PoplarV1, Main, Exploration, bibRecord, 000D25

Predictors of longer-term outcome in the Vienna omega-3 high-risk study.

Identifieur interne : 000D25 ( Main/Exploration ); précédent : 000D24; suivant : 000D26

Predictors of longer-term outcome in the Vienna omega-3 high-risk study.

Auteurs : Nilufar Mossaheb [Autriche] ; Miriam R. Sch Fer [Australie] ; Monika Schlögelhofer [Autriche] ; Claudia M. Klier [Autriche] ; Stefan Smesny [Allemagne] ; Patrick D. Mcgorry [Australie] ; Maximus Berger [Australie] ; G Paul Amminger [Australie]

Source :

Schizophrenia research [ 1573-2509 ] ; 2018.

RBID : pubmed:28823721

Descripteurs français

KwdFr :
- Acides gras omega-3 (administration et posologie), Analyse de régression (MeSH), Autriche (épidémiologie), Chromatographie en phase gazeuse (MeSH), Femelle (MeSH), Hormones thyroïdiennes (sang), Humains (MeSH), Jeûne (MeSH), Mâle (MeSH), Méthode en double aveugle (MeSH), Protéine C-réactive (métabolisme), Résultat thérapeutique (MeSH), Transaminases (métabolisme), Troubles psychotiques (prévention et contrôle), Troubles psychotiques (épidémiologie), Valeur prédictive des tests (MeSH), Échelles d'évaluation en psychiatrie (MeSH), Études longitudinales (MeSH).
MESH :
- administration et posologie : Acides gras omega-3.
- métabolisme : Protéine C-réactive, Transaminases.
- prévention et contrôle : Troubles psychotiques.
- sang : Hormones thyroïdiennes.
- épidémiologie : Autriche, Troubles psychotiques.
- Analyse de régression, Chromatographie en phase gazeuse, Femelle, Humains, Jeûne, Mâle, Méthode en double aveugle, Résultat thérapeutique, Valeur prédictive des tests, Échelles d'évaluation en psychiatrie, Études longitudinales.

English descriptors

KwdEn :
- Austria (epidemiology), C-Reactive Protein (metabolism), Chromatography, Gas (MeSH), Double-Blind Method (MeSH), Fasting (MeSH), Fatty Acids, Omega-3 (administration & dosage), Female (MeSH), Humans (MeSH), Longitudinal Studies (MeSH), Male (MeSH), Predictive Value of Tests (MeSH), Psychiatric Status Rating Scales (MeSH), Psychotic Disorders (epidemiology), Psychotic Disorders (prevention & control), Regression Analysis (MeSH), Thyroid Hormones (blood), Transaminases (metabolism), Treatment Outcome (MeSH).
MESH :
- chemical , administration & dosage : Fatty Acids, Omega-3.
- chemical , blood : Thyroid Hormones.
- chemical , metabolism : C-Reactive Protein, Transaminases.
- epidemiology : Austria, Psychotic Disorders.
- prevention & control : Psychotic Disorders.
- Chromatography, Gas, Double-Blind Method, Fasting, Female, Humans, Longitudinal Studies, Male, Predictive Value of Tests, Psychiatric Status Rating Scales, Regression Analysis, Treatment Outcome.

Abstract

Longer-term data on ω-3 polyunsaturated fatty acids (PUFA) for prevention of psychosis in (ultra high risk) UHR individuals have initially shown promising results. This analysis aimed to assess clinical predictors of longer-term outcome in UHR individuals treated with ω-3 PUFAs versus placebo. Data derived from an RCT in 81 UHR individuals treated with ω-3 PUFAs versus placebo for 12weeks and follow-up assessment after a median of 6.7years. Baseline GAF, baseline PANSS global score, pre-to-post-intervention change in EPA (Eicosapentaenoic acid) level were significant predictors of transition to psychosis, PANSS negative score and baseline MADRS reached trend-levels. In the final multivariate Cox regression analysis change in EPA levels remained the only significant predictor. Taking into account all other significant predictors, changes in EPA levels were found to be the single most significant predictor for transition to psychosis in a longer term observation of UHR individuals.

DOI: 10.1016/j.schres.2017.08.010
PubMed: 28823721

Affiliations:

Links toward previous steps (curation, corpus...)

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Le document en format XML

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<front><div type="abstract" xml:lang="en">Longer-term data on ω-3 polyunsaturated fatty acids (PUFA) for prevention of psychosis in (ultra high risk) UHR individuals have initially shown promising results. This analysis aimed to assess clinical predictors of longer-term outcome in UHR individuals treated with ω-3 PUFAs versus placebo. Data derived from an RCT in 81 UHR individuals treated with ω-3 PUFAs versus placebo for 12weeks and follow-up assessment after a median of 6.7years. Baseline GAF, baseline PANSS global score, pre-to-post-intervention change in EPA (Eicosapentaenoic acid) level were significant predictors of transition to psychosis, PANSS negative score and baseline MADRS reached trend-levels. In the final multivariate Cox regression analysis change in EPA levels remained the only significant predictor. Taking into account all other significant predictors, changes in EPA levels were found to be the single most significant predictor for transition to psychosis in a longer term observation of UHR individuals.</div>
</front>
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<Abstract><AbstractText>Longer-term data on ω-3 polyunsaturated fatty acids (PUFA) for prevention of psychosis in (ultra high risk) UHR individuals have initially shown promising results. This analysis aimed to assess clinical predictors of longer-term outcome in UHR individuals treated with ω-3 PUFAs versus placebo. Data derived from an RCT in 81 UHR individuals treated with ω-3 PUFAs versus placebo for 12weeks and follow-up assessment after a median of 6.7years. Baseline GAF, baseline PANSS global score, pre-to-post-intervention change in EPA (Eicosapentaenoic acid) level were significant predictors of transition to psychosis, PANSS negative score and baseline MADRS reached trend-levels. In the final multivariate Cox regression analysis change in EPA levels remained the only significant predictor. Taking into account all other significant predictors, changes in EPA levels were found to be the single most significant predictor for transition to psychosis in a longer term observation of UHR individuals.</AbstractText>
<CopyrightInformation>Copyright © 2017 Elsevier B.V. All rights reserved.</CopyrightInformation>
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<ForeName>Nilufar</ForeName>
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</AffiliationInfo>
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<ForeName>Monika</ForeName>
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<AffiliationInfo><Affiliation>Department of Child and Adolescent Psychiatry, Medical University Vienna, Waehringer Guertel 18-10, 1090 Vienna, Austria. Electronic address: monika.schloegelhofer@meduniwien.ac.at.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Klier</LastName>
<ForeName>Claudia M</ForeName>
<Initials>CM</Initials>
<AffiliationInfo><Affiliation>Department of Child and Adolescent Medicine, Medical University Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria. Electronic address: claudia.klier@meduniwien.ac.at.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Smesny</LastName>
<ForeName>Stefan</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Department of Psychiatry, University Hospital Jena, Philosophenweg 3, D-07743 Jena, Germany. Electronic address: Stefan.Smesny@med.uni-jena.de.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>McGorry</LastName>
<ForeName>Patrick D</ForeName>
<Initials>PD</Initials>
<AffiliationInfo><Affiliation>Orygen Youth Health Research Centre, The University of Melbourne, 35 Poplar Road, 3502 Parkville, Melbourne, VIC, Australia. Electronic address: pat.mcgorry@orygen.org.au.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Berger</LastName>
<ForeName>Maximus</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Laboratory of Psychiatric Neuroscience, Australian Institute of Tropical Health and Medicine (AITHM), James Cook University, 1 James Cook Drive, Townsville, QLD 4810, Australia. Electronic address: maximus.berger@jcu.edu.au.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Amminger</LastName>
<ForeName>G Paul</ForeName>
<Initials>GP</Initials>
<AffiliationInfo><Affiliation>Orygen Youth Health Research Centre, The University of Melbourne, 35 Poplar Road, 3502 Parkville, Melbourne, VIC, Australia. Electronic address: amminger@unimelb.edu.au.</Affiliation>
</AffiliationInfo>
</Author>
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<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D016449">Randomized Controlled Trial</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2017</Year>
<Month>08</Month>
<Day>18</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>Netherlands</Country>
<MedlineTA>Schizophr Res</MedlineTA>
<NlmUniqueID>8804207</NlmUniqueID>
<ISSNLinking>0920-9964</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D015525">Fatty Acids, Omega-3</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D013963">Thyroid Hormones</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>9007-41-4</RegistryNumber>
<NameOfSubstance UI="D002097">C-Reactive Protein</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.6.1.-</RegistryNumber>
<NameOfSubstance UI="D000637">Transaminases</NameOfSubstance>
</Chemical>
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<MeshHeadingList><MeshHeading><DescriptorName UI="D001317" MajorTopicYN="N">Austria</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002097" MajorTopicYN="N">C-Reactive Protein</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002849" MajorTopicYN="N">Chromatography, Gas</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004311" MajorTopicYN="N">Double-Blind Method</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005215" MajorTopicYN="N">Fasting</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015525" MajorTopicYN="N">Fatty Acids, Omega-3</DescriptorName>
<QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008137" MajorTopicYN="N">Longitudinal Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011237" MajorTopicYN="N">Predictive Value of Tests</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011569" MajorTopicYN="N">Psychiatric Status Rating Scales</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011618" MajorTopicYN="N">Psychotic Disorders</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName>
<QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012044" MajorTopicYN="N">Regression Analysis</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013963" MajorTopicYN="N">Thyroid Hormones</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000637" MajorTopicYN="N">Transaminases</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016896" MajorTopicYN="Y">Treatment Outcome</DescriptorName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Fish oil</Keyword>
<Keyword MajorTopicYN="Y">Outcome</Keyword>
<Keyword MajorTopicYN="Y">Polyunsaturated fatty acids</Keyword>
<Keyword MajorTopicYN="Y">Prodrome</Keyword>
<Keyword MajorTopicYN="Y">Psychosis</Keyword>
<Keyword MajorTopicYN="Y">Ultra-high risk</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year>
<Month>12</Month>
<Day>11</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2017</Year>
<Month>07</Month>
<Day>24</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2017</Year>
<Month>08</Month>
<Day>08</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2017</Year>
<Month>8</Month>
<Day>22</Day>
<Hour>6</Hour>
<Minute>0</Minute>
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<PubMedPubDate PubStatus="medline"><Year>2018</Year>
<Month>11</Month>
<Day>14</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2017</Year>
<Month>8</Month>
<Day>22</Day>
<Hour>6</Hour>
<Minute>0</Minute>
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</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">28823721</ArticleId>
<ArticleId IdType="pii">S0920-9964(17)30484-X</ArticleId>
<ArticleId IdType="doi">10.1016/j.schres.2017.08.010</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>Autriche</li>
</country>
<region><li>Victoria (État)</li>
<li>Vienne (Autriche)</li>
</region>
<settlement><li>Melbourne</li>
<li>Vienne (Autriche)</li>
</settlement>
<orgName><li>Université de Melbourne</li>
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<tree><country name="Autriche"><region name="Vienne (Autriche)"><name sortKey="Mossaheb, Nilufar" sort="Mossaheb, Nilufar" uniqKey="Mossaheb N" first="Nilufar" last="Mossaheb">Nilufar Mossaheb</name>
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<name sortKey="Klier, Claudia M" sort="Klier, Claudia M" uniqKey="Klier C" first="Claudia M" last="Klier">Claudia M. Klier</name>
<name sortKey="Schlogelhofer, Monika" sort="Schlogelhofer, Monika" uniqKey="Schlogelhofer M" first="Monika" last="Schlögelhofer">Monika Schlögelhofer</name>
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<country name="Australie"><region name="Victoria (État)"><name sortKey="Sch Fer, Miriam R" sort="Sch Fer, Miriam R" uniqKey="Sch Fer M" first="Miriam R" last="Sch Fer">Miriam R. Sch Fer</name>
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<name sortKey="Amminger, G Paul" sort="Amminger, G Paul" uniqKey="Amminger G" first="G Paul" last="Amminger">G Paul Amminger</name>
<name sortKey="Berger, Maximus" sort="Berger, Maximus" uniqKey="Berger M" first="Maximus" last="Berger">Maximus Berger</name>
<name sortKey="Mcgorry, Patrick D" sort="Mcgorry, Patrick D" uniqKey="Mcgorry P" first="Patrick D" last="Mcgorry">Patrick D. Mcgorry</name>
</country>
<country name="Allemagne"><noRegion><name sortKey="Smesny, Stefan" sort="Smesny, Stefan" uniqKey="Smesny S" first="Stefan" last="Smesny">Stefan Smesny</name>
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Predictors of longer-term outcome in the Vienna omega-3 high-risk study.

Predictors of longer-term outcome in the Vienna omega-3 high-risk study.

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