PoplarV1, Main, Exploration, bibRecord, 000826

Natural rubber latex membranes incorporated with three different types of propolis: Physical-chemistry and antimicrobial behaviours.

Identifieur interne : 000826 ( Main/Exploration ); précédent : 000825; suivant : 000827

Natural rubber latex membranes incorporated with three different types of propolis: Physical-chemistry and antimicrobial behaviours.

Auteurs : Daniela Cervelle Zancanela [Brésil] ; Cristiano Soleo Funari [Brésil] ; Rondinelli Donizetti Herculano [Brésil] ; Vinicius Moreira Mello [Brésil] ; Clenilson Martins Rodrigues [Brésil] ; Felipe Azevedo Borges [Brésil] ; Natan Roberto De Barros [Brésil] ; Caroline Maria Marcos [Brésil] ; Ana Marisa Fusco Almeida [Brésil] ; Antônio Carlos Guastaldi [Brésil]

Source :

Materials science & engineering. C, Materials for biological applications [ 1873-0191 ] ; 2019.

RBID : pubmed:30678944

Descripteurs français

KwdFr :
- Animaux (MeSH), Anti-infectieux (composition chimique), Anti-infectieux (métabolisme), Anti-infectieux (pharmacologie), Candida albicans (effets des médicaments et des substances chimiques), Caoutchouc (composition chimique), Caoutchouc (toxicité), Chromatographie en phase liquide à haute performance (MeSH), Lignée cellulaire (MeSH), Propolis (composition chimique), Propolis (métabolisme), Propolis (pharmacologie), Résistance à la traction (MeSH), Souris (MeSH), Spectrométrie de masse (MeSH), Spectroscopie infrarouge à transformée de Fourier (MeSH), Survie cellulaire (effets des médicaments et des substances chimiques), Tests de sensibilité microbienne (MeSH).
MESH :
- composition chimique : Anti-infectieux, Caoutchouc, Propolis.
- effets des médicaments et des substances chimiques : Candida albicans, Survie cellulaire.
- métabolisme : Anti-infectieux, Propolis.
- pharmacologie : Anti-infectieux, Propolis.
- toxicité : Caoutchouc.
- Animaux, Chromatographie en phase liquide à haute performance, Lignée cellulaire, Résistance à la traction, Souris, Spectrométrie de masse, Spectroscopie infrarouge à transformée de Fourier, Tests de sensibilité microbienne.

English descriptors

KwdEn :
- Animals (MeSH), Anti-Infective Agents (chemistry), Anti-Infective Agents (metabolism), Anti-Infective Agents (pharmacology), Candida albicans (drug effects), Cell Line (MeSH), Cell Survival (drug effects), Chromatography, High Pressure Liquid (MeSH), Mass Spectrometry (MeSH), Mice (MeSH), Microbial Sensitivity Tests (MeSH), Propolis (chemistry), Propolis (metabolism), Propolis (pharmacology), Rubber (chemistry), Rubber (toxicity), Spectroscopy, Fourier Transform Infrared (MeSH), Tensile Strength (MeSH).
MESH :
- chemical , chemistry : Anti-Infective Agents, Propolis, Rubber.
- chemical , metabolism : Anti-Infective Agents, Propolis.
- chemical , pharmacology : Anti-Infective Agents, Propolis.
- drug effects : Candida albicans, Cell Survival.
- chemical , toxicity : Rubber.
- Animals, Cell Line, Chromatography, High Pressure Liquid, Mass Spectrometry, Mice, Microbial Sensitivity Tests, Spectroscopy, Fourier Transform Infrared, Tensile Strength.

Abstract

Natural Rubber Latex (NRL) is a biocompatible material with demonstrated capacity to induce vascularisation and tissue regeneration. Propolis is a complex resinous product prepared by Apis mellifera with the aim of protecting beehives against infectious microorganisms. It is flora-dependent and its antimicrobial activity can vary according to its geographical origin. This study compares the incorporation of three different types of propolis into an NRL membrane aiming at optimal controlled release of propolis potential antimicrobial compounds towards Candida albicans whilst keeping NRL mechanical characteristics desirable for wound healing bandage purposes. The propolis samples were classified as red, green and poplar propolis according to their chemical composition determined by ultra-high performance liquid chromatography coupled in series with both UV spectrophotometry and high-resolution mass spectrometry. The Minimum Inhibitory Concentrations (MIC) towards C. albicans were determined before their incorporation into NRL membranes. The release of NRL-propolis components in Simulated Body Fluid (SBF) was monitored by UV-Vis spectroscopy. The antimicrobial activity and the effects of the materials released on mouse fibroblasts were assessed. FTIR analyses were carried out in order to verify the formation of new chemical bonds that might prevent the release of propolis components from the NRL membrane. The mechanical characteristics of the NRL membranes remained adequate after the incorporation of the three types of propolis investigated whilst allowing the release of the red, and poplar propolis most active compounds against C. albicans. At 30 and 50% the released materials (eluates) from the NRL membranes incorporated with red and poplar propolis types were not toxic to fibroblast cells. These results suggest that red and poplar propolis can be incorporated into NRL membranes for the preparation of wound healing dressing.

DOI: 10.1016/j.msec.2018.12.042
PubMed: 30678944

Affiliations:

Links toward previous steps (curation, corpus...)

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Le document en format XML

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<term>Anti-Infective Agents (chemistry)</term>
<term>Anti-Infective Agents (metabolism)</term>
<term>Anti-Infective Agents (pharmacology)</term>
<term>Candida albicans (drug effects)</term>
<term>Cell Line (MeSH)</term>
<term>Cell Survival (drug effects)</term>
<term>Chromatography, High Pressure Liquid (MeSH)</term>
<term>Mass Spectrometry (MeSH)</term>
<term>Mice (MeSH)</term>
<term>Microbial Sensitivity Tests (MeSH)</term>
<term>Propolis (chemistry)</term>
<term>Propolis (metabolism)</term>
<term>Propolis (pharmacology)</term>
<term>Rubber (chemistry)</term>
<term>Rubber (toxicity)</term>
<term>Spectroscopy, Fourier Transform Infrared (MeSH)</term>
<term>Tensile Strength (MeSH)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term>
<term>Anti-infectieux (composition chimique)</term>
<term>Anti-infectieux (métabolisme)</term>
<term>Anti-infectieux (pharmacologie)</term>
<term>Candida albicans (effets des médicaments et des substances chimiques)</term>
<term>Caoutchouc (composition chimique)</term>
<term>Caoutchouc (toxicité)</term>
<term>Chromatographie en phase liquide à haute performance (MeSH)</term>
<term>Lignée cellulaire (MeSH)</term>
<term>Propolis (composition chimique)</term>
<term>Propolis (métabolisme)</term>
<term>Propolis (pharmacologie)</term>
<term>Résistance à la traction (MeSH)</term>
<term>Souris (MeSH)</term>
<term>Spectrométrie de masse (MeSH)</term>
<term>Spectroscopie infrarouge à transformée de Fourier (MeSH)</term>
<term>Survie cellulaire (effets des médicaments et des substances chimiques)</term>
<term>Tests de sensibilité microbienne (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Anti-Infective Agents</term>
<term>Propolis</term>
<term>Rubber</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Anti-Infective Agents</term>
<term>Propolis</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Anti-Infective Agents</term>
<term>Propolis</term>
</keywords>
<keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Anti-infectieux</term>
<term>Caoutchouc</term>
<term>Propolis</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Candida albicans</term>
<term>Cell Survival</term>
</keywords>
<keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Candida albicans</term>
<term>Survie cellulaire</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Anti-infectieux</term>
<term>Propolis</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Anti-infectieux</term>
<term>Propolis</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Rubber</term>
</keywords>
<keywords scheme="MESH" qualifier="toxicité" xml:lang="fr"><term>Caoutchouc</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Cell Line</term>
<term>Chromatography, High Pressure Liquid</term>
<term>Mass Spectrometry</term>
<term>Mice</term>
<term>Microbial Sensitivity Tests</term>
<term>Spectroscopy, Fourier Transform Infrared</term>
<term>Tensile Strength</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Chromatographie en phase liquide à haute performance</term>
<term>Lignée cellulaire</term>
<term>Résistance à la traction</term>
<term>Souris</term>
<term>Spectrométrie de masse</term>
<term>Spectroscopie infrarouge à transformée de Fourier</term>
<term>Tests de sensibilité microbienne</term>
</keywords>
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<front><div type="abstract" xml:lang="en">Natural Rubber Latex (NRL) is a biocompatible material with demonstrated capacity to induce vascularisation and tissue regeneration. Propolis is a complex resinous product prepared by Apis mellifera with the aim of protecting beehives against infectious microorganisms. It is flora-dependent and its antimicrobial activity can vary according to its geographical origin. This study compares the incorporation of three different types of propolis into an NRL membrane aiming at optimal controlled release of propolis potential antimicrobial compounds towards Candida albicans whilst keeping NRL mechanical characteristics desirable for wound healing bandage purposes. The propolis samples were classified as red, green and poplar propolis according to their chemical composition determined by ultra-high performance liquid chromatography coupled in series with both UV spectrophotometry and high-resolution mass spectrometry. The Minimum Inhibitory Concentrations (MIC) towards C. albicans were determined before their incorporation into NRL membranes. The release of NRL-propolis components in Simulated Body Fluid (SBF) was monitored by UV-Vis spectroscopy. The antimicrobial activity and the effects of the materials released on mouse fibroblasts were assessed. FTIR analyses were carried out in order to verify the formation of new chemical bonds that might prevent the release of propolis components from the NRL membrane. The mechanical characteristics of the NRL membranes remained adequate after the incorporation of the three types of propolis investigated whilst allowing the release of the red, and poplar propolis most active compounds against C. albicans. At 30 and 50% the released materials (eluates) from the NRL membranes incorporated with red and poplar propolis types were not toxic to fibroblast cells. These results suggest that red and poplar propolis can be incorporated into NRL membranes for the preparation of wound healing dressing.</div>
</front>
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<ELocationID EIdType="pii" ValidYN="Y">S0928-4931(17)34364-3</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.msec.2018.12.042</ELocationID>
<Abstract><AbstractText>Natural Rubber Latex (NRL) is a biocompatible material with demonstrated capacity to induce vascularisation and tissue regeneration. Propolis is a complex resinous product prepared by Apis mellifera with the aim of protecting beehives against infectious microorganisms. It is flora-dependent and its antimicrobial activity can vary according to its geographical origin. This study compares the incorporation of three different types of propolis into an NRL membrane aiming at optimal controlled release of propolis potential antimicrobial compounds towards Candida albicans whilst keeping NRL mechanical characteristics desirable for wound healing bandage purposes. The propolis samples were classified as red, green and poplar propolis according to their chemical composition determined by ultra-high performance liquid chromatography coupled in series with both UV spectrophotometry and high-resolution mass spectrometry. The Minimum Inhibitory Concentrations (MIC) towards C. albicans were determined before their incorporation into NRL membranes. The release of NRL-propolis components in Simulated Body Fluid (SBF) was monitored by UV-Vis spectroscopy. The antimicrobial activity and the effects of the materials released on mouse fibroblasts were assessed. FTIR analyses were carried out in order to verify the formation of new chemical bonds that might prevent the release of propolis components from the NRL membrane. The mechanical characteristics of the NRL membranes remained adequate after the incorporation of the three types of propolis investigated whilst allowing the release of the red, and poplar propolis most active compounds against C. albicans. At 30 and 50% the released materials (eluates) from the NRL membranes incorporated with red and poplar propolis types were not toxic to fibroblast cells. These results suggest that red and poplar propolis can be incorporated into NRL membranes for the preparation of wound healing dressing.</AbstractText>
<CopyrightInformation>Copyright © 2018. Published by Elsevier B.V.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Zancanela</LastName>
<ForeName>Daniela Cervelle</ForeName>
<Initials>DC</Initials>
<AffiliationInfo><Affiliation>São Paulo State University (UNESP), Institute of Chemistry, Araraquara, SP, Brazil. Electronic address: daniela.zancanela@iq.unesp.br.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Funari</LastName>
<ForeName>Cristiano Soleo</ForeName>
<Initials>CS</Initials>
<AffiliationInfo><Affiliation>São Paulo State University (UNESP), Faculty of Agricultural Sciences, Botucatu, SP, Brazil.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Herculano</LastName>
<ForeName>Rondinelli Donizetti</ForeName>
<Initials>RD</Initials>
<AffiliationInfo><Affiliation>São Paulo State University (UNESP), School of Pharmaceutical Sciences, Araraquara, SP, Brazil. Electronic address: rond@fcfar.unesp.br.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mello</LastName>
<ForeName>Vinicius Moreira</ForeName>
<Initials>VM</Initials>
<AffiliationInfo><Affiliation>Brazilian Agricultural Research Corporation (EMBRAPA), Embrapa Agroenergy, Brasília, DF, Brazil.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Rodrigues</LastName>
<ForeName>Clenilson Martins</ForeName>
<Initials>CM</Initials>
<AffiliationInfo><Affiliation>Brazilian Agricultural Research Corporation (EMBRAPA), Embrapa Agroenergy, Brasília, DF, Brazil.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Borges</LastName>
<ForeName>Felipe Azevedo</ForeName>
<Initials>FA</Initials>
<AffiliationInfo><Affiliation>São Paulo State University (UNESP), School of Pharmaceutical Sciences, Araraquara, SP, Brazil.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>de Barros</LastName>
<ForeName>Natan Roberto</ForeName>
<Initials>NR</Initials>
<AffiliationInfo><Affiliation>São Paulo State University (UNESP), School of Pharmaceutical Sciences, Araraquara, SP, Brazil.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Marcos</LastName>
<ForeName>Caroline Maria</ForeName>
<Initials>CM</Initials>
<AffiliationInfo><Affiliation>São Paulo State University (UNESP), School of Pharmaceutical Sciences, Araraquara, SP, Brazil.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Almeida</LastName>
<ForeName>Ana Marisa Fusco</ForeName>
<Initials>AMF</Initials>
<AffiliationInfo><Affiliation>São Paulo State University (UNESP), School of Pharmaceutical Sciences, Araraquara, SP, Brazil.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Guastaldi</LastName>
<ForeName>Antônio Carlos</ForeName>
<Initials>AC</Initials>
<AffiliationInfo><Affiliation>São Paulo State University (UNESP), Institute of Chemistry, Araraquara, SP, Brazil.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2018</Year>
<Month>12</Month>
<Day>13</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>Netherlands</Country>
<MedlineTA>Mater Sci Eng C Mater Biol Appl</MedlineTA>
<NlmUniqueID>101484109</NlmUniqueID>
<ISSNLinking>0928-4931</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000890">Anti-Infective Agents</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>9006-04-6</RegistryNumber>
<NameOfSubstance UI="D012408">Rubber</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>9009-62-5</RegistryNumber>
<NameOfSubstance UI="D011429">Propolis</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000890" MajorTopicYN="N">Anti-Infective Agents</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002176" MajorTopicYN="N">Candida albicans</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002460" MajorTopicYN="N">Cell Line</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002470" MajorTopicYN="N">Cell Survival</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002851" MajorTopicYN="N">Chromatography, High Pressure Liquid</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013058" MajorTopicYN="N">Mass Spectrometry</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008826" MajorTopicYN="N">Microbial Sensitivity Tests</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011429" MajorTopicYN="N">Propolis</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012408" MajorTopicYN="N">Rubber</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName>
<QualifierName UI="Q000633" MajorTopicYN="N">toxicity</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017550" MajorTopicYN="N">Spectroscopy, Fourier Transform Infrared</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013718" MajorTopicYN="N">Tensile Strength</DescriptorName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Antifungal</Keyword>
<Keyword MajorTopicYN="N">Propolis release</Keyword>
<Keyword MajorTopicYN="N">Red propolis</Keyword>
<Keyword MajorTopicYN="N">Skin wound healing</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year>
<Month>11</Month>
<Day>06</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2018</Year>
<Month>10</Month>
<Day>31</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2018</Year>
<Month>12</Month>
<Day>12</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2019</Year>
<Month>1</Month>
<Day>26</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2019</Year>
<Month>1</Month>
<Day>27</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2019</Year>
<Month>5</Month>
<Day>6</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">30678944</ArticleId>
<ArticleId IdType="pii">S0928-4931(17)34364-3</ArticleId>
<ArticleId IdType="doi">10.1016/j.msec.2018.12.042</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Brésil</li>
</country>
<region><li>District fédéral (Brésil)</li>
<li>État de São Paulo</li>
</region>
</list>
<tree><country name="Brésil"><region name="État de São Paulo"><name sortKey="Zancanela, Daniela Cervelle" sort="Zancanela, Daniela Cervelle" uniqKey="Zancanela D" first="Daniela Cervelle" last="Zancanela">Daniela Cervelle Zancanela</name>
</region>
<name sortKey="Almeida, Ana Marisa Fusco" sort="Almeida, Ana Marisa Fusco" uniqKey="Almeida A" first="Ana Marisa Fusco" last="Almeida">Ana Marisa Fusco Almeida</name>
<name sortKey="Borges, Felipe Azevedo" sort="Borges, Felipe Azevedo" uniqKey="Borges F" first="Felipe Azevedo" last="Borges">Felipe Azevedo Borges</name>
<name sortKey="De Barros, Natan Roberto" sort="De Barros, Natan Roberto" uniqKey="De Barros N" first="Natan Roberto" last="De Barros">Natan Roberto De Barros</name>
<name sortKey="Funari, Cristiano Soleo" sort="Funari, Cristiano Soleo" uniqKey="Funari C" first="Cristiano Soleo" last="Funari">Cristiano Soleo Funari</name>
<name sortKey="Guastaldi, Antonio Carlos" sort="Guastaldi, Antonio Carlos" uniqKey="Guastaldi A" first="Antônio Carlos" last="Guastaldi">Antônio Carlos Guastaldi</name>
<name sortKey="Herculano, Rondinelli Donizetti" sort="Herculano, Rondinelli Donizetti" uniqKey="Herculano R" first="Rondinelli Donizetti" last="Herculano">Rondinelli Donizetti Herculano</name>
<name sortKey="Marcos, Caroline Maria" sort="Marcos, Caroline Maria" uniqKey="Marcos C" first="Caroline Maria" last="Marcos">Caroline Maria Marcos</name>
<name sortKey="Mello, Vinicius Moreira" sort="Mello, Vinicius Moreira" uniqKey="Mello V" first="Vinicius Moreira" last="Mello">Vinicius Moreira Mello</name>
<name sortKey="Rodrigues, Clenilson Martins" sort="Rodrigues, Clenilson Martins" uniqKey="Rodrigues C" first="Clenilson Martins" last="Rodrigues">Clenilson Martins Rodrigues</name>
</country>
</tree>
</affiliations>
</record>

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Natural rubber latex membranes incorporated with three different types of propolis: Physical-chemistry and antimicrobial behaviours.

Natural rubber latex membranes incorporated with three different types of propolis: Physical-chemistry and antimicrobial behaviours.

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