Immunodiversity of the Arabidopsis ZAR1 NLR Is Conveyed by Receptor-Like Cytoplasmic Kinase Sensors.
Identifieur interne : 000090 ( Main/Corpus ); précédent : 000089; suivant : 000091Immunodiversity of the Arabidopsis ZAR1 NLR Is Conveyed by Receptor-Like Cytoplasmic Kinase Sensors.
Auteurs : Alexandre Martel ; Bradley Laflamme ; Derek Seto ; D Patrick Bastedo ; Marcus M. Dillon ; Renan N D. Almeida ; David S. Guttman ; Darrell DesveauxSource :
- Frontiers in plant science [ 1664-462X ] ; 2020.
Abstract
The Arabidopsis nucleotide-binding leucine-rich repeat protein ZAR1 can recognize at least six distinct families of pathogenic effector proteins to mount an effector-triggered immune response. This remarkable immunodiversity appears to be conveyed by receptor-like cytoplasmic kinase (RLCK) complexes, which associate with ZAR1 to sense several effector-induced kinase perturbations. Here we show that the recently identified ZAR1-mediated immune responses against the HopX1, HopO1, and HopBA1 effector families of Pseudomonas syringae rely on an expanded diversity of RLCK sensors. We show that individual sensors can recognize distinct effector families, thereby contributing to the expanded surveillance potential of ZAR1 and supporting its role as a guardian of the plant kinome.
DOI: 10.3389/fpls.2020.01290
PubMed: 32983191
PubMed Central: PMC7475706
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Dillon</name><affiliation><nlm:affiliation>Department of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Almeida, Renan N D" sort="Almeida, Renan N D" uniqKey="Almeida R" first="Renan N D" last="Almeida">Renan N D. Almeida</name><affiliation><nlm:affiliation>Department of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Guttman, David S" sort="Guttman, David S" uniqKey="Guttman D" first="David S" last="Guttman">David S. 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Dillon</name><affiliation><nlm:affiliation>Department of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Almeida, Renan N D" sort="Almeida, Renan N D" uniqKey="Almeida R" first="Renan N D" last="Almeida">Renan N D. Almeida</name><affiliation><nlm:affiliation>Department of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Guttman, David S" sort="Guttman, David S" uniqKey="Guttman D" first="David S" last="Guttman">David S. Guttman</name><affiliation><nlm:affiliation>Department of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Centre for the Analysis of Genome Evolution & Function, University of Toronto, Toronto, ON, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Desveaux, Darrell" sort="Desveaux, Darrell" uniqKey="Desveaux D" first="Darrell" last="Desveaux">Darrell Desveaux</name><affiliation><nlm:affiliation>Department of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Centre for the Analysis of Genome Evolution & Function, University of Toronto, Toronto, ON, Canada.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Frontiers in plant science</title><idno type="ISSN">1664-462X</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The <i>Arabidopsis</i> nucleotide-binding leucine-rich repeat protein ZAR1 can recognize at least six distinct families of pathogenic effector proteins to mount an effector-triggered immune response. This remarkable immunodiversity appears to be conveyed by receptor-like cytoplasmic kinase (RLCK) complexes, which associate with ZAR1 to sense several effector-induced kinase perturbations. Here we show that the recently identified ZAR1-mediated immune responses against the HopX1, HopO1, and HopBA1 effector families of <i>Pseudomonas syringae</i> rely on an expanded diversity of RLCK sensors. We show that individual sensors can recognize distinct effector families, thereby contributing to the expanded surveillance potential of ZAR1 and supporting its role as a guardian of the plant kinome.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">32983191</PMID><DateRevised><Year>2020</Year><Month>10</Month><Day>01</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Print">1664-462X</ISSN><JournalIssue CitedMedium="Print"><Volume>11</Volume><PubDate><Year>2020</Year></PubDate></JournalIssue><Title>Frontiers in plant science</Title><ISOAbbreviation>Front Plant Sci</ISOAbbreviation></Journal><ArticleTitle>Immunodiversity of the <i>Arabidopsis</i> ZAR1 NLR Is Conveyed by Receptor-Like Cytoplasmic Kinase Sensors.</ArticleTitle><Pagination><MedlinePgn>1290</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3389/fpls.2020.01290</ELocationID><Abstract><AbstractText>The <i>Arabidopsis</i> nucleotide-binding leucine-rich repeat protein ZAR1 can recognize at least six distinct families of pathogenic effector proteins to mount an effector-triggered immune response. This remarkable immunodiversity appears to be conveyed by receptor-like cytoplasmic kinase (RLCK) complexes, which associate with ZAR1 to sense several effector-induced kinase perturbations. Here we show that the recently identified ZAR1-mediated immune responses against the HopX1, HopO1, and HopBA1 effector families of <i>Pseudomonas syringae</i> rely on an expanded diversity of RLCK sensors. We show that individual sensors can recognize distinct effector families, thereby contributing to the expanded surveillance potential of ZAR1 and supporting its role as a guardian of the plant kinome.</AbstractText><CopyrightInformation>Copyright © 2020 Martel, Laflamme, Seto, Bastedo, Dillon, Almeida, Guttman and Desveaux.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Martel</LastName><ForeName>Alexandre</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Laflamme</LastName><ForeName>Bradley</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Seto</LastName><ForeName>Derek</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bastedo</LastName><ForeName>D Patrick</ForeName><Initials>DP</Initials><AffiliationInfo><Affiliation>Department of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dillon</LastName><ForeName>Marcus M</ForeName><Initials>MM</Initials><AffiliationInfo><Affiliation>Department of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Almeida</LastName><ForeName>Renan N D</ForeName><Initials>RND</Initials><AffiliationInfo><Affiliation>Department of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guttman</LastName><ForeName>David S</ForeName><Initials>DS</Initials><AffiliationInfo><Affiliation>Department of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centre for the Analysis of Genome Evolution & Function, University of Toronto, Toronto, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Desveaux</LastName><ForeName>Darrell</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centre for the Analysis of Genome Evolution & Function, University of Toronto, Toronto, ON, Canada.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal 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