Immune responses to ISCOM formulations in animal and primate models.
Identifieur interne : 004689 ( Main/Exploration ); précédent : 004688; suivant : 004690Immune responses to ISCOM formulations in animal and primate models.
Auteurs : A. Sjölander [Australie] ; D. Drane ; E. Maraskovsky ; J P Scheerlinck ; A. Suhrbier ; J. Tennent ; M. PearseSource :
- Vaccine [ 0264-410X ] ; 2001.
Descripteurs français
- KwdFr :
- MESH :
- administration et posologie : Complexes immunostimulants, Vaccins.
- immunologie : Lymphocytes T cytotoxiques.
- Animaux, Humains, Immunité cellulaire, Modèles animaux, Primates, Souris.
English descriptors
- KwdEn :
- MESH :
- chemical , administration & dosage : ISCOMs, Vaccines.
- immunology : T-Lymphocytes, Cytotoxic.
- Animals, Humans, Immunity, Cellular, Mice, Models, Animal, Primates.
Abstract
ISCOMs are typically 40 nm cage-like structures comprising antigen, saponin, cholesterol and phospholipid. ISCOMs have been shown to induce antibody responses and activate T helper cells and cytolytic T lymphocytes in a number of animal species, including non-human primates. Recent clinical studies have demonstrated that ISCOMs are also able to induce antibody and cellular immune responses in humans. This review describes the current understanding of the ability of ISCOMs to induce immune responses and the mechanisms underlying this property. Recent progress in the characterisation and manufacture of ISCOMs will also be discussed.
DOI: 10.1016/s0264-410x(00)00497-7
PubMed: 11257406
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Maraskovsky</name></author><author><name sortKey="Scheerlinck, J P" sort="Scheerlinck, J P" uniqKey="Scheerlinck J" first="J P" last="Scheerlinck">J P Scheerlinck</name></author><author><name sortKey="Suhrbier, A" sort="Suhrbier, A" uniqKey="Suhrbier A" first="A" last="Suhrbier">A. Suhrbier</name></author><author><name sortKey="Tennent, J" sort="Tennent, J" uniqKey="Tennent J" first="J" last="Tennent">J. Tennent</name></author><author><name sortKey="Pearse, M" sort="Pearse, M" uniqKey="Pearse M" first="M" last="Pearse">M. Pearse</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2001">2001</date><idno type="RBID">pubmed:11257406</idno><idno type="pmid">11257406</idno><idno type="doi">10.1016/s0264-410x(00)00497-7</idno><idno type="wicri:Area/Main/Corpus">004795</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">004795</idno><idno type="wicri:Area/Main/Curation">004795</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">004795</idno><idno type="wicri:Area/Main/Exploration">004795</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Immune responses to ISCOM formulations in animal and primate models.</title><author><name sortKey="Sjolander, A" sort="Sjolander, A" uniqKey="Sjolander A" first="A" last="Sjölander">A. Sjölander</name><affiliation wicri:level="3"><nlm:affiliation>CSL Limited, Immunology Department, 45 Poplar Road, Parkville, Victoria 3052, Melbourne, Australia. anders-sjolander@csl.com.au</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>CSL Limited, Immunology Department, 45 Poplar Road, Parkville, Victoria 3052, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Drane, D" sort="Drane, D" uniqKey="Drane D" first="D" last="Drane">D. Drane</name></author><author><name sortKey="Maraskovsky, E" sort="Maraskovsky, E" uniqKey="Maraskovsky E" first="E" last="Maraskovsky">E. Maraskovsky</name></author><author><name sortKey="Scheerlinck, J P" sort="Scheerlinck, J P" uniqKey="Scheerlinck J" first="J P" last="Scheerlinck">J P Scheerlinck</name></author><author><name sortKey="Suhrbier, A" sort="Suhrbier, A" uniqKey="Suhrbier A" first="A" last="Suhrbier">A. Suhrbier</name></author><author><name sortKey="Tennent, J" sort="Tennent, J" uniqKey="Tennent J" first="J" last="Tennent">J. Tennent</name></author><author><name sortKey="Pearse, M" sort="Pearse, M" uniqKey="Pearse M" first="M" last="Pearse">M. Pearse</name></author></analytic><series><title level="j">Vaccine</title><idno type="ISSN">0264-410X</idno><imprint><date when="2001" type="published">2001</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term><term>Humans (MeSH)</term><term>ISCOMs (administration & dosage)</term><term>Immunity, Cellular (MeSH)</term><term>Mice (MeSH)</term><term>Models, Animal (MeSH)</term><term>Primates (MeSH)</term><term>T-Lymphocytes, Cytotoxic (immunology)</term><term>Vaccines (administration & dosage)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term><term>Complexes immunostimulants (administration et posologie)</term><term>Humains (MeSH)</term><term>Immunité cellulaire (MeSH)</term><term>Lymphocytes T cytotoxiques (immunologie)</term><term>Modèles animaux (MeSH)</term><term>Primates (MeSH)</term><term>Souris (MeSH)</term><term>Vaccins (administration et posologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>ISCOMs</term><term>Vaccines</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Complexes immunostimulants</term><term>Vaccins</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Lymphocytes T cytotoxiques</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>T-Lymphocytes, Cytotoxic</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term><term>Immunity, Cellular</term><term>Mice</term><term>Models, Animal</term><term>Primates</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Humains</term><term>Immunité cellulaire</term><term>Modèles animaux</term><term>Primates</term><term>Souris</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">ISCOMs are typically 40 nm cage-like structures comprising antigen, saponin, cholesterol and phospholipid. ISCOMs have been shown to induce antibody responses and activate T helper cells and cytolytic T lymphocytes in a number of animal species, including non-human primates. Recent clinical studies have demonstrated that ISCOMs are also able to induce antibody and cellular immune responses in humans. This review describes the current understanding of the ability of ISCOMs to induce immune responses and the mechanisms underlying this property. Recent progress in the characterisation and manufacture of ISCOMs will also be discussed.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">11257406</PMID><DateCompleted><Year>2001</Year><Month>07</Month><Day>19</Day></DateCompleted><DateRevised><Year>2019</Year><Month>07</Month><Day>28</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0264-410X</ISSN><JournalIssue CitedMedium="Print"><Volume>19</Volume><Issue>17-19</Issue><PubDate><Year>2001</Year><Month>Mar</Month><Day>21</Day></PubDate></JournalIssue><Title>Vaccine</Title><ISOAbbreviation>Vaccine</ISOAbbreviation></Journal><ArticleTitle>Immune responses to ISCOM formulations in animal and primate models.</ArticleTitle><Pagination><MedlinePgn>2661-5</MedlinePgn></Pagination><Abstract><AbstractText>ISCOMs are typically 40 nm cage-like structures comprising antigen, saponin, cholesterol and phospholipid. ISCOMs have been shown to induce antibody responses and activate T helper cells and cytolytic T lymphocytes in a number of animal species, including non-human primates. Recent clinical studies have demonstrated that ISCOMs are also able to induce antibody and cellular immune responses in humans. This review describes the current understanding of the ability of ISCOMs to induce immune responses and the mechanisms underlying this property. Recent progress in the characterisation and manufacture of ISCOMs will also be discussed.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Sjölander</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>CSL Limited, Immunology Department, 45 Poplar Road, Parkville, Victoria 3052, Melbourne, Australia. anders-sjolander@csl.com.au</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Drane</LastName><ForeName>D</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Maraskovsky</LastName><ForeName>E</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Scheerlinck</LastName><ForeName>J P</ForeName><Initials>JP</Initials></Author><Author ValidYN="Y"><LastName>Suhrbier</LastName><ForeName>A</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Tennent</LastName><ForeName>J</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Pearse</LastName><ForeName>M</ForeName><Initials>M</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Vaccine</MedlineTA><NlmUniqueID>8406899</NlmUniqueID><ISSNLinking>0264-410X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016882">ISCOMs</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014612">Vaccines</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016882" MajorTopicYN="N">ISCOMs</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007111" MajorTopicYN="N">Immunity, Cellular</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D023421" MajorTopicYN="N">Models, Animal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011323" MajorTopicYN="N">Primates</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013602" MajorTopicYN="N">T-Lymphocytes, Cytotoxic</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014612" MajorTopicYN="N">Vaccines</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName></MeshHeading></MeshHeadingList><NumberOfReferences>29</NumberOfReferences></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2001</Year><Month>3</Month><Day>21</Day><Hour>10</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2001</Year><Month>7</Month><Day>20</Day><Hour>10</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2001</Year><Month>3</Month><Day>21</Day><Hour>10</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">11257406</ArticleId><ArticleId IdType="pii">S0264410X00004977</ArticleId><ArticleId IdType="doi">10.1016/s0264-410x(00)00497-7</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Australie</li></country><region><li>Victoria (État)</li></region><settlement><li>Melbourne</li></settlement></list><tree><noCountry><name sortKey="Drane, D" sort="Drane, D" uniqKey="Drane D" first="D" last="Drane">D. Drane</name><name sortKey="Maraskovsky, E" sort="Maraskovsky, E" uniqKey="Maraskovsky E" first="E" last="Maraskovsky">E. Maraskovsky</name><name sortKey="Pearse, M" sort="Pearse, M" uniqKey="Pearse M" first="M" last="Pearse">M. Pearse</name><name sortKey="Scheerlinck, J P" sort="Scheerlinck, J P" uniqKey="Scheerlinck J" first="J P" last="Scheerlinck">J P Scheerlinck</name><name sortKey="Suhrbier, A" sort="Suhrbier, A" uniqKey="Suhrbier A" first="A" last="Suhrbier">A. Suhrbier</name><name sortKey="Tennent, J" sort="Tennent, J" uniqKey="Tennent J" first="J" last="Tennent">J. Tennent</name></noCountry><country name="Australie"><region name="Victoria (État)"><name sortKey="Sjolander, A" sort="Sjolander, A" uniqKey="Sjolander A" first="A" last="Sjölander">A. Sjölander</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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