A new bisepoxylignan dendranlignan A isolated from Chrysanthemum Flower inhibits the production of inflammatory mediators via the TLR4 pathway in LPS-induced H9c2 cardiomyocytes.
Identifieur interne : 000088 ( Main/Corpus ); précédent : 000087; suivant : 000089A new bisepoxylignan dendranlignan A isolated from Chrysanthemum Flower inhibits the production of inflammatory mediators via the TLR4 pathway in LPS-induced H9c2 cardiomyocytes.
Auteurs : Mengnan Zeng ; Meng Li ; Yingjie Chen ; Jingke Zhang ; Yangang Cao ; Beibei Zhang ; Weisheng Feng ; Xiaoke Zheng ; Zhiling YuSource :
- Archives of biochemistry and biophysics [ 1096-0384 ] ; 2020.
English descriptors
- KwdEn :
- Animals (MeSH), Chrysanthemum (chemistry), Cytokines (chemistry), Drug Discovery (MeSH), Flowers (chemistry), Humans (MeSH), Inflammation (metabolism), Inflammation Mediators (metabolism), Lipopolysaccharides (chemistry), Molecular Docking Simulation (MeSH), Molecular Structure (MeSH), Myocytes, Cardiac (metabolism), Plant Extracts (chemistry), Polyynes (chemistry), Polyynes (pharmacology), Signal Transduction (MeSH), Structure-Activity Relationship (MeSH), Toll-Like Receptor 4 (metabolism).
- MESH :
- chemical , chemistry : Cytokines, Lipopolysaccharides, Plant Extracts, Polyynes.
- chemistry : Chrysanthemum, Flowers.
- metabolism : Inflammation, Inflammation Mediators, Myocytes, Cardiac, Toll-Like Receptor 4.
- chemical , pharmacology : Polyynes.
- Animals, Drug Discovery, Humans, Molecular Docking Simulation, Molecular Structure, Signal Transduction, Structure-Activity Relationship.
Abstract
A new bisepoxylignan dendranlignan A (A1) and the known compound lantibeside D (D2) was isolated from Chrysanthemum Flower, the dried capitulum of Dendranthema morifolium (Ramat.) kitam. Their structures were determined on the basis of extensive spectroscopic methods, including 1D-NMR, 2D-NMR and MS data. Additionally, A1 and D2 were evaluated for their effects on the production of inflammatory mediators in H9c2 cardiomyocytes stimulated with lipopolysaccharide (LPS). Results demonstrated that A1 and D2 decreased LPS-induced production of inflammatory cytokines TNF-α, IL-2 and IFN-γ in H9c2 cells. Both compounds also decreased the nuclear localization of c-JUN, p-P65 and p-IRF3, but did not affect the level of TLR4. Molecular docking indicated that A1 and D2 occupied the ligand binding sites of TLR4-MD2. In the present study, we for the first time discovered a new bisepoxylignan compound A1, and found that this compound has a potential to inhibit inflammation by inhibiting TLR4 signaling.
DOI: 10.1016/j.abb.2020.108506
PubMed: 32679197
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pubmed:32679197Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A new bisepoxylignan dendranlignan A isolated from Chrysanthemum Flower inhibits the production of inflammatory mediators via the TLR4 pathway in LPS-induced H9c2 cardiomyocytes.</title><author><name sortKey="Zeng, Mengnan" sort="Zeng, Mengnan" uniqKey="Zeng M" first="Mengnan" last="Zeng">Mengnan Zeng</name><affiliation><nlm:affiliation>Henan University of Chinese Medicine, Zhengzhou, 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou, 450046, China.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Meng" sort="Li, Meng" uniqKey="Li M" first="Meng" last="Li">Meng Li</name><affiliation><nlm:affiliation>Henan University of Chinese Medicine, Zhengzhou, 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou, 450046, China.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, Yingjie" sort="Chen, Yingjie" uniqKey="Chen Y" first="Yingjie" last="Chen">Yingjie Chen</name><affiliation><nlm:affiliation>Centre for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Jingke" sort="Zhang, Jingke" uniqKey="Zhang J" first="Jingke" last="Zhang">Jingke Zhang</name><affiliation><nlm:affiliation>Henan University of Chinese Medicine, Zhengzhou, 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou, 450046, China.</nlm:affiliation></affiliation></author><author><name sortKey="Cao, Yangang" sort="Cao, Yangang" uniqKey="Cao Y" first="Yangang" last="Cao">Yangang Cao</name><affiliation><nlm:affiliation>Henan University of Chinese Medicine, Zhengzhou, 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou, 450046, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Beibei" sort="Zhang, Beibei" uniqKey="Zhang B" first="Beibei" last="Zhang">Beibei Zhang</name><affiliation><nlm:affiliation>Henan University of Chinese Medicine, Zhengzhou, 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou, 450046, China.</nlm:affiliation></affiliation></author><author><name sortKey="Feng, Weisheng" sort="Feng, Weisheng" uniqKey="Feng W" first="Weisheng" last="Feng">Weisheng Feng</name><affiliation><nlm:affiliation>Henan University of Chinese Medicine, Zhengzhou, 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou, 450046, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zheng, Xiaoke" sort="Zheng, Xiaoke" uniqKey="Zheng X" first="Xiaoke" last="Zheng">Xiaoke Zheng</name><affiliation><nlm:affiliation>Henan University of Chinese Medicine, Zhengzhou, 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou, 450046, China. Electronic address: zhengxk.2006@163.com.</nlm:affiliation></affiliation></author><author><name sortKey="Yu, Zhiling" sort="Yu, Zhiling" uniqKey="Yu Z" first="Zhiling" last="Yu">Zhiling Yu</name><affiliation><nlm:affiliation>Centre for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong. Electronic address: zlyu@hkbu.edu.hk.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32679197</idno><idno type="pmid">32679197</idno><idno type="doi">10.1016/j.abb.2020.108506</idno><idno type="wicri:Area/Main/Corpus">000088</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000088</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">A new bisepoxylignan dendranlignan A isolated from Chrysanthemum Flower inhibits the production of inflammatory mediators via the TLR4 pathway in LPS-induced H9c2 cardiomyocytes.</title><author><name sortKey="Zeng, Mengnan" sort="Zeng, Mengnan" uniqKey="Zeng M" first="Mengnan" last="Zeng">Mengnan Zeng</name><affiliation><nlm:affiliation>Henan University of Chinese Medicine, Zhengzhou, 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou, 450046, China.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Meng" sort="Li, Meng" uniqKey="Li M" first="Meng" last="Li">Meng Li</name><affiliation><nlm:affiliation>Henan University of Chinese Medicine, Zhengzhou, 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou, 450046, China.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, Yingjie" sort="Chen, Yingjie" uniqKey="Chen Y" first="Yingjie" last="Chen">Yingjie Chen</name><affiliation><nlm:affiliation>Centre for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Jingke" sort="Zhang, Jingke" uniqKey="Zhang J" first="Jingke" last="Zhang">Jingke Zhang</name><affiliation><nlm:affiliation>Henan University of Chinese Medicine, Zhengzhou, 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou, 450046, China.</nlm:affiliation></affiliation></author><author><name sortKey="Cao, Yangang" sort="Cao, Yangang" uniqKey="Cao Y" first="Yangang" last="Cao">Yangang Cao</name><affiliation><nlm:affiliation>Henan University of Chinese Medicine, Zhengzhou, 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou, 450046, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Beibei" sort="Zhang, Beibei" uniqKey="Zhang B" first="Beibei" last="Zhang">Beibei Zhang</name><affiliation><nlm:affiliation>Henan University of Chinese Medicine, Zhengzhou, 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou, 450046, China.</nlm:affiliation></affiliation></author><author><name sortKey="Feng, Weisheng" sort="Feng, Weisheng" uniqKey="Feng W" first="Weisheng" last="Feng">Weisheng Feng</name><affiliation><nlm:affiliation>Henan University of Chinese Medicine, Zhengzhou, 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou, 450046, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zheng, Xiaoke" sort="Zheng, Xiaoke" uniqKey="Zheng X" first="Xiaoke" last="Zheng">Xiaoke Zheng</name><affiliation><nlm:affiliation>Henan University of Chinese Medicine, Zhengzhou, 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou, 450046, China. Electronic address: zhengxk.2006@163.com.</nlm:affiliation></affiliation></author><author><name sortKey="Yu, Zhiling" sort="Yu, Zhiling" uniqKey="Yu Z" first="Zhiling" last="Yu">Zhiling Yu</name><affiliation><nlm:affiliation>Centre for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong. Electronic address: zlyu@hkbu.edu.hk.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Archives of biochemistry and biophysics</title><idno type="eISSN">1096-0384</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term><term>Chrysanthemum (chemistry)</term><term>Cytokines (chemistry)</term><term>Drug Discovery (MeSH)</term><term>Flowers (chemistry)</term><term>Humans (MeSH)</term><term>Inflammation (metabolism)</term><term>Inflammation Mediators (metabolism)</term><term>Lipopolysaccharides (chemistry)</term><term>Molecular Docking Simulation (MeSH)</term><term>Molecular Structure (MeSH)</term><term>Myocytes, Cardiac (metabolism)</term><term>Plant Extracts (chemistry)</term><term>Polyynes (chemistry)</term><term>Polyynes (pharmacology)</term><term>Signal Transduction (MeSH)</term><term>Structure-Activity Relationship (MeSH)</term><term>Toll-Like Receptor 4 (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Cytokines</term><term>Lipopolysaccharides</term><term>Plant Extracts</term><term>Polyynes</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Chrysanthemum</term><term>Flowers</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Inflammation</term><term>Inflammation Mediators</term><term>Myocytes, Cardiac</term><term>Toll-Like Receptor 4</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Polyynes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Drug Discovery</term><term>Humans</term><term>Molecular Docking Simulation</term><term>Molecular Structure</term><term>Signal Transduction</term><term>Structure-Activity Relationship</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A new bisepoxylignan dendranlignan A (A1) and the known compound lantibeside D (D2) was isolated from Chrysanthemum Flower, the dried capitulum of Dendranthema morifolium (Ramat.) kitam. Their structures were determined on the basis of extensive spectroscopic methods, including 1D-NMR, 2D-NMR and MS data. Additionally, A1 and D2 were evaluated for their effects on the production of inflammatory mediators in H9c2 cardiomyocytes stimulated with lipopolysaccharide (LPS). Results demonstrated that A1 and D2 decreased LPS-induced production of inflammatory cytokines TNF-α, IL-2 and IFN-γ in H9c2 cells. Both compounds also decreased the nuclear localization of c-JUN, p-P65 and p-IRF3, but did not affect the level of TLR4. Molecular docking indicated that A1 and D2 occupied the ligand binding sites of TLR4-MD2. In the present study, we for the first time discovered a new bisepoxylignan compound A1, and found that this compound has a potential to inhibit inflammation by inhibiting TLR4 signaling.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32679197</PMID><DateCompleted><Year>2020</Year><Month>09</Month><Day>30</Day></DateCompleted><DateRevised><Year>2020</Year><Month>09</Month><Day>30</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1096-0384</ISSN><JournalIssue CitedMedium="Internet"><Volume>690</Volume><PubDate><Year>2020</Year><Month>09</Month><Day>15</Day></PubDate></JournalIssue><Title>Archives of biochemistry and biophysics</Title><ISOAbbreviation>Arch Biochem Biophys</ISOAbbreviation></Journal><ArticleTitle>A new bisepoxylignan dendranlignan A isolated from Chrysanthemum Flower inhibits the production of inflammatory mediators via the TLR4 pathway in LPS-induced H9c2 cardiomyocytes.</ArticleTitle><Pagination><MedlinePgn>108506</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0003-9861(20)30515-4</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.abb.2020.108506</ELocationID><Abstract><AbstractText>A new bisepoxylignan dendranlignan A (A1) and the known compound lantibeside D (D2) was isolated from Chrysanthemum Flower, the dried capitulum of Dendranthema morifolium (Ramat.) kitam. Their structures were determined on the basis of extensive spectroscopic methods, including 1D-NMR, 2D-NMR and MS data. Additionally, A1 and D2 were evaluated for their effects on the production of inflammatory mediators in H9c2 cardiomyocytes stimulated with lipopolysaccharide (LPS). Results demonstrated that A1 and D2 decreased LPS-induced production of inflammatory cytokines TNF-α, IL-2 and IFN-γ in H9c2 cells. Both compounds also decreased the nuclear localization of c-JUN, p-P65 and p-IRF3, but did not affect the level of TLR4. Molecular docking indicated that A1 and D2 occupied the ligand binding sites of TLR4-MD2. In the present study, we for the first time discovered a new bisepoxylignan compound A1, and found that this compound has a potential to inhibit inflammation by inhibiting TLR4 signaling.</AbstractText><CopyrightInformation>Copyright © 2020 Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Zeng</LastName><ForeName>Mengnan</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Henan University of Chinese Medicine, Zhengzhou, 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou, 450046, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Meng</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Henan University of Chinese Medicine, Zhengzhou, 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou, 450046, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Yingjie</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Centre for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Jingke</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Henan University of Chinese Medicine, Zhengzhou, 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou, 450046, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cao</LastName><ForeName>Yangang</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Henan University of Chinese Medicine, Zhengzhou, 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou, 450046, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Beibei</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Henan University of Chinese Medicine, Zhengzhou, 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou, 450046, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Feng</LastName><ForeName>Weisheng</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Henan University of Chinese Medicine, Zhengzhou, 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou, 450046, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zheng</LastName><ForeName>Xiaoke</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Henan University of Chinese Medicine, Zhengzhou, 450046, China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou, 450046, China. Electronic address: zhengxk.2006@163.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yu</LastName><ForeName>Zhiling</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Centre for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong. Electronic address: zlyu@hkbu.edu.hk.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>07</Month><Day>14</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Arch Biochem Biophys</MedlineTA><NlmUniqueID>0372430</NlmUniqueID><ISSNLinking>0003-9861</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016207">Cytokines</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018836">Inflammation Mediators</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008070">Lipopolysaccharides</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010936">Plant Extracts</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D051197">Toll-Like Receptor 4</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C524031">dendrazawayne A</NameOfSubstance></Chemical><Chemical><RegistryNumber>25067-58-7</RegistryNumber><NameOfSubstance UI="D053279">Polyynes</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D031202" MajorTopicYN="N">Chrysanthemum</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016207" MajorTopicYN="N">Cytokines</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D055808" MajorTopicYN="N">Drug Discovery</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D035264" MajorTopicYN="N">Flowers</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007249" MajorTopicYN="N">Inflammation</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018836" MajorTopicYN="N">Inflammation Mediators</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008070" MajorTopicYN="N">Lipopolysaccharides</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D062105" MajorTopicYN="N">Molecular Docking Simulation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015394" MajorTopicYN="N">Molecular Structure</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D032383" MajorTopicYN="N">Myocytes, Cardiac</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010936" MajorTopicYN="N">Plant Extracts</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D053279" MajorTopicYN="N">Polyynes</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013329" MajorTopicYN="N">Structure-Activity Relationship</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051197" MajorTopicYN="N">Toll-Like Receptor 4</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Bisepoxylignan</Keyword><Keyword MajorTopicYN="Y">Cardiomyocyte</Keyword><Keyword MajorTopicYN="Y">Dendranlignan A</Keyword><Keyword MajorTopicYN="Y">Structural elucidation</Keyword><Keyword MajorTopicYN="Y">TLR4</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>05</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>07</Month><Day>01</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>07</Month><Day>10</Day></PubMedPubDate><PubMedPubDate 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