Total glucosides of paeony improve complete freund's adjuvant-induced rheumatoid arthritis in rats by inhibiting toll-like receptor 2-mediated tumor necrosis factor receptor-associated factor 6/ nuclear factor-kappa B pathway activation.
Identifieur interne : 000186 ( Main/Corpus ); précédent : 000185; suivant : 000187Total glucosides of paeony improve complete freund's adjuvant-induced rheumatoid arthritis in rats by inhibiting toll-like receptor 2-mediated tumor necrosis factor receptor-associated factor 6/ nuclear factor-kappa B pathway activation.
Auteurs : Huan Chen ; Yueqiang Wen ; Ting Pan ; Shijun XuSource :
- Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan [ 2589-451X ] ; 2019.
English descriptors
- KwdEn :
- Animals (MeSH), Anti-Inflammatory Agents (administration & dosage), Arthritis, Rheumatoid (drug therapy), Arthritis, Rheumatoid (etiology), Arthritis, Rheumatoid (genetics), Arthritis, Rheumatoid (immunology), Drugs, Chinese Herbal (administration & dosage), Freund's Adjuvant (adverse effects), Glucosides (administration & dosage), Humans (MeSH), Male (MeSH), NF-kappa B (genetics), NF-kappa B (immunology), Paeonia (chemistry), Rats (MeSH), Rats, Sprague-Dawley (MeSH), TNF Receptor-Associated Factor 6 (genetics), TNF Receptor-Associated Factor 6 (immunology), Toll-Like Receptor 2 (genetics), Toll-Like Receptor 2 (immunology), Tumor Necrosis Factor-alpha (genetics), Tumor Necrosis Factor-alpha (immunology).
- MESH :
- chemical , administration & dosage : Anti-Inflammatory Agents, Drugs, Chinese Herbal, Glucosides.
- chemical , adverse effects : Freund's Adjuvant.
- chemistry : Paeonia.
- drug therapy : Arthritis, Rheumatoid.
- etiology : Arthritis, Rheumatoid.
- genetics : Arthritis, Rheumatoid, NF-kappa B, TNF Receptor-Associated Factor 6, Toll-Like Receptor 2, Tumor Necrosis Factor-alpha.
- immunology : Arthritis, Rheumatoid, NF-kappa B, TNF Receptor-Associated Factor 6, Toll-Like Receptor 2, Tumor Necrosis Factor-alpha.
- Animals, Humans, Male, Rats, Rats, Sprague-Dawley.
Abstract
OBJECTIVE
To investigate the mechanism underlying anti-inflammatory and immunoregulatory effect of total glucosides of paeony (TGP) based on toll-like receptor 2 (TLR2) mediated tumor necrosis factor (TNF) receptor-associated factor 6 (TRAF6)/nuclear factor-kappa B (NF-κB) pathway activation in rats with rheumatoid arthritis.
METHODS
Adjuvant arthritis (AA) model was developed by complete freund's adjuvant (CFA) immunization. TGP (100, 50, 25 mg/kg) and celecoxib (2.8 mg/kg) were administered by intragastric administration for 21 d. Right hind paw swelling was assessed every 2 d. After 21 d, synovial changes of the ankle were detected by histopathology. CD4+ and CD8+ T cell amounts in peripheral blood were measured by flow-cytometrically. Gene and protein levels of toll-like receptor (TLR)2, TRAF6, tumor necrosis factor ligand superfamily member 6 (FASLG) in the spleen were assessed by RT-qPCR and Western Bolt, respectively. Nuclear expression of NF-κB p65 was detected by NF-κB p65 Assay Kit.
RESULTS
Paw swelling and synovium lesions were obviously aggravated in AA rats. These symptoms were significantly relieved by TGP. The ratio of CD4+/CD8+ T cell was increased in AA rats, while TGP reduced this increased ratio. Gene and protein levels of splenic TLR2, TFAR6 and FASLG, and nuclear NF-κB p65 in AA rats were significantly increased, but overtly inhibited by TGP.
CONCLUSION
These findings suggest that TGP's anti-inflammatory effect onRA in rats with CFA may be related to the downregulation of TLR2/TRAF6/NF-κB pathway and the regulation of T cell subsets.
PubMed: 32186105
Links to Exploration step
pubmed:32186105Le document en format XML
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<author><name sortKey="Chen, Huan" sort="Chen, Huan" uniqKey="Chen H" first="Huan" last="Chen">Huan Chen</name>
<affiliation><nlm:affiliation>Institute of Meterial Medica Integration and Transformation for Brain Disorders, CDUTCM, Chengdu 610075, China.</nlm:affiliation>
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<affiliation><nlm:affiliation>Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.</nlm:affiliation>
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<author><name sortKey="Wen, Yueqiang" sort="Wen, Yueqiang" uniqKey="Wen Y" first="Yueqiang" last="Wen">Yueqiang Wen</name>
<affiliation><nlm:affiliation>Institute of Meterial Medica Integration and Transformation for Brain Disorders, CDUTCM, Chengdu 610075, China.</nlm:affiliation>
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<author><name sortKey="Pan, Ting" sort="Pan, Ting" uniqKey="Pan T" first="Ting" last="Pan">Ting Pan</name>
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<author><name sortKey="Xu, Shijun" sort="Xu, Shijun" uniqKey="Xu S" first="Shijun" last="Xu">Shijun Xu</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Total glucosides of paeony improve complete freund's adjuvant-induced rheumatoid arthritis in rats by inhibiting toll-like receptor 2-mediated tumor necrosis factor receptor-associated factor 6/ nuclear factor-kappa B pathway activation.</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term>
<term>Anti-Inflammatory Agents (administration & dosage)</term>
<term>Arthritis, Rheumatoid (drug therapy)</term>
<term>Arthritis, Rheumatoid (etiology)</term>
<term>Arthritis, Rheumatoid (genetics)</term>
<term>Arthritis, Rheumatoid (immunology)</term>
<term>Drugs, Chinese Herbal (administration & dosage)</term>
<term>Freund's Adjuvant (adverse effects)</term>
<term>Glucosides (administration & dosage)</term>
<term>Humans (MeSH)</term>
<term>Male (MeSH)</term>
<term>NF-kappa B (genetics)</term>
<term>NF-kappa B (immunology)</term>
<term>Paeonia (chemistry)</term>
<term>Rats (MeSH)</term>
<term>Rats, Sprague-Dawley (MeSH)</term>
<term>TNF Receptor-Associated Factor 6 (genetics)</term>
<term>TNF Receptor-Associated Factor 6 (immunology)</term>
<term>Toll-Like Receptor 2 (genetics)</term>
<term>Toll-Like Receptor 2 (immunology)</term>
<term>Tumor Necrosis Factor-alpha (genetics)</term>
<term>Tumor Necrosis Factor-alpha (immunology)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Anti-Inflammatory Agents</term>
<term>Drugs, Chinese Herbal</term>
<term>Glucosides</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Freund's Adjuvant</term>
</keywords>
<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Paeonia</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Arthritis, Rheumatoid</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Arthritis, Rheumatoid</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Arthritis, Rheumatoid</term>
<term>NF-kappa B</term>
<term>TNF Receptor-Associated Factor 6</term>
<term>Toll-Like Receptor 2</term>
<term>Tumor Necrosis Factor-alpha</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Arthritis, Rheumatoid</term>
<term>NF-kappa B</term>
<term>TNF Receptor-Associated Factor 6</term>
<term>Toll-Like Receptor 2</term>
<term>Tumor Necrosis Factor-alpha</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Humans</term>
<term>Male</term>
<term>Rats</term>
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<front><div type="abstract" xml:lang="en"><p><b>OBJECTIVE</b>
</p>
<p>To investigate the mechanism underlying anti-inflammatory and immunoregulatory effect of total glucosides of paeony (TGP) based on toll-like receptor 2 (TLR2) mediated tumor necrosis factor (TNF) receptor-associated factor 6 (TRAF6)/nuclear factor-kappa B (NF-κB) pathway activation in rats with rheumatoid arthritis.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>METHODS</b>
</p>
<p>Adjuvant arthritis (AA) model was developed by complete freund's adjuvant (CFA) immunization. TGP (100, 50, 25 mg/kg) and celecoxib (2.8 mg/kg) were administered by intragastric administration for 21 d. Right hind paw swelling was assessed every 2 d. After 21 d, synovial changes of the ankle were detected by histopathology. CD4+ and CD8+ T cell amounts in peripheral blood were measured by flow-cytometrically. Gene and protein levels of toll-like receptor (TLR)2, TRAF6, tumor necrosis factor ligand superfamily member 6 (FASLG) in the spleen were assessed by RT-qPCR and Western Bolt, respectively. Nuclear expression of NF-κB p65 was detected by NF-κB p65 Assay Kit.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>Paw swelling and synovium lesions were obviously aggravated in AA rats. These symptoms were significantly relieved by TGP. The ratio of CD4+/CD8+ T cell was increased in AA rats, while TGP reduced this increased ratio. Gene and protein levels of splenic TLR2, TFAR6 and FASLG, and nuclear NF-κB p65 in AA rats were significantly increased, but overtly inhibited by TGP.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSION</b>
</p>
<p>These findings suggest that TGP's anti-inflammatory effect onRA in rats with CFA may be related to the downregulation of TLR2/TRAF6/NF-κB pathway and the regulation of T cell subsets.</p>
</div>
</front>
</TEI>
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<Title>Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan</Title>
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<ArticleTitle>Total glucosides of paeony improve complete freund's adjuvant-induced rheumatoid arthritis in rats by inhibiting toll-like receptor 2-mediated tumor necrosis factor receptor-associated factor 6/ nuclear factor-kappa B pathway activation.</ArticleTitle>
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<Abstract><AbstractText Label="OBJECTIVE">To investigate the mechanism underlying anti-inflammatory and immunoregulatory effect of total glucosides of paeony (TGP) based on toll-like receptor 2 (TLR2) mediated tumor necrosis factor (TNF) receptor-associated factor 6 (TRAF6)/nuclear factor-kappa B (NF-κB) pathway activation in rats with rheumatoid arthritis.</AbstractText>
<AbstractText Label="METHODS">Adjuvant arthritis (AA) model was developed by complete freund's adjuvant (CFA) immunization. TGP (100, 50, 25 mg/kg) and celecoxib (2.8 mg/kg) were administered by intragastric administration for 21 d. Right hind paw swelling was assessed every 2 d. After 21 d, synovial changes of the ankle were detected by histopathology. CD4+ and CD8+ T cell amounts in peripheral blood were measured by flow-cytometrically. Gene and protein levels of toll-like receptor (TLR)2, TRAF6, tumor necrosis factor ligand superfamily member 6 (FASLG) in the spleen were assessed by RT-qPCR and Western Bolt, respectively. Nuclear expression of NF-κB p65 was detected by NF-κB p65 Assay Kit.</AbstractText>
<AbstractText Label="RESULTS">Paw swelling and synovium lesions were obviously aggravated in AA rats. These symptoms were significantly relieved by TGP. The ratio of CD4+/CD8+ T cell was increased in AA rats, while TGP reduced this increased ratio. Gene and protein levels of splenic TLR2, TFAR6 and FASLG, and nuclear NF-κB p65 in AA rats were significantly increased, but overtly inhibited by TGP.</AbstractText>
<AbstractText Label="CONCLUSION">These findings suggest that TGP's anti-inflammatory effect onRA in rats with CFA may be related to the downregulation of TLR2/TRAF6/NF-κB pathway and the regulation of T cell subsets.</AbstractText>
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