Glutamatergic dysfunction linked to energy and membrane lipid metabolism in frontal and anterior cingulate cortices of never treated first-episode schizophrenia patients.
Identifieur interne : 001D22 ( Main/Exploration ); précédent : 001D21; suivant : 001D23Glutamatergic dysfunction linked to energy and membrane lipid metabolism in frontal and anterior cingulate cortices of never treated first-episode schizophrenia patients.
Auteurs : Stefan Smesny [Allemagne] ; Alexander Gussew [Allemagne] ; Natalie Joan Biesel [Allemagne] ; Stephan Schack [Allemagne] ; Mario Walther [Allemagne] ; Reinhard Rzanny [Allemagne] ; Berko Milleit [Allemagne] ; Christian Gaser [Allemagne] ; Thomas Sobanski [Allemagne] ; Carl Christoph Schultz [Allemagne] ; Paul Amminger [Australie] ; Uta-Christina Hipler [Allemagne] ; Heinrich Sauer [Allemagne] ; Jürgen R. Reichenbach [Allemagne]Source :
- Schizophrenia research [ 1573-2509 ] ; 2015.
Descripteurs français
- KwdFr :
- Acide aspartique (analogues et dérivés), Acide aspartique (métabolisme), Acide glutamique (métabolisme), Adulte (MeSH), Analyse de variance (MeSH), Créatine (métabolisme), Femelle (MeSH), Gyrus du cingulum (métabolisme), Humains (MeSH), Imagerie par résonance magnétique (MeSH), Isotopes du phosphore (pharmacocinétique), Jeune adulte (MeSH), Lipides membranaires (métabolisme), Mâle (MeSH), Métabolisme lipidique (MeSH), Phospholipides (métabolisme), Protons (MeSH), Schizophrénie (anatomopathologie), Spectroscopie par résonance magnétique (MeSH), Échelles d'évaluation en psychiatrie (MeSH).
- MESH :
- analogues et dérivés : Acide aspartique.
- anatomopathologie : Schizophrénie.
- métabolisme : Acide aspartique, Acide glutamique, Créatine, Gyrus du cingulum, Lipides membranaires, Phospholipides.
- pharmacocinétique : Isotopes du phosphore.
- Adulte, Analyse de variance, Femelle, Humains, Imagerie par résonance magnétique, Jeune adulte, Mâle, Métabolisme lipidique, Protons, Spectroscopie par résonance magnétique, Échelles d'évaluation en psychiatrie.
English descriptors
- KwdEn :
- Adult (MeSH), Analysis of Variance (MeSH), Aspartic Acid (analogs & derivatives), Aspartic Acid (metabolism), Creatine (metabolism), Female (MeSH), Glutamic Acid (metabolism), Gyrus Cinguli (metabolism), Humans (MeSH), Lipid Metabolism (MeSH), Magnetic Resonance Imaging (MeSH), Magnetic Resonance Spectroscopy (MeSH), Male (MeSH), Membrane Lipids (metabolism), Phospholipids (metabolism), Phosphorus Isotopes (pharmacokinetics), Protons (MeSH), Psychiatric Status Rating Scales (MeSH), Schizophrenia (pathology), Young Adult (MeSH).
- MESH :
- chemical , analogs & derivatives : Aspartic Acid.
- chemical , metabolism : Aspartic Acid, Creatine, Glutamic Acid, Membrane Lipids, Phospholipids.
- metabolism : Gyrus Cinguli.
- pathology : Schizophrenia.
- chemical , pharmacokinetics : Phosphorus Isotopes.
- Adult, Analysis of Variance, Female, Humans, Lipid Metabolism, Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy, Male, Protons, Psychiatric Status Rating Scales, Young Adult.
Abstract
BACKGROUND
Glutamatergic dysfunction and altered membrane lipid and energy metabolism have been repeatedly demonstrated in the frontal/prefrontal and anterior cingulate cortex (ACC) in schizophrenia. Though having been already studied in animals, the presumed link between glutamatergic function and structural plasticity has not been investigated directly in the human brain yet. We measured glutamate (Glu), focal energy metabolism, and membrane phospholipid turnover to investigate main pathologies in those key brain regions of schizophrenia.
METHODS
(1)H- and (31)P-Chemical Shift Imaging (CSI) was combined in a single session to assess Glu and markers of energy (PCr, ATP) and membrane lipid (PME, PDE) metabolism in 31 neuroleptic-naïve first acute onset psychosis patients and 31 matched healthy controls. Multivariate analyses of covariance were used to assess disease effects on Glu and to investigate the impact of Glu alterations on phospholipid and energy metabolites.
RESULTS
Glu levels of patients were increased in the frontal and prefrontal cortex bilaterally and in the ACC. Higher Glu was associated with increased left frontal/prefrontal PME and right frontal/prefrontal PDE in patients, which was not observed in healthy controls. In contrast, higher Glu levels were associated with lower PCr or ATP values in the frontal/prefrontal cortex bilaterally and in the right ACC of controls. This was not observed in the right ACC and left frontal/prefrontal cortex of patients.
CONCLUSION
Frontal glutamatergic hyperactivity is disconnected from physiologically regulated energy metabolism and is associated with increased membrane breakdown in right and increased membrane restoration in left frontal and prefrontal cortical regions. As indicated by previous findings, this pathology is likely dynamic during the course of first acute illness and possibly associated with negative symptoms and cognitive impairment. Our findings underline the importance of further research on neuroprotective treatment options during the early acute or even better for the ultra-high risk state of psychotic illness.
DOI: 10.1016/j.schres.2015.07.013
PubMed: 26255566
Affiliations:
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Department of Psychiatry, Thüringen-Kliniken "Georgius Agricola" GmbH Rainweg 68, D-07318 Saalfeld/Saale, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry, Jena University Hospital, Philosophenweg 3, D-07743 Jena, Germany; Department of Psychiatry, Thüringen-Kliniken "Georgius Agricola" GmbH Rainweg 68, D-07318 Saalfeld/Saale</wicri:regionArea><wicri:noRegion>07318 Saalfeld/Saale</wicri:noRegion><wicri:noRegion>07318 Saalfeld/Saale</wicri:noRegion><wicri:noRegion>D-07318 Saalfeld/Saale</wicri:noRegion></affiliation></author><author><name sortKey="Gaser, Christian" sort="Gaser, Christian" uniqKey="Gaser C" first="Christian" last="Gaser">Christian Gaser</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, Jena University Hospital, Philosophenweg 3, D-07743 Jena, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry, Jena University Hospital, Philosophenweg 3, D-07743 Jena</wicri:regionArea><wicri:noRegion>07743 Jena</wicri:noRegion><wicri:noRegion>07743 Jena</wicri:noRegion><wicri:noRegion>D-07743 Jena</wicri:noRegion></affiliation></author><author><name sortKey="Sobanski, Thomas" sort="Sobanski, Thomas" uniqKey="Sobanski T" first="Thomas" last="Sobanski">Thomas Sobanski</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, Thüringen-Kliniken "Georgius Agricola" GmbH Rainweg 68, D-07318 Saalfeld/Saale, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry, Thüringen-Kliniken "Georgius Agricola" GmbH Rainweg 68, D-07318 Saalfeld/Saale</wicri:regionArea><wicri:noRegion>07318 Saalfeld/Saale</wicri:noRegion><wicri:noRegion>07318 Saalfeld/Saale</wicri:noRegion><wicri:noRegion>D-07318 Saalfeld/Saale</wicri:noRegion></affiliation></author><author><name sortKey="Schultz, Carl Christoph" sort="Schultz, Carl Christoph" uniqKey="Schultz C" first="Carl Christoph" last="Schultz">Carl Christoph Schultz</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, Jena University Hospital, Philosophenweg 3, D-07743 Jena, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry, Jena University Hospital, Philosophenweg 3, D-07743 Jena</wicri:regionArea><wicri:noRegion>07743 Jena</wicri:noRegion><wicri:noRegion>07743 Jena</wicri:noRegion><wicri:noRegion>D-07743 Jena</wicri:noRegion></affiliation></author><author><name sortKey="Amminger, Paul" sort="Amminger, Paul" uniqKey="Amminger P" first="Paul" last="Amminger">Paul Amminger</name><affiliation wicri:level="3"><nlm:affiliation>Department of Child and Adolescent Psychiatry, Medical University Vienna, Währingergürtel 18-20, A-1090 Vienna, Austria; Orygen Youth Health Research Centre, The University of Melbourne, Locked Bag 10, 35 Poplar Road Parkville, Victoria 3052, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Child and Adolescent Psychiatry, Medical University Vienna, Währingergürtel 18-20, A-1090 Vienna, Austria; Orygen Youth Health Research Centre, The University of Melbourne, Locked Bag 10, 35 Poplar Road Parkville, Victoria 3052, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Hipler, Uta Christina" sort="Hipler, Uta Christina" uniqKey="Hipler U" first="Uta-Christina" last="Hipler">Uta-Christina Hipler</name><affiliation wicri:level="1"><nlm:affiliation>Department of Dermatology, Jena University Hospital, Erfurter Straße 35, D-07743 Jena, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Dermatology, Jena University Hospital, Erfurter Straße 35, D-07743 Jena</wicri:regionArea><wicri:noRegion>07743 Jena</wicri:noRegion><wicri:noRegion>07743 Jena</wicri:noRegion><wicri:noRegion>D-07743 Jena</wicri:noRegion></affiliation></author><author><name sortKey="Sauer, Heinrich" sort="Sauer, Heinrich" uniqKey="Sauer H" first="Heinrich" last="Sauer">Heinrich Sauer</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, Jena University Hospital, Philosophenweg 3, D-07743 Jena, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry, Jena University Hospital, Philosophenweg 3, D-07743 Jena</wicri:regionArea><wicri:noRegion>07743 Jena</wicri:noRegion><wicri:noRegion>07743 Jena</wicri:noRegion><wicri:noRegion>D-07743 Jena</wicri:noRegion></affiliation></author><author><name sortKey="Reichenbach, Jurgen R" sort="Reichenbach, Jurgen R" uniqKey="Reichenbach J" first="Jürgen R" last="Reichenbach">Jürgen R. Reichenbach</name><affiliation wicri:level="1"><nlm:affiliation>Medical Physics Group, Department of Diagnostic and Interventional Radiology, Jena University Hospital, Philosophenweg 3, D-07740 Jena, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Medical Physics Group, Department of Diagnostic and Interventional Radiology, Jena University Hospital, Philosophenweg 3, D-07740 Jena</wicri:regionArea><wicri:noRegion>07740 Jena</wicri:noRegion><wicri:noRegion>07740 Jena</wicri:noRegion><wicri:noRegion>D-07740 Jena</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:26255566</idno><idno type="pmid">26255566</idno><idno type="doi">10.1016/j.schres.2015.07.013</idno><idno type="wicri:Area/Main/Corpus">001B75</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">001B75</idno><idno type="wicri:Area/Main/Curation">001B75</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">001B75</idno><idno type="wicri:Area/Main/Exploration">001B75</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Glutamatergic dysfunction linked to energy and membrane lipid metabolism in frontal and anterior cingulate cortices of never treated first-episode schizophrenia patients.</title><author><name sortKey="Smesny, Stefan" sort="Smesny, Stefan" uniqKey="Smesny S" first="Stefan" last="Smesny">Stefan Smesny</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, Jena University Hospital, Philosophenweg 3, D-07743 Jena, Germany. Electronic address: Stefan.Smesny@med.uni-jena.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry, Jena University Hospital, Philosophenweg 3, D-07743 Jena</wicri:regionArea><wicri:noRegion>07743 Jena</wicri:noRegion><wicri:noRegion>07743 Jena</wicri:noRegion><wicri:noRegion>D-07743 Jena</wicri:noRegion></affiliation></author><author><name sortKey="Gussew, Alexander" sort="Gussew, Alexander" uniqKey="Gussew A" first="Alexander" last="Gussew">Alexander Gussew</name><affiliation wicri:level="1"><nlm:affiliation>Medical Physics Group, Department of Diagnostic and Interventional Radiology, Jena University Hospital, Philosophenweg 3, D-07740 Jena, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Medical Physics Group, Department of Diagnostic and Interventional Radiology, Jena University Hospital, Philosophenweg 3, D-07740 Jena</wicri:regionArea><wicri:noRegion>07740 Jena</wicri:noRegion><wicri:noRegion>07740 Jena</wicri:noRegion><wicri:noRegion>D-07740 Jena</wicri:noRegion></affiliation></author><author><name sortKey="Biesel, Natalie Joan" sort="Biesel, Natalie Joan" uniqKey="Biesel N" first="Natalie Joan" last="Biesel">Natalie Joan Biesel</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, Jena University Hospital, Philosophenweg 3, D-07743 Jena, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry, Jena University Hospital, Philosophenweg 3, D-07743 Jena</wicri:regionArea><wicri:noRegion>07743 Jena</wicri:noRegion><wicri:noRegion>07743 Jena</wicri:noRegion><wicri:noRegion>D-07743 Jena</wicri:noRegion></affiliation></author><author><name sortKey="Schack, Stephan" sort="Schack, Stephan" uniqKey="Schack S" first="Stephan" last="Schack">Stephan Schack</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, Jena University Hospital, Philosophenweg 3, D-07743 Jena, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry, Jena University Hospital, Philosophenweg 3, D-07743 Jena</wicri:regionArea><wicri:noRegion>07743 Jena</wicri:noRegion><wicri:noRegion>07743 Jena</wicri:noRegion><wicri:noRegion>D-07743 Jena</wicri:noRegion></affiliation></author><author><name sortKey="Walther, Mario" sort="Walther, Mario" uniqKey="Walther M" first="Mario" last="Walther">Mario Walther</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Medical Statistics, Computer Sciences and Documentation (IMSID), Jena University Hospital, Friedrich-Schiller University Jena, Bachstraße 18, D-07743 Jena, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Statistics, Computer Sciences and Documentation (IMSID), Jena University Hospital, Friedrich-Schiller University Jena, Bachstraße 18, D-07743 Jena</wicri:regionArea><wicri:noRegion>07743 Jena</wicri:noRegion><wicri:noRegion>07743 Jena</wicri:noRegion><wicri:noRegion>D-07743 Jena</wicri:noRegion></affiliation></author><author><name sortKey="Rzanny, Reinhard" sort="Rzanny, Reinhard" uniqKey="Rzanny R" first="Reinhard" last="Rzanny">Reinhard Rzanny</name><affiliation wicri:level="1"><nlm:affiliation>Medical Physics Group, Department of Diagnostic and Interventional Radiology, Jena University Hospital, Philosophenweg 3, D-07740 Jena, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Medical Physics Group, Department of Diagnostic and Interventional Radiology, Jena University Hospital, Philosophenweg 3, D-07740 Jena</wicri:regionArea><wicri:noRegion>07740 Jena</wicri:noRegion><wicri:noRegion>07740 Jena</wicri:noRegion><wicri:noRegion>D-07740 Jena</wicri:noRegion></affiliation></author><author><name sortKey="Milleit, Berko" sort="Milleit, Berko" uniqKey="Milleit B" first="Berko" last="Milleit">Berko Milleit</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, Jena University Hospital, Philosophenweg 3, D-07743 Jena, Germany; Department of Psychiatry, Thüringen-Kliniken "Georgius Agricola" GmbH Rainweg 68, D-07318 Saalfeld/Saale, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry, Jena University Hospital, Philosophenweg 3, D-07743 Jena, Germany; Department of Psychiatry, Thüringen-Kliniken "Georgius Agricola" GmbH Rainweg 68, D-07318 Saalfeld/Saale</wicri:regionArea><wicri:noRegion>07318 Saalfeld/Saale</wicri:noRegion><wicri:noRegion>07318 Saalfeld/Saale</wicri:noRegion><wicri:noRegion>D-07318 Saalfeld/Saale</wicri:noRegion></affiliation></author><author><name sortKey="Gaser, Christian" sort="Gaser, Christian" uniqKey="Gaser C" first="Christian" last="Gaser">Christian Gaser</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, Jena University Hospital, Philosophenweg 3, D-07743 Jena, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry, Jena University Hospital, Philosophenweg 3, D-07743 Jena</wicri:regionArea><wicri:noRegion>07743 Jena</wicri:noRegion><wicri:noRegion>07743 Jena</wicri:noRegion><wicri:noRegion>D-07743 Jena</wicri:noRegion></affiliation></author><author><name sortKey="Sobanski, Thomas" sort="Sobanski, Thomas" uniqKey="Sobanski T" first="Thomas" last="Sobanski">Thomas Sobanski</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, Thüringen-Kliniken "Georgius Agricola" GmbH Rainweg 68, D-07318 Saalfeld/Saale, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry, Thüringen-Kliniken "Georgius Agricola" GmbH Rainweg 68, D-07318 Saalfeld/Saale</wicri:regionArea><wicri:noRegion>07318 Saalfeld/Saale</wicri:noRegion><wicri:noRegion>07318 Saalfeld/Saale</wicri:noRegion><wicri:noRegion>D-07318 Saalfeld/Saale</wicri:noRegion></affiliation></author><author><name sortKey="Schultz, Carl Christoph" sort="Schultz, Carl Christoph" uniqKey="Schultz C" first="Carl Christoph" last="Schultz">Carl Christoph Schultz</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, Jena University Hospital, Philosophenweg 3, D-07743 Jena, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry, Jena University Hospital, Philosophenweg 3, D-07743 Jena</wicri:regionArea><wicri:noRegion>07743 Jena</wicri:noRegion><wicri:noRegion>07743 Jena</wicri:noRegion><wicri:noRegion>D-07743 Jena</wicri:noRegion></affiliation></author><author><name sortKey="Amminger, Paul" sort="Amminger, Paul" uniqKey="Amminger P" first="Paul" last="Amminger">Paul Amminger</name><affiliation wicri:level="3"><nlm:affiliation>Department of Child and Adolescent Psychiatry, Medical University Vienna, Währingergürtel 18-20, A-1090 Vienna, Austria; Orygen Youth Health Research Centre, The University of Melbourne, Locked Bag 10, 35 Poplar Road Parkville, Victoria 3052, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Child and Adolescent Psychiatry, Medical University Vienna, Währingergürtel 18-20, A-1090 Vienna, Austria; Orygen Youth Health Research Centre, The University of Melbourne, Locked Bag 10, 35 Poplar Road Parkville, Victoria 3052, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Hipler, Uta Christina" sort="Hipler, Uta Christina" uniqKey="Hipler U" first="Uta-Christina" last="Hipler">Uta-Christina Hipler</name><affiliation wicri:level="1"><nlm:affiliation>Department of Dermatology, Jena University Hospital, Erfurter Straße 35, D-07743 Jena, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Dermatology, Jena University Hospital, Erfurter Straße 35, D-07743 Jena</wicri:regionArea><wicri:noRegion>07743 Jena</wicri:noRegion><wicri:noRegion>07743 Jena</wicri:noRegion><wicri:noRegion>D-07743 Jena</wicri:noRegion></affiliation></author><author><name sortKey="Sauer, Heinrich" sort="Sauer, Heinrich" uniqKey="Sauer H" first="Heinrich" last="Sauer">Heinrich Sauer</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, Jena University Hospital, Philosophenweg 3, D-07743 Jena, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry, Jena University Hospital, Philosophenweg 3, D-07743 Jena</wicri:regionArea><wicri:noRegion>07743 Jena</wicri:noRegion><wicri:noRegion>07743 Jena</wicri:noRegion><wicri:noRegion>D-07743 Jena</wicri:noRegion></affiliation></author><author><name sortKey="Reichenbach, Jurgen R" sort="Reichenbach, Jurgen R" uniqKey="Reichenbach J" first="Jürgen R" last="Reichenbach">Jürgen R. Reichenbach</name><affiliation wicri:level="1"><nlm:affiliation>Medical Physics Group, Department of Diagnostic and Interventional Radiology, Jena University Hospital, Philosophenweg 3, D-07740 Jena, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Medical Physics Group, Department of Diagnostic and Interventional Radiology, Jena University Hospital, Philosophenweg 3, D-07740 Jena</wicri:regionArea><wicri:noRegion>07740 Jena</wicri:noRegion><wicri:noRegion>07740 Jena</wicri:noRegion><wicri:noRegion>D-07740 Jena</wicri:noRegion></affiliation></author></analytic><series><title level="j">Schizophrenia research</title><idno type="eISSN">1573-2509</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term><term>Analysis of Variance (MeSH)</term><term>Aspartic Acid (analogs & derivatives)</term><term>Aspartic Acid (metabolism)</term><term>Creatine (metabolism)</term><term>Female (MeSH)</term><term>Glutamic Acid (metabolism)</term><term>Gyrus Cinguli (metabolism)</term><term>Humans (MeSH)</term><term>Lipid Metabolism (MeSH)</term><term>Magnetic Resonance Imaging (MeSH)</term><term>Magnetic Resonance Spectroscopy (MeSH)</term><term>Male (MeSH)</term><term>Membrane Lipids (metabolism)</term><term>Phospholipids (metabolism)</term><term>Phosphorus Isotopes (pharmacokinetics)</term><term>Protons (MeSH)</term><term>Psychiatric Status Rating Scales (MeSH)</term><term>Schizophrenia (pathology)</term><term>Young Adult (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Acide aspartique (analogues et dérivés)</term><term>Acide aspartique (métabolisme)</term><term>Acide glutamique (métabolisme)</term><term>Adulte (MeSH)</term><term>Analyse de variance (MeSH)</term><term>Créatine (métabolisme)</term><term>Femelle (MeSH)</term><term>Gyrus du cingulum (métabolisme)</term><term>Humains (MeSH)</term><term>Imagerie par résonance magnétique (MeSH)</term><term>Isotopes du phosphore (pharmacocinétique)</term><term>Jeune adulte (MeSH)</term><term>Lipides membranaires (métabolisme)</term><term>Mâle (MeSH)</term><term>Métabolisme lipidique (MeSH)</term><term>Phospholipides (métabolisme)</term><term>Protons (MeSH)</term><term>Schizophrénie (anatomopathologie)</term><term>Spectroscopie par résonance magnétique (MeSH)</term><term>Échelles d'évaluation en psychiatrie (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Aspartic Acid</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Aspartic Acid</term><term>Creatine</term><term>Glutamic Acid</term><term>Membrane Lipids</term><term>Phospholipids</term></keywords><keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Acide aspartique</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Schizophrénie</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Gyrus Cinguli</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Acide aspartique</term><term>Acide glutamique</term><term>Créatine</term><term>Gyrus du cingulum</term><term>Lipides membranaires</term><term>Phospholipides</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Schizophrenia</term></keywords><keywords scheme="MESH" qualifier="pharmacocinétique" xml:lang="fr"><term>Isotopes du phosphore</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Phosphorus Isotopes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Analysis of Variance</term><term>Female</term><term>Humans</term><term>Lipid Metabolism</term><term>Magnetic Resonance Imaging</term><term>Magnetic Resonance Spectroscopy</term><term>Male</term><term>Protons</term><term>Psychiatric Status Rating Scales</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Analyse de variance</term><term>Femelle</term><term>Humains</term><term>Imagerie par résonance magnétique</term><term>Jeune adulte</term><term>Mâle</term><term>Métabolisme lipidique</term><term>Protons</term><term>Spectroscopie par résonance magnétique</term><term>Échelles d'évaluation en psychiatrie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>Glutamatergic dysfunction and altered membrane lipid and energy metabolism have been repeatedly demonstrated in the frontal/prefrontal and anterior cingulate cortex (ACC) in schizophrenia. Though having been already studied in animals, the presumed link between glutamatergic function and structural plasticity has not been investigated directly in the human brain yet. We measured glutamate (Glu), focal energy metabolism, and membrane phospholipid turnover to investigate main pathologies in those key brain regions of schizophrenia.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>(1)H- and (31)P-Chemical Shift Imaging (CSI) was combined in a single session to assess Glu and markers of energy (PCr, ATP) and membrane lipid (PME, PDE) metabolism in 31 neuroleptic-naïve first acute onset psychosis patients and 31 matched healthy controls. Multivariate analyses of covariance were used to assess disease effects on Glu and to investigate the impact of Glu alterations on phospholipid and energy metabolites.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>Glu levels of patients were increased in the frontal and prefrontal cortex bilaterally and in the ACC. Higher Glu was associated with increased left frontal/prefrontal PME and right frontal/prefrontal PDE in patients, which was not observed in healthy controls. In contrast, higher Glu levels were associated with lower PCr or ATP values in the frontal/prefrontal cortex bilaterally and in the right ACC of controls. This was not observed in the right ACC and left frontal/prefrontal cortex of patients.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSION</b></p><p>Frontal glutamatergic hyperactivity is disconnected from physiologically regulated energy metabolism and is associated with increased membrane breakdown in right and increased membrane restoration in left frontal and prefrontal cortical regions. As indicated by previous findings, this pathology is likely dynamic during the course of first acute illness and possibly associated with negative symptoms and cognitive impairment. Our findings underline the importance of further research on neuroprotective treatment options during the early acute or even better for the ultra-high risk state of psychotic illness.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26255566</PMID><DateCompleted><Year>2016</Year><Month>07</Month><Day>06</Day></DateCompleted><DateRevised><Year>2015</Year><Month>10</Month><Day>01</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1573-2509</ISSN><JournalIssue CitedMedium="Internet"><Volume>168</Volume><Issue>1-2</Issue><PubDate><Year>2015</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Schizophrenia research</Title><ISOAbbreviation>Schizophr Res</ISOAbbreviation></Journal><ArticleTitle>Glutamatergic dysfunction linked to energy and membrane lipid metabolism in frontal and anterior cingulate cortices of never treated first-episode schizophrenia patients.</ArticleTitle><Pagination><MedlinePgn>322-9</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.schres.2015.07.013</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0920-9964(15)00352-7</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Glutamatergic dysfunction and altered membrane lipid and energy metabolism have been repeatedly demonstrated in the frontal/prefrontal and anterior cingulate cortex (ACC) in schizophrenia. Though having been already studied in animals, the presumed link between glutamatergic function and structural plasticity has not been investigated directly in the human brain yet. We measured glutamate (Glu), focal energy metabolism, and membrane phospholipid turnover to investigate main pathologies in those key brain regions of schizophrenia.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">(1)H- and (31)P-Chemical Shift Imaging (CSI) was combined in a single session to assess Glu and markers of energy (PCr, ATP) and membrane lipid (PME, PDE) metabolism in 31 neuroleptic-naïve first acute onset psychosis patients and 31 matched healthy controls. Multivariate analyses of covariance were used to assess disease effects on Glu and to investigate the impact of Glu alterations on phospholipid and energy metabolites.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Glu levels of patients were increased in the frontal and prefrontal cortex bilaterally and in the ACC. Higher Glu was associated with increased left frontal/prefrontal PME and right frontal/prefrontal PDE in patients, which was not observed in healthy controls. In contrast, higher Glu levels were associated with lower PCr or ATP values in the frontal/prefrontal cortex bilaterally and in the right ACC of controls. This was not observed in the right ACC and left frontal/prefrontal cortex of patients.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Frontal glutamatergic hyperactivity is disconnected from physiologically regulated energy metabolism and is associated with increased membrane breakdown in right and increased membrane restoration in left frontal and prefrontal cortical regions. As indicated by previous findings, this pathology is likely dynamic during the course of first acute illness and possibly associated with negative symptoms and cognitive impairment. Our findings underline the importance of further research on neuroprotective treatment options during the early acute or even better for the ultra-high risk state of psychotic illness.</AbstractText><CopyrightInformation>Copyright © 2015. Published by Elsevier B.V.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Smesny</LastName><ForeName>Stefan</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, Jena University Hospital, Philosophenweg 3, D-07743 Jena, Germany. Electronic address: Stefan.Smesny@med.uni-jena.de.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gussew</LastName><ForeName>Alexander</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Medical Physics Group, Department of Diagnostic and Interventional Radiology, Jena University Hospital, Philosophenweg 3, D-07740 Jena, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Biesel</LastName><ForeName>Natalie Joan</ForeName><Initials>NJ</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, Jena University Hospital, Philosophenweg 3, D-07743 Jena, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schack</LastName><ForeName>Stephan</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, Jena University Hospital, Philosophenweg 3, D-07743 Jena, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Walther</LastName><ForeName>Mario</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Institute of Medical Statistics, Computer Sciences and Documentation (IMSID), Jena University Hospital, Friedrich-Schiller University Jena, Bachstraße 18, D-07743 Jena, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rzanny</LastName><ForeName>Reinhard</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Medical Physics Group, Department of Diagnostic and Interventional Radiology, Jena University Hospital, Philosophenweg 3, D-07740 Jena, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Milleit</LastName><ForeName>Berko</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, Jena University Hospital, Philosophenweg 3, D-07743 Jena, Germany; Department of Psychiatry, Thüringen-Kliniken "Georgius Agricola" GmbH Rainweg 68, D-07318 Saalfeld/Saale, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gaser</LastName><ForeName>Christian</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, Jena University Hospital, Philosophenweg 3, D-07743 Jena, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sobanski</LastName><ForeName>Thomas</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, Thüringen-Kliniken "Georgius Agricola" GmbH Rainweg 68, D-07318 Saalfeld/Saale, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schultz</LastName><ForeName>Carl Christoph</ForeName><Initials>CC</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, Jena University Hospital, Philosophenweg 3, D-07743 Jena, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Amminger</LastName><ForeName>Paul</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Child and Adolescent Psychiatry, Medical University Vienna, Währingergürtel 18-20, A-1090 Vienna, Austria; Orygen Youth Health Research Centre, The University of Melbourne, Locked Bag 10, 35 Poplar Road Parkville, Victoria 3052, Melbourne, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hipler</LastName><ForeName>Uta-Christina</ForeName><Initials>UC</Initials><AffiliationInfo><Affiliation>Department of Dermatology, Jena University Hospital, Erfurter Straße 35, D-07743 Jena, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sauer</LastName><ForeName>Heinrich</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, Jena University Hospital, Philosophenweg 3, D-07743 Jena, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Reichenbach</LastName><ForeName>Jürgen R</ForeName><Initials>JR</Initials><AffiliationInfo><Affiliation>Medical Physics Group, Department of Diagnostic and Interventional Radiology, Jena University Hospital, Philosophenweg 3, D-07740 Jena, Germany.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>08</Month><Day>06</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Schizophr Res</MedlineTA><NlmUniqueID>8804207</NlmUniqueID><ISSNLinking>0920-9964</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008563">Membrane Lipids</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010743">Phospholipids</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010759">Phosphorus Isotopes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011522">Protons</NameOfSubstance></Chemical><Chemical><RegistryNumber>30KYC7MIAI</RegistryNumber><NameOfSubstance UI="D001224">Aspartic Acid</NameOfSubstance></Chemical><Chemical><RegistryNumber>3KX376GY7L</RegistryNumber><NameOfSubstance UI="D018698">Glutamic Acid</NameOfSubstance></Chemical><Chemical><RegistryNumber>997-55-7</RegistryNumber><NameOfSubstance UI="C000179">N-acetylaspartate</NameOfSubstance></Chemical><Chemical><RegistryNumber>MU72812GK0</RegistryNumber><NameOfSubstance UI="D003401">Creatine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000704" MajorTopicYN="N">Analysis of Variance</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001224" MajorTopicYN="N">Aspartic Acid</DescriptorName><QualifierName UI="Q000031" MajorTopicYN="N">analogs & derivatives</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003401" MajorTopicYN="N">Creatine</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018698" MajorTopicYN="N">Glutamic Acid</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006179" MajorTopicYN="N">Gyrus Cinguli</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D050356" MajorTopicYN="Y">Lipid Metabolism</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008279" MajorTopicYN="N">Magnetic Resonance Imaging</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009682" MajorTopicYN="N">Magnetic Resonance Spectroscopy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008563" MajorTopicYN="N">Membrane Lipids</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010743" MajorTopicYN="N">Phospholipids</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010759" MajorTopicYN="N">Phosphorus Isotopes</DescriptorName><QualifierName UI="Q000493" MajorTopicYN="N">pharmacokinetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011522" MajorTopicYN="N">Protons</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011569" MajorTopicYN="N">Psychiatric Status Rating Scales</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012559" MajorTopicYN="N">Schizophrenia</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">(1)H-MRS</Keyword><Keyword MajorTopicYN="N">(31)P-MRS</Keyword><Keyword MajorTopicYN="N">CSI</Keyword><Keyword MajorTopicYN="N">Energy metabolism</Keyword><Keyword MajorTopicYN="N">First-episode psychosis</Keyword><Keyword MajorTopicYN="N">Glutamate</Keyword><Keyword MajorTopicYN="N">Phospholipids</Keyword><Keyword MajorTopicYN="N">Schizophrenia</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>03</Month><Day>08</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2015</Year><Month>06</Month><Day>10</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>07</Month><Day>06</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>8</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>8</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>7</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26255566</ArticleId><ArticleId IdType="pii">S0920-9964(15)00352-7</ArticleId><ArticleId IdType="doi">10.1016/j.schres.2015.07.013</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li><li>Australie</li></country><region><li>Victoria (État)</li></region><settlement><li>Melbourne</li></settlement></list><tree><country name="Allemagne"><noRegion><name sortKey="Smesny, Stefan" sort="Smesny, Stefan" uniqKey="Smesny S" first="Stefan" last="Smesny">Stefan Smesny</name></noRegion><name sortKey="Biesel, Natalie Joan" sort="Biesel, Natalie Joan" uniqKey="Biesel N" first="Natalie Joan" last="Biesel">Natalie Joan Biesel</name><name sortKey="Gaser, Christian" sort="Gaser, Christian" uniqKey="Gaser C" first="Christian" last="Gaser">Christian Gaser</name><name sortKey="Gussew, Alexander" sort="Gussew, Alexander" uniqKey="Gussew A" first="Alexander" last="Gussew">Alexander Gussew</name><name sortKey="Hipler, Uta Christina" sort="Hipler, Uta Christina" uniqKey="Hipler U" first="Uta-Christina" last="Hipler">Uta-Christina Hipler</name><name sortKey="Milleit, Berko" sort="Milleit, Berko" uniqKey="Milleit B" first="Berko" last="Milleit">Berko Milleit</name><name sortKey="Reichenbach, Jurgen R" sort="Reichenbach, Jurgen R" uniqKey="Reichenbach J" first="Jürgen R" last="Reichenbach">Jürgen R. Reichenbach</name><name sortKey="Rzanny, Reinhard" sort="Rzanny, Reinhard" uniqKey="Rzanny R" first="Reinhard" last="Rzanny">Reinhard Rzanny</name><name sortKey="Sauer, Heinrich" sort="Sauer, Heinrich" uniqKey="Sauer H" first="Heinrich" last="Sauer">Heinrich Sauer</name><name sortKey="Schack, Stephan" sort="Schack, Stephan" uniqKey="Schack S" first="Stephan" last="Schack">Stephan Schack</name><name sortKey="Schultz, Carl Christoph" sort="Schultz, Carl Christoph" uniqKey="Schultz C" first="Carl Christoph" last="Schultz">Carl Christoph Schultz</name><name sortKey="Sobanski, Thomas" sort="Sobanski, Thomas" uniqKey="Sobanski T" first="Thomas" last="Sobanski">Thomas Sobanski</name><name sortKey="Walther, Mario" sort="Walther, Mario" uniqKey="Walther M" first="Mario" last="Walther">Mario Walther</name></country><country name="Australie"><region name="Victoria (État)"><name sortKey="Amminger, Paul" sort="Amminger, Paul" uniqKey="Amminger P" first="Paul" last="Amminger">Paul Amminger</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|clé= pubmed:26255566
|texte= Glutamatergic dysfunction linked to energy and membrane lipid metabolism in frontal and anterior cingulate cortices of never treated first-episode schizophrenia patients.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:26255566" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a PoplarV1
| This area was generated with Dilib version V0.6.37. |  |