Poplar bark lipids enhance mouse immunity by inducing T cell proliferation and differentiation.
Identifieur interne : 000197 ( Main/Exploration ); précédent : 000196; suivant : 000198Poplar bark lipids enhance mouse immunity by inducing T cell proliferation and differentiation.
Auteurs : Jinxiu Tang [République populaire de Chine] ; Xiuli Wei [République populaire de Chine] ; Youzhi Li [République populaire de Chine] ; Linlin Jiang [République populaire de Chine] ; Tao Feng [République populaire de Chine] ; Hongwei Zhu [République populaire de Chine] ; Meng Li [République populaire de Chine] ; Guozhong Chen [République populaire de Chine] ; Xin Yu [République populaire de Chine] ; Jianlong Zhang [République populaire de Chine] ; Xingxiao Zhang [République populaire de Chine]Source :
- The Journal of veterinary medical science [ 1347-7439 ] ; 2020.
Abstract
Research on the composition and application of immune enhancers in livestock and poultry breeding has been gaining interest in recent years. Poplar bark lipids (PBLs), which are extracted from poplar tree bark, are natural substances known to efficiently enhance the immune response. To understand the chemical makeup of PBLs and their underlying mechanism for enhancing the immune system, we extracted PBLs from poplar bark using petroleum ether and subjected these extracts to chemical analysis. To evaluate PBLs effect on the immune system mice were treated with different doses of PBL via gavage and sacrificed 4 weeks later. PBLs were shown to be rich in vitamin E, unsaturated fatty acids, and other immune-potentiating compounds. Treatment with PBLs increased the spleen index and stimulated spleen and thymus development. In addition, PBLs increased the number of CD3+CD4+ cells in the peripheral blood and the ratio of CD4+/CD8+ cells while decreasing the number of CD3+CD8+ cells. Moreover, PBLs significantly increased IL-4 and IFN-γ levels in mouse serum and TLR4 mRNA and protein expression in the spleen. Taken together these results demonstrate that PBLs exert their immune-potentiating effects by promoting spleen and thymus development, T lymphocyte proliferation and differentiation, and immune factor expression. These immune-potentiating effects may be related to the activation of TLR4. This study provides a theoretical basis for the development of PBLs as an immune adjuvant or feed additive in the future.
DOI: 10.1292/jvms.19-0571
PubMed: 32669484
PubMed Central: PMC7468065
Affiliations:
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Provincial Key Laboratory of Quality Safety Monitoring and Risk Assessment for Animal Products, Ji'nan 250022, Shandong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shandong Provincial Key Laboratory of Quality Safety Monitoring and Risk Assessment for Animal Products, Ji'nan 250022, Shandong</wicri:regionArea><wicri:noRegion>Shandong</wicri:noRegion></affiliation></author><author><name sortKey="Zhu, Hongwei" sort="Zhu, Hongwei" uniqKey="Zhu H" first="Hongwei" last="Zhu">Hongwei Zhu</name><affiliation wicri:level="1"><nlm:affiliation>College of Life Science, Ludong University, Yantai 264000, Shandong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Life Science, Ludong University, Yantai 264000, Shandong</wicri:regionArea><wicri:noRegion>Shandong</wicri:noRegion></affiliation></author><author><name sortKey="Li, Meng" sort="Li, Meng" uniqKey="Li M" first="Meng" last="Li">Meng Li</name><affiliation wicri:level="1"><nlm:affiliation>College of Life Science, Ludong University, Yantai 264000, Shandong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Life Science, Ludong University, Yantai 264000, Shandong</wicri:regionArea><wicri:noRegion>Shandong</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Guozhong" sort="Chen, Guozhong" uniqKey="Chen G" first="Guozhong" last="Chen">Guozhong Chen</name><affiliation wicri:level="1"><nlm:affiliation>College of Life Science, Ludong University, Yantai 264000, Shandong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Life Science, Ludong University, Yantai 264000, Shandong</wicri:regionArea><wicri:noRegion>Shandong</wicri:noRegion></affiliation></author><author><name sortKey="Yu, Xin" sort="Yu, Xin" uniqKey="Yu X" first="Xin" last="Yu">Xin Yu</name><affiliation wicri:level="1"><nlm:affiliation>College of Life Science, Ludong University, Yantai 264000, Shandong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Life Science, Ludong University, Yantai 264000, Shandong</wicri:regionArea><wicri:noRegion>Shandong</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Jianlong" sort="Zhang, Jianlong" uniqKey="Zhang J" first="Jianlong" last="Zhang">Jianlong Zhang</name><affiliation wicri:level="1"><nlm:affiliation>College of Life Science, Ludong University, Yantai 264000, Shandong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Life Science, Ludong University, Yantai 264000, Shandong</wicri:regionArea><wicri:noRegion>Shandong</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Yantai Key Laboratory of Animal Pathogenetic Microbiology and Immunology, Yantai 264000, Shandong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Yantai Key Laboratory of Animal Pathogenetic Microbiology and Immunology, Yantai 264000, Shandong</wicri:regionArea><wicri:noRegion>Shandong</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Xingxiao" sort="Zhang, Xingxiao" uniqKey="Zhang X" first="Xingxiao" last="Zhang">Xingxiao Zhang</name><affiliation wicri:level="1"><nlm:affiliation>College of Life Science, Ludong University, Yantai 264000, Shandong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Life Science, Ludong University, Yantai 264000, Shandong</wicri:regionArea><wicri:noRegion>Shandong</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Yantai Key Laboratory of Animal Pathogenetic Microbiology and Immunology, Yantai 264000, Shandong, China.</nlm:affiliation><country xml:lang="fr">République populaire de 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sortKey="Tang, Jinxiu" sort="Tang, Jinxiu" uniqKey="Tang J" first="Jinxiu" last="Tang">Jinxiu Tang</name><affiliation wicri:level="1"><nlm:affiliation>College of Life Science, Ludong University, Yantai 264000, Shandong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Life Science, Ludong University, Yantai 264000, Shandong</wicri:regionArea><wicri:noRegion>Shandong</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Shandong Provincial Key Laboratory of Quality Safety Monitoring and Risk Assessment for Animal Products, Ji'nan 250022, Shandong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shandong Provincial Key Laboratory of Quality Safety Monitoring and Risk Assessment for Animal Products, Ji'nan 250022, Shandong</wicri:regionArea><wicri:noRegion>Shandong</wicri:noRegion></affiliation></author><author><name sortKey="Wei, Xiuli" sort="Wei, Xiuli" uniqKey="Wei X" first="Xiuli" last="Wei">Xiuli Wei</name><affiliation wicri:level="1"><nlm:affiliation>Shandong Provincial Key Laboratory of Quality Safety Monitoring and Risk Assessment for Animal Products, Ji'nan 250022, Shandong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shandong Provincial Key Laboratory of Quality Safety Monitoring and Risk Assessment for Animal Products, Ji'nan 250022, Shandong</wicri:regionArea><wicri:noRegion>Shandong</wicri:noRegion></affiliation></author><author><name sortKey="Li, Youzhi" sort="Li, Youzhi" uniqKey="Li Y" first="Youzhi" last="Li">Youzhi Li</name><affiliation wicri:level="1"><nlm:affiliation>Shandong Provincial Key Laboratory of Quality Safety Monitoring and Risk Assessment for Animal Products, Ji'nan 250022, Shandong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shandong Provincial Key Laboratory of Quality Safety Monitoring and Risk Assessment for Animal Products, Ji'nan 250022, Shandong</wicri:regionArea><wicri:noRegion>Shandong</wicri:noRegion></affiliation></author><author><name sortKey="Jiang, Linlin" sort="Jiang, Linlin" uniqKey="Jiang L" first="Linlin" last="Jiang">Linlin Jiang</name><affiliation wicri:level="1"><nlm:affiliation>College of Life Science, Ludong University, Yantai 264000, Shandong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Life Science, Ludong University, Yantai 264000, Shandong</wicri:regionArea><wicri:noRegion>Shandong</wicri:noRegion></affiliation></author><author><name sortKey="Feng, Tao" sort="Feng, Tao" uniqKey="Feng T" first="Tao" last="Feng">Tao Feng</name><affiliation wicri:level="1"><nlm:affiliation>Shandong Provincial Key Laboratory of Quality Safety Monitoring and Risk Assessment for Animal Products, Ji'nan 250022, Shandong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shandong Provincial Key Laboratory of Quality Safety Monitoring and Risk Assessment for Animal Products, Ji'nan 250022, Shandong</wicri:regionArea><wicri:noRegion>Shandong</wicri:noRegion></affiliation></author><author><name sortKey="Zhu, Hongwei" sort="Zhu, Hongwei" uniqKey="Zhu H" first="Hongwei" last="Zhu">Hongwei Zhu</name><affiliation wicri:level="1"><nlm:affiliation>College of Life Science, Ludong University, Yantai 264000, Shandong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Life Science, Ludong University, Yantai 264000, Shandong</wicri:regionArea><wicri:noRegion>Shandong</wicri:noRegion></affiliation></author><author><name sortKey="Li, Meng" sort="Li, Meng" uniqKey="Li M" first="Meng" last="Li">Meng Li</name><affiliation wicri:level="1"><nlm:affiliation>College of Life Science, Ludong University, Yantai 264000, Shandong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Life Science, Ludong University, Yantai 264000, Shandong</wicri:regionArea><wicri:noRegion>Shandong</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Guozhong" sort="Chen, Guozhong" uniqKey="Chen G" first="Guozhong" last="Chen">Guozhong Chen</name><affiliation wicri:level="1"><nlm:affiliation>College of Life Science, Ludong University, Yantai 264000, Shandong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Life Science, Ludong University, Yantai 264000, Shandong</wicri:regionArea><wicri:noRegion>Shandong</wicri:noRegion></affiliation></author><author><name sortKey="Yu, Xin" sort="Yu, Xin" uniqKey="Yu X" first="Xin" last="Yu">Xin Yu</name><affiliation wicri:level="1"><nlm:affiliation>College of Life Science, Ludong University, Yantai 264000, Shandong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Life Science, Ludong University, Yantai 264000, Shandong</wicri:regionArea><wicri:noRegion>Shandong</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Jianlong" sort="Zhang, Jianlong" uniqKey="Zhang J" first="Jianlong" last="Zhang">Jianlong Zhang</name><affiliation wicri:level="1"><nlm:affiliation>College of Life Science, Ludong University, Yantai 264000, Shandong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Life Science, Ludong University, Yantai 264000, Shandong</wicri:regionArea><wicri:noRegion>Shandong</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Yantai Key Laboratory of Animal Pathogenetic Microbiology and Immunology, Yantai 264000, Shandong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Yantai Key Laboratory of Animal Pathogenetic Microbiology and Immunology, Yantai 264000, Shandong</wicri:regionArea><wicri:noRegion>Shandong</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Xingxiao" sort="Zhang, Xingxiao" uniqKey="Zhang X" first="Xingxiao" last="Zhang">Xingxiao Zhang</name><affiliation wicri:level="1"><nlm:affiliation>College of Life Science, Ludong University, Yantai 264000, Shandong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Life Science, Ludong University, Yantai 264000, Shandong</wicri:regionArea><wicri:noRegion>Shandong</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Yantai Key Laboratory of Animal Pathogenetic Microbiology and Immunology, Yantai 264000, Shandong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Yantai Key Laboratory of Animal Pathogenetic Microbiology and Immunology, Yantai 264000, Shandong</wicri:regionArea><wicri:noRegion>Shandong</wicri:noRegion></affiliation></author></analytic><series><title level="j">The Journal of veterinary medical science</title><idno type="eISSN">1347-7439</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Research on the composition and application of immune enhancers in livestock and poultry breeding has been gaining interest in recent years. Poplar bark lipids (PBLs), which are extracted from poplar tree bark, are natural substances known to efficiently enhance the immune response. To understand the chemical makeup of PBLs and their underlying mechanism for enhancing the immune system, we extracted PBLs from poplar bark using petroleum ether and subjected these extracts to chemical analysis. To evaluate PBLs effect on the immune system mice were treated with different doses of PBL via gavage and sacrificed 4 weeks later. PBLs were shown to be rich in vitamin E, unsaturated fatty acids, and other immune-potentiating compounds. Treatment with PBLs increased the spleen index and stimulated spleen and thymus development. In addition, PBLs increased the number of CD3<sup>+</sup>CD4<sup>+</sup> cells in the peripheral blood and the ratio of CD4<sup>+</sup>/CD8<sup>+</sup> cells while decreasing the number of CD3<sup>+</sup>CD8<sup>+</sup> cells. Moreover, PBLs significantly increased IL-4 and IFN-γ levels in mouse serum and TLR4 mRNA and protein expression in the spleen. Taken together these results demonstrate that PBLs exert their immune-potentiating effects by promoting spleen and thymus development, T lymphocyte proliferation and differentiation, and immune factor expression. These immune-potentiating effects may be related to the activation of TLR4. This study provides a theoretical basis for the development of PBLs as an immune adjuvant or feed additive in the future.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">32669484</PMID><DateRevised><Year>2020</Year><Month>09</Month><Day>09</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1347-7439</ISSN><JournalIssue CitedMedium="Internet"><Volume>82</Volume><Issue>8</Issue><PubDate><Year>2020</Year><Month>Aug</Month><Day>28</Day></PubDate></JournalIssue><Title>The Journal of veterinary medical science</Title><ISOAbbreviation>J Vet Med Sci</ISOAbbreviation></Journal><ArticleTitle>Poplar bark lipids enhance mouse immunity by inducing T cell proliferation and differentiation.</ArticleTitle><Pagination><MedlinePgn>1187-1196</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1292/jvms.19-0571</ELocationID><Abstract><AbstractText>Research on the composition and application of immune enhancers in livestock and poultry breeding has been gaining interest in recent years. Poplar bark lipids (PBLs), which are extracted from poplar tree bark, are natural substances known to efficiently enhance the immune response. To understand the chemical makeup of PBLs and their underlying mechanism for enhancing the immune system, we extracted PBLs from poplar bark using petroleum ether and subjected these extracts to chemical analysis. To evaluate PBLs effect on the immune system mice were treated with different doses of PBL via gavage and sacrificed 4 weeks later. PBLs were shown to be rich in vitamin E, unsaturated fatty acids, and other immune-potentiating compounds. Treatment with PBLs increased the spleen index and stimulated spleen and thymus development. In addition, PBLs increased the number of CD3<sup>+</sup>CD4<sup>+</sup> cells in the peripheral blood and the ratio of CD4<sup>+</sup>/CD8<sup>+</sup> cells while decreasing the number of CD3<sup>+</sup>CD8<sup>+</sup> cells. Moreover, PBLs significantly increased IL-4 and IFN-γ levels in mouse serum and TLR4 mRNA and protein expression in the spleen. Taken together these results demonstrate that PBLs exert their immune-potentiating effects by promoting spleen and thymus development, T lymphocyte proliferation and differentiation, and immune factor expression. These immune-potentiating effects may be related to the activation of TLR4. This study provides a theoretical basis for the development of PBLs as an immune adjuvant or feed additive in the future.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Tang</LastName><ForeName>Jinxiu</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>College of Life Science, Ludong University, Yantai 264000, Shandong, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Shandong Provincial Key Laboratory of Quality Safety Monitoring and Risk Assessment for Animal Products, Ji'nan 250022, Shandong, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wei</LastName><ForeName>Xiuli</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Shandong Provincial Key Laboratory of Quality Safety Monitoring and Risk Assessment for Animal Products, Ji'nan 250022, Shandong, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Youzhi</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Shandong Provincial Key Laboratory of Quality Safety Monitoring and Risk Assessment for Animal Products, Ji'nan 250022, Shandong, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jiang</LastName><ForeName>Linlin</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>College of Life Science, Ludong University, Yantai 264000, Shandong, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Feng</LastName><ForeName>Tao</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Shandong Provincial Key Laboratory of Quality Safety Monitoring and Risk Assessment for Animal Products, Ji'nan 250022, Shandong, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhu</LastName><ForeName>Hongwei</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>College of Life Science, Ludong University, Yantai 264000, Shandong, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Meng</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>College of Life Science, Ludong University, Yantai 264000, Shandong, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Guozhong</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>College of Life Science, Ludong University, Yantai 264000, Shandong, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yu</LastName><ForeName>Xin</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>College of Life Science, Ludong University, Yantai 264000, Shandong, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Jianlong</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>College of Life Science, Ludong University, Yantai 264000, Shandong, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Yantai Key Laboratory of Animal Pathogenetic Microbiology and Immunology, Yantai 264000, Shandong, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Xingxiao</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>College of Life Science, Ludong University, Yantai 264000, Shandong, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Yantai Key Laboratory of Animal Pathogenetic Microbiology and Immunology, Yantai 264000, Shandong, China.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>07</Month><Day>14</Day></ArticleDate></Article><MedlineJournalInfo><Country>Japan</Country><MedlineTA>J Vet Med Sci</MedlineTA><NlmUniqueID>9105360</NlmUniqueID><ISSNLinking>0916-7250</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">T lymphocytes</Keyword><Keyword MajorTopicYN="N">TLR4</Keyword><Keyword MajorTopicYN="N">immune enhancement</Keyword><Keyword MajorTopicYN="N">immune factors</Keyword><Keyword MajorTopicYN="N">poplar bark lipids</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>7</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>7</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>7</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32669484</ArticleId><ArticleId 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