INdividual Vocational and Educational Support Trial (INVEST) for young people with borderline personality disorder: study protocol for a randomised controlled trial.
Identifieur interne : 000228 ( Main/Corpus ); précédent : 000227; suivant : 000229INdividual Vocational and Educational Support Trial (INVEST) for young people with borderline personality disorder: study protocol for a randomised controlled trial.
Auteurs : Andrew M. Chanen ; Katie Nicol ; Jennifer K. Betts ; Gary R. Bond ; Cathrine Mihalopoulos ; Henry J. Jackson ; Katherine N. Thompson ; Martina Jovev ; Hok Pan Yuen ; Gina Chinnery ; Judith Ring ; Kelly Allott ; Louise Mccutcheon ; Ashleigh P. Salmon ; Eoin KillackeySource :
- Trials [ 1745-6215 ] ; 2020.
Abstract
BACKGROUND
The clinical onset of borderline personality disorder (BPD) usually occurs in young people (aged 12-25 years) and commonly leads to difficulty achieving and maintaining vocational (education and/or employment) engagement. While current psychosocial interventions lead to improvements in psychopathology, they have little effect upon functioning. Individual Placement and Support (IPS) is a client-driven model that assists individuals with severe mental illness to engage with education and/or employment appropriate to their personal goals, and that provides ongoing support to maintain this engagement. The objective of the INdividual Vocational and Educational Support Trial (INVEST) is to evaluate the effectiveness of adding IPS to an evidence-based early intervention programme for BPD, with the aim of improving vocational outcomes.
METHODS/DESIGN
INVEST is a single-blind, parallel-groups, randomised controlled trial (RCT). The randomisation is stratified by gender and age and uses random permuted blocks. The interventions are 39 weeks of either IPS, or 'usual vocational services' (UVS). Participants will comprise 108 help-seeking young people (aged 15-25 years) with three or more DSM-5 BPD features and a desire to study or work, recruited from the Helping Young People Early (HYPE) early intervention programme for BPD at Orygen, in Melbourne, Australia. All participants will receive the HYPE intervention. After baseline assessment, staff who are blind to the intervention group allocation will conduct assessments at 13, 26, 39 and 52 weeks. At the 52-week primary endpoint, the primary outcome is the number of days in mainstream education/employment since baseline. Secondary outcomes include the cost-effectiveness of the intervention, quality of life, and BPD severity.
DISCUSSION
Current treatments for BPD have little impact on vocational outcomes and enduring functional impairment is prevalent among this patient group. IPS is a targeted functional intervention, which has proven effective in improving vocational outcomes for adults and young people with psychotic disorders. This trial will investigate whether IPS is effective for improving vocational (employment and educational) outcomes among young people with subthreshold or full-syndrome BPD.
TRIAL REGISTRATION
Australian New Zealand Clinical Trials Registry, ID: ACTRN12619001220156 . 13 September 2019.
DOI: 10.1186/s13063-020-04471-3
PubMed: 32591007
PubMed Central: PMC7320570
Links to Exploration step
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Chanen</name><affiliation><nlm:affiliation>Orygen, 35 Poplar Road, Parkville, Melbourne, VIC, 3052, Australia. andrew.chanen@orygen.org.au.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Centre for Youth Mental Health, The University of Melbourne, 35 Poplar Road, Parkville, Melbourne, VIC, 3052, Australia. andrew.chanen@orygen.org.au.</nlm:affiliation></affiliation></author><author><name sortKey="Nicol, Katie" sort="Nicol, Katie" uniqKey="Nicol K" first="Katie" last="Nicol">Katie Nicol</name><affiliation><nlm:affiliation>Orygen, 35 Poplar Road, Parkville, Melbourne, VIC, 3052, Australia.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Centre for Youth Mental Health, The University of Melbourne, 35 Poplar Road, Parkville, Melbourne, VIC, 3052, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Betts, Jennifer K" sort="Betts, Jennifer K" uniqKey="Betts J" first="Jennifer K" last="Betts">Jennifer K. 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Salmon</name><affiliation><nlm:affiliation>Orygen, 35 Poplar Road, Parkville, Melbourne, VIC, 3052, Australia.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Centre for Youth Mental Health, The University of Melbourne, 35 Poplar Road, Parkville, Melbourne, VIC, 3052, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Killackey, Eoin" sort="Killackey, Eoin" uniqKey="Killackey E" first="Eoin" last="Killackey">Eoin Killackey</name><affiliation><nlm:affiliation>Orygen, 35 Poplar Road, Parkville, Melbourne, VIC, 3052, Australia.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Centre for Youth Mental Health, The University of Melbourne, 35 Poplar Road, Parkville, Melbourne, VIC, 3052, Australia.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32591007</idno><idno type="pmid">32591007</idno><idno type="doi">10.1186/s13063-020-04471-3</idno><idno type="pmc">PMC7320570</idno><idno type="wicri:Area/Main/Corpus">000228</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000228</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">INdividual Vocational and Educational Support Trial (INVEST) for young people with borderline personality disorder: study protocol for a randomised controlled trial.</title><author><name sortKey="Chanen, Andrew M" sort="Chanen, Andrew M" uniqKey="Chanen A" first="Andrew M" last="Chanen">Andrew M. Chanen</name><affiliation><nlm:affiliation>Orygen, 35 Poplar Road, Parkville, Melbourne, VIC, 3052, Australia. andrew.chanen@orygen.org.au.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Centre for Youth Mental Health, The University of Melbourne, 35 Poplar Road, Parkville, Melbourne, VIC, 3052, Australia. andrew.chanen@orygen.org.au.</nlm:affiliation></affiliation></author><author><name sortKey="Nicol, Katie" sort="Nicol, Katie" uniqKey="Nicol K" first="Katie" last="Nicol">Katie Nicol</name><affiliation><nlm:affiliation>Orygen, 35 Poplar Road, Parkville, Melbourne, VIC, 3052, Australia.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Centre for Youth Mental Health, The University of Melbourne, 35 Poplar Road, Parkville, Melbourne, VIC, 3052, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Betts, Jennifer K" sort="Betts, Jennifer K" uniqKey="Betts J" first="Jennifer K" last="Betts">Jennifer K. Betts</name><affiliation><nlm:affiliation>Orygen, 35 Poplar Road, Parkville, Melbourne, VIC, 3052, Australia.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Centre for Youth Mental Health, The University of Melbourne, 35 Poplar Road, Parkville, Melbourne, VIC, 3052, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Bond, Gary R" sort="Bond, Gary R" uniqKey="Bond G" first="Gary R" last="Bond">Gary R. Bond</name><affiliation><nlm:affiliation>IPS Employment Center, Rockville Institute and Westat Inc., 85 Mechanic Street, Suite C3-1, Box 4A, Lebanon, NH, 03766, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Mihalopoulos, Cathrine" sort="Mihalopoulos, Cathrine" uniqKey="Mihalopoulos C" first="Cathrine" last="Mihalopoulos">Cathrine Mihalopoulos</name><affiliation><nlm:affiliation>Deakin Health Economics, Centre for Population Health Research, Deakin University, Geelong, VIC, 3220, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Jackson, Henry J" sort="Jackson, Henry J" uniqKey="Jackson H" first="Henry J" last="Jackson">Henry J. Jackson</name><affiliation><nlm:affiliation>Melbourne School of Psychological Sciences, Redmond Barry Building, The University of Melbourne, Parkville, Melbourne, VIC, 3010, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Thompson, Katherine N" sort="Thompson, Katherine N" uniqKey="Thompson K" first="Katherine N" last="Thompson">Katherine N. Thompson</name><affiliation><nlm:affiliation>Orygen, 35 Poplar Road, Parkville, Melbourne, VIC, 3052, Australia.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Centre for Youth Mental Health, The University of Melbourne, 35 Poplar Road, Parkville, Melbourne, VIC, 3052, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Jovev, Martina" sort="Jovev, Martina" uniqKey="Jovev M" first="Martina" last="Jovev">Martina Jovev</name><affiliation><nlm:affiliation>Orygen, 35 Poplar Road, Parkville, Melbourne, VIC, 3052, Australia.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Centre for Youth Mental Health, The University of Melbourne, 35 Poplar Road, Parkville, Melbourne, VIC, 3052, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Yuen, Hok Pan" sort="Yuen, Hok Pan" uniqKey="Yuen H" first="Hok Pan" last="Yuen">Hok Pan Yuen</name><affiliation><nlm:affiliation>Orygen, 35 Poplar Road, Parkville, Melbourne, VIC, 3052, Australia.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Centre for Youth Mental Health, The University of Melbourne, 35 Poplar Road, Parkville, Melbourne, VIC, 3052, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Chinnery, Gina" sort="Chinnery, Gina" uniqKey="Chinnery G" first="Gina" last="Chinnery">Gina Chinnery</name><affiliation><nlm:affiliation>Orygen, 35 Poplar Road, Parkville, Melbourne, VIC, 3052, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Ring, Judith" sort="Ring, Judith" uniqKey="Ring J" first="Judith" last="Ring">Judith Ring</name><affiliation><nlm:affiliation>Travancore School, 35 Poplar Road, Parkville, Melbourne, VIC, 3052, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Allott, Kelly" sort="Allott, Kelly" uniqKey="Allott K" first="Kelly" last="Allott">Kelly Allott</name><affiliation><nlm:affiliation>Orygen, 35 Poplar Road, Parkville, Melbourne, VIC, 3052, Australia.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Centre for Youth Mental Health, The University of Melbourne, 35 Poplar Road, Parkville, Melbourne, VIC, 3052, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Mccutcheon, Louise" sort="Mccutcheon, Louise" uniqKey="Mccutcheon L" first="Louise" last="Mccutcheon">Louise Mccutcheon</name><affiliation><nlm:affiliation>Orygen, 35 Poplar Road, Parkville, Melbourne, VIC, 3052, Australia.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Centre for Youth Mental Health, The University of Melbourne, 35 Poplar Road, Parkville, Melbourne, VIC, 3052, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Salmon, Ashleigh P" sort="Salmon, Ashleigh P" uniqKey="Salmon A" first="Ashleigh P" last="Salmon">Ashleigh P. Salmon</name><affiliation><nlm:affiliation>Orygen, 35 Poplar Road, Parkville, Melbourne, VIC, 3052, Australia.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Centre for Youth Mental Health, The University of Melbourne, 35 Poplar Road, Parkville, Melbourne, VIC, 3052, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Killackey, Eoin" sort="Killackey, Eoin" uniqKey="Killackey E" first="Eoin" last="Killackey">Eoin Killackey</name><affiliation><nlm:affiliation>Orygen, 35 Poplar Road, Parkville, Melbourne, VIC, 3052, Australia.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Centre for Youth Mental Health, The University of Melbourne, 35 Poplar Road, Parkville, Melbourne, VIC, 3052, Australia.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Trials</title><idno type="eISSN">1745-6215</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>The clinical onset of borderline personality disorder (BPD) usually occurs in young people (aged 12-25 years) and commonly leads to difficulty achieving and maintaining vocational (education and/or employment) engagement. While current psychosocial interventions lead to improvements in psychopathology, they have little effect upon functioning. Individual Placement and Support (IPS) is a client-driven model that assists individuals with severe mental illness to engage with education and/or employment appropriate to their personal goals, and that provides ongoing support to maintain this engagement. The objective of the INdividual Vocational and Educational Support Trial (INVEST) is to evaluate the effectiveness of adding IPS to an evidence-based early intervention programme for BPD, with the aim of improving vocational outcomes.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS/DESIGN</b></p><p>INVEST is a single-blind, parallel-groups, randomised controlled trial (RCT). The randomisation is stratified by gender and age and uses random permuted blocks. The interventions are 39 weeks of either IPS, or 'usual vocational services' (UVS). Participants will comprise 108 help-seeking young people (aged 15-25 years) with three or more DSM-5 BPD features and a desire to study or work, recruited from the Helping Young People Early (HYPE) early intervention programme for BPD at Orygen, in Melbourne, Australia. All participants will receive the HYPE intervention. After baseline assessment, staff who are blind to the intervention group allocation will conduct assessments at 13, 26, 39 and 52 weeks. At the 52-week primary endpoint, the primary outcome is the number of days in mainstream education/employment since baseline. Secondary outcomes include the cost-effectiveness of the intervention, quality of life, and BPD severity.</p></div><div type="abstract" xml:lang="en"><p><b>DISCUSSION</b></p><p>Current treatments for BPD have little impact on vocational outcomes and enduring functional impairment is prevalent among this patient group. IPS is a targeted functional intervention, which has proven effective in improving vocational outcomes for adults and young people with psychotic disorders. This trial will investigate whether IPS is effective for improving vocational (employment and educational) outcomes among young people with subthreshold or full-syndrome BPD.</p></div><div type="abstract" xml:lang="en"><p><b>TRIAL REGISTRATION</b></p><p>Australian New Zealand Clinical Trials Registry, ID: ACTRN12619001220156 . 13 September 2019.</p></div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">32591007</PMID><DateRevised><Year>2020</Year><Month>06</Month><Day>30</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1745-6215</ISSN><JournalIssue CitedMedium="Internet"><Volume>21</Volume><Issue>1</Issue><PubDate><Year>2020</Year><Month>Jun</Month><Day>26</Day></PubDate></JournalIssue><Title>Trials</Title><ISOAbbreviation>Trials</ISOAbbreviation></Journal><ArticleTitle>INdividual Vocational and Educational Support Trial (INVEST) for young people with borderline personality disorder: study protocol for a randomised controlled trial.</ArticleTitle><Pagination><MedlinePgn>583</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1186/s13063-020-04471-3</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">The clinical onset of borderline personality disorder (BPD) usually occurs in young people (aged 12-25 years) and commonly leads to difficulty achieving and maintaining vocational (education and/or employment) engagement. While current psychosocial interventions lead to improvements in psychopathology, they have little effect upon functioning. Individual Placement and Support (IPS) is a client-driven model that assists individuals with severe mental illness to engage with education and/or employment appropriate to their personal goals, and that provides ongoing support to maintain this engagement. The objective of the INdividual Vocational and Educational Support Trial (INVEST) is to evaluate the effectiveness of adding IPS to an evidence-based early intervention programme for BPD, with the aim of improving vocational outcomes.</AbstractText><AbstractText Label="METHODS/DESIGN" NlmCategory="METHODS">INVEST is a single-blind, parallel-groups, randomised controlled trial (RCT). The randomisation is stratified by gender and age and uses random permuted blocks. The interventions are 39 weeks of either IPS, or 'usual vocational services' (UVS). Participants will comprise 108 help-seeking young people (aged 15-25 years) with three or more DSM-5 BPD features and a desire to study or work, recruited from the Helping Young People Early (HYPE) early intervention programme for BPD at Orygen, in Melbourne, Australia. All participants will receive the HYPE intervention. After baseline assessment, staff who are blind to the intervention group allocation will conduct assessments at 13, 26, 39 and 52 weeks. At the 52-week primary endpoint, the primary outcome is the number of days in mainstream education/employment since baseline. Secondary outcomes include the cost-effectiveness of the intervention, quality of life, and BPD severity.</AbstractText><AbstractText Label="DISCUSSION" NlmCategory="CONCLUSIONS">Current treatments for BPD have little impact on vocational outcomes and enduring functional impairment is prevalent among this patient group. IPS is a targeted functional intervention, which has proven effective in improving vocational outcomes for adults and young people with psychotic disorders. This trial will investigate whether IPS is effective for improving vocational (employment and educational) outcomes among young people with subthreshold or full-syndrome BPD.</AbstractText><AbstractText Label="TRIAL REGISTRATION" NlmCategory="BACKGROUND">Australian New Zealand Clinical Trials Registry, ID: ACTRN12619001220156 . 13 September 2019.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Chanen</LastName><ForeName>Andrew M</ForeName><Initials>AM</Initials><Identifier Source="ORCID">http://orcid.org/0000-0003-4468-622X</Identifier><AffiliationInfo><Affiliation>Orygen, 35 Poplar Road, Parkville, Melbourne, VIC, 3052, Australia. andrew.chanen@orygen.org.au.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centre for Youth Mental Health, The University of Melbourne, 35 Poplar Road, Parkville, Melbourne, VIC, 3052, Australia. andrew.chanen@orygen.org.au.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nicol</LastName><ForeName>Katie</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Orygen, 35 Poplar Road, Parkville, Melbourne, VIC, 3052, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centre for Youth Mental Health, The University of Melbourne, 35 Poplar Road, Parkville, Melbourne, VIC, 3052, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Betts</LastName><ForeName>Jennifer K</ForeName><Initials>JK</Initials><AffiliationInfo><Affiliation>Orygen, 35 Poplar Road, Parkville, Melbourne, VIC, 3052, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centre for Youth Mental Health, The University of Melbourne, 35 Poplar Road, Parkville, Melbourne, VIC, 3052, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bond</LastName><ForeName>Gary R</ForeName><Initials>GR</Initials><AffiliationInfo><Affiliation>IPS Employment Center, Rockville Institute and Westat Inc., 85 Mechanic Street, Suite C3-1, Box 4A, Lebanon, NH, 03766, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mihalopoulos</LastName><ForeName>Cathrine</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Deakin Health Economics, Centre for Population Health Research, Deakin University, Geelong, VIC, 3220, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jackson</LastName><ForeName>Henry J</ForeName><Initials>HJ</Initials><AffiliationInfo><Affiliation>Melbourne School of Psychological Sciences, Redmond Barry Building, The University of Melbourne, Parkville, Melbourne, VIC, 3010, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Thompson</LastName><ForeName>Katherine N</ForeName><Initials>KN</Initials><AffiliationInfo><Affiliation>Orygen, 35 Poplar Road, Parkville, Melbourne, VIC, 3052, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centre for Youth Mental Health, The University of Melbourne, 35 Poplar Road, Parkville, Melbourne, VIC, 3052, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jovev</LastName><ForeName>Martina</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Orygen, 35 Poplar Road, Parkville, Melbourne, VIC, 3052, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centre for Youth Mental Health, The University of Melbourne, 35 Poplar Road, Parkville, Melbourne, VIC, 3052, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yuen</LastName><ForeName>Hok Pan</ForeName><Initials>HP</Initials><AffiliationInfo><Affiliation>Orygen, 35 Poplar Road, Parkville, Melbourne, VIC, 3052, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centre for Youth Mental Health, The University of Melbourne, 35 Poplar Road, Parkville, Melbourne, VIC, 3052, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chinnery</LastName><ForeName>Gina</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Orygen, 35 Poplar Road, Parkville, Melbourne, VIC, 3052, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ring</LastName><ForeName>Judith</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Travancore School, 35 Poplar Road, Parkville, Melbourne, VIC, 3052, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Allott</LastName><ForeName>Kelly</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Orygen, 35 Poplar Road, Parkville, Melbourne, VIC, 3052, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centre for Youth Mental Health, The University of Melbourne, 35 Poplar Road, Parkville, Melbourne, VIC, 3052, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McCutcheon</LastName><ForeName>Louise</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Orygen, 35 Poplar Road, Parkville, Melbourne, VIC, 3052, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centre for Youth Mental Health, The University of Melbourne, 35 Poplar Road, Parkville, Melbourne, VIC, 3052, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Salmon</LastName><ForeName>Ashleigh P</ForeName><Initials>AP</Initials><AffiliationInfo><Affiliation>Orygen, 35 Poplar Road, Parkville, Melbourne, VIC, 3052, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centre for Youth Mental Health, The University of Melbourne, 35 Poplar Road, Parkville, Melbourne, VIC, 3052, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Killackey</LastName><ForeName>Eoin</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Orygen, 35 Poplar Road, Parkville, Melbourne, VIC, 3052, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centre for Youth Mental Health, The University of Melbourne, 35 Poplar Road, Parkville, Melbourne, VIC, 3052, Australia.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>APP1144022</GrantID><Agency>National Health and Medical Research Council</Agency><Country></Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>06</Month><Day>26</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Trials</MedlineTA><NlmUniqueID>101263253</NlmUniqueID><ISSNLinking>1745-6215</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Adolescents</Keyword><Keyword MajorTopicYN="N">Borderline personality disorder</Keyword><Keyword MajorTopicYN="N">Early intervention</Keyword><Keyword MajorTopicYN="N">Education</Keyword><Keyword MajorTopicYN="N">Employment</Keyword><Keyword MajorTopicYN="N">Individual placement and support</Keyword><Keyword MajorTopicYN="N">Young adults</Keyword><Keyword MajorTopicYN="N">Youth</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>04</Month><Day>22</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>05</Month><Day>30</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>6</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>6</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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