Phenolic glycosides as inhibitors of inducible nitric oxide synthase from Populus davidiana in LPS-activated RAW 264.7 murine macrophages.
Identifieur interne : 002814 ( Main/Corpus ); précédent : 002813; suivant : 002815Phenolic glycosides as inhibitors of inducible nitric oxide synthase from Populus davidiana in LPS-activated RAW 264.7 murine macrophages.
Auteurs : Hwa Jin Lee ; Ji Sun Kim ; Young-Kyoon Kim ; Jae-Ha RyuSource :
- Die Pharmazie [ 0031-7144 ] ; 2012.
English descriptors
- KwdEn :
- Animals (MeSH), Blotting, Western (MeSH), Cells, Cultured (MeSH), Dose-Response Relationship, Drug (MeSH), Enzyme Inhibitors (isolation & purification), Enzyme Inhibitors (pharmacology), Glucosides (isolation & purification), Glucosides (pharmacology), Glycosides (pharmacology), Indicators and Reagents (MeSH), Lipopolysaccharides (pharmacology), Macrophage Activation (drug effects), Macrophages (drug effects), Macrophages (enzymology), Mice (MeSH), Nitric Oxide (biosynthesis), Nitric Oxide Synthase Type II (antagonists & inhibitors), Phenols (pharmacology), Populus (chemistry), Solvents (MeSH).
- MESH :
- chemical , antagonists & inhibitors : Nitric Oxide Synthase Type II.
- chemical , biosynthesis : Nitric Oxide.
- chemical , isolation & purification : Enzyme Inhibitors, Glucosides.
- chemical , pharmacology : Enzyme Inhibitors, Glucosides, Glycosides, Lipopolysaccharides, Phenols.
- chemistry : Populus.
- drug effects : Macrophage Activation, Macrophages.
- enzymology : Macrophages.
- Animals, Blotting, Western, Cells, Cultured, Dose-Response Relationship, Drug, Indicators and Reagents, Mice, Solvents.
Abstract
Nitric oxide (NO) produced in large amounts by inducible nitric oxide synthase (i-NOS) is known to be responsible for the vasodilation and hypotension observed in septic shock and inflammation. Inhibitors of i-NOS, thus, may be useful candidates for the treatment of inflammatory diseases that accompany the overproduction of NO. Two phenolic glycosides, salicortin (1) and salicortin-6'-benzoate (2), were purified as active principles from the extracts of Populus davidiana by activity-guided purification procedures. They showed dose dependent inhibition of NO production in lipopolysaccharide (LPS)-activated RAW 264.7 cells. The IC50 values of salicortin (1) and salicortin-6'-benzoate (2) was 15 microM and over 50 microM, respectively. In immunoblot analysis, salicortin inhibited the expression of i-NOS. These new inhibitors of overproduction of NO may have potentials for the treatment of inflammation.
PubMed: 23136723
Links to Exploration step
pubmed:23136723Le document en format XML
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<author><name sortKey="Lee, Hwa Jin" sort="Lee, Hwa Jin" uniqKey="Lee H" first="Hwa Jin" last="Lee">Hwa Jin Lee</name>
<affiliation><nlm:affiliation>Research Center for Cell Fate Control, College of Pharmacy, Sookmyung Women's University, Seoul, Republic of Korea.</nlm:affiliation>
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<author><name sortKey="Kim, Ji Sun" sort="Kim, Ji Sun" uniqKey="Kim J" first="Ji Sun" last="Kim">Ji Sun Kim</name>
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<author><name sortKey="Kim, Young Kyoon" sort="Kim, Young Kyoon" uniqKey="Kim Y" first="Young-Kyoon" last="Kim">Young-Kyoon Kim</name>
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<author><name sortKey="Ryu, Jae Ha" sort="Ryu, Jae Ha" uniqKey="Ryu J" first="Jae-Ha" last="Ryu">Jae-Ha Ryu</name>
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<author><name sortKey="Lee, Hwa Jin" sort="Lee, Hwa Jin" uniqKey="Lee H" first="Hwa Jin" last="Lee">Hwa Jin Lee</name>
<affiliation><nlm:affiliation>Research Center for Cell Fate Control, College of Pharmacy, Sookmyung Women's University, Seoul, Republic of Korea.</nlm:affiliation>
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<author><name sortKey="Kim, Ji Sun" sort="Kim, Ji Sun" uniqKey="Kim J" first="Ji Sun" last="Kim">Ji Sun Kim</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term>
<term>Blotting, Western (MeSH)</term>
<term>Cells, Cultured (MeSH)</term>
<term>Dose-Response Relationship, Drug (MeSH)</term>
<term>Enzyme Inhibitors (isolation & purification)</term>
<term>Enzyme Inhibitors (pharmacology)</term>
<term>Glucosides (isolation & purification)</term>
<term>Glucosides (pharmacology)</term>
<term>Glycosides (pharmacology)</term>
<term>Indicators and Reagents (MeSH)</term>
<term>Lipopolysaccharides (pharmacology)</term>
<term>Macrophage Activation (drug effects)</term>
<term>Macrophages (drug effects)</term>
<term>Macrophages (enzymology)</term>
<term>Mice (MeSH)</term>
<term>Nitric Oxide (biosynthesis)</term>
<term>Nitric Oxide Synthase Type II (antagonists & inhibitors)</term>
<term>Phenols (pharmacology)</term>
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<term>Blotting, Western</term>
<term>Cells, Cultured</term>
<term>Dose-Response Relationship, Drug</term>
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<front><div type="abstract" xml:lang="en">Nitric oxide (NO) produced in large amounts by inducible nitric oxide synthase (i-NOS) is known to be responsible for the vasodilation and hypotension observed in septic shock and inflammation. Inhibitors of i-NOS, thus, may be useful candidates for the treatment of inflammatory diseases that accompany the overproduction of NO. Two phenolic glycosides, salicortin (1) and salicortin-6'-benzoate (2), were purified as active principles from the extracts of Populus davidiana by activity-guided purification procedures. They showed dose dependent inhibition of NO production in lipopolysaccharide (LPS)-activated RAW 264.7 cells. The IC50 values of salicortin (1) and salicortin-6'-benzoate (2) was 15 microM and over 50 microM, respectively. In immunoblot analysis, salicortin inhibited the expression of i-NOS. These new inhibitors of overproduction of NO may have potentials for the treatment of inflammation.</div>
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<Abstract><AbstractText>Nitric oxide (NO) produced in large amounts by inducible nitric oxide synthase (i-NOS) is known to be responsible for the vasodilation and hypotension observed in septic shock and inflammation. Inhibitors of i-NOS, thus, may be useful candidates for the treatment of inflammatory diseases that accompany the overproduction of NO. Two phenolic glycosides, salicortin (1) and salicortin-6'-benzoate (2), were purified as active principles from the extracts of Populus davidiana by activity-guided purification procedures. They showed dose dependent inhibition of NO production in lipopolysaccharide (LPS)-activated RAW 264.7 cells. The IC50 values of salicortin (1) and salicortin-6'-benzoate (2) was 15 microM and over 50 microM, respectively. In immunoblot analysis, salicortin inhibited the expression of i-NOS. These new inhibitors of overproduction of NO may have potentials for the treatment of inflammation.</AbstractText>
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