrition and exercise. The most effective known antiaging intervention consists of calorie restriction (CR), which increases lifespan in yeasts, worms, fruit flies, mice, and nonhuman primates. CR also improves healthspan by preventing the development of various aging-related diseases such as cancer, cardiovascular disease, diabetes, and neurodegeneration. Many compounds isolated from plants and fungi prolong lifespan and prevent age-related diseases in model organisms. These plant and fungal compounds modulate the same cellular and physiological pathways as CR, including those involving insulin and insulin-like growth factor-1, mammalian target of rapamycin, and sirtuins. Modulation of these aging-related pathways results in the activation of various cellular processes such as autophagy, DNA repair, and neutralization of reactive oxygen species. Together, these cellular processes are believed to delay aging and prevent chronic diseases by improving bodily functions and stress resistance. We review here the mechanisms of action of plant and fungal molecules possessing antiaging properties and discuss the possibilities and challenges associated with the development of antiaging compounds isolated from natural products.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">30648267</PMID><DateCompleted><Year>2020</Year><Month>07</Month><Day>06</Day></DateCompleted><DateRevised><Year>2020</Year><Month>07</Month><Day>06</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1098-1128</ISSN><JournalIssue CitedMedium="Internet"><Volume>39</Volume><Issue>5</Issue><PubDate><Year>2019</Year><Month>09</Month></PubDate></JournalIssue><Title>Medicinal research reviews</Title><ISOAbbreviation>Med Res Rev</ISOAbbreviation></Journal><ArticleTitle>Antiaging effects of bioactive molecules isolated from plants and fungi.</ArticleTitle><Pagination><MedlinePgn>1515-1552</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/med.21559</ELocationID><Abstract><AbstractText>Aging is influenced by many lifestyle choices that are under human control, including nutrition and exercise. The most effective known antiaging intervention consists of calorie restriction (CR), which increases lifespan in yeasts, worms, fruit flies, mice, and nonhuman primates. CR also improves healthspan by preventing the development of various aging-related diseases such as cancer, cardiovascular disease, diabetes, and neurodegeneration. Many compounds isolated from plants and fungi prolong lifespan and prevent age-related diseases in model organisms. These plant and fungal compounds modulate the same cellular and physiological pathways as CR, including those involving insulin and insulin-like growth factor-1, mammalian target of rapamycin, and sirtuins. Modulation of these aging-related pathways results in the activation of various cellular processes such as autophagy, DNA repair, and neutralization of reactive oxygen species. Together, these cellular processes are believed to delay aging and prevent chronic diseases by improving bodily functions and stress resistance. We review here the mechanisms of action of plant and fungal molecules possessing antiaging properties and discuss the possibilities and challenges associated with the development of antiaging compounds isolated from natural products.</AbstractText><CopyrightInformation>© 2019 Wiley Periodicals, Inc.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Martel</LastName><ForeName>Jan</ForeName><Initials>J</Initials><Identifier Source="ORCID">0000-0003-0879-109X</Identifier><AffiliationInfo><Affiliation>Center for Molecular and Clinical Immunology, Chang Gung University, Taoyuan, Taiwan, Republic of China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Chang Gung Immunology Consortium, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan, Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ojcius</LastName><ForeName>David M</ForeName><Initials>DM</Initials><Identifier Source="ORCID">0000-0003-1461-4495</Identifier><AffiliationInfo><Affiliation>Center for Molecular and Clinical Immunology, Chang Gung University, Taoyuan, Taiwan, Republic of China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Chang Gung Immunology Consortium, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan, Republic of China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Biomedical Sciences, University of the Pacific, Arthur Dugoni School of Dentistry, San Francisco, California.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ko</LastName><ForeName>Yun-Fei</ForeName><Initials>YF</Initials><AffiliationInfo><Affiliation>Chang Gung Immunology Consortium, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan, Republic of China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Chang Gung Biotechnology Corporation, Taipei, Taiwan, Republic of China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Biochemical Engineering Research Center, Ming Chi University of Technology, New Taipei City, Taiwan, Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chang</LastName><ForeName>Chih-Jung</ForeName><Initials>CJ</Initials><AffiliationInfo><Affiliation>Center for Molecular and Clinical Immunology, Chang Gung University, Taoyuan, Taiwan, Republic of China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Chang Gung Immunology Consortium, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan, Republic of China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Taoyuan, Taiwan, Republic of China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Research Center of Bacterial Pathogenesis, Chang Gung University, Taoyuan, Taiwan, Republic of China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Microbiology and Immunology, College of Medicine, Chang Gung University, Taoyuan, Taiwan, Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Young</LastName><ForeName>John D</ForeName><Initials>JD</Initials><Identifier Source="ORCID">0000-0002-5516-4200</Identifier><AffiliationInfo><Affiliation>Center for Molecular and Clinical Immunology, Chang Gung University, Taoyuan, Taiwan, Republic of China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Chang Gung Immunology Consortium, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan, Republic of China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Chang Gung Biotechnology Corporation, Taipei, Taiwan, Republic of China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Biochemical Engineering Research Center, Ming Chi University of Technology, New Taipei City, Taiwan, Republic of China.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2019</Year><Month>01</Month><Day>15</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Med Res Rev</MedlineTA><NlmUniqueID>8103150</NlmUniqueID><ISSNLinking>0198-6325</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D001688">Biological Products</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.1.1</RegistryNumber><NameOfSubstance UI="D058570">TOR Serine-Threonine Kinases</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000375" MajorTopicYN="N">Aging</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001343" MajorTopicYN="N">Autophagy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001688" MajorTopicYN="N">Biological Products</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D031204" MajorTopicYN="N">Caloric Restriction</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005658" MajorTopicYN="N">Fungi</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008136" MajorTopicYN="N">Longevity</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010944" MajorTopicYN="N">Plants</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D058570" MajorTopicYN="N">TOR Serine-Threonine Kinases</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">antiaging medicine</Keyword><Keyword MajorTopicYN="Y">autophagy</Keyword><Keyword MajorTopicYN="Y">dietary supplements</Keyword><Keyword MajorTopicYN="Y">life extension</Keyword><Keyword MajorTopicYN="Y">medicinal mushrooms</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year><Month>08</Month><Day>25</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2018</Year><Month>12</Month><Day>06</Day></PubMedPubDate><PubMedPubDate 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