PoplarV1, Main, Corpus, bibRecord, 001D97

Horizontal gene transfer and gene dosage drives adaptation to wood colonization in a tree pathogen.

Identifieur interne : 001D97 ( Main/Corpus ); précédent : 001D96; suivant : 001D98

Horizontal gene transfer and gene dosage drives adaptation to wood colonization in a tree pathogen.

Auteurs : Braham Dhillon ; Nicolas Feau ; Andrea L. Aerts ; Stéphanie Beauseigle ; Louis Bernier ; Alex Copeland ; Adam Foster ; Navdeep Gill ; Bernard Henrissat ; Padmini Herath ; Kurt M. Labutti ; Anthony Levasseur ; Erika A. Lindquist ; Eline Majoor ; Robin A. Ohm ; Jasmyn L. Pangilinan ; Amadeus Pribowo ; John N. Saddler ; Monique L. Sakalidis ; Ronald P. De Vries ; Igor V. Grigoriev ; Stephen B. Goodwin ; Philippe Tanguay ; Richard C. Hamelin

Source :

Proceedings of the National Academy of Sciences of the United States of America [ 1091-6490 ] ; 2015.

RBID : pubmed:25733908

English descriptors

KwdEn :
- Adaptation, Physiological (genetics), Ascomycota (genetics), Ascomycota (growth & development), Ascomycota (pathogenicity), Base Sequence (MeSH), Colony Count, Microbial (MeSH), Gene Dosage (MeSH), Gene Expression Regulation, Fungal (MeSH), Gene Transfer, Horizontal (MeSH), Genetic Speciation (MeSH), Genome, Fungal (genetics), Host-Pathogen Interactions (genetics), Indole Alkaloids (metabolism), Molecular Sequence Data (MeSH), Nitrogen (metabolism), Phylogeny (MeSH), Populus (microbiology), Proteolysis (MeSH), Synteny (genetics), Time Factors (MeSH), Trees (microbiology), Wood (microbiology).
MESH :
- chemical , metabolism : Indole Alkaloids, Nitrogen.
- genetics : Adaptation, Physiological, Ascomycota, Genome, Fungal, Host-Pathogen Interactions, Synteny.
- growth & development : Ascomycota.
- microbiology : Populus, Trees, Wood.
- pathogenicity : Ascomycota.
- Base Sequence, Colony Count, Microbial, Gene Dosage, Gene Expression Regulation, Fungal, Gene Transfer, Horizontal, Genetic Speciation, Molecular Sequence Data, Phylogeny, Proteolysis, Time Factors.

Abstract

Some of the most damaging tree pathogens can attack woody stems, causing lesions (cankers) that may be lethal. To identify the genomic determinants of wood colonization leading to canker formation, we sequenced the genomes of the poplar canker pathogen, Mycosphaerella populorum, and the closely related poplar leaf pathogen, M. populicola. A secondary metabolite cluster unique to M. populorum is fully activated following induction by poplar wood and leaves. In addition, genes encoding hemicellulose-degrading enzymes, peptidases, and metabolite transporters were more abundant and were up-regulated in M. populorum growing on poplar wood-chip medium compared with M. populicola. The secondary gene cluster and several of the carbohydrate degradation genes have the signature of horizontal transfer from ascomycete fungi associated with wood decay and from prokaryotes. Acquisition and maintenance of the gene battery necessary for growth in woody tissues and gene dosage resulting in gene expression reconfiguration appear to be responsible for the adaptation of M. populorum to infect, colonize, and cause mortality on poplar woody stems.

DOI: 10.1073/pnas.1424293112
PubMed: 25733908
PubMed Central: PMC4371944

Links to Exploration step

pubmed:25733908

Le document en format XML

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<author><name sortKey="Dhillon, Braham" sort="Dhillon, Braham" uniqKey="Dhillon B" first="Braham" last="Dhillon">Braham Dhillon</name>
<affiliation><nlm:affiliation>Department of Forest and Conservation Sciences, The University of British Columbia, Vancouver, BC, Canada V6T 1Z4;</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Feau, Nicolas" sort="Feau, Nicolas" uniqKey="Feau N" first="Nicolas" last="Feau">Nicolas Feau</name>
<affiliation><nlm:affiliation>Department of Forest and Conservation Sciences, The University of British Columbia, Vancouver, BC, Canada V6T 1Z4; feaunico@mail.ubc.ca Richard.Hamelin@RNCan-NRCan.gc.ca.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Aerts, Andrea L" sort="Aerts, Andrea L" uniqKey="Aerts A" first="Andrea L" last="Aerts">Andrea L. Aerts</name>
<affiliation><nlm:affiliation>US Department of Energy Joint Genome Institute, Walnut Creek, CA 94598;</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Beauseigle, Stephanie" sort="Beauseigle, Stephanie" uniqKey="Beauseigle S" first="Stéphanie" last="Beauseigle">Stéphanie Beauseigle</name>
<affiliation><nlm:affiliation>Department of Forest and Conservation Sciences, The University of British Columbia, Vancouver, BC, Canada V6T 1Z4;</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Bernier, Louis" sort="Bernier, Louis" uniqKey="Bernier L" first="Louis" last="Bernier">Louis Bernier</name>
<affiliation><nlm:affiliation>Centre d'Étude de la Forêt, Université Laval, Québec, QC, Canada G1V 0A6;</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Copeland, Alex" sort="Copeland, Alex" uniqKey="Copeland A" first="Alex" last="Copeland">Alex Copeland</name>
<affiliation><nlm:affiliation>US Department of Energy Joint Genome Institute, Walnut Creek, CA 94598;</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Foster, Adam" sort="Foster, Adam" uniqKey="Foster A" first="Adam" last="Foster">Adam Foster</name>
<affiliation><nlm:affiliation>Natural Resources Canada, Canadian Forest Service, Laurentian Forestry Centre, Québec, QC, Canada G1V 4C7;</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Gill, Navdeep" sort="Gill, Navdeep" uniqKey="Gill N" first="Navdeep" last="Gill">Navdeep Gill</name>
<affiliation><nlm:affiliation>Department of Botany, The University of British Columbia, Vancouver, BC, Canada V6T 1Z4;</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Henrissat, Bernard" sort="Henrissat, Bernard" uniqKey="Henrissat B" first="Bernard" last="Henrissat">Bernard Henrissat</name>
<affiliation><nlm:affiliation>UMR 7257 Centre National de la Recherche Scientifique, Aix-Marseille University, 13288 Marseille, France; Department of Biological Sciences, King Abdulaziz University, Jeddah, Saudi Arabia;</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Herath, Padmini" sort="Herath, Padmini" uniqKey="Herath P" first="Padmini" last="Herath">Padmini Herath</name>
<affiliation><nlm:affiliation>Department of Forest and Conservation Sciences, The University of British Columbia, Vancouver, BC, Canada V6T 1Z4;</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Labutti, Kurt M" sort="Labutti, Kurt M" uniqKey="Labutti K" first="Kurt M" last="Labutti">Kurt M. Labutti</name>
<affiliation><nlm:affiliation>US Department of Energy Joint Genome Institute, Walnut Creek, CA 94598;</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Levasseur, Anthony" sort="Levasseur, Anthony" uniqKey="Levasseur A" first="Anthony" last="Levasseur">Anthony Levasseur</name>
<affiliation><nlm:affiliation>Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (URMITE), UM63, CNRS 7278, IRD 198, INSERM U1095, IHU Méditerranée Infection, Aix-Marseille University, 13005 Marseille, France;</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Lindquist, Erika A" sort="Lindquist, Erika A" uniqKey="Lindquist E" first="Erika A" last="Lindquist">Erika A. Lindquist</name>
<affiliation><nlm:affiliation>US Department of Energy Joint Genome Institute, Walnut Creek, CA 94598;</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Majoor, Eline" sort="Majoor, Eline" uniqKey="Majoor E" first="Eline" last="Majoor">Eline Majoor</name>
<affiliation><nlm:affiliation>Fungal Physiology, Centraalbureau voor Schimmelcultures-Royal Netherlands Academy of Arts and Sciences Fungal Biodiversity Centre (CBS-KNAW), 3584 CT, Utrecht, The Netherlands; Fungal Molecular Physiology, Utrecht University, 3584 CT, Utrecht, The Netherlands;</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Ohm, Robin A" sort="Ohm, Robin A" uniqKey="Ohm R" first="Robin A" last="Ohm">Robin A. Ohm</name>
<affiliation><nlm:affiliation>US Department of Energy Joint Genome Institute, Walnut Creek, CA 94598;</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Pangilinan, Jasmyn L" sort="Pangilinan, Jasmyn L" uniqKey="Pangilinan J" first="Jasmyn L" last="Pangilinan">Jasmyn L. Pangilinan</name>
<affiliation><nlm:affiliation>US Department of Energy Joint Genome Institute, Walnut Creek, CA 94598;</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Pribowo, Amadeus" sort="Pribowo, Amadeus" uniqKey="Pribowo A" first="Amadeus" last="Pribowo">Amadeus Pribowo</name>
<affiliation><nlm:affiliation>Forest Products Biotechnology and Bioenergy, The University of British Columbia, Vancouver, BC, Canada V6T 1Z4; and.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Saddler, John N" sort="Saddler, John N" uniqKey="Saddler J" first="John N" last="Saddler">John N. Saddler</name>
<affiliation><nlm:affiliation>Forest Products Biotechnology and Bioenergy, The University of British Columbia, Vancouver, BC, Canada V6T 1Z4; and.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Sakalidis, Monique L" sort="Sakalidis, Monique L" uniqKey="Sakalidis M" first="Monique L" last="Sakalidis">Monique L. Sakalidis</name>
<affiliation><nlm:affiliation>Department of Forest and Conservation Sciences, The University of British Columbia, Vancouver, BC, Canada V6T 1Z4;</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="De Vries, Ronald P" sort="De Vries, Ronald P" uniqKey="De Vries R" first="Ronald P" last="De Vries">Ronald P. De Vries</name>
<affiliation><nlm:affiliation>Fungal Physiology, Centraalbureau voor Schimmelcultures-Royal Netherlands Academy of Arts and Sciences Fungal Biodiversity Centre (CBS-KNAW), 3584 CT, Utrecht, The Netherlands; Fungal Molecular Physiology, Utrecht University, 3584 CT, Utrecht, The Netherlands;</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Grigoriev, Igor V" sort="Grigoriev, Igor V" uniqKey="Grigoriev I" first="Igor V" last="Grigoriev">Igor V. Grigoriev</name>
<affiliation><nlm:affiliation>US Department of Energy Joint Genome Institute, Walnut Creek, CA 94598;</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Goodwin, Stephen B" sort="Goodwin, Stephen B" uniqKey="Goodwin S" first="Stephen B" last="Goodwin">Stephen B. Goodwin</name>
<affiliation><nlm:affiliation>US Department of Agriculture-Agricultural Research Service Crop Production and Pest Control Research Unit, Purdue University, West Lafayette, IN 47907-2054.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Tanguay, Philippe" sort="Tanguay, Philippe" uniqKey="Tanguay P" first="Philippe" last="Tanguay">Philippe Tanguay</name>
<affiliation><nlm:affiliation>Natural Resources Canada, Canadian Forest Service, Laurentian Forestry Centre, Québec, QC, Canada G1V 4C7;</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Hamelin, Richard C" sort="Hamelin, Richard C" uniqKey="Hamelin R" first="Richard C" last="Hamelin">Richard C. Hamelin</name>
<affiliation><nlm:affiliation>Department of Forest and Conservation Sciences, The University of British Columbia, Vancouver, BC, Canada V6T 1Z4; Natural Resources Canada, Canadian Forest Service, Laurentian Forestry Centre, Québec, QC, Canada G1V 4C7; feaunico@mail.ubc.ca Richard.Hamelin@RNCan-NRCan.gc.ca.</nlm:affiliation>
</affiliation>
</author>
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<idno type="doi">10.1073/pnas.1424293112</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Horizontal gene transfer and gene dosage drives adaptation to wood colonization in a tree pathogen.</title>
<author><name sortKey="Dhillon, Braham" sort="Dhillon, Braham" uniqKey="Dhillon B" first="Braham" last="Dhillon">Braham Dhillon</name>
<affiliation><nlm:affiliation>Department of Forest and Conservation Sciences, The University of British Columbia, Vancouver, BC, Canada V6T 1Z4;</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Feau, Nicolas" sort="Feau, Nicolas" uniqKey="Feau N" first="Nicolas" last="Feau">Nicolas Feau</name>
<affiliation><nlm:affiliation>Department of Forest and Conservation Sciences, The University of British Columbia, Vancouver, BC, Canada V6T 1Z4; feaunico@mail.ubc.ca Richard.Hamelin@RNCan-NRCan.gc.ca.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Aerts, Andrea L" sort="Aerts, Andrea L" uniqKey="Aerts A" first="Andrea L" last="Aerts">Andrea L. Aerts</name>
<affiliation><nlm:affiliation>US Department of Energy Joint Genome Institute, Walnut Creek, CA 94598;</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Beauseigle, Stephanie" sort="Beauseigle, Stephanie" uniqKey="Beauseigle S" first="Stéphanie" last="Beauseigle">Stéphanie Beauseigle</name>
<affiliation><nlm:affiliation>Department of Forest and Conservation Sciences, The University of British Columbia, Vancouver, BC, Canada V6T 1Z4;</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Bernier, Louis" sort="Bernier, Louis" uniqKey="Bernier L" first="Louis" last="Bernier">Louis Bernier</name>
<affiliation><nlm:affiliation>Centre d'Étude de la Forêt, Université Laval, Québec, QC, Canada G1V 0A6;</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Copeland, Alex" sort="Copeland, Alex" uniqKey="Copeland A" first="Alex" last="Copeland">Alex Copeland</name>
<affiliation><nlm:affiliation>US Department of Energy Joint Genome Institute, Walnut Creek, CA 94598;</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Foster, Adam" sort="Foster, Adam" uniqKey="Foster A" first="Adam" last="Foster">Adam Foster</name>
<affiliation><nlm:affiliation>Natural Resources Canada, Canadian Forest Service, Laurentian Forestry Centre, Québec, QC, Canada G1V 4C7;</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Gill, Navdeep" sort="Gill, Navdeep" uniqKey="Gill N" first="Navdeep" last="Gill">Navdeep Gill</name>
<affiliation><nlm:affiliation>Department of Botany, The University of British Columbia, Vancouver, BC, Canada V6T 1Z4;</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Henrissat, Bernard" sort="Henrissat, Bernard" uniqKey="Henrissat B" first="Bernard" last="Henrissat">Bernard Henrissat</name>
<affiliation><nlm:affiliation>UMR 7257 Centre National de la Recherche Scientifique, Aix-Marseille University, 13288 Marseille, France; Department of Biological Sciences, King Abdulaziz University, Jeddah, Saudi Arabia;</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Herath, Padmini" sort="Herath, Padmini" uniqKey="Herath P" first="Padmini" last="Herath">Padmini Herath</name>
<affiliation><nlm:affiliation>Department of Forest and Conservation Sciences, The University of British Columbia, Vancouver, BC, Canada V6T 1Z4;</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Labutti, Kurt M" sort="Labutti, Kurt M" uniqKey="Labutti K" first="Kurt M" last="Labutti">Kurt M. Labutti</name>
<affiliation><nlm:affiliation>US Department of Energy Joint Genome Institute, Walnut Creek, CA 94598;</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Levasseur, Anthony" sort="Levasseur, Anthony" uniqKey="Levasseur A" first="Anthony" last="Levasseur">Anthony Levasseur</name>
<affiliation><nlm:affiliation>Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (URMITE), UM63, CNRS 7278, IRD 198, INSERM U1095, IHU Méditerranée Infection, Aix-Marseille University, 13005 Marseille, France;</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Lindquist, Erika A" sort="Lindquist, Erika A" uniqKey="Lindquist E" first="Erika A" last="Lindquist">Erika A. Lindquist</name>
<affiliation><nlm:affiliation>US Department of Energy Joint Genome Institute, Walnut Creek, CA 94598;</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Majoor, Eline" sort="Majoor, Eline" uniqKey="Majoor E" first="Eline" last="Majoor">Eline Majoor</name>
<affiliation><nlm:affiliation>Fungal Physiology, Centraalbureau voor Schimmelcultures-Royal Netherlands Academy of Arts and Sciences Fungal Biodiversity Centre (CBS-KNAW), 3584 CT, Utrecht, The Netherlands; Fungal Molecular Physiology, Utrecht University, 3584 CT, Utrecht, The Netherlands;</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Ohm, Robin A" sort="Ohm, Robin A" uniqKey="Ohm R" first="Robin A" last="Ohm">Robin A. Ohm</name>
<affiliation><nlm:affiliation>US Department of Energy Joint Genome Institute, Walnut Creek, CA 94598;</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Pangilinan, Jasmyn L" sort="Pangilinan, Jasmyn L" uniqKey="Pangilinan J" first="Jasmyn L" last="Pangilinan">Jasmyn L. Pangilinan</name>
<affiliation><nlm:affiliation>US Department of Energy Joint Genome Institute, Walnut Creek, CA 94598;</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Pribowo, Amadeus" sort="Pribowo, Amadeus" uniqKey="Pribowo A" first="Amadeus" last="Pribowo">Amadeus Pribowo</name>
<affiliation><nlm:affiliation>Forest Products Biotechnology and Bioenergy, The University of British Columbia, Vancouver, BC, Canada V6T 1Z4; and.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Saddler, John N" sort="Saddler, John N" uniqKey="Saddler J" first="John N" last="Saddler">John N. Saddler</name>
<affiliation><nlm:affiliation>Forest Products Biotechnology and Bioenergy, The University of British Columbia, Vancouver, BC, Canada V6T 1Z4; and.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Sakalidis, Monique L" sort="Sakalidis, Monique L" uniqKey="Sakalidis M" first="Monique L" last="Sakalidis">Monique L. Sakalidis</name>
<affiliation><nlm:affiliation>Department of Forest and Conservation Sciences, The University of British Columbia, Vancouver, BC, Canada V6T 1Z4;</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="De Vries, Ronald P" sort="De Vries, Ronald P" uniqKey="De Vries R" first="Ronald P" last="De Vries">Ronald P. De Vries</name>
<affiliation><nlm:affiliation>Fungal Physiology, Centraalbureau voor Schimmelcultures-Royal Netherlands Academy of Arts and Sciences Fungal Biodiversity Centre (CBS-KNAW), 3584 CT, Utrecht, The Netherlands; Fungal Molecular Physiology, Utrecht University, 3584 CT, Utrecht, The Netherlands;</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Grigoriev, Igor V" sort="Grigoriev, Igor V" uniqKey="Grigoriev I" first="Igor V" last="Grigoriev">Igor V. Grigoriev</name>
<affiliation><nlm:affiliation>US Department of Energy Joint Genome Institute, Walnut Creek, CA 94598;</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Goodwin, Stephen B" sort="Goodwin, Stephen B" uniqKey="Goodwin S" first="Stephen B" last="Goodwin">Stephen B. Goodwin</name>
<affiliation><nlm:affiliation>US Department of Agriculture-Agricultural Research Service Crop Production and Pest Control Research Unit, Purdue University, West Lafayette, IN 47907-2054.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Tanguay, Philippe" sort="Tanguay, Philippe" uniqKey="Tanguay P" first="Philippe" last="Tanguay">Philippe Tanguay</name>
<affiliation><nlm:affiliation>Natural Resources Canada, Canadian Forest Service, Laurentian Forestry Centre, Québec, QC, Canada G1V 4C7;</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Hamelin, Richard C" sort="Hamelin, Richard C" uniqKey="Hamelin R" first="Richard C" last="Hamelin">Richard C. Hamelin</name>
<affiliation><nlm:affiliation>Department of Forest and Conservation Sciences, The University of British Columbia, Vancouver, BC, Canada V6T 1Z4; Natural Resources Canada, Canadian Forest Service, Laurentian Forestry Centre, Québec, QC, Canada G1V 4C7; feaunico@mail.ubc.ca Richard.Hamelin@RNCan-NRCan.gc.ca.</nlm:affiliation>
</affiliation>
</author>
</analytic>
<series><title level="j">Proceedings of the National Academy of Sciences of the United States of America</title>
<idno type="eISSN">1091-6490</idno>
<imprint><date when="2015" type="published">2015</date>
</imprint>
</series>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adaptation, Physiological (genetics)</term>
<term>Ascomycota (genetics)</term>
<term>Ascomycota (growth & development)</term>
<term>Ascomycota (pathogenicity)</term>
<term>Base Sequence (MeSH)</term>
<term>Colony Count, Microbial (MeSH)</term>
<term>Gene Dosage (MeSH)</term>
<term>Gene Expression Regulation, Fungal (MeSH)</term>
<term>Gene Transfer, Horizontal (MeSH)</term>
<term>Genetic Speciation (MeSH)</term>
<term>Genome, Fungal (genetics)</term>
<term>Host-Pathogen Interactions (genetics)</term>
<term>Indole Alkaloids (metabolism)</term>
<term>Molecular Sequence Data (MeSH)</term>
<term>Nitrogen (metabolism)</term>
<term>Phylogeny (MeSH)</term>
<term>Populus (microbiology)</term>
<term>Proteolysis (MeSH)</term>
<term>Synteny (genetics)</term>
<term>Time Factors (MeSH)</term>
<term>Trees (microbiology)</term>
<term>Wood (microbiology)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Indole Alkaloids</term>
<term>Nitrogen</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Adaptation, Physiological</term>
<term>Ascomycota</term>
<term>Genome, Fungal</term>
<term>Host-Pathogen Interactions</term>
<term>Synteny</term>
</keywords>
<keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Ascomycota</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Populus</term>
<term>Trees</term>
<term>Wood</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Ascomycota</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Base Sequence</term>
<term>Colony Count, Microbial</term>
<term>Gene Dosage</term>
<term>Gene Expression Regulation, Fungal</term>
<term>Gene Transfer, Horizontal</term>
<term>Genetic Speciation</term>
<term>Molecular Sequence Data</term>
<term>Phylogeny</term>
<term>Proteolysis</term>
<term>Time Factors</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Some of the most damaging tree pathogens can attack woody stems, causing lesions (cankers) that may be lethal. To identify the genomic determinants of wood colonization leading to canker formation, we sequenced the genomes of the poplar canker pathogen, Mycosphaerella populorum, and the closely related poplar leaf pathogen, M. populicola. A secondary metabolite cluster unique to M. populorum is fully activated following induction by poplar wood and leaves. In addition, genes encoding hemicellulose-degrading enzymes, peptidases, and metabolite transporters were more abundant and were up-regulated in M. populorum growing on poplar wood-chip medium compared with M. populicola. The secondary gene cluster and several of the carbohydrate degradation genes have the signature of horizontal transfer from ascomycete fungi associated with wood decay and from prokaryotes. Acquisition and maintenance of the gene battery necessary for growth in woody tissues and gene dosage resulting in gene expression reconfiguration appear to be responsible for the adaptation of M. populorum to infect, colonize, and cause mortality on poplar woody stems. </div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25733908</PMID>
<DateCompleted><Year>2015</Year>
<Month>06</Month>
<Day>04</Day>
</DateCompleted>
<DateRevised><Year>2018</Year>
<Month>11</Month>
<Day>13</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1091-6490</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>112</Volume>
<Issue>11</Issue>
<PubDate><Year>2015</Year>
<Month>Mar</Month>
<Day>17</Day>
</PubDate>
</JournalIssue>
<Title>Proceedings of the National Academy of Sciences of the United States of America</Title>
<ISOAbbreviation>Proc Natl Acad Sci U S A</ISOAbbreviation>
</Journal>
<ArticleTitle>Horizontal gene transfer and gene dosage drives adaptation to wood colonization in a tree pathogen.</ArticleTitle>
<Pagination><MedlinePgn>3451-6</MedlinePgn>
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<Abstract><AbstractText>Some of the most damaging tree pathogens can attack woody stems, causing lesions (cankers) that may be lethal. To identify the genomic determinants of wood colonization leading to canker formation, we sequenced the genomes of the poplar canker pathogen, Mycosphaerella populorum, and the closely related poplar leaf pathogen, M. populicola. A secondary metabolite cluster unique to M. populorum is fully activated following induction by poplar wood and leaves. In addition, genes encoding hemicellulose-degrading enzymes, peptidases, and metabolite transporters were more abundant and were up-regulated in M. populorum growing on poplar wood-chip medium compared with M. populicola. The secondary gene cluster and several of the carbohydrate degradation genes have the signature of horizontal transfer from ascomycete fungi associated with wood decay and from prokaryotes. Acquisition and maintenance of the gene battery necessary for growth in woody tissues and gene dosage resulting in gene expression reconfiguration appear to be responsible for the adaptation of M. populorum to infect, colonize, and cause mortality on poplar woody stems. </AbstractText>
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<ForeName>Stephen B</ForeName>
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<AccessionNumberList><AccessionNumber>AEFD01000000</AccessionNumber>
<AccessionNumber>AIDU01000000</AccessionNumber>
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<Month>03</Month>
<Day>02</Day>
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<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Proc Natl Acad Sci U S A</MedlineTA>
<NlmUniqueID>7505876</NlmUniqueID>
<ISSNLinking>0027-8424</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D026121">Indole Alkaloids</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>50335-03-0</RegistryNumber>
<NameOfSubstance UI="C019290">chaetoglobosins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>N762921K75</RegistryNumber>
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<MeshHeadingList><MeshHeading><DescriptorName UI="D000222" MajorTopicYN="N">Adaptation, Physiological</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001203" MajorTopicYN="N">Ascomycota</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
<QualifierName UI="Q000254" MajorTopicYN="Y">growth & development</QualifierName>
<QualifierName UI="Q000472" MajorTopicYN="N">pathogenicity</QualifierName>
</MeshHeading>
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</MeshHeading>
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</MeshHeading>
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</MeshHeading>
<MeshHeading><DescriptorName UI="D015966" MajorTopicYN="N">Gene Expression Regulation, Fungal</DescriptorName>
</MeshHeading>
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</MeshHeading>
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</MeshHeading>
<MeshHeading><DescriptorName UI="D054884" MajorTopicYN="N">Host-Pathogen Interactions</DescriptorName>
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<MeshHeading><DescriptorName UI="D026121" MajorTopicYN="N">Indole Alkaloids</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
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<MeshHeading><DescriptorName UI="D008969" MajorTopicYN="N">Molecular Sequence Data</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009584" MajorTopicYN="N">Nitrogen</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010802" MajorTopicYN="N">Phylogeny</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D032107" MajorTopicYN="N">Populus</DescriptorName>
<QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D059748" MajorTopicYN="N">Proteolysis</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D026801" MajorTopicYN="N">Synteny</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013997" MajorTopicYN="N">Time Factors</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014197" MajorTopicYN="N">Trees</DescriptorName>
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</MeshHeading>
<MeshHeading><DescriptorName UI="D014934" MajorTopicYN="N">Wood</DescriptorName>
<QualifierName UI="Q000382" MajorTopicYN="Y">microbiology</QualifierName>
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<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Septoria canker</Keyword>
<Keyword MajorTopicYN="N">fungal genomics</Keyword>
<Keyword MajorTopicYN="N">poplar pathogen</Keyword>
<Keyword MajorTopicYN="N">tree disease</Keyword>
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Horizontal gene transfer and gene dosage drives adaptation to wood colonization in a tree pathogen.

Horizontal gene transfer and gene dosage drives adaptation to wood colonization in a tree pathogen.

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