Phytochemical drug candidates for the modulation of peroxisome proliferator-activated receptor γ in inflammatory bowel diseases.
Identifieur interne : 000084 ( Main/Exploration ); précédent : 000083; suivant : 000085Phytochemical drug candidates for the modulation of peroxisome proliferator-activated receptor γ in inflammatory bowel diseases.
Auteurs : Balaji Venkataraman [Émirats arabes unis] ; Shreesh Ojha [Émirats arabes unis] ; Prasanna D. Belur [Inde] ; Bhoomendra Bhongade [Émirats arabes unis] ; Vishnu Raj [Émirats arabes unis] ; Peter D. Collin [États-Unis] ; Thomas E. Adrian [Émirats arabes unis] ; Sandeep B. Subramanya [Émirats arabes unis]Source :
- Phytotherapy research : PTR [ 1099-1573 ] ; 2020.
Descripteurs français
- KwdFr :
- MESH :
- anatomopathologie : Maladies inflammatoires intestinales.
- métabolisme : Récepteur PPAR gamma.
- pharmacologie : Anti-inflammatoires.
- traitement médicamenteux : Maladies inflammatoires intestinales.
- usage thérapeutique : Anti-inflammatoires.
- Humains.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : PPAR gamma.
- chemical , pharmacology : Anti-Inflammatory Agents.
- chemical , therapeutic use : Anti-Inflammatory Agents.
- drug therapy : Inflammatory Bowel Diseases.
- pathology : Inflammatory Bowel Diseases.
- Humans.
Abstract
Plant-based compounds or phytochemicals such as alkaloids, glycosides, flavonoids, volatile oils, tannins, resins, and polyphenols have been used extensively in traditional medicine for centuries and more recently in Western alternative medicine. Extensive evidence suggests that consumption of dietary polyphenolic compounds lowers the risk of inflammatory diseases. The anti-inflammatory properties of several phytochemicals are mediated through ligand-inducible peroxisome proliferator-activated receptors (PPARs), particularly the PPARγ transcription factor. Inflammatory bowel disease (IBD) is represented by ulcerative colitis, which occurs in the mucosa of the colon and rectum, and Crohn's disease (CD) that can involve any segment of gastrointestinal tract. Because of the lack of cost-effective pharmaceutical treatment options, many IBD patients seek and use alternative and unconventional therapies to alleviate their symptoms. PPARγ plays a role in the inhibition of inflammatory cytokine expression and activation of anti-inflammatory immune cells. The phytochemicals reported here are ligands that activate PPARγ, which in turn modulates inflammatory responses. PPARγ is highly expressed in the gut making it a potential therapeutic target for IBDs. This review summarizes the effects of the currently published phytochemicals that modulate the PPARγ pathway and reduce or eliminate colonic inflammation.
DOI: 10.1002/ptr.6625
PubMed: 32009281
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Belur</name><affiliation wicri:level="1"><nlm:affiliation>Department of Chemical Engineering, National Institute of Technology Karnataka, Mangalore, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Chemical Engineering, National Institute of Technology Karnataka, Mangalore</wicri:regionArea><wicri:noRegion>Mangalore</wicri:noRegion></affiliation></author><author><name sortKey="Bhongade, Bhoomendra" sort="Bhongade, Bhoomendra" uniqKey="Bhongade B" first="Bhoomendra" last="Bhongade">Bhoomendra Bhongade</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pharmaceutical Chemistry, RAK College of Pharmaceutical Sciences, RAK Medical & Health Sciences University, Ras Al Khaimah, United Arab Emirates.</nlm:affiliation><country xml:lang="fr">Émirats arabes unis</country><wicri:regionArea>Department of Pharmaceutical Chemistry, RAK College of Pharmaceutical Sciences, RAK Medical & Health Sciences University, Ras Al Khaimah</wicri:regionArea><wicri:noRegion>Ras Al Khaimah</wicri:noRegion></affiliation></author><author><name sortKey="Raj, Vishnu" sort="Raj, Vishnu" uniqKey="Raj V" first="Vishnu" last="Raj">Vishnu Raj</name><affiliation wicri:level="1"><nlm:affiliation>Department of Physiology, Zayed Bin Sultan Center for Health Sciences, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates.</nlm:affiliation><country xml:lang="fr">Émirats arabes unis</country><wicri:regionArea>Department of Physiology, Zayed Bin Sultan Center for Health Sciences, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain</wicri:regionArea><wicri:noRegion>Al Ain</wicri:noRegion></affiliation></author><author><name sortKey="Collin, Peter D" sort="Collin, Peter D" uniqKey="Collin P" first="Peter D" last="Collin">Peter D. Collin</name><affiliation wicri:level="2"><nlm:affiliation>Coastside Bio Resources, Deer Isle, Maine.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maine (État)</region></placeName><wicri:cityArea>Coastside Bio Resources, Deer Isle</wicri:cityArea></affiliation></author><author><name sortKey="Adrian, Thomas E" sort="Adrian, Thomas E" uniqKey="Adrian T" first="Thomas E" last="Adrian">Thomas E. Adrian</name><affiliation wicri:level="1"><nlm:affiliation>Department of Basic Medical Sciences, Mohamed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab Emirates.</nlm:affiliation><country xml:lang="fr">Émirats arabes unis</country><wicri:regionArea>Department of Basic Medical Sciences, Mohamed Bin Rashid University of Medicine and Health Sciences, Dubai</wicri:regionArea><wicri:noRegion>Dubai</wicri:noRegion></affiliation></author><author><name sortKey="Subramanya, Sandeep B" sort="Subramanya, Sandeep B" uniqKey="Subramanya S" first="Sandeep B" last="Subramanya">Sandeep B. Subramanya</name><affiliation wicri:level="1"><nlm:affiliation>Department of Physiology, Zayed Bin Sultan Center for Health Sciences, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates.</nlm:affiliation><country xml:lang="fr">Émirats arabes unis</country><wicri:regionArea>Department of Physiology, Zayed Bin Sultan Center for Health Sciences, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain</wicri:regionArea><wicri:noRegion>Al Ain</wicri:noRegion></affiliation></author></analytic><series><title level="j">Phytotherapy research : PTR</title><idno type="eISSN">1099-1573</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anti-Inflammatory Agents (pharmacology)</term><term>Anti-Inflammatory Agents (therapeutic use)</term><term>Humans (MeSH)</term><term>Inflammatory Bowel Diseases (drug therapy)</term><term>Inflammatory Bowel Diseases (pathology)</term><term>PPAR gamma (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Anti-inflammatoires (pharmacologie)</term><term>Anti-inflammatoires (usage thérapeutique)</term><term>Humains (MeSH)</term><term>Maladies inflammatoires intestinales (anatomopathologie)</term><term>Maladies inflammatoires intestinales (traitement médicamenteux)</term><term>Récepteur PPAR gamma (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>PPAR gamma</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Anti-Inflammatory Agents</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anti-Inflammatory Agents</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Maladies inflammatoires intestinales</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Inflammatory Bowel Diseases</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Récepteur PPAR gamma</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Inflammatory Bowel Diseases</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Anti-inflammatoires</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Maladies inflammatoires intestinales</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Anti-inflammatoires</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Humains</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Plant-based compounds or phytochemicals such as alkaloids, glycosides, flavonoids, volatile oils, tannins, resins, and polyphenols have been used extensively in traditional medicine for centuries and more recently in Western alternative medicine. Extensive evidence suggests that consumption of dietary polyphenolic compounds lowers the risk of inflammatory diseases. The anti-inflammatory properties of several phytochemicals are mediated through ligand-inducible peroxisome proliferator-activated receptors (PPARs), particularly the PPARγ transcription factor. Inflammatory bowel disease (IBD) is represented by ulcerative colitis, which occurs in the mucosa of the colon and rectum, and Crohn's disease (CD) that can involve any segment of gastrointestinal tract. Because of the lack of cost-effective pharmaceutical treatment options, many IBD patients seek and use alternative and unconventional therapies to alleviate their symptoms. PPARγ plays a role in the inhibition of inflammatory cytokine expression and activation of anti-inflammatory immune cells. The phytochemicals reported here are ligands that activate PPARγ, which in turn modulates inflammatory responses. PPARγ is highly expressed in the gut making it a potential therapeutic target for IBDs. This review summarizes the effects of the currently published phytochemicals that modulate the PPARγ pathway and reduce or eliminate colonic inflammation.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" IndexingMethod="Curated" Owner="NLM"><PMID Version="1">32009281</PMID><DateCompleted><Year>2020</Year><Month>08</Month><Day>07</Day></DateCompleted><DateRevised><Year>2020</Year><Month>08</Month><Day>07</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1099-1573</ISSN><JournalIssue CitedMedium="Internet"><Volume>34</Volume><Issue>7</Issue><PubDate><Year>2020</Year><Month>Jul</Month></PubDate></JournalIssue><Title>Phytotherapy research : PTR</Title><ISOAbbreviation>Phytother Res</ISOAbbreviation></Journal><ArticleTitle>Phytochemical drug candidates for the modulation of peroxisome proliferator-activated receptor γ in inflammatory bowel diseases.</ArticleTitle><Pagination><MedlinePgn>1530-1549</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/ptr.6625</ELocationID><Abstract><AbstractText>Plant-based compounds or phytochemicals such as alkaloids, glycosides, flavonoids, volatile oils, tannins, resins, and polyphenols have been used extensively in traditional medicine for centuries and more recently in Western alternative medicine. Extensive evidence suggests that consumption of dietary polyphenolic compounds lowers the risk of inflammatory diseases. The anti-inflammatory properties of several phytochemicals are mediated through ligand-inducible peroxisome proliferator-activated receptors (PPARs), particularly the PPARγ transcription factor. Inflammatory bowel disease (IBD) is represented by ulcerative colitis, which occurs in the mucosa of the colon and rectum, and Crohn's disease (CD) that can involve any segment of gastrointestinal tract. Because of the lack of cost-effective pharmaceutical treatment options, many IBD patients seek and use alternative and unconventional therapies to alleviate their symptoms. PPARγ plays a role in the inhibition of inflammatory cytokine expression and activation of anti-inflammatory immune cells. The phytochemicals reported here are ligands that activate PPARγ, which in turn modulates inflammatory responses. PPARγ is highly expressed in the gut making it a potential therapeutic target for IBDs. This review summarizes the effects of the currently published phytochemicals that modulate the PPARγ pathway and reduce or eliminate colonic inflammation.</AbstractText><CopyrightInformation>© 2020 John Wiley & Sons, Ltd.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Venkataraman</LastName><ForeName>Balaji</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Physiology, Zayed Bin Sultan Center for Health Sciences, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ojha</LastName><ForeName>Shreesh</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Belur</LastName><ForeName>Prasanna D</ForeName><Initials>PD</Initials><AffiliationInfo><Affiliation>Department of Chemical Engineering, National Institute of Technology Karnataka, Mangalore, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bhongade</LastName><ForeName>Bhoomendra</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Pharmaceutical Chemistry, RAK College of Pharmaceutical Sciences, RAK Medical & Health Sciences University, Ras Al Khaimah, United Arab Emirates.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Raj</LastName><ForeName>Vishnu</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Department of Physiology, Zayed Bin Sultan Center for Health Sciences, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Collin</LastName><ForeName>Peter D</ForeName><Initials>PD</Initials><AffiliationInfo><Affiliation>Coastside Bio Resources, Deer Isle, Maine.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Adrian</LastName><ForeName>Thomas E</ForeName><Initials>TE</Initials><AffiliationInfo><Affiliation>Department of Basic Medical Sciences, Mohamed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab Emirates.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Subramanya</LastName><ForeName>Sandeep B</ForeName><Initials>SB</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-4802-500X</Identifier><AffiliationInfo><Affiliation>Department of Physiology, Zayed Bin Sultan Center for Health Sciences, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>31M384</GrantID><Agency>United Arab Emirates University, CMHS Faculty grant</Agency><Country></Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>02</Month><Day>03</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Phytother Res</MedlineTA><NlmUniqueID>8904486</NlmUniqueID><ISSNLinking>0951-418X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000893">Anti-Inflammatory Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D047495">PPAR gamma</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000893" MajorTopicYN="N">Anti-Inflammatory Agents</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015212" MajorTopicYN="N">Inflammatory Bowel Diseases</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D047495" MajorTopicYN="N">PPAR gamma</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">PPARγ</Keyword><Keyword MajorTopicYN="N">colitis</Keyword><Keyword MajorTopicYN="N">inflammatory bowel disease</Keyword><Keyword MajorTopicYN="N">phytochemicals</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2019</Year><Month>09</Month><Day>07</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2019</Year><Month>12</Month><Day>23</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>01</Month><Day>14</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>2</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>8</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>2</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32009281</ArticleId><ArticleId IdType="doi">10.1002/ptr.6625</ArticleId></ArticleIdList><ReferenceList><Title>REFERENCES</Title><Reference><Citation>Adachi, M., Kurotani, R., Morimura, K., Shah, Y., Sanford, M., Madison, B. 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Adrian</name><name sortKey="Bhongade, Bhoomendra" sort="Bhongade, Bhoomendra" uniqKey="Bhongade B" first="Bhoomendra" last="Bhongade">Bhoomendra Bhongade</name><name sortKey="Ojha, Shreesh" sort="Ojha, Shreesh" uniqKey="Ojha S" first="Shreesh" last="Ojha">Shreesh Ojha</name><name sortKey="Raj, Vishnu" sort="Raj, Vishnu" uniqKey="Raj V" first="Vishnu" last="Raj">Vishnu Raj</name><name sortKey="Subramanya, Sandeep B" sort="Subramanya, Sandeep B" uniqKey="Subramanya S" first="Sandeep B" last="Subramanya">Sandeep B. Subramanya</name></country><country name="Inde"><noRegion><name sortKey="Belur, Prasanna D" sort="Belur, Prasanna D" uniqKey="Belur P" first="Prasanna D" last="Belur">Prasanna D. Belur</name></noRegion></country><country name="États-Unis"><region name="Maine (État)"><name sortKey="Collin, Peter D" sort="Collin, Peter D" uniqKey="Collin P" first="Peter D" last="Collin">Peter D. 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