Pretreatment of Populus tomentiglandulosa protects hippocampal CA1 pyramidal neurons from ischemia-reperfusion injury in gerbils via increasing SODs expressions and maintaining BDNF and IGF-I expressions.
Identifieur interne : 000814 ( Main/Corpus ); précédent : 000813; suivant : 000815Pretreatment of Populus tomentiglandulosa protects hippocampal CA1 pyramidal neurons from ischemia-reperfusion injury in gerbils via increasing SODs expressions and maintaining BDNF and IGF-I expressions.
Auteurs : Tae-Kyeong Lee ; Joon Ha Park ; Ji Hyeon Ahn ; Hyunjung Kim ; Minah Song ; Jae-Chul Lee ; Jong Dai Kim ; Yong Hwan Jeon ; Jung Hoon Choi ; Choong Hyun Lee ; In Koo Hwang ; Bing-Chun Yan ; Moo-Ho Won ; Il Jun KangSource :
- Chinese journal of natural medicines [ 1875-5364 ] ; 2019.
English descriptors
- KwdEn :
- Animals (MeSH), Brain-Derived Neurotrophic Factor (genetics), Brain-Derived Neurotrophic Factor (metabolism), CA1 Region, Hippocampal (drug effects), CA1 Region, Hippocampal (metabolism), Gerbillinae (MeSH), Humans (MeSH), Insulin-Like Growth Factor I (genetics), Insulin-Like Growth Factor I (metabolism), Male (MeSH), Neuroprotective Agents (administration & dosage), Plant Extracts (administration & dosage), Populus (chemistry), Pyramidal Cells (drug effects), Pyramidal Cells (metabolism), Reperfusion Injury (drug therapy), Reperfusion Injury (genetics), Reperfusion Injury (metabolism), Superoxide Dismutase (genetics), Superoxide Dismutase (metabolism), Up-Regulation (drug effects).
- MESH :
- chemical , administration & dosage : Neuroprotective Agents, Plant Extracts.
- chemical , genetics : Brain-Derived Neurotrophic Factor, Insulin-Like Growth Factor I, Superoxide Dismutase.
- chemical , metabolism : Brain-Derived Neurotrophic Factor, Insulin-Like Growth Factor I, Superoxide Dismutase.
- chemistry : Populus.
- drug effects : CA1 Region, Hippocampal, Pyramidal Cells, Up-Regulation.
- drug therapy : Reperfusion Injury.
- genetics : Reperfusion Injury.
- metabolism : CA1 Region, Hippocampal, Pyramidal Cells, Reperfusion Injury.
- Animals, Gerbillinae, Humans, Male.
Abstract
To examine the effects of Populus tomentiglandulosa (PT) extract on the expressions of antioxidant enzymes and neurotrophic factors in the cornu ammonis 1 (CA1) region of the hippocampus at 5 min after inducing transient global cerebral ischemia (TGCI) in gerbils, TGCI was induced by occlusion of common carotid arteries for 5 min. Before ischemic surgery, 200 mg·kg-1 PT extract was orally administrated once daily for 7 d. We performed neuronal nuclear antigen immunohistochemistry and Fluoro-Jade B staining. Furthermore, we determined in situ production of superoxide anion radical, expression levels of SOD1 and SOD2 as antioxidant enzymes and brain-derived neurotrophic factor (BDNF) and insulin-like growth factor I (IGF-I) as neurotrophic factors. Pretreatment with 200 mg·kg-1 PT extract prevented neuronal death (loss). Furthermore, pretreatment with 200 mg·kg-1 PT extract significantly inhibited the production of superoxide anion radical, increased expressions of SODs and maintained expressions of BDNF and IGF-I. Such increased expressions of SODs were maintained in the neurons after IRI. In summary, pretreated PT extract can significantly increase levels of SODs and protect the neurons against TGCI, suggesting that PT can be a useful natural agent to protect against TGCI.
DOI: 10.1016/S1875-5364(19)30050-0
PubMed: 31262455
Links to Exploration step
pubmed:31262455Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Pretreatment of Populus tomentiglandulosa protects hippocampal CA1 pyramidal neurons from ischemia-reperfusion injury in gerbils via increasing SODs expressions and maintaining BDNF and IGF-I expressions.</title><author><name sortKey="Lee, Tae Kyeong" sort="Lee, Tae Kyeong" uniqKey="Lee T" first="Tae-Kyeong" last="Lee">Tae-Kyeong Lee</name><affiliation><nlm:affiliation>Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon 24341, Republic of Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Park, Joon Ha" sort="Park, Joon Ha" uniqKey="Park J" first="Joon Ha" last="Park">Joon Ha Park</name><affiliation><nlm:affiliation>Department of Biomedical Science, Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon 24252, Republic of Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Ahn, Ji Hyeon" sort="Ahn, Ji Hyeon" uniqKey="Ahn J" first="Ji Hyeon" last="Ahn">Ji Hyeon Ahn</name><affiliation><nlm:affiliation>Department of Biomedical Science, Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon 24252, Republic of Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Kim, Hyunjung" sort="Kim, Hyunjung" uniqKey="Kim H" first="Hyunjung" last="Kim">Hyunjung Kim</name><affiliation><nlm:affiliation>Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon 24341, Republic of Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Song, Minah" sort="Song, Minah" uniqKey="Song M" first="Minah" last="Song">Minah Song</name><affiliation><nlm:affiliation>Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon 24341, Republic of Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Lee, Jae Chul" sort="Lee, Jae Chul" uniqKey="Lee J" first="Jae-Chul" last="Lee">Jae-Chul Lee</name><affiliation><nlm:affiliation>Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon 24341, Republic of Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Kim, Jong Dai" sort="Kim, Jong Dai" uniqKey="Kim J" first="Jong Dai" last="Kim">Jong Dai Kim</name><affiliation><nlm:affiliation>Division of Food Biotechnology, School of Biotechnology, Kangwon National University, Chuncheon 24341, Republic of Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Jeon, Yong Hwan" sort="Jeon, Yong Hwan" uniqKey="Jeon Y" first="Yong Hwan" last="Jeon">Yong Hwan Jeon</name><affiliation><nlm:affiliation>Department of Radiology, School of Medicine, Kangwon National University, Chuncheon 24289, Republic of Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Choi, Jung Hoon" sort="Choi, Jung Hoon" uniqKey="Choi J" first="Jung Hoon" last="Choi">Jung Hoon Choi</name><affiliation><nlm:affiliation>Department of Anatomy, College of Veterinary Medicine, Kangwon National University, Chuncheon 24341, Republic of Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Lee, Choong Hyun" sort="Lee, Choong Hyun" uniqKey="Lee C" first="Choong Hyun" last="Lee">Choong Hyun Lee</name><affiliation><nlm:affiliation>Department of Pharmacy, College of Pharmacy, Dankook University, Cheonan 31116, Republic of Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Hwang, In Koo" sort="Hwang, In Koo" uniqKey="Hwang I" first="In Koo" last="Hwang">In Koo Hwang</name><affiliation><nlm:affiliation>Department of Anatomy and Cell Biology, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 08826, Republic of Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Yan, Bing Chun" sort="Yan, Bing Chun" uniqKey="Yan B" first="Bing-Chun" last="Yan">Bing-Chun Yan</name><affiliation><nlm:affiliation>Jiangsu Key Laboratory of Integrated Traditional Chinese, Western Medicine for Prevention and Treatment of Senile Diseases, Yangzhou 225001, China.</nlm:affiliation></affiliation></author><author><name sortKey="Won, Moo Ho" sort="Won, Moo Ho" uniqKey="Won M" first="Moo-Ho" last="Won">Moo-Ho Won</name><affiliation><nlm:affiliation>Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon 24341, Republic of Korea. Electronic address: mhwon@kangwon.ac.kr.</nlm:affiliation></affiliation></author><author><name sortKey="Kang, Il Jun" sort="Kang, Il Jun" uniqKey="Kang I" first="Il Jun" last="Kang">Il Jun Kang</name><affiliation><nlm:affiliation>Department of Food Science and Nutrition, Hallym University, Chuncheon 24252, Republic of Korea. Electronic address: ijkang@hallym.ac.kr.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2019">2019</date><idno type="RBID">pubmed:31262455</idno><idno type="pmid">31262455</idno><idno type="doi">10.1016/S1875-5364(19)30050-0</idno><idno type="wicri:Area/Main/Corpus">000814</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000814</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Pretreatment of Populus tomentiglandulosa protects hippocampal CA1 pyramidal neurons from ischemia-reperfusion injury in gerbils via increasing SODs expressions and maintaining BDNF and IGF-I expressions.</title><author><name sortKey="Lee, Tae Kyeong" sort="Lee, Tae Kyeong" uniqKey="Lee T" first="Tae-Kyeong" last="Lee">Tae-Kyeong Lee</name><affiliation><nlm:affiliation>Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon 24341, Republic of Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Park, Joon Ha" sort="Park, Joon Ha" uniqKey="Park J" first="Joon Ha" last="Park">Joon Ha Park</name><affiliation><nlm:affiliation>Department of Biomedical Science, Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon 24252, Republic of Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Ahn, Ji Hyeon" sort="Ahn, Ji Hyeon" uniqKey="Ahn J" first="Ji Hyeon" last="Ahn">Ji Hyeon Ahn</name><affiliation><nlm:affiliation>Department of Biomedical Science, Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon 24252, Republic of Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Kim, Hyunjung" sort="Kim, Hyunjung" uniqKey="Kim H" first="Hyunjung" last="Kim">Hyunjung Kim</name><affiliation><nlm:affiliation>Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon 24341, Republic of Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Song, Minah" sort="Song, Minah" uniqKey="Song M" first="Minah" last="Song">Minah Song</name><affiliation><nlm:affiliation>Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon 24341, Republic of Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Lee, Jae Chul" sort="Lee, Jae Chul" uniqKey="Lee J" first="Jae-Chul" last="Lee">Jae-Chul Lee</name><affiliation><nlm:affiliation>Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon 24341, Republic of Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Kim, Jong Dai" sort="Kim, Jong Dai" uniqKey="Kim J" first="Jong Dai" last="Kim">Jong Dai Kim</name><affiliation><nlm:affiliation>Division of Food Biotechnology, School of Biotechnology, Kangwon National University, Chuncheon 24341, Republic of Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Jeon, Yong Hwan" sort="Jeon, Yong Hwan" uniqKey="Jeon Y" first="Yong Hwan" last="Jeon">Yong Hwan Jeon</name><affiliation><nlm:affiliation>Department of Radiology, School of Medicine, Kangwon National University, Chuncheon 24289, Republic of Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Choi, Jung Hoon" sort="Choi, Jung Hoon" uniqKey="Choi J" first="Jung Hoon" last="Choi">Jung Hoon Choi</name><affiliation><nlm:affiliation>Department of Anatomy, College of Veterinary Medicine, Kangwon National University, Chuncheon 24341, Republic of Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Lee, Choong Hyun" sort="Lee, Choong Hyun" uniqKey="Lee C" first="Choong Hyun" last="Lee">Choong Hyun Lee</name><affiliation><nlm:affiliation>Department of Pharmacy, College of Pharmacy, Dankook University, Cheonan 31116, Republic of Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Hwang, In Koo" sort="Hwang, In Koo" uniqKey="Hwang I" first="In Koo" last="Hwang">In Koo Hwang</name><affiliation><nlm:affiliation>Department of Anatomy and Cell Biology, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 08826, Republic of Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Yan, Bing Chun" sort="Yan, Bing Chun" uniqKey="Yan B" first="Bing-Chun" last="Yan">Bing-Chun Yan</name><affiliation><nlm:affiliation>Jiangsu Key Laboratory of Integrated Traditional Chinese, Western Medicine for Prevention and Treatment of Senile Diseases, Yangzhou 225001, China.</nlm:affiliation></affiliation></author><author><name sortKey="Won, Moo Ho" sort="Won, Moo Ho" uniqKey="Won M" first="Moo-Ho" last="Won">Moo-Ho Won</name><affiliation><nlm:affiliation>Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon 24341, Republic of Korea. Electronic address: mhwon@kangwon.ac.kr.</nlm:affiliation></affiliation></author><author><name sortKey="Kang, Il Jun" sort="Kang, Il Jun" uniqKey="Kang I" first="Il Jun" last="Kang">Il Jun Kang</name><affiliation><nlm:affiliation>Department of Food Science and Nutrition, Hallym University, Chuncheon 24252, Republic of Korea. Electronic address: ijkang@hallym.ac.kr.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Chinese journal of natural medicines</title><idno type="eISSN">1875-5364</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term><term>Brain-Derived Neurotrophic Factor (genetics)</term><term>Brain-Derived Neurotrophic Factor (metabolism)</term><term>CA1 Region, Hippocampal (drug effects)</term><term>CA1 Region, Hippocampal (metabolism)</term><term>Gerbillinae (MeSH)</term><term>Humans (MeSH)</term><term>Insulin-Like Growth Factor I (genetics)</term><term>Insulin-Like Growth Factor I (metabolism)</term><term>Male (MeSH)</term><term>Neuroprotective Agents (administration & dosage)</term><term>Plant Extracts (administration & dosage)</term><term>Populus (chemistry)</term><term>Pyramidal Cells (drug effects)</term><term>Pyramidal Cells (metabolism)</term><term>Reperfusion Injury (drug therapy)</term><term>Reperfusion Injury (genetics)</term><term>Reperfusion Injury (metabolism)</term><term>Superoxide Dismutase (genetics)</term><term>Superoxide Dismutase (metabolism)</term><term>Up-Regulation (drug effects)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Neuroprotective Agents</term><term>Plant Extracts</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Brain-Derived Neurotrophic Factor</term><term>Insulin-Like Growth Factor I</term><term>Superoxide Dismutase</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Brain-Derived Neurotrophic Factor</term><term>Insulin-Like Growth Factor I</term><term>Superoxide Dismutase</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Populus</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>CA1 Region, Hippocampal</term><term>Pyramidal Cells</term><term>Up-Regulation</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Reperfusion Injury</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Reperfusion Injury</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>CA1 Region, Hippocampal</term><term>Pyramidal Cells</term><term>Reperfusion Injury</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Gerbillinae</term><term>Humans</term><term>Male</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To examine the effects of Populus tomentiglandulosa (PT) extract on the expressions of antioxidant enzymes and neurotrophic factors in the cornu ammonis 1 (CA1) region of the hippocampus at 5 min after inducing transient global cerebral ischemia (TGCI) in gerbils, TGCI was induced by occlusion of common carotid arteries for 5 min. Before ischemic surgery, 200 mg·kg<sup>-1</sup> PT extract was orally administrated once daily for 7 d. We performed neuronal nuclear antigen immunohistochemistry and Fluoro-Jade B staining. Furthermore, we determined in situ production of superoxide anion radical, expression levels of SOD1 and SOD2 as antioxidant enzymes and brain-derived neurotrophic factor (BDNF) and insulin-like growth factor I (IGF-I) as neurotrophic factors. Pretreatment with 200 mg·kg<sup>-1</sup> PT extract prevented neuronal death (loss). Furthermore, pretreatment with 200 mg·kg<sup>-1</sup> PT extract significantly inhibited the production of superoxide anion radical, increased expressions of SODs and maintained expressions of BDNF and IGF-I. Such increased expressions of SODs were maintained in the neurons after IRI. In summary, pretreated PT extract can significantly increase levels of SODs and protect the neurons against TGCI, suggesting that PT can be a useful natural agent to protect against TGCI.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">31262455</PMID><DateCompleted><Year>2019</Year><Month>12</Month><Day>03</Day></DateCompleted><DateRevised><Year>2019</Year><Month>12</Month><Day>03</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1875-5364</ISSN><JournalIssue CitedMedium="Internet"><Volume>17</Volume><Issue>6</Issue><PubDate><Year>2019</Year><Month>Jun</Month></PubDate></JournalIssue><Title>Chinese journal of natural medicines</Title><ISOAbbreviation>Chin J Nat Med</ISOAbbreviation></Journal><ArticleTitle>Pretreatment of Populus tomentiglandulosa protects hippocampal CA1 pyramidal neurons from ischemia-reperfusion injury in gerbils via increasing SODs expressions and maintaining BDNF and IGF-I expressions.</ArticleTitle><Pagination><MedlinePgn>424-434</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S1875-5364(19)30050-0</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/S1875-5364(19)30050-0</ELocationID><Abstract><AbstractText>To examine the effects of Populus tomentiglandulosa (PT) extract on the expressions of antioxidant enzymes and neurotrophic factors in the cornu ammonis 1 (CA1) region of the hippocampus at 5 min after inducing transient global cerebral ischemia (TGCI) in gerbils, TGCI was induced by occlusion of common carotid arteries for 5 min. Before ischemic surgery, 200 mg·kg<sup>-1</sup> PT extract was orally administrated once daily for 7 d. We performed neuronal nuclear antigen immunohistochemistry and Fluoro-Jade B staining. Furthermore, we determined in situ production of superoxide anion radical, expression levels of SOD1 and SOD2 as antioxidant enzymes and brain-derived neurotrophic factor (BDNF) and insulin-like growth factor I (IGF-I) as neurotrophic factors. Pretreatment with 200 mg·kg<sup>-1</sup> PT extract prevented neuronal death (loss). Furthermore, pretreatment with 200 mg·kg<sup>-1</sup> PT extract significantly inhibited the production of superoxide anion radical, increased expressions of SODs and maintained expressions of BDNF and IGF-I. Such increased expressions of SODs were maintained in the neurons after IRI. In summary, pretreated PT extract can significantly increase levels of SODs and protect the neurons against TGCI, suggesting that PT can be a useful natural agent to protect against TGCI.</AbstractText><CopyrightInformation>Copyright © 2019 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Tae-Kyeong</ForeName><Initials>TK</Initials><AffiliationInfo><Affiliation>Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon 24341, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Park</LastName><ForeName>Joon Ha</ForeName><Initials>JH</Initials><AffiliationInfo><Affiliation>Department of Biomedical Science, Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon 24252, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ahn</LastName><ForeName>Ji Hyeon</ForeName><Initials>JH</Initials><AffiliationInfo><Affiliation>Department of Biomedical Science, Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon 24252, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Hyunjung</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon 24341, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Song</LastName><ForeName>Minah</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon 24341, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Jae-Chul</ForeName><Initials>JC</Initials><AffiliationInfo><Affiliation>Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon 24341, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Jong Dai</ForeName><Initials>JD</Initials><AffiliationInfo><Affiliation>Division of Food Biotechnology, School of Biotechnology, Kangwon National University, Chuncheon 24341, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jeon</LastName><ForeName>Yong Hwan</ForeName><Initials>YH</Initials><AffiliationInfo><Affiliation>Department of Radiology, School of Medicine, Kangwon National University, Chuncheon 24289, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Choi</LastName><ForeName>Jung Hoon</ForeName><Initials>JH</Initials><AffiliationInfo><Affiliation>Department of Anatomy, College of Veterinary Medicine, Kangwon National University, Chuncheon 24341, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Choong Hyun</ForeName><Initials>CH</Initials><AffiliationInfo><Affiliation>Department of Pharmacy, College of Pharmacy, Dankook University, Cheonan 31116, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hwang</LastName><ForeName>In Koo</ForeName><Initials>IK</Initials><AffiliationInfo><Affiliation>Department of Anatomy and Cell Biology, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 08826, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yan</LastName><ForeName>Bing-Chun</ForeName><Initials>BC</Initials><AffiliationInfo><Affiliation>Jiangsu Key Laboratory of Integrated Traditional Chinese, Western Medicine for Prevention and Treatment of Senile Diseases, Yangzhou 225001, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Won</LastName><ForeName>Moo-Ho</ForeName><Initials>MH</Initials><AffiliationInfo><Affiliation>Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon 24341, Republic of Korea. Electronic address: mhwon@kangwon.ac.kr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kang</LastName><ForeName>Il Jun</ForeName><Initials>IJ</Initials><AffiliationInfo><Affiliation>Department of Food Science and Nutrition, Hallym University, Chuncheon 24252, Republic of Korea. Electronic address: ijkang@hallym.ac.kr.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>China</Country><MedlineTA>Chin J Nat Med</MedlineTA><NlmUniqueID>101504416</NlmUniqueID><ISSNLinking>1875-5364</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D019208">Brain-Derived Neurotrophic Factor</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018696">Neuroprotective Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010936">Plant Extracts</NameOfSubstance></Chemical><Chemical><RegistryNumber>67763-96-6</RegistryNumber><NameOfSubstance UI="D007334">Insulin-Like Growth Factor I</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.15.1.1</RegistryNumber><NameOfSubstance UI="D013482">Superoxide Dismutase</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019208" MajorTopicYN="N">Brain-Derived Neurotrophic Factor</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D056547" MajorTopicYN="N">CA1 Region, Hippocampal</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005849" MajorTopicYN="N">Gerbillinae</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007334" MajorTopicYN="N">Insulin-Like Growth Factor I</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018696" MajorTopicYN="N">Neuroprotective Agents</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010936" MajorTopicYN="N">Plant Extracts</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D032107" MajorTopicYN="N">Populus</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017966" MajorTopicYN="N">Pyramidal Cells</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015427" MajorTopicYN="N">Reperfusion Injury</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013482" MajorTopicYN="N">Superoxide Dismutase</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015854" MajorTopicYN="N">Up-Regulation</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Antioxidant enzymes</Keyword><Keyword MajorTopicYN="N">Neuroprotective effects</Keyword><Keyword MajorTopicYN="N">Populus tomentiglandulosa</Keyword><Keyword MajorTopicYN="N">Transient global cerebral ischemia</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2019</Year><Month>02</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2019</Year><Month>7</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>7</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>12</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">31262455</ArticleId><ArticleId IdType="pii">S1875-5364(19)30050-0</ArticleId><ArticleId IdType="doi">10.1016/S1875-5364(19)30050-0</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= Pretreatment of Populus tomentiglandulosa protects hippocampal CA1 pyramidal neurons from ischemia-reperfusion injury in gerbils via increasing SODs expressions and maintaining BDNF and IGF-I expressions.
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