Biochemical model reactions indicative of inflammatory processes. Activities of extracts from Fraxinus excelsior and Populus tremula.
Identifieur interne : 004866 ( Main/Corpus ); précédent : 004865; suivant : 004867Biochemical model reactions indicative of inflammatory processes. Activities of extracts from Fraxinus excelsior and Populus tremula.
Auteurs : H. Schempp ; D. Weiser ; E F ElstnerSource :
- Arzneimittel-Forschung [ 0004-4172 ] ; 2000.
English descriptors
- KwdEn :
- Animals (MeSH), Antioxidants (therapeutic use), Cells, Cultured (MeSH), Chromatography, High Pressure Liquid (MeSH), Enzymes (metabolism), Free Radical Scavengers (pharmacology), Humans (MeSH), Indicators and Reagents (MeSH), Inflammation (pathology), Inflammatory Bowel Diseases (drug therapy), Inflammatory Bowel Diseases (pathology), Lipoproteins, LDL (metabolism), Lipoxygenase (metabolism), Models, Biological (MeSH), Nervous System Diseases (drug therapy), Nervous System Diseases (pathology), Oxidative Stress (drug effects), Peroxidase (metabolism), Plant Extracts (pharmacology), Plants, Medicinal (chemistry), Respiratory Burst (drug effects), Respiratory Tract Diseases (drug therapy), Respiratory Tract Diseases (pathology), Tyrosine (analogs & derivatives), Tyrosine (metabolism), Xanthine Oxidase (metabolism).
- MESH :
- chemical , analogs & derivatives : Tyrosine.
- chemical , metabolism : Enzymes, Lipoproteins, LDL, Lipoxygenase, Peroxidase, Tyrosine, Xanthine Oxidase.
- chemical , pharmacology : Free Radical Scavengers, Plant Extracts.
- chemical , therapeutic use : Antioxidants.
- chemistry : Plants, Medicinal.
- drug effects : Oxidative Stress, Respiratory Burst.
- drug therapy : Inflammatory Bowel Diseases, Nervous System Diseases, Respiratory Tract Diseases.
- pathology : Inflammation, Inflammatory Bowel Diseases, Nervous System Diseases, Respiratory Tract Diseases.
- Animals, Cells, Cultured, Chromatography, High Pressure Liquid, Humans, Indicators and Reagents, Models, Biological.
Abstract
All processes of oxygen activation include very reactive intermediates. Therefore, aerobic cells must cope with--and to some extent also adapt to--oxidative stress provoked for example by infections or intoxications, where these reactive intermediates accumulate. All inflammatory processes include such oxygen activating processes where reactive oxygen species (ROS) are produced. Dependent on the strength of these impact(s), several symptoms indicate the deviation from normal, steady-state metabolism. Intrinsic radical scavenging processes or compounds administered with food thus have to warrant metabolic control within certain limits. Antioxidants which in many cases are free radical scavengers or quenchers of activated states comprise a vast number of classes of organic molecules including phenolics as the most prominent ones. In this publication the activities of extracts from Fraxinus excelsior, Populus tremula and Solidago virgaurea as components of the drug Phytodolor and their mechanisms of protection from oxidative damage are summarized. In addition, new results on tyrosine nitration, a process characteristic for sites of inflammation, and its inhibition by these plant extracts, is reported.
DOI: 10.1055/s-0031-1300215
PubMed: 10800635
Links to Exploration step
pubmed:10800635Le document en format XML
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<author><name sortKey="Schempp, H" sort="Schempp, H" uniqKey="Schempp H" first="H" last="Schempp">H. Schempp</name>
<affiliation><nlm:affiliation>Lehrstuhl für Phytopathologie, Labor für Angewandte Biochemie, Technische Universität München, Freising-Weihenstephan, Germany.</nlm:affiliation>
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<author><name sortKey="Weiser, D" sort="Weiser, D" uniqKey="Weiser D" first="D" last="Weiser">D. Weiser</name>
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<author><name sortKey="Elstner, E F" sort="Elstner, E F" uniqKey="Elstner E" first="E F" last="Elstner">E F Elstner</name>
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<term>Antioxidants (therapeutic use)</term>
<term>Cells, Cultured (MeSH)</term>
<term>Chromatography, High Pressure Liquid (MeSH)</term>
<term>Enzymes (metabolism)</term>
<term>Free Radical Scavengers (pharmacology)</term>
<term>Humans (MeSH)</term>
<term>Indicators and Reagents (MeSH)</term>
<term>Inflammation (pathology)</term>
<term>Inflammatory Bowel Diseases (drug therapy)</term>
<term>Inflammatory Bowel Diseases (pathology)</term>
<term>Lipoproteins, LDL (metabolism)</term>
<term>Lipoxygenase (metabolism)</term>
<term>Models, Biological (MeSH)</term>
<term>Nervous System Diseases (drug therapy)</term>
<term>Nervous System Diseases (pathology)</term>
<term>Oxidative Stress (drug effects)</term>
<term>Peroxidase (metabolism)</term>
<term>Plant Extracts (pharmacology)</term>
<term>Plants, Medicinal (chemistry)</term>
<term>Respiratory Burst (drug effects)</term>
<term>Respiratory Tract Diseases (drug therapy)</term>
<term>Respiratory Tract Diseases (pathology)</term>
<term>Tyrosine (analogs & derivatives)</term>
<term>Tyrosine (metabolism)</term>
<term>Xanthine Oxidase (metabolism)</term>
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</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Enzymes</term>
<term>Lipoproteins, LDL</term>
<term>Lipoxygenase</term>
<term>Peroxidase</term>
<term>Tyrosine</term>
<term>Xanthine Oxidase</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Free Radical Scavengers</term>
<term>Plant Extracts</term>
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<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antioxidants</term>
</keywords>
<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Plants, Medicinal</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Oxidative Stress</term>
<term>Respiratory Burst</term>
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<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Inflammatory Bowel Diseases</term>
<term>Nervous System Diseases</term>
<term>Respiratory Tract Diseases</term>
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<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Inflammation</term>
<term>Inflammatory Bowel Diseases</term>
<term>Nervous System Diseases</term>
<term>Respiratory Tract Diseases</term>
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<term>Cells, Cultured</term>
<term>Chromatography, High Pressure Liquid</term>
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<front><div type="abstract" xml:lang="en">All processes of oxygen activation include very reactive intermediates. Therefore, aerobic cells must cope with--and to some extent also adapt to--oxidative stress provoked for example by infections or intoxications, where these reactive intermediates accumulate. All inflammatory processes include such oxygen activating processes where reactive oxygen species (ROS) are produced. Dependent on the strength of these impact(s), several symptoms indicate the deviation from normal, steady-state metabolism. Intrinsic radical scavenging processes or compounds administered with food thus have to warrant metabolic control within certain limits. Antioxidants which in many cases are free radical scavengers or quenchers of activated states comprise a vast number of classes of organic molecules including phenolics as the most prominent ones. In this publication the activities of extracts from Fraxinus excelsior, Populus tremula and Solidago virgaurea as components of the drug Phytodolor and their mechanisms of protection from oxidative damage are summarized. In addition, new results on tyrosine nitration, a process characteristic for sites of inflammation, and its inhibition by these plant extracts, is reported.</div>
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<Title>Arzneimittel-Forschung</Title>
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<ArticleTitle>Biochemical model reactions indicative of inflammatory processes. Activities of extracts from Fraxinus excelsior and Populus tremula.</ArticleTitle>
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<Abstract><AbstractText>All processes of oxygen activation include very reactive intermediates. Therefore, aerobic cells must cope with--and to some extent also adapt to--oxidative stress provoked for example by infections or intoxications, where these reactive intermediates accumulate. All inflammatory processes include such oxygen activating processes where reactive oxygen species (ROS) are produced. Dependent on the strength of these impact(s), several symptoms indicate the deviation from normal, steady-state metabolism. Intrinsic radical scavenging processes or compounds administered with food thus have to warrant metabolic control within certain limits. Antioxidants which in many cases are free radical scavengers or quenchers of activated states comprise a vast number of classes of organic molecules including phenolics as the most prominent ones. In this publication the activities of extracts from Fraxinus excelsior, Populus tremula and Solidago virgaurea as components of the drug Phytodolor and their mechanisms of protection from oxidative damage are summarized. In addition, new results on tyrosine nitration, a process characteristic for sites of inflammation, and its inhibition by these plant extracts, is reported.</AbstractText>
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