A mechanism study on toxicity of graphene oxide to Daphnia magna: Direct link between bioaccumulation and oxidative stress.
Identifieur interne : 001076 ( Main/Exploration ); précédent : 001075; suivant : 001077A mechanism study on toxicity of graphene oxide to Daphnia magna: Direct link between bioaccumulation and oxidative stress.
Auteurs : Xiaohui Lv [République populaire de Chine] ; Yao Yang [République populaire de Chine] ; Yi Tao [République populaire de Chine] ; Yuelu Jiang [République populaire de Chine] ; Baiyang Chen [République populaire de Chine] ; Xiaoshan Zhu [République populaire de Chine] ; Zhonghua Cai [République populaire de Chine] ; Bing Li [République populaire de Chine]Source :
- Environmental pollution (Barking, Essex : 1987) [ 1873-6424 ] ; 2018.
Descripteurs français
- KwdFr :
- Animaux (MeSH), Daphnia (effets des médicaments et des substances chimiques), Daphnia (physiologie), Eau douce (MeSH), Espèces réactives de l'oxygène (MeSH), Graphite (toxicité), Oxydes (pharmacologie), Peroxydation lipidique (MeSH), Polluants chimiques de l'eau (toxicité), Stress oxydatif (physiologie), Superoxide dismutase (métabolisme).
- MESH :
- effets des médicaments et des substances chimiques : Daphnia.
- métabolisme : Superoxide dismutase.
- pharmacologie : Oxydes.
- physiologie : Daphnia, Stress oxydatif.
- toxicité : Graphite, Polluants chimiques de l'eau.
- Animaux, Eau douce, Espèces réactives de l'oxygène, Peroxydation lipidique.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Superoxide Dismutase.
- chemical , pharmacology : Oxides.
- chemical , toxicity : Graphite, Water Pollutants, Chemical.
- drug effects : Daphnia.
- physiology : Daphnia, Oxidative Stress.
- Animals, Fresh Water, Lipid Peroxidation, Reactive Oxygen Species.
Abstract
Graphene oxide (GO) possesses versatile applicability and high hydrophilicity, thus may have frequent contact with aquatic organisms. However, the ecological risks of GO in aquatic ecosystems remain largely unexplored currently. This study evaluated the comprehensive toxicological effects of GO on Daphnia magna, a key species in fresh water ecosystem. The results revealed nonsevere acute toxicities, including immobility (72 h EC50: 44.3 mg/L) and mortality (72 h LC50: 45.4 mg/L), of GO on D. magna. To understand the underlying mechanism of GO exposure, changes in superoxide dismutase (SOD) and lipid peroxidation (LPO) of D. magna exposed to GO were correlated, which revealed elevated GO-mediated oxidative stress and damages, especially in the long-time and high-dose exposure groups. The observations of in vivo fluorescence labeled with 2', 7'-dichlorofluorescin further demonstrated that reactive oxygen species were concentrated in daphnia guts, which corresponded with the high bioaccumulation level (5 mg/L, 24 h body burden: 107.9 g/kg) of GO in daphnia guts. However, depuration of GO from daphnia was not difficult. Daphnia almost released all GO within 24 h after it was transferred to clean water. These results hence suggest that GO could accumulate and induce significant oxidative stress in the gut of D. magna, while D. daphnia can also relieve the acute toxicity by depurating GO.
DOI: 10.1016/j.envpol.2017.12.034
PubMed: 29665635
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Electronic address: poplar_chen@hotmail.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shenzhen Key Laboratory of Organic Pollution Prevention and Control, State Key Laboratory of Urban Water Resource and Environment of Harbin Institute of Technology (Shenzhen), 518055</wicri:regionArea><wicri:noRegion>518055</wicri:noRegion></affiliation></author><author><name sortKey="Zhu, Xiaoshan" sort="Zhu, Xiaoshan" uniqKey="Zhu X" first="Xiaoshan" last="Zhu">Xiaoshan Zhu</name><affiliation wicri:level="1"><nlm:affiliation>Graduate School at Shenzhen, Tsinghua University, Shenzhen, 518055, China. Electronic address: zhu.xiaoshan@sz.tsinghua.edu.cn.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Graduate School at Shenzhen, Tsinghua University, Shenzhen, 518055</wicri:regionArea><wicri:noRegion>518055</wicri:noRegion></affiliation></author><author><name sortKey="Cai, Zhonghua" sort="Cai, Zhonghua" uniqKey="Cai Z" first="Zhonghua" last="Cai">Zhonghua Cai</name><affiliation wicri:level="1"><nlm:affiliation>Graduate School at Shenzhen, Tsinghua University, Shenzhen, 518055, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Graduate School at Shenzhen, Tsinghua University, Shenzhen, 518055</wicri:regionArea><wicri:noRegion>518055</wicri:noRegion></affiliation></author><author><name sortKey="Li, Bing" sort="Li, Bing" uniqKey="Li B" first="Bing" last="Li">Bing Li</name><affiliation wicri:level="1"><nlm:affiliation>Graduate School at Shenzhen, Tsinghua University, Shenzhen, 518055, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Graduate School at Shenzhen, Tsinghua University, Shenzhen, 518055</wicri:regionArea><wicri:noRegion>518055</wicri:noRegion></affiliation></author></analytic><series><title level="j">Environmental pollution (Barking, Essex : 1987)</title><idno type="eISSN">1873-6424</idno><imprint><date when="2018" type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term><term>Daphnia (drug effects)</term><term>Daphnia (physiology)</term><term>Fresh Water (MeSH)</term><term>Graphite (toxicity)</term><term>Lipid Peroxidation (MeSH)</term><term>Oxidative Stress (physiology)</term><term>Oxides (pharmacology)</term><term>Reactive Oxygen Species (MeSH)</term><term>Superoxide Dismutase (metabolism)</term><term>Water Pollutants, Chemical (toxicity)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term><term>Daphnia (effets des médicaments et des substances chimiques)</term><term>Daphnia (physiologie)</term><term>Eau douce (MeSH)</term><term>Espèces réactives de l'oxygène (MeSH)</term><term>Graphite (toxicité)</term><term>Oxydes (pharmacologie)</term><term>Peroxydation lipidique (MeSH)</term><term>Polluants chimiques de l'eau (toxicité)</term><term>Stress oxydatif (physiologie)</term><term>Superoxide dismutase (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Superoxide Dismutase</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Oxides</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Graphite</term><term>Water Pollutants, Chemical</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Daphnia</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Daphnia</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Superoxide dismutase</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Oxydes</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Daphnia</term><term>Stress oxydatif</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Daphnia</term><term>Oxidative Stress</term></keywords><keywords scheme="MESH" qualifier="toxicité" xml:lang="fr"><term>Graphite</term><term>Polluants chimiques de l'eau</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Fresh Water</term><term>Lipid Peroxidation</term><term>Reactive Oxygen Species</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Eau douce</term><term>Espèces réactives de l'oxygène</term><term>Peroxydation lipidique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Graphene oxide (GO) possesses versatile applicability and high hydrophilicity, thus may have frequent contact with aquatic organisms. However, the ecological risks of GO in aquatic ecosystems remain largely unexplored currently. This study evaluated the comprehensive toxicological effects of GO on Daphnia magna, a key species in fresh water ecosystem. The results revealed nonsevere acute toxicities, including immobility (72 h EC<sub>50</sub>: 44.3 mg/L) and mortality (72 h LC<sub>50</sub>: 45.4 mg/L), of GO on D. magna. To understand the underlying mechanism of GO exposure, changes in superoxide dismutase (SOD) and lipid peroxidation (LPO) of D. magna exposed to GO were correlated, which revealed elevated GO-mediated oxidative stress and damages, especially in the long-time and high-dose exposure groups. The observations of in vivo fluorescence labeled with 2', 7'-dichlorofluorescin further demonstrated that reactive oxygen species were concentrated in daphnia guts, which corresponded with the high bioaccumulation level (5 mg/L, 24 h body burden: 107.9 g/kg) of GO in daphnia guts. However, depuration of GO from daphnia was not difficult. Daphnia almost released all GO within 24 h after it was transferred to clean water. These results hence suggest that GO could accumulate and induce significant oxidative stress in the gut of D. magna, while D. daphnia can also relieve the acute toxicity by depurating GO.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" IndexingMethod="Curated" Owner="NLM"><PMID Version="1">29665635</PMID><DateCompleted><Year>2018</Year><Month>07</Month><Day>12</Day></DateCompleted><DateRevised><Year>2018</Year><Month>12</Month><Day>02</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-6424</ISSN><JournalIssue CitedMedium="Internet"><Volume>234</Volume><PubDate><Year>2018</Year><Month>Mar</Month></PubDate></JournalIssue><Title>Environmental pollution (Barking, Essex : 1987)</Title><ISOAbbreviation>Environ Pollut</ISOAbbreviation></Journal><ArticleTitle>A mechanism study on toxicity of graphene oxide to Daphnia magna: Direct link between bioaccumulation and oxidative stress.</ArticleTitle><Pagination><MedlinePgn>953-959</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0269-7491(17)33470-X</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.envpol.2017.12.034</ELocationID><Abstract><AbstractText>Graphene oxide (GO) possesses versatile applicability and high hydrophilicity, thus may have frequent contact with aquatic organisms. However, the ecological risks of GO in aquatic ecosystems remain largely unexplored currently. This study evaluated the comprehensive toxicological effects of GO on Daphnia magna, a key species in fresh water ecosystem. The results revealed nonsevere acute toxicities, including immobility (72 h EC<sub>50</sub>: 44.3 mg/L) and mortality (72 h LC<sub>50</sub>: 45.4 mg/L), of GO on D. magna. To understand the underlying mechanism of GO exposure, changes in superoxide dismutase (SOD) and lipid peroxidation (LPO) of D. magna exposed to GO were correlated, which revealed elevated GO-mediated oxidative stress and damages, especially in the long-time and high-dose exposure groups. The observations of in vivo fluorescence labeled with 2', 7'-dichlorofluorescin further demonstrated that reactive oxygen species were concentrated in daphnia guts, which corresponded with the high bioaccumulation level (5 mg/L, 24 h body burden: 107.9 g/kg) of GO in daphnia guts. However, depuration of GO from daphnia was not difficult. Daphnia almost released all GO within 24 h after it was transferred to clean water. These results hence suggest that GO could accumulate and induce significant oxidative stress in the gut of D. magna, while D. daphnia can also relieve the acute toxicity by depurating GO.</AbstractText><CopyrightInformation>Copyright © 2017 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lv</LastName><ForeName>Xiaohui</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Shenzhen Key Laboratory of Organic Pollution Prevention and Control, State Key Laboratory of Urban Water Resource and Environment of Harbin Institute of Technology (Shenzhen), 518055, China; Graduate School at Shenzhen, Tsinghua University, Shenzhen, 518055, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Yao</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>College of Life Science and Oceanography, Shenzhen University, Shenzhen, 518055, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tao</LastName><ForeName>Yi</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Graduate School at Shenzhen, Tsinghua University, Shenzhen, 518055, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jiang</LastName><ForeName>Yuelu</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Graduate School at Shenzhen, Tsinghua University, Shenzhen, 518055, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Baiyang</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Shenzhen Key Laboratory of Organic Pollution Prevention and Control, State Key Laboratory of Urban Water Resource and Environment of Harbin Institute of Technology (Shenzhen), 518055, China. Electronic address: poplar_chen@hotmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhu</LastName><ForeName>Xiaoshan</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Graduate School at Shenzhen, Tsinghua University, Shenzhen, 518055, China. Electronic address: zhu.xiaoshan@sz.tsinghua.edu.cn.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cai</LastName><ForeName>Zhonghua</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Graduate School at Shenzhen, Tsinghua University, Shenzhen, 518055, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Bing</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Graduate School at Shenzhen, Tsinghua University, Shenzhen, 518055, China.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>12</Month><Day>21</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Environ Pollut</MedlineTA><NlmUniqueID>8804476</NlmUniqueID><ISSNLinking>0269-7491</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010087">Oxides</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D017382">Reactive Oxygen Species</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014874">Water Pollutants, Chemical</NameOfSubstance></Chemical><Chemical><RegistryNumber>7782-42-5</RegistryNumber><NameOfSubstance UI="D006108">Graphite</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.15.1.1</RegistryNumber><NameOfSubstance UI="D013482">Superoxide Dismutase</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003621" MajorTopicYN="N">Daphnia</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005618" MajorTopicYN="N">Fresh Water</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006108" MajorTopicYN="N">Graphite</DescriptorName><QualifierName UI="Q000633" MajorTopicYN="Y">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015227" MajorTopicYN="N">Lipid Peroxidation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018384" MajorTopicYN="N">Oxidative Stress</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010087" MajorTopicYN="N">Oxides</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017382" MajorTopicYN="N">Reactive Oxygen Species</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013482" MajorTopicYN="N">Superoxide Dismutase</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014874" MajorTopicYN="N">Water Pollutants, Chemical</DescriptorName><QualifierName UI="Q000633" MajorTopicYN="Y">toxicity</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Acute toxicity</Keyword><Keyword MajorTopicYN="N">Bioaccumulation</Keyword><Keyword MajorTopicYN="N">Daphnia magna</Keyword><Keyword MajorTopicYN="N">Graphene oxide</Keyword><Keyword MajorTopicYN="N">Oxidative stress</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year><Month>08</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2017</Year><Month>11</Month><Day>04</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>12</Month><Day>10</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2018</Year><Month>4</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2018</Year><Month>4</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2018</Year><Month>7</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">29665635</ArticleId><ArticleId IdType="pii">S0269-7491(17)33470-X</ArticleId><ArticleId IdType="doi">10.1016/j.envpol.2017.12.034</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Lv, Xiaohui" sort="Lv, Xiaohui" uniqKey="Lv X" first="Xiaohui" last="Lv">Xiaohui Lv</name></noRegion><name sortKey="Cai, Zhonghua" sort="Cai, Zhonghua" uniqKey="Cai Z" first="Zhonghua" last="Cai">Zhonghua Cai</name><name sortKey="Chen, Baiyang" sort="Chen, Baiyang" uniqKey="Chen B" first="Baiyang" last="Chen">Baiyang Chen</name><name sortKey="Jiang, Yuelu" sort="Jiang, Yuelu" uniqKey="Jiang Y" first="Yuelu" last="Jiang">Yuelu Jiang</name><name sortKey="Li, Bing" sort="Li, Bing" uniqKey="Li B" first="Bing" last="Li">Bing Li</name><name sortKey="Tao, Yi" sort="Tao, Yi" uniqKey="Tao Y" first="Yi" last="Tao">Yi Tao</name><name sortKey="Yang, Yao" sort="Yang, Yao" uniqKey="Yang Y" first="Yao" last="Yang">Yao Yang</name><name sortKey="Zhu, Xiaoshan" sort="Zhu, Xiaoshan" uniqKey="Zhu X" first="Xiaoshan" last="Zhu">Xiaoshan Zhu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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