Impact of aspen furniture and restricted feeding on activity, blood pressure, heart rate and faecal corticosterone and immunoglobulin A excretion in rats (Rattus norvegicus) housed in individually ventilated cages.
Identifieur interne : 003220 ( Main/Exploration ); précédent : 003219; suivant : 003221Impact of aspen furniture and restricted feeding on activity, blood pressure, heart rate and faecal corticosterone and immunoglobulin A excretion in rats (Rattus norvegicus) housed in individually ventilated cages.
Auteurs : N. Kemppinen [Finlande] ; J. Hau ; A. Meller ; K. Mauranen ; T. Kohila ; T. NevalainenSource :
- Laboratory animals [ 1758-1117 ] ; 2010.
Descripteurs français
- KwdFr :
- Analyse de variance (MeSH), Animaux (MeSH), Animaux de laboratoire (physiologie), Bois (MeSH), Corticostérone (analyse), Fèces (composition chimique), Hébergement animal (MeSH), Immunoglobuline A (sang), Mâle (MeSH), Populus (MeSH), Pression sanguine (physiologie), Rats (MeSH), Restriction calorique (MeSH), Rythme cardiaque (physiologie), Télémétrie (MeSH), Études croisées (MeSH).
- MESH :
- analyse : Corticostérone.
- composition chimique : Fèces.
- physiologie : Animaux de laboratoire, Pression sanguine, Rythme cardiaque.
- sang : Immunoglobuline A.
- Analyse de variance, Animaux, Bois, Hébergement animal, Mâle, Populus, Rats, Restriction calorique, Télémétrie, Études croisées.
English descriptors
- KwdEn :
- Analysis of Variance (MeSH), Animals (MeSH), Animals, Laboratory (physiology), Blood Pressure (physiology), Caloric Restriction (MeSH), Corticosterone (analysis), Cross-Over Studies (MeSH), Feces (chemistry), Heart Rate (physiology), Housing, Animal (MeSH), Immunoglobulin A (blood), Male (MeSH), Populus (MeSH), Rats (MeSH), Telemetry (MeSH), Wood (MeSH).
- MESH :
- chemical , analysis : Corticosterone.
- chemical , blood : Immunoglobulin A.
- chemistry : Feces.
- physiology : Animals, Laboratory, Blood Pressure, Heart Rate.
- Analysis of Variance, Animals, Caloric Restriction, Cross-Over Studies, Housing, Animal, Male, Populus, Rats, Telemetry, Wood.
Abstract
This study aims to evaluate the impact of adding different items in individually ventilated rat cages on the animal's activity, cardiovascular parameters and faecal stress indicators. The following three cage items made of aspen were compared: a cross made of two intersecting boards, a similar cross where drilled holes were loaded with food pellets (restricted feeding) and a rectangular tube. Male rats of the strains BN and F344 (n = 12) were housed in groups of three; one rat in each group was implanted with a telemetric transponder to measure mean arterial pressure (MAP) and heart rate (HR). In a crossover design, each group spent 14 days with each type of cage furniture, thereafter faecal pellets were collected for faecal analyses. The means of activity and means and coefficient of variation for MAP and HR were calculated for days 2, 6, 10 and 14. As a way of determining which of the statistically significant MAP and HR mean changes were biologically meaningful, the night-day differences of the controls on day 14 were used. Both board types lowered MAP of F344 rats; hence dividing walls seem beneficial for F344 welfare. None of the MAP or HR differences in BN rats were biologically significant. No statistically significant differences in faecal corticosterone or IgA excretion were detected. In conclusion, provision of general recommendations with respect to cage furniture for rat cages is complicated because there is a clear genetic component involved in how animals respond to these structures.
DOI: 10.1258/la.2009.009058
PubMed: 19854757
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Hau</name></author><author><name sortKey="Meller, A" sort="Meller, A" uniqKey="Meller A" first="A" last="Meller">A. Meller</name></author><author><name sortKey="Mauranen, K" sort="Mauranen, K" uniqKey="Mauranen K" first="K" last="Mauranen">K. Mauranen</name></author><author><name sortKey="Kohila, T" sort="Kohila, T" uniqKey="Kohila T" first="T" last="Kohila">T. Kohila</name></author><author><name sortKey="Nevalainen, T" sort="Nevalainen, T" uniqKey="Nevalainen T" first="T" last="Nevalainen">T. Nevalainen</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2010">2010</date><idno type="RBID">pubmed:19854757</idno><idno type="pmid">19854757</idno><idno type="doi">10.1258/la.2009.009058</idno><idno type="wicri:Area/Main/Corpus">003409</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">003409</idno><idno type="wicri:Area/Main/Curation">003409</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">003409</idno><idno type="wicri:Area/Main/Exploration">003409</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Impact of aspen furniture and restricted feeding on activity, blood pressure, heart rate and faecal corticosterone and immunoglobulin A excretion in rats (Rattus norvegicus) housed in individually ventilated cages.</title><author><name sortKey="Kemppinen, N" sort="Kemppinen, N" uniqKey="Kemppinen N" first="N" last="Kemppinen">N. Kemppinen</name><affiliation wicri:level="4"><nlm:affiliation>Laboratory Animal Centre, University of Helsinki, Finland. Niina.Kemppinen@helsinki.fi</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Laboratory Animal Centre, University of Helsinki</wicri:regionArea><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName><orgName type="university">Université d'Helsinki</orgName></affiliation></author><author><name sortKey="Hau, J" sort="Hau, J" uniqKey="Hau J" first="J" last="Hau">J. Hau</name></author><author><name sortKey="Meller, A" sort="Meller, A" uniqKey="Meller A" first="A" last="Meller">A. Meller</name></author><author><name sortKey="Mauranen, K" sort="Mauranen, K" uniqKey="Mauranen K" first="K" last="Mauranen">K. Mauranen</name></author><author><name sortKey="Kohila, T" sort="Kohila, T" uniqKey="Kohila T" first="T" last="Kohila">T. Kohila</name></author><author><name sortKey="Nevalainen, T" sort="Nevalainen, T" uniqKey="Nevalainen T" first="T" last="Nevalainen">T. Nevalainen</name></author></analytic><series><title level="j">Laboratory animals</title><idno type="eISSN">1758-1117</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Analysis of Variance (MeSH)</term><term>Animals (MeSH)</term><term>Animals, Laboratory (physiology)</term><term>Blood Pressure (physiology)</term><term>Caloric Restriction (MeSH)</term><term>Corticosterone (analysis)</term><term>Cross-Over Studies (MeSH)</term><term>Feces (chemistry)</term><term>Heart Rate (physiology)</term><term>Housing, Animal (MeSH)</term><term>Immunoglobulin A (blood)</term><term>Male (MeSH)</term><term>Populus (MeSH)</term><term>Rats (MeSH)</term><term>Telemetry (MeSH)</term><term>Wood (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Analyse de variance (MeSH)</term><term>Animaux (MeSH)</term><term>Animaux de laboratoire (physiologie)</term><term>Bois (MeSH)</term><term>Corticostérone (analyse)</term><term>Fèces (composition chimique)</term><term>Hébergement animal (MeSH)</term><term>Immunoglobuline A (sang)</term><term>Mâle (MeSH)</term><term>Populus (MeSH)</term><term>Pression sanguine (physiologie)</term><term>Rats (MeSH)</term><term>Restriction calorique (MeSH)</term><term>Rythme cardiaque (physiologie)</term><term>Télémétrie (MeSH)</term><term>Études croisées (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Corticosterone</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Immunoglobulin A</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Corticostérone</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Feces</term></keywords><keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Fèces</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Animaux de laboratoire</term><term>Pression sanguine</term><term>Rythme cardiaque</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Animals, Laboratory</term><term>Blood Pressure</term><term>Heart Rate</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Immunoglobuline A</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Analysis of Variance</term><term>Animals</term><term>Caloric Restriction</term><term>Cross-Over Studies</term><term>Housing, Animal</term><term>Male</term><term>Populus</term><term>Rats</term><term>Telemetry</term><term>Wood</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Analyse de variance</term><term>Animaux</term><term>Bois</term><term>Hébergement animal</term><term>Mâle</term><term>Populus</term><term>Rats</term><term>Restriction calorique</term><term>Télémétrie</term><term>Études croisées</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This study aims to evaluate the impact of adding different items in individually ventilated rat cages on the animal's activity, cardiovascular parameters and faecal stress indicators. The following three cage items made of aspen were compared: a cross made of two intersecting boards, a similar cross where drilled holes were loaded with food pellets (restricted feeding) and a rectangular tube. Male rats of the strains BN and F344 (n = 12) were housed in groups of three; one rat in each group was implanted with a telemetric transponder to measure mean arterial pressure (MAP) and heart rate (HR). In a crossover design, each group spent 14 days with each type of cage furniture, thereafter faecal pellets were collected for faecal analyses. The means of activity and means and coefficient of variation for MAP and HR were calculated for days 2, 6, 10 and 14. As a way of determining which of the statistically significant MAP and HR mean changes were biologically meaningful, the night-day differences of the controls on day 14 were used. Both board types lowered MAP of F344 rats; hence dividing walls seem beneficial for F344 welfare. None of the MAP or HR differences in BN rats were biologically significant. No statistically significant differences in faecal corticosterone or IgA excretion were detected. In conclusion, provision of general recommendations with respect to cage furniture for rat cages is complicated because there is a clear genetic component involved in how animals respond to these structures.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">19854757</PMID><DateCompleted><Year>2010</Year><Month>08</Month><Day>18</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1758-1117</ISSN><JournalIssue CitedMedium="Internet"><Volume>44</Volume><Issue>2</Issue><PubDate><Year>2010</Year><Month>Apr</Month></PubDate></JournalIssue><Title>Laboratory animals</Title><ISOAbbreviation>Lab Anim</ISOAbbreviation></Journal><ArticleTitle>Impact of aspen furniture and restricted feeding on activity, blood pressure, heart rate and faecal corticosterone and immunoglobulin A excretion in rats (Rattus norvegicus) housed in individually ventilated cages.</ArticleTitle><Pagination><MedlinePgn>104-12</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1258/la.2009.009058</ELocationID><Abstract><AbstractText>This study aims to evaluate the impact of adding different items in individually ventilated rat cages on the animal's activity, cardiovascular parameters and faecal stress indicators. The following three cage items made of aspen were compared: a cross made of two intersecting boards, a similar cross where drilled holes were loaded with food pellets (restricted feeding) and a rectangular tube. Male rats of the strains BN and F344 (n = 12) were housed in groups of three; one rat in each group was implanted with a telemetric transponder to measure mean arterial pressure (MAP) and heart rate (HR). In a crossover design, each group spent 14 days with each type of cage furniture, thereafter faecal pellets were collected for faecal analyses. The means of activity and means and coefficient of variation for MAP and HR were calculated for days 2, 6, 10 and 14. As a way of determining which of the statistically significant MAP and HR mean changes were biologically meaningful, the night-day differences of the controls on day 14 were used. Both board types lowered MAP of F344 rats; hence dividing walls seem beneficial for F344 welfare. None of the MAP or HR differences in BN rats were biologically significant. No statistically significant differences in faecal corticosterone or IgA excretion were detected. In conclusion, provision of general recommendations with respect to cage furniture for rat cages is complicated because there is a clear genetic component involved in how animals respond to these structures.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kemppinen</LastName><ForeName>N</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Laboratory Animal Centre, University of Helsinki, Finland. Niina.Kemppinen@helsinki.fi</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hau</LastName><ForeName>J</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Meller</LastName><ForeName>A</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Mauranen</LastName><ForeName>K</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Kohila</LastName><ForeName>T</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Nevalainen</LastName><ForeName>T</ForeName><Initials>T</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2009</Year><Month>10</Month><Day>23</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Lab Anim</MedlineTA><NlmUniqueID>0112725</NlmUniqueID><ISSNLinking>0023-6772</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007070">Immunoglobulin A</NameOfSubstance></Chemical><Chemical><RegistryNumber>W980KJ009P</RegistryNumber><NameOfSubstance UI="D003345">Corticosterone</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000704" MajorTopicYN="N">Analysis of Variance</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000830" MajorTopicYN="N">Animals, Laboratory</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001794" MajorTopicYN="N">Blood Pressure</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D031204" MajorTopicYN="Y">Caloric Restriction</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003345" MajorTopicYN="N">Corticosterone</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="Y">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018592" MajorTopicYN="N">Cross-Over Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005243" MajorTopicYN="N">Feces</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006339" MajorTopicYN="N">Heart Rate</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006799" MajorTopicYN="N">Housing, Animal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007070" MajorTopicYN="N">Immunoglobulin A</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D032107" MajorTopicYN="N">Populus</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013686" MajorTopicYN="N">Telemetry</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014934" MajorTopicYN="N">Wood</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2009</Year><Month>10</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2009</Year><Month>10</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2010</Year><Month>8</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">19854757</ArticleId><ArticleId IdType="pii">la.2009.009058</ArticleId><ArticleId IdType="doi">10.1258/la.2009.009058</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Finlande</li></country><region><li>Uusimaa</li></region><settlement><li>Helsinki</li></settlement><orgName><li>Université d'Helsinki</li></orgName></list><tree><noCountry><name sortKey="Hau, J" sort="Hau, J" uniqKey="Hau J" first="J" last="Hau">J. Hau</name><name sortKey="Kohila, T" sort="Kohila, T" uniqKey="Kohila T" first="T" last="Kohila">T. Kohila</name><name sortKey="Mauranen, K" sort="Mauranen, K" uniqKey="Mauranen K" first="K" last="Mauranen">K. Mauranen</name><name sortKey="Meller, A" sort="Meller, A" uniqKey="Meller A" first="A" last="Meller">A. Meller</name><name sortKey="Nevalainen, T" sort="Nevalainen, T" uniqKey="Nevalainen T" first="T" last="Nevalainen">T. Nevalainen</name></noCountry><country name="Finlande"><region name="Uusimaa"><name sortKey="Kemppinen, N" sort="Kemppinen, N" uniqKey="Kemppinen N" first="N" last="Kemppinen">N. Kemppinen</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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