PoplarV1, Main, Exploration, bibRecord, 001048

Anticancer Activity in Honeybee Propolis: Functional Insights to the Role of Caffeic Acid Phenethyl Ester and Its Complex With γ-Cyclodextrin.

Identifieur interne : 001048 ( Main/Exploration ); précédent : 001047; suivant : 001049

Anticancer Activity in Honeybee Propolis: Functional Insights to the Role of Caffeic Acid Phenethyl Ester and Its Complex With γ-Cyclodextrin.

Auteurs : Yoshiyuki Ishida [Japon] ; Ran Gao [Japon, République populaire de Chine] ; Navjot Shah [Japon] ; Priyanshu Bhargava [Japon] ; Takahiro Furune [Japon] ; Sunil C. Kaul [Japon] ; Keiji Terao [Japon] ; Renu Wadhwa [Japon]

Source :

Integrative cancer therapies [ 1552-695X ] ; 2018.

RBID : pubmed:29390900

Descripteurs français

English descriptors

KwdEn :
- A549 Cells (MeSH), Animals (MeSH), Antineoplastic Agents (pharmacology), Antineoplastic Agents (therapeutic use), Apitherapy (MeSH), Caffeic Acids (chemistry), Caffeic Acids (pharmacology), Caffeic Acids (therapeutic use), Drug Combinations (MeSH), Female (MeSH), HeLa Cells (MeSH), Humans (MeSH), MCF-7 Cells (MeSH), Mice (MeSH), Mice, Inbred BALB C (MeSH), Mice, Nude (MeSH), Phenylethyl Alcohol (analogs & derivatives), Phenylethyl Alcohol (chemistry), Phenylethyl Alcohol (pharmacology), Phenylethyl Alcohol (therapeutic use), Propolis (pharmacology), Propolis (therapeutic use), Tumor Cells, Cultured (MeSH), Xenograft Model Antitumor Assays (MeSH), gamma-Cyclodextrins (chemistry), gamma-Cyclodextrins (pharmacology), gamma-Cyclodextrins (therapeutic use).
MESH :
- chemical , analogs & derivatives : Phenylethyl Alcohol.
- chemical , chemistry : Caffeic Acids, Phenylethyl Alcohol, gamma-Cyclodextrins.
- chemical , pharmacology : Antineoplastic Agents, Caffeic Acids, Phenylethyl Alcohol, Propolis, gamma-Cyclodextrins.
- chemical , therapeutic use : Antineoplastic Agents, Caffeic Acids, Phenylethyl Alcohol, Propolis, gamma-Cyclodextrins.
- A549 Cells, Animals, Apitherapy, Drug Combinations, Female, HeLa Cells, Humans, MCF-7 Cells, Mice, Mice, Inbred BALB C, Mice, Nude, Tumor Cells, Cultured, Xenograft Model Antitumor Assays.

Abstract

Besides honey, honeybees make a sticky substance (called propolis/bee glue) by mixing saliva with poplar tree resin and other botanical sources. It is known to be rich in bioactivities of which the anticancer activity is most studied. Caffeic acid phenethyl ester (CAPE) is a key anticancer component in New Zealand propolis. We have earlier investigated the molecular mechanism of anticancer activity in CAPE and reported that it activates DNA damage signaling in cancer cells. CAPE-induced growth arrest of cells was mediated by downregulation of mortalin and activation of p53 tumor suppressor protein. When antitumor and antimetastasis activities of CAPE were examined in vitro and in vivo, we failed to find significant activities, which was contrary to our expectations. On careful examination, it was revealed that CAPE is unstable and rather gets easily degraded into caffeic acid by secreted esterases. Interestingly, when CAPE was complexed with γ-cyclodextrin (γCD) the activities were significantly enhanced. In the present study, we report that the CAPE-γCD complex with higher cytotoxicity to a wide range of cancer cells is stable in acidic milieu and therefore recommended as an anticancer amalgam. We also report a method for preparation of stable and less-pungent powder of propolis that could be conveniently used for health and therapeutic benefits.

DOI: 10.1177/1534735417753545
PubMed: 29390900
PubMed Central: PMC6142091

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000F88
to stream Main, to step Curation: 000F88

Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>A549 Cells (MeSH)</term>
<term>Animals (MeSH)</term>
<term>Antineoplastic Agents (pharmacology)</term>
<term>Antineoplastic Agents (therapeutic use)</term>
<term>Apitherapy (MeSH)</term>
<term>Caffeic Acids (chemistry)</term>
<term>Caffeic Acids (pharmacology)</term>
<term>Caffeic Acids (therapeutic use)</term>
<term>Drug Combinations (MeSH)</term>
<term>Female (MeSH)</term>
<term>HeLa Cells (MeSH)</term>
<term>Humans (MeSH)</term>
<term>MCF-7 Cells (MeSH)</term>
<term>Mice (MeSH)</term>
<term>Mice, Inbred BALB C (MeSH)</term>
<term>Mice, Nude (MeSH)</term>
<term>Phenylethyl Alcohol (analogs & derivatives)</term>
<term>Phenylethyl Alcohol (chemistry)</term>
<term>Phenylethyl Alcohol (pharmacology)</term>
<term>Phenylethyl Alcohol (therapeutic use)</term>
<term>Propolis (pharmacology)</term>
<term>Propolis (therapeutic use)</term>
<term>Tumor Cells, Cultured (MeSH)</term>
<term>Xenograft Model Antitumor Assays (MeSH)</term>
<term>gamma-Cyclodextrins (chemistry)</term>
<term>gamma-Cyclodextrins (pharmacology)</term>
<term>gamma-Cyclodextrins (therapeutic use)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Acides caféiques (composition chimique)</term>
<term>Acides caféiques (pharmacologie)</term>
<term>Acides caféiques (usage thérapeutique)</term>
<term>Alcool phénéthylique (analogues et dérivés)</term>
<term>Alcool phénéthylique (composition chimique)</term>
<term>Alcool phénéthylique (pharmacologie)</term>
<term>Alcool phénéthylique (usage thérapeutique)</term>
<term>Animaux (MeSH)</term>
<term>Antinéoplasiques (pharmacologie)</term>
<term>Antinéoplasiques (usage thérapeutique)</term>
<term>Apithérapie (MeSH)</term>
<term>Association médicamenteuse (MeSH)</term>
<term>Cellules A549 (MeSH)</term>
<term>Cellules HeLa (MeSH)</term>
<term>Cellules MCF-7 (MeSH)</term>
<term>Cellules cancéreuses en culture (MeSH)</term>
<term>Cyclodextrines gamma (composition chimique)</term>
<term>Cyclodextrines gamma (pharmacologie)</term>
<term>Cyclodextrines gamma (usage thérapeutique)</term>
<term>Femelle (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Propolis (pharmacologie)</term>
<term>Propolis (usage thérapeutique)</term>
<term>Souris (MeSH)</term>
<term>Souris de lignée BALB C (MeSH)</term>
<term>Souris nude (MeSH)</term>
<term>Tests d'activité antitumorale sur modèle de xénogreffe (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Phenylethyl Alcohol</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Caffeic Acids</term>
<term>Phenylethyl Alcohol</term>
<term>gamma-Cyclodextrins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antineoplastic Agents</term>
<term>Caffeic Acids</term>
<term>Phenylethyl Alcohol</term>
<term>Propolis</term>
<term>gamma-Cyclodextrins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antineoplastic Agents</term>
<term>Caffeic Acids</term>
<term>Phenylethyl Alcohol</term>
<term>Propolis</term>
<term>gamma-Cyclodextrins</term>
</keywords>
<keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Alcool phénéthylique</term>
</keywords>
<keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Acides caféiques</term>
<term>Alcool phénéthylique</term>
<term>Cyclodextrines gamma</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Acides caféiques</term>
<term>Alcool phénéthylique</term>
<term>Antinéoplasiques</term>
<term>Cyclodextrines gamma</term>
<term>Propolis</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Acides caféiques</term>
<term>Alcool phénéthylique</term>
<term>Antinéoplasiques</term>
<term>Cyclodextrines gamma</term>
<term>Propolis</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>A549 Cells</term>
<term>Animals</term>
<term>Apitherapy</term>
<term>Drug Combinations</term>
<term>Female</term>
<term>HeLa Cells</term>
<term>Humans</term>
<term>MCF-7 Cells</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
<term>Mice, Nude</term>
<term>Tumor Cells, Cultured</term>
<term>Xenograft Model Antitumor Assays</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Apithérapie</term>
<term>Association médicamenteuse</term>
<term>Cellules A549</term>
<term>Cellules HeLa</term>
<term>Cellules MCF-7</term>
<term>Cellules cancéreuses en culture</term>
<term>Femelle</term>
<term>Humains</term>
<term>Souris</term>
<term>Souris de lignée BALB C</term>
<term>Souris nude</term>
<term>Tests d'activité antitumorale sur modèle de xénogreffe</term>
</keywords>
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<front><div type="abstract" xml:lang="en">Besides honey, honeybees make a sticky substance (called propolis/bee glue) by mixing saliva with poplar tree resin and other botanical sources. It is known to be rich in bioactivities of which the anticancer activity is most studied. Caffeic acid phenethyl ester (CAPE) is a key anticancer component in New Zealand propolis. We have earlier investigated the molecular mechanism of anticancer activity in CAPE and reported that it activates DNA damage signaling in cancer cells. CAPE-induced growth arrest of cells was mediated by downregulation of mortalin and activation of p53 tumor suppressor protein. When antitumor and antimetastasis activities of CAPE were examined in vitro and in vivo, we failed to find significant activities, which was contrary to our expectations. On careful examination, it was revealed that CAPE is unstable and rather gets easily degraded into caffeic acid by secreted esterases. Interestingly, when CAPE was complexed with γ-cyclodextrin (γCD) the activities were significantly enhanced. In the present study, we report that the CAPE-γCD complex with higher cytotoxicity to a wide range of cancer cells is stable in acidic milieu and therefore recommended as an anticancer amalgam. We also report a method for preparation of stable and less-pungent powder of propolis that could be conveniently used for health and therapeutic benefits.</div>
</front>
</TEI>
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<DateCompleted><Year>2019</Year>
<Month>04</Month>
<Day>19</Day>
</DateCompleted>
<DateRevised><Year>2019</Year>
<Month>04</Month>
<Day>19</Day>
</DateRevised>
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<JournalIssue CitedMedium="Internet"><Volume>17</Volume>
<Issue>3</Issue>
<PubDate><Year>2018</Year>
<Month>09</Month>
</PubDate>
</JournalIssue>
<Title>Integrative cancer therapies</Title>
<ISOAbbreviation>Integr Cancer Ther</ISOAbbreviation>
</Journal>
<ArticleTitle>Anticancer Activity in Honeybee Propolis: Functional Insights to the Role of Caffeic Acid Phenethyl Ester and Its Complex With γ-Cyclodextrin.</ArticleTitle>
<Pagination><MedlinePgn>867-873</MedlinePgn>
</Pagination>
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<Abstract><AbstractText>Besides honey, honeybees make a sticky substance (called propolis/bee glue) by mixing saliva with poplar tree resin and other botanical sources. It is known to be rich in bioactivities of which the anticancer activity is most studied. Caffeic acid phenethyl ester (CAPE) is a key anticancer component in New Zealand propolis. We have earlier investigated the molecular mechanism of anticancer activity in CAPE and reported that it activates DNA damage signaling in cancer cells. CAPE-induced growth arrest of cells was mediated by downregulation of mortalin and activation of p53 tumor suppressor protein. When antitumor and antimetastasis activities of CAPE were examined in vitro and in vivo, we failed to find significant activities, which was contrary to our expectations. On careful examination, it was revealed that CAPE is unstable and rather gets easily degraded into caffeic acid by secreted esterases. Interestingly, when CAPE was complexed with γ-cyclodextrin (γCD) the activities were significantly enhanced. In the present study, we report that the CAPE-γCD complex with higher cytotoxicity to a wide range of cancer cells is stable in acidic milieu and therefore recommended as an anticancer amalgam. We also report a method for preparation of stable and less-pungent powder of propolis that could be conveniently used for health and therapeutic benefits.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ishida</LastName>
<ForeName>Yoshiyuki</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>1 CycloChem Co, Ltd, Chuo-ku, Kobe, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gao</LastName>
<ForeName>Ran</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>2 National Institute of Advanced Industrial Science & Technology, Tsukuba, Japan.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>3 Peking Union Medical College, Beijing, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Shah</LastName>
<ForeName>Navjot</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>2 National Institute of Advanced Industrial Science & Technology, Tsukuba, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bhargava</LastName>
<ForeName>Priyanshu</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>2 National Institute of Advanced Industrial Science & Technology, Tsukuba, Japan.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>4 University of Tsukuba, Ibaraki, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Furune</LastName>
<ForeName>Takahiro</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>1 CycloChem Co, Ltd, Chuo-ku, Kobe, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kaul</LastName>
<ForeName>Sunil C</ForeName>
<Initials>SC</Initials>
<Identifier Source="ORCID">0000-0002-0046-3916</Identifier>
<AffiliationInfo><Affiliation>2 National Institute of Advanced Industrial Science & Technology, Tsukuba, Japan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Terao</LastName>
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<ReferenceList><Reference><Citation>Adv Drug Deliv Rev. 2017 Jan 1;108:25-38</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27137110</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Dent Res. 2016 Feb;95(2):129-34</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26516128</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Rev Cancer. 2004 Aug;4(8):630-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15286742</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Diet Suppl. 2016;13(3):245-68</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25723108</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>CA Cancer J Clin. 2012 Mar-Apr;62(2):75-100</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22307864</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Oncogene. 2010 Aug 26;29(34):4741-51</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20531305</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Oncol. 2012 Apr;6(2):155-76</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22440008</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cancer Treat Rev. 2014 Jul;40(6):716-22</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24759599</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Molecules. 2015 Jul 10;20(7):12576-89</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26184141</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Cancer Res. 2008 Apr;6(4):517-24</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18403632</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Mol Med (Berl). 2016 Feb;94(2):155-71</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26099350</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Mol Cell Biol. 2011 Feb;3(1):1-3</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21278445</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Crit Rev Oncol Hematol. 2016 Jan;97:118-30</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26318097</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Cancer Sci Ther. 2013 Oct 21;5(10):334-342</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24466386</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Crit Rev Food Sci Nutr. 2016 Sep 9;56(12):1981-2004</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25764389</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Eur J Pharm Biopharm. 2005 Oct;61(3):115-25</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16185857</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Breast Cancer. 2016 Mar;19(1):18-25</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27066092</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Contact Dermatitis. 1987 Sep;17(3):163-70</Citation>
<ArticleIdList><ArticleId IdType="pubmed">3315436</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Curr Med Chem. 2008;15(5):470-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18289002</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Agric Food Chem. 2002 Apr 24;50(9):2502-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11958612</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Molecules. 2017 Sep 15;22(9):null</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28926932</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Cancer. 2016 Jun 23;7(10):1281-94</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27390604</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Fitoterapia. 2015 Oct;106:167-74</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26347954</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Acc Chem Res. 2008 Jan;41(1):98-107</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17705444</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Cancer Ther. 2016 Jul;15(7):1682-90</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27196769</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2006 Sep 21;355(12):1253-61</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16990388</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Ethnopharmacol. 2011 Jan 27;133(2):253-60</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20970490</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Cancer Res Clin Oncol. 2004 Mar;130(3):146-52</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14691717</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Cancer. 2016 Aug 11;7(13):1755-1771</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27698914</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
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Anticancer Activity in Honeybee Propolis: Functional Insights to the Role of Caffeic Acid Phenethyl Ester and Its Complex With γ-Cyclodextrin.

Anticancer Activity in Honeybee Propolis: Functional Insights to the Role of Caffeic Acid Phenethyl Ester and Its Complex With γ-Cyclodextrin.

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