Totally synthetic peptide-based immunocontraceptive vaccines show activity in dogs of different breeds.
Identifieur interne : 003A82 ( Main/Corpus ); précédent : 003A81; suivant : 003A83Totally synthetic peptide-based immunocontraceptive vaccines show activity in dogs of different breeds.
Auteurs : John Walker ; Souravi Ghosh ; Joanne Pagnon ; Caterina Colantoni ; Andrea Newbold ; Weiguang Zeng ; David C. JacksonSource :
- Vaccine [ 0264-410X ] ; 2007.
English descriptors
- KwdEn :
- Animals (MeSH), Antibody Formation (MeSH), Cell Proliferation (MeSH), Contraception, Immunologic (methods), Contraception, Immunologic (veterinary), Distemper Virus, Canine (immunology), Dogs (MeSH), Enzyme-Linked Immunosorbent Assay (MeSH), Epitopes, T-Lymphocyte (immunology), Female (MeSH), Gonadotropin-Releasing Hormone (immunology), Injections, Subcutaneous (MeSH), Leukocytes, Mononuclear (immunology), Lymphocyte Activation (MeSH), Male (MeSH), Progesterone (blood), T-Lymphocytes (immunology), Testosterone (blood), Vaccines, Subunit (chemical synthesis), Vaccines, Subunit (immunology), Viral Fusion Proteins (immunology).
- MESH :
- chemical , blood : Progesterone, Testosterone.
- chemical , chemical synthesis : Vaccines, Subunit.
- chemical , immunology : Epitopes, T-Lymphocyte, Gonadotropin-Releasing Hormone, Vaccines, Subunit, Viral Fusion Proteins.
- immunology : Distemper Virus, Canine, Leukocytes, Mononuclear, T-Lymphocytes.
- methods : Contraception, Immunologic.
- veterinary : Contraception, Immunologic.
- Animals, Antibody Formation, Cell Proliferation, Dogs, Enzyme-Linked Immunosorbent Assay, Female, Injections, Subcutaneous, Lymphocyte Activation, Male.
Abstract
In this study we examine the immunogenicity of totally synthetic peptide-based immunocontraceptive vaccines in dogs. Seven individual epitope-based vaccines were assembled in which a different T helper (T(H)) cell epitope derived from the sequence of F protein of canine distemper virus was synthesized in tandem with a peptide representing luteinising hormone releasing hormone (LHRH). Each of the individual T(H)-LHRH peptide vaccines was inoculated subcutaneously into dogs. The results demonstrate that five of the seven peptide vaccines were able to elicit strong anti-LHRH antibody responses in beagle foxhounds accompanied by a concomitant suppression in the levels of the hormones testosterone and progesterone in the majority of the animals. A pool of these five peptides was then used to inoculate five different breeds of dogs. All animals responded with high levels of anti-LHRH antibody. An investigation of the proliferative responses of peripheral blood mononuclear cells (PBMC) obtained from inoculated dogs showed that the majority of breeds responded to each of the individual T helper cell epitope tested. The results provide a strategy for development of an immunocontraceptive vaccine for use in multiple breeds of dogs.
DOI: 10.1016/j.vaccine.2007.07.047
PubMed: 17825958
Links to Exploration step
pubmed:17825958Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Totally synthetic peptide-based immunocontraceptive vaccines show activity in dogs of different breeds.</title><author><name sortKey="Walker, John" sort="Walker, John" uniqKey="Walker J" first="John" last="Walker">John Walker</name><affiliation><nlm:affiliation>Pfizer Animal Health, 45 Poplar Road, Parkville, 3052 Victoria, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Ghosh, Souravi" sort="Ghosh, Souravi" uniqKey="Ghosh S" first="Souravi" last="Ghosh">Souravi Ghosh</name></author><author><name sortKey="Pagnon, Joanne" sort="Pagnon, Joanne" uniqKey="Pagnon J" first="Joanne" last="Pagnon">Joanne Pagnon</name></author><author><name sortKey="Colantoni, Caterina" sort="Colantoni, Caterina" uniqKey="Colantoni C" first="Caterina" last="Colantoni">Caterina Colantoni</name></author><author><name sortKey="Newbold, Andrea" sort="Newbold, Andrea" uniqKey="Newbold A" first="Andrea" last="Newbold">Andrea Newbold</name></author><author><name sortKey="Zeng, Weiguang" sort="Zeng, Weiguang" uniqKey="Zeng W" first="Weiguang" last="Zeng">Weiguang Zeng</name></author><author><name sortKey="Jackson, David C" sort="Jackson, David C" uniqKey="Jackson D" first="David C" last="Jackson">David C. Jackson</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2007">2007</date><idno type="RBID">pubmed:17825958</idno><idno type="pmid">17825958</idno><idno type="doi">10.1016/j.vaccine.2007.07.047</idno><idno type="wicri:Area/Main/Corpus">003A82</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">003A82</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Totally synthetic peptide-based immunocontraceptive vaccines show activity in dogs of different breeds.</title><author><name sortKey="Walker, John" sort="Walker, John" uniqKey="Walker J" first="John" last="Walker">John Walker</name><affiliation><nlm:affiliation>Pfizer Animal Health, 45 Poplar Road, Parkville, 3052 Victoria, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Ghosh, Souravi" sort="Ghosh, Souravi" uniqKey="Ghosh S" first="Souravi" last="Ghosh">Souravi Ghosh</name></author><author><name sortKey="Pagnon, Joanne" sort="Pagnon, Joanne" uniqKey="Pagnon J" first="Joanne" last="Pagnon">Joanne Pagnon</name></author><author><name sortKey="Colantoni, Caterina" sort="Colantoni, Caterina" uniqKey="Colantoni C" first="Caterina" last="Colantoni">Caterina Colantoni</name></author><author><name sortKey="Newbold, Andrea" sort="Newbold, Andrea" uniqKey="Newbold A" first="Andrea" last="Newbold">Andrea Newbold</name></author><author><name sortKey="Zeng, Weiguang" sort="Zeng, Weiguang" uniqKey="Zeng W" first="Weiguang" last="Zeng">Weiguang Zeng</name></author><author><name sortKey="Jackson, David C" sort="Jackson, David C" uniqKey="Jackson D" first="David C" last="Jackson">David C. Jackson</name></author></analytic><series><title level="j">Vaccine</title><idno type="ISSN">0264-410X</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term><term>Antibody Formation (MeSH)</term><term>Cell Proliferation (MeSH)</term><term>Contraception, Immunologic (methods)</term><term>Contraception, Immunologic (veterinary)</term><term>Distemper Virus, Canine (immunology)</term><term>Dogs (MeSH)</term><term>Enzyme-Linked Immunosorbent Assay (MeSH)</term><term>Epitopes, T-Lymphocyte (immunology)</term><term>Female (MeSH)</term><term>Gonadotropin-Releasing Hormone (immunology)</term><term>Injections, Subcutaneous (MeSH)</term><term>Leukocytes, Mononuclear (immunology)</term><term>Lymphocyte Activation (MeSH)</term><term>Male (MeSH)</term><term>Progesterone (blood)</term><term>T-Lymphocytes (immunology)</term><term>Testosterone (blood)</term><term>Vaccines, Subunit (chemical synthesis)</term><term>Vaccines, Subunit (immunology)</term><term>Viral Fusion Proteins (immunology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Progesterone</term><term>Testosterone</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemical synthesis" xml:lang="en"><term>Vaccines, Subunit</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Epitopes, T-Lymphocyte</term><term>Gonadotropin-Releasing Hormone</term><term>Vaccines, Subunit</term><term>Viral Fusion Proteins</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Distemper Virus, Canine</term><term>Leukocytes, Mononuclear</term><term>T-Lymphocytes</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Contraception, Immunologic</term></keywords><keywords scheme="MESH" qualifier="veterinary" xml:lang="en"><term>Contraception, Immunologic</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Antibody Formation</term><term>Cell Proliferation</term><term>Dogs</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Female</term><term>Injections, Subcutaneous</term><term>Lymphocyte Activation</term><term>Male</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In this study we examine the immunogenicity of totally synthetic peptide-based immunocontraceptive vaccines in dogs. Seven individual epitope-based vaccines were assembled in which a different T helper (T(H)) cell epitope derived from the sequence of F protein of canine distemper virus was synthesized in tandem with a peptide representing luteinising hormone releasing hormone (LHRH). Each of the individual T(H)-LHRH peptide vaccines was inoculated subcutaneously into dogs. The results demonstrate that five of the seven peptide vaccines were able to elicit strong anti-LHRH antibody responses in beagle foxhounds accompanied by a concomitant suppression in the levels of the hormones testosterone and progesterone in the majority of the animals. A pool of these five peptides was then used to inoculate five different breeds of dogs. All animals responded with high levels of anti-LHRH antibody. An investigation of the proliferative responses of peripheral blood mononuclear cells (PBMC) obtained from inoculated dogs showed that the majority of breeds responded to each of the individual T helper cell epitope tested. The results provide a strategy for development of an immunocontraceptive vaccine for use in multiple breeds of dogs.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">17825958</PMID><DateCompleted><Year>2007</Year><Month>12</Month><Day>06</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0264-410X</ISSN><JournalIssue CitedMedium="Print"><Volume>25</Volume><Issue>41</Issue><PubDate><Year>2007</Year><Month>Oct</Month><Day>10</Day></PubDate></JournalIssue><Title>Vaccine</Title><ISOAbbreviation>Vaccine</ISOAbbreviation></Journal><ArticleTitle>Totally synthetic peptide-based immunocontraceptive vaccines show activity in dogs of different breeds.</ArticleTitle><Pagination><MedlinePgn>7111-9</MedlinePgn></Pagination><Abstract><AbstractText>In this study we examine the immunogenicity of totally synthetic peptide-based immunocontraceptive vaccines in dogs. Seven individual epitope-based vaccines were assembled in which a different T helper (T(H)) cell epitope derived from the sequence of F protein of canine distemper virus was synthesized in tandem with a peptide representing luteinising hormone releasing hormone (LHRH). Each of the individual T(H)-LHRH peptide vaccines was inoculated subcutaneously into dogs. The results demonstrate that five of the seven peptide vaccines were able to elicit strong anti-LHRH antibody responses in beagle foxhounds accompanied by a concomitant suppression in the levels of the hormones testosterone and progesterone in the majority of the animals. A pool of these five peptides was then used to inoculate five different breeds of dogs. All animals responded with high levels of anti-LHRH antibody. An investigation of the proliferative responses of peripheral blood mononuclear cells (PBMC) obtained from inoculated dogs showed that the majority of breeds responded to each of the individual T helper cell epitope tested. The results provide a strategy for development of an immunocontraceptive vaccine for use in multiple breeds of dogs.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Walker</LastName><ForeName>John</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Pfizer Animal Health, 45 Poplar Road, Parkville, 3052 Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ghosh</LastName><ForeName>Souravi</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Pagnon</LastName><ForeName>Joanne</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Colantoni</LastName><ForeName>Caterina</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Newbold</LastName><ForeName>Andrea</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Zeng</LastName><ForeName>Weiguang</ForeName><Initials>W</Initials></Author><Author ValidYN="Y"><LastName>Jackson</LastName><ForeName>David C</ForeName><Initials>DC</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2007</Year><Month>08</Month><Day>20</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Vaccine</MedlineTA><NlmUniqueID>8406899</NlmUniqueID><ISSNLinking>0264-410X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018984">Epitopes, T-Lymphocyte</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D022223">Vaccines, Subunit</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014760">Viral Fusion Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>149346-80-5</RegistryNumber><NameOfSubstance UI="C076619">F protein, Phocine distemper virus</NameOfSubstance></Chemical><Chemical><RegistryNumber>33515-09-2</RegistryNumber><NameOfSubstance UI="D007987">Gonadotropin-Releasing Hormone</NameOfSubstance></Chemical><Chemical><RegistryNumber>3XMK78S47O</RegistryNumber><NameOfSubstance UI="D013739">Testosterone</NameOfSubstance></Chemical><Chemical><RegistryNumber>4G7DS2Q64Y</RegistryNumber><NameOfSubstance UI="D011374">Progesterone</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000917" MajorTopicYN="N">Antibody Formation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D049109" MajorTopicYN="N">Cell Proliferation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003269" MajorTopicYN="N">Contraception, Immunologic</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName><QualifierName UI="Q000662" MajorTopicYN="Y">veterinary</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004217" MajorTopicYN="N">Distemper Virus, Canine</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004285" MajorTopicYN="N">Dogs</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004797" MajorTopicYN="N">Enzyme-Linked Immunosorbent Assay</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018984" MajorTopicYN="N">Epitopes, T-Lymphocyte</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007987" MajorTopicYN="N">Gonadotropin-Releasing Hormone</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007279" MajorTopicYN="N">Injections, Subcutaneous</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007963" MajorTopicYN="N">Leukocytes, Mononuclear</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008213" MajorTopicYN="N">Lymphocyte Activation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011374" MajorTopicYN="N">Progesterone</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013601" MajorTopicYN="N">T-Lymphocytes</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013739" 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