Sourdough Fermentation Degrades Wheat Alpha-Amylase/Trypsin Inhibitor (ATI) and Reduces Pro-Inflammatory Activity.
Identifieur interne : 000084 ( Main/Corpus ); précédent : 000083; suivant : 000085Sourdough Fermentation Degrades Wheat Alpha-Amylase/Trypsin Inhibitor (ATI) and Reduces Pro-Inflammatory Activity.
Auteurs : Xin Huang ; Detlef Schuppan ; Luis E. Rojas Tovar ; Victor F. Zevallos ; Jussi Loponen ; Michael G NzleSource :
- Foods (Basel, Switzerland) [ 2304-8158 ] ; 2020.
Abstract
The ingestion of gluten-containing foods can cause wheat-related disorders in up to 15% of wheat consuming populations. Besides the role of gluten, α-amylase/trypsin inhibitors (ATI) have recently been identified as inducers of an innate immune response via toll-like receptor 4 in celiac disease and non-celiac wheat sensitivity. ATI are involved in plant self-defense against insects and possibly in grain development. Notably, they are largely resistant to gastrointestinal proteases and heat, and their inflammatory activity affects not only the intestine, but also peripheral organs. The aim of this study was to understand the changes of ATI throughout the sourdough and yeast-fermented bread-making processes. ATI tetramers were isolated, fluorescein-labelled, and added to a mini-dough bread-making system. When the pH decreased below 4.0 in sourdough fermentation, the ATI tetramers were degraded due to the activation of aspartic proteases, whilst in yeast fermentation, ATI tetramers remained intact. The amylase inhibitory activity after sourdough fermentation decreased significantly, while the concentration of free thiol groups increased. The glutathione reductase activity of Fructilactobacillus sanfranciscensis did not contribute to the reduction of ATI tetramers. Compared to the unfermented wheat, sourdough fermentation was able to decrease the release of pro-inflammatory cytokines monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor alpha (TNF-α) in quantitative ATI extracts added to the human monocytic cell line THP-1. The current data suggest that sourdough fermentation can degrade ATI structure and bioactivity, and point to strategies to improve product development for wheat sensitivity patients.
DOI: 10.3390/foods9070943
PubMed: 32708800
PubMed Central: PMC7404469
Links to Exploration step
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<front><div type="abstract" xml:lang="en">The ingestion of gluten-containing foods can cause wheat-related disorders in up to 15% of wheat consuming populations. Besides the role of gluten, α-amylase/trypsin inhibitors (ATI) have recently been identified as inducers of an innate immune response via toll-like receptor 4 in celiac disease and non-celiac wheat sensitivity. ATI are involved in plant self-defense against insects and possibly in grain development. Notably, they are largely resistant to gastrointestinal proteases and heat, and their inflammatory activity affects not only the intestine, but also peripheral organs. The aim of this study was to understand the changes of ATI throughout the sourdough and yeast-fermented bread-making processes. ATI tetramers were isolated, fluorescein-labelled, and added to a mini-dough bread-making system. When the pH decreased below 4.0 in sourdough fermentation, the ATI tetramers were degraded due to the activation of aspartic proteases, whilst in yeast fermentation, ATI tetramers remained intact. The amylase inhibitory activity after sourdough fermentation decreased significantly, while the concentration of free thiol groups increased. The glutathione reductase activity of <i>Fructilactobacillus sanfranciscensis</i>
did not contribute to the reduction of ATI tetramers. Compared to the unfermented wheat, sourdough fermentation was able to decrease the release of pro-inflammatory cytokines monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor alpha (TNF-α) in quantitative ATI extracts added to the human monocytic cell line THP-1. The current data suggest that sourdough fermentation can degrade ATI structure and bioactivity, and point to strategies to improve product development for wheat sensitivity patients.</div>
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<Abstract><AbstractText>The ingestion of gluten-containing foods can cause wheat-related disorders in up to 15% of wheat consuming populations. Besides the role of gluten, α-amylase/trypsin inhibitors (ATI) have recently been identified as inducers of an innate immune response via toll-like receptor 4 in celiac disease and non-celiac wheat sensitivity. ATI are involved in plant self-defense against insects and possibly in grain development. Notably, they are largely resistant to gastrointestinal proteases and heat, and their inflammatory activity affects not only the intestine, but also peripheral organs. The aim of this study was to understand the changes of ATI throughout the sourdough and yeast-fermented bread-making processes. ATI tetramers were isolated, fluorescein-labelled, and added to a mini-dough bread-making system. When the pH decreased below 4.0 in sourdough fermentation, the ATI tetramers were degraded due to the activation of aspartic proteases, whilst in yeast fermentation, ATI tetramers remained intact. The amylase inhibitory activity after sourdough fermentation decreased significantly, while the concentration of free thiol groups increased. The glutathione reductase activity of <i>Fructilactobacillus sanfranciscensis</i>
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<ReferenceList><Reference><Citation>Gastroenterology. 2019 Jun;156(8):2266-2280</Citation>
<ArticleIdList><ArticleId IdType="pubmed">30802444</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Gastroenterology. 2019 Jul;157(1):109-118.e5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31100380</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Exp Allergy. 2008 Nov;38(11):1712-26</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18823308</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Gastroenterology. 2015 May;148(6):1195-204</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25583468</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Nutr. 2018 Feb 1;148(2):202-208</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29490103</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Gastroenterology. 2013 Aug;145(2):320-8.e1-3</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23648697</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Allergy Clin Immunol. 2019 Jan;143(1):201-212.e4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29574077</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Foods. 2018 Jun 22;7(7):</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29932101</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Agric Food Chem. 2008 May 14;56(9):3357-62</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18412365</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Sci Rep. 2019 Nov 25;9(1):17463</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31767938</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Best Pract Res Clin Gastroenterol. 2015 Jun;29(3):469-76</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26060111</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int J Food Microbiol. 2014 Sep 1;186:42-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24984221</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>BMC Res Notes. 2011 Jul 20;4:242</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21774824</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Gastroenterology. 2009 Dec;137(6):1912-33</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19766641</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nutrients. 2017 Nov 21;9(11):</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29160841</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Eur J Nutr. 2019 Jun;58(4):1507-1514</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29600329</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochim Biophys Acta. 1973 Jul 12;317(1):139-48</Citation>
<ArticleIdList><ArticleId IdType="pubmed">4198764</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 1989 May;86(9):3242-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16594035</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nutrients. 2017 Nov 04;9(11):</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29113045</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int J Syst Evol Microbiol. 2020 Apr;70(4):2782-2858</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32293557</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Agric Food Chem. 2007 Feb 7;55(3):978-84</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17263502</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Agric Food Chem. 2004 Mar 10;52(5):1307-14</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14995138</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Med Food. 2018 Mar;21(3):207-214</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29315017</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Sci Rep. 2017 Oct 13;7(1):13169</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29030601</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nutrients. 2018 Dec 02;10(12):</Citation>
<ArticleIdList><ArticleId IdType="pubmed">30513824</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Exp Med. 2012 Dec 17;209(13):2395-408</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23209313</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Curr Opin Gastroenterol. 2014 Mar;30(2):154-62</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24457347</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Agric Food Chem. 2009 Jan 28;57(2):746-53</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19154169</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS One. 2014 Dec 15;9(12):e114361</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25501681</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Gastroenterology. 2014 Nov;147(5):1012-20.e4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25083606</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Sci Transl Med. 2010 Jul 21;2(41):41ra51</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20650871</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Appl Environ Microbiol. 2007 Jul;73(14):4469-76</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17496130</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Agric Food Chem. 2017 May 31;65(21):4321-4328</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28502176</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>FEMS Yeast Res. 2002 Aug;2(3):295-305</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12702279</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Agric Food Chem. 2001 May;49(5):2254-61</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11368585</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Dig Dis. 2015;33(2):260-3</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25925932</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Gastroenterology. 2017 Apr;152(5):1100-1113.e12</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27993525</ArticleId>
</ArticleIdList>
</Reference>
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