PoplarV1, Main, Exploration, bibRecord, 001038

Autism and psychosis: Clinical implications for depression and suicide.

Identifieur interne : 001038 ( Main/Exploration ); précédent : 001037; suivant : 001039

Autism and psychosis: Clinical implications for depression and suicide.

Auteurs : Rachel Upthegrove [Royaume-Uni] ; Ahmad Abu-Akel [Suisse] ; Katharine Chisholm [Royaume-Uni] ; Ashleigh Lin [Australie] ; Sofia Zahid [Royaume-Uni] ; Mirabel Pelton [Royaume-Uni] ; Ian Apperly [Royaume-Uni] ; Peter C. Hansen [Royaume-Uni] ; Stephen J. Wood [Australie]

Source :

Schizophrenia research [ 1573-2509 ] ; 2018.

RBID : pubmed:28823724

Descripteurs français

KwdFr :
- Adolescent (MeSH), Adulte (MeSH), Comportement de recherche d'aide (MeSH), Dépression (psychologie), Dépression (étiologie), Femelle (MeSH), Humains (MeSH), Jeune adulte (MeSH), Mâle (MeSH), Suicide (psychologie), Trouble autistique (complications), Trouble autistique (psychologie), Troubles psychotiques (complications), Troubles psychotiques (psychologie).
MESH :
- psychologie : Dépression, Suicide, Trouble autistique, Troubles psychotiques.
- étiologie : Dépression.
- complications : Adolescent, Adulte, Comportement de recherche d'aide, Femelle, Humains, Jeune adulte, Mâle, Trouble autistique, Troubles psychotiques.

English descriptors

KwdEn :
- Adolescent (MeSH), Adult (MeSH), Autistic Disorder (complications), Autistic Disorder (psychology), Depression (etiology), Depression (psychology), Female (MeSH), Help-Seeking Behavior (MeSH), Humans (MeSH), Male (MeSH), Psychotic Disorders (complications), Psychotic Disorders (psychology), Suicide (psychology), Young Adult (MeSH).
MESH :
- complications : Autistic Disorder, Psychotic Disorders.
- etiology : Depression.
- psychology : Autistic Disorder, Depression, Psychotic Disorders, Suicide.
- Adolescent, Adult, Female, Help-Seeking Behavior, Humans, Male, Young Adult.

Abstract

There is increasing recognition of the co-occurrence of autism and schizophrenia spectrum disorders. However, the clinical significance of this on outcomes such as depression and suicidal thinking has not been explored. This study examines the association of autism spectrum traits, depressive symptoms and suicidal behaviour in individuals with psychotic experiences. In two cross sectional studies, individuals from a non-help seeking university student sample and patients with first episode psychosis (FEP) service completed standardized measures of autism spectrum traits, psychotic experiences, depressive symptoms and suicidal thinking. In healthy non-help seeking students, increased autism traits and increased subclinical psychotic experiences were significantly associated with depressive symptoms; a significant interaction effect suggests their combined presence has a greater impact on depression. In FEP, high autism traits and positive symptoms were associated with increased depression, hopelessness and suicidality, however there was no significant interaction effect. In FEP a multiple mediation model revealed that the relationship between autism traits and risk for suicidality was mediated through hopelessness. Young people with subclinical psychotic experiences and all patients with FEP should be screened for autism spectrum traits, which may have significant impact on clinical outcomes. Tailored interventions for patients with high levels of autistic spectrum co-morbidities in FEP should be a priority for future research.

DOI: 10.1016/j.schres.2017.08.028
PubMed: 28823724

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 001193
to stream Main, to step Curation: 001193

Le document en format XML

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<term>Autistic Disorder (psychology)</term>
<term>Depression (etiology)</term>
<term>Depression (psychology)</term>
<term>Female (MeSH)</term>
<term>Help-Seeking Behavior (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Male (MeSH)</term>
<term>Psychotic Disorders (complications)</term>
<term>Psychotic Disorders (psychology)</term>
<term>Suicide (psychology)</term>
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<term>Adulte (MeSH)</term>
<term>Comportement de recherche d'aide (MeSH)</term>
<term>Dépression (psychologie)</term>
<term>Dépression (étiologie)</term>
<term>Femelle (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Jeune adulte (MeSH)</term>
<term>Mâle (MeSH)</term>
<term>Suicide (psychologie)</term>
<term>Trouble autistique (complications)</term>
<term>Trouble autistique (psychologie)</term>
<term>Troubles psychotiques (complications)</term>
<term>Troubles psychotiques (psychologie)</term>
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<term>Suicide</term>
<term>Trouble autistique</term>
<term>Troubles psychotiques</term>
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<keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Autistic Disorder</term>
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<term>Suicide</term>
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<term>Femelle</term>
<term>Humains</term>
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<front><div type="abstract" xml:lang="en">There is increasing recognition of the co-occurrence of autism and schizophrenia spectrum disorders. However, the clinical significance of this on outcomes such as depression and suicidal thinking has not been explored. This study examines the association of autism spectrum traits, depressive symptoms and suicidal behaviour in individuals with psychotic experiences. In two cross sectional studies, individuals from a non-help seeking university student sample and patients with first episode psychosis (FEP) service completed standardized measures of autism spectrum traits, psychotic experiences, depressive symptoms and suicidal thinking. In healthy non-help seeking students, increased autism traits and increased subclinical psychotic experiences were significantly associated with depressive symptoms; a significant interaction effect suggests their combined presence has a greater impact on depression. In FEP, high autism traits and positive symptoms were associated with increased depression, hopelessness and suicidality, however there was no significant interaction effect. In FEP a multiple mediation model revealed that the relationship between autism traits and risk for suicidality was mediated through hopelessness. Young people with subclinical psychotic experiences and all patients with FEP should be screened for autism spectrum traits, which may have significant impact on clinical outcomes. Tailored interventions for patients with high levels of autistic spectrum co-morbidities in FEP should be a priority for future research.</div>
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<Title>Schizophrenia research</Title>
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<Abstract><AbstractText>There is increasing recognition of the co-occurrence of autism and schizophrenia spectrum disorders. However, the clinical significance of this on outcomes such as depression and suicidal thinking has not been explored. This study examines the association of autism spectrum traits, depressive symptoms and suicidal behaviour in individuals with psychotic experiences. In two cross sectional studies, individuals from a non-help seeking university student sample and patients with first episode psychosis (FEP) service completed standardized measures of autism spectrum traits, psychotic experiences, depressive symptoms and suicidal thinking. In healthy non-help seeking students, increased autism traits and increased subclinical psychotic experiences were significantly associated with depressive symptoms; a significant interaction effect suggests their combined presence has a greater impact on depression. In FEP, high autism traits and positive symptoms were associated with increased depression, hopelessness and suicidality, however there was no significant interaction effect. In FEP a multiple mediation model revealed that the relationship between autism traits and risk for suicidality was mediated through hopelessness. Young people with subclinical psychotic experiences and all patients with FEP should be screened for autism spectrum traits, which may have significant impact on clinical outcomes. Tailored interventions for patients with high levels of autistic spectrum co-morbidities in FEP should be a priority for future research.</AbstractText>
<CopyrightInformation>Copyright © 2017 Elsevier B.V. All rights reserved.</CopyrightInformation>
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<ForeName>Rachel</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>University of Birmingham, School of Psychology, Edgbaston, Birmingham B15 2TT, United Kingdom; University of Birmingham, Institute of Clinical Sciences, College of Medical and Dental Science, Edgbaston, Birmingham B15 2TT, United Kingdom; Forward Thinking Birmingham and Birmingham and Solihull Mental Health Foundation Trust, 1 Printing House Street, Birmingham B4 6DF, United Kingdom. Electronic address: r.upthegrove@bham.ac.uk.</Affiliation>
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<Author ValidYN="Y"><LastName>Abu-Akel</LastName>
<ForeName>Ahmad</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>University of Lausanne, Institute of Psychology, UNIL - Mouline, Géopolis - office 4129, CH-1015 Lausanne, Switzerland.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Chisholm</LastName>
<ForeName>Katharine</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>University of Birmingham, School of Psychology, Edgbaston, Birmingham B15 2TT, United Kingdom.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lin</LastName>
<ForeName>Ashleigh</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Telethon Kids Institute, The University of Western Australia, 100 Roberts Rd, Subiaco, WA 6008, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zahid</LastName>
<ForeName>Sofia</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>University of Birmingham, School of Psychology, Edgbaston, Birmingham B15 2TT, United Kingdom.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pelton</LastName>
<ForeName>Mirabel</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>University of Birmingham, School of Psychology, Edgbaston, Birmingham B15 2TT, United Kingdom.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Apperly</LastName>
<ForeName>Ian</ForeName>
<Initials>I</Initials>
<AffiliationInfo><Affiliation>University of Birmingham, School of Psychology, Edgbaston, Birmingham B15 2TT, United Kingdom.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hansen</LastName>
<ForeName>Peter C</ForeName>
<Initials>PC</Initials>
<AffiliationInfo><Affiliation>University of Birmingham, School of Psychology, Edgbaston, Birmingham B15 2TT, United Kingdom.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wood</LastName>
<ForeName>Stephen J</ForeName>
<Initials>SJ</Initials>
<AffiliationInfo><Affiliation>University of Birmingham, School of Psychology, Edgbaston, Birmingham B15 2TT, United Kingdom; University of Melbourne, Centre for Youth Mental Health, 35 Poplar Rd, Parkville, VIC 3052, Australia; Orygen, National Centre of Excellence in Youth Mental Health, 2a/2A Hartington Street, Glenroy, Victoria 3046, Australia.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2017</Year>
<Month>08</Month>
<Day>18</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>Netherlands</Country>
<MedlineTA>Schizophr Res</MedlineTA>
<NlmUniqueID>8804207</NlmUniqueID>
<ISSNLinking>0920-9964</ISSNLinking>
</MedlineJournalInfo>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001321" MajorTopicYN="N">Autistic Disorder</DescriptorName>
<QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName>
<QualifierName UI="Q000523" MajorTopicYN="Y">psychology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D003863" MajorTopicYN="N">Depression</DescriptorName>
<QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName>
<QualifierName UI="Q000523" MajorTopicYN="N">psychology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000066505" MajorTopicYN="N">Help-Seeking Behavior</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011618" MajorTopicYN="N">Psychotic Disorders</DescriptorName>
<QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName>
<QualifierName UI="Q000523" MajorTopicYN="N">psychology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013405" MajorTopicYN="N">Suicide</DescriptorName>
<QualifierName UI="Q000523" MajorTopicYN="Y">psychology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Autism</Keyword>
<Keyword MajorTopicYN="Y">Autism spectrum disorders</Keyword>
<Keyword MajorTopicYN="Y">Depression</Keyword>
<Keyword MajorTopicYN="Y">Psychosis</Keyword>
<Keyword MajorTopicYN="Y">Schizophrenia</Keyword>
<Keyword MajorTopicYN="Y">Suicide</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year>
<Month>06</Month>
<Day>04</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2017</Year>
<Month>08</Month>
<Day>15</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2017</Year>
<Month>08</Month>
<Day>16</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2017</Year>
<Month>8</Month>
<Day>22</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2018</Year>
<Month>11</Month>
<Day>20</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2017</Year>
<Month>8</Month>
<Day>22</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">28823724</ArticleId>
<ArticleId IdType="pii">S0920-9964(17)30504-2</ArticleId>
<ArticleId IdType="doi">10.1016/j.schres.2017.08.028</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Australie</li>
<li>Royaume-Uni</li>
<li>Suisse</li>
</country>
<region><li>Angleterre</li>
<li>Midlands de l'Ouest</li>
</region>
<settlement><li>Birmingham</li>
</settlement>
<orgName><li>Université de Birmingham</li>
</orgName>
</list>
<tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Upthegrove, Rachel" sort="Upthegrove, Rachel" uniqKey="Upthegrove R" first="Rachel" last="Upthegrove">Rachel Upthegrove</name>
</region>
<name sortKey="Apperly, Ian" sort="Apperly, Ian" uniqKey="Apperly I" first="Ian" last="Apperly">Ian Apperly</name>
<name sortKey="Chisholm, Katharine" sort="Chisholm, Katharine" uniqKey="Chisholm K" first="Katharine" last="Chisholm">Katharine Chisholm</name>
<name sortKey="Hansen, Peter C" sort="Hansen, Peter C" uniqKey="Hansen P" first="Peter C" last="Hansen">Peter C. Hansen</name>
<name sortKey="Pelton, Mirabel" sort="Pelton, Mirabel" uniqKey="Pelton M" first="Mirabel" last="Pelton">Mirabel Pelton</name>
<name sortKey="Zahid, Sofia" sort="Zahid, Sofia" uniqKey="Zahid S" first="Sofia" last="Zahid">Sofia Zahid</name>
</country>
<country name="Suisse"><noRegion><name sortKey="Abu Akel, Ahmad" sort="Abu Akel, Ahmad" uniqKey="Abu Akel A" first="Ahmad" last="Abu-Akel">Ahmad Abu-Akel</name>
</noRegion>
</country>
<country name="Australie"><noRegion><name sortKey="Lin, Ashleigh" sort="Lin, Ashleigh" uniqKey="Lin A" first="Ashleigh" last="Lin">Ashleigh Lin</name>
</noRegion>
<name sortKey="Wood, Stephen J" sort="Wood, Stephen J" uniqKey="Wood S" first="Stephen J" last="Wood">Stephen J. Wood</name>
</country>
</tree>
</affiliations>
</record>

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Autism and psychosis: Clinical implications for depression and suicide.

Autism and psychosis: Clinical implications for depression and suicide.

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