The influence of phytoestrogens on different physiological and pathological processes: An overview.
Identifieur interne : 000073 ( Main/Corpus ); précédent : 000072; suivant : 000074The influence of phytoestrogens on different physiological and pathological processes: An overview.
Auteurs : Jéssica C P. Petrine ; Bruno Del Bianco-BorgesSource :
- Phytotherapy research : PTR [ 1099-1573 ] ; 2020.
Abstract
Functional foods have nutritional properties and organic functions, which are beneficial to health. Certain types of functional food components are so-called phytoestrogens, non-steroidal compounds derived from the metabolism of precursors contained in plants, which originate secondary metabotypes known to induce biological responses and by mimicry or modulating the action of endogenous estrogen. These molecules are involved in several physiological and pathological processes related to reproduction, bone remodeling, skin, cardiovascular, nervous, immune systems, and metabolism. This review aimed to present an overview of phytoestrogens regarding their chemical structure, actions, and effects in the organism given several pathologies. Several studies have demonstrated beneficial phytoestrogen actions, such as lipid profile improvement, cognitive function, menopause, oxidative stress, among others. Phytoestrogens effects are not completely elucidated, being necessary future research to understand the exact action mechanisms, whether they are via estrogen receptor or whether other hidden mechanisms produce these effects. Thus, this review makes a general approach to the phytoestrogen actions, beneficial effects, risk and limitations. However, the complexities of biological effects after ingestion of phytoestrogens and the differences in their metabolism and bioavailability indicate that interpretation of either risk or benefits needs to be made with caution.
DOI: 10.1002/ptr.6816
PubMed: 32780464
Links to Exploration step
pubmed:32780464Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The influence of phytoestrogens on different physiological and pathological processes: An overview.</title>
<author><name sortKey="Petrine, Jessica C P" sort="Petrine, Jessica C P" uniqKey="Petrine J" first="Jéssica C P" last="Petrine">Jéssica C P. Petrine</name>
<affiliation><nlm:affiliation>Departamento de Ciências da Saúde, Universidade Federal de Lavras, Lavras, Brasil.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Del Bianco Borges, Bruno" sort="Del Bianco Borges, Bruno" uniqKey="Del Bianco Borges B" first="Bruno" last="Del Bianco-Borges">Bruno Del Bianco-Borges</name>
<affiliation><nlm:affiliation>Departamento de Ciências da Saúde, Universidade Federal de Lavras, Lavras, Brasil.</nlm:affiliation>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2020">2020</date>
<idno type="RBID">pubmed:32780464</idno>
<idno type="pmid">32780464</idno>
<idno type="doi">10.1002/ptr.6816</idno>
<idno type="wicri:Area/Main/Corpus">000073</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000073</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">The influence of phytoestrogens on different physiological and pathological processes: An overview.</title>
<author><name sortKey="Petrine, Jessica C P" sort="Petrine, Jessica C P" uniqKey="Petrine J" first="Jéssica C P" last="Petrine">Jéssica C P. Petrine</name>
<affiliation><nlm:affiliation>Departamento de Ciências da Saúde, Universidade Federal de Lavras, Lavras, Brasil.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Del Bianco Borges, Bruno" sort="Del Bianco Borges, Bruno" uniqKey="Del Bianco Borges B" first="Bruno" last="Del Bianco-Borges">Bruno Del Bianco-Borges</name>
<affiliation><nlm:affiliation>Departamento de Ciências da Saúde, Universidade Federal de Lavras, Lavras, Brasil.</nlm:affiliation>
</affiliation>
</author>
</analytic>
<series><title level="j">Phytotherapy research : PTR</title>
<idno type="eISSN">1099-1573</idno>
<imprint><date when="2020" type="published">2020</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Functional foods have nutritional properties and organic functions, which are beneficial to health. Certain types of functional food components are so-called phytoestrogens, non-steroidal compounds derived from the metabolism of precursors contained in plants, which originate secondary metabotypes known to induce biological responses and by mimicry or modulating the action of endogenous estrogen. These molecules are involved in several physiological and pathological processes related to reproduction, bone remodeling, skin, cardiovascular, nervous, immune systems, and metabolism. This review aimed to present an overview of phytoestrogens regarding their chemical structure, actions, and effects in the organism given several pathologies. Several studies have demonstrated beneficial phytoestrogen actions, such as lipid profile improvement, cognitive function, menopause, oxidative stress, among others. Phytoestrogens effects are not completely elucidated, being necessary future research to understand the exact action mechanisms, whether they are via estrogen receptor or whether other hidden mechanisms produce these effects. Thus, this review makes a general approach to the phytoestrogen actions, beneficial effects, risk and limitations. However, the complexities of biological effects after ingestion of phytoestrogens and the differences in their metabolism and bioavailability indicate that interpretation of either risk or benefits needs to be made with caution.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">32780464</PMID>
<DateRevised><Year>2020</Year>
<Month>08</Month>
<Day>11</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1099-1573</ISSN>
<JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year>
<Month>Aug</Month>
<Day>11</Day>
</PubDate>
</JournalIssue>
<Title>Phytotherapy research : PTR</Title>
<ISOAbbreviation>Phytother Res</ISOAbbreviation>
</Journal>
<ArticleTitle>The influence of phytoestrogens on different physiological and pathological processes: An overview.</ArticleTitle>
<ELocationID EIdType="doi" ValidYN="Y">10.1002/ptr.6816</ELocationID>
<Abstract><AbstractText>Functional foods have nutritional properties and organic functions, which are beneficial to health. Certain types of functional food components are so-called phytoestrogens, non-steroidal compounds derived from the metabolism of precursors contained in plants, which originate secondary metabotypes known to induce biological responses and by mimicry or modulating the action of endogenous estrogen. These molecules are involved in several physiological and pathological processes related to reproduction, bone remodeling, skin, cardiovascular, nervous, immune systems, and metabolism. This review aimed to present an overview of phytoestrogens regarding their chemical structure, actions, and effects in the organism given several pathologies. Several studies have demonstrated beneficial phytoestrogen actions, such as lipid profile improvement, cognitive function, menopause, oxidative stress, among others. Phytoestrogens effects are not completely elucidated, being necessary future research to understand the exact action mechanisms, whether they are via estrogen receptor or whether other hidden mechanisms produce these effects. Thus, this review makes a general approach to the phytoestrogen actions, beneficial effects, risk and limitations. However, the complexities of biological effects after ingestion of phytoestrogens and the differences in their metabolism and bioavailability indicate that interpretation of either risk or benefits needs to be made with caution.</AbstractText>
<CopyrightInformation>© 2020 John Wiley & Sons Ltd.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Petrine</LastName>
<ForeName>Jéssica C P</ForeName>
<Initials>JCP</Initials>
<AffiliationInfo><Affiliation>Departamento de Ciências da Saúde, Universidade Federal de Lavras, Lavras, Brasil.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Del Bianco-Borges</LastName>
<ForeName>Bruno</ForeName>
<Initials>B</Initials>
<Identifier Source="ORCID">https://orcid.org/0000-0002-2620-0081</Identifier>
<AffiliationInfo><Affiliation>Departamento de Ciências da Saúde, Universidade Federal de Lavras, Lavras, Brasil.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>13539</GrantID>
<Agency>Fundação de Amparo à Pesquisa do Estado de Minas Gerais</Agency>
<Country></Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D016454">Review</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2020</Year>
<Month>08</Month>
<Day>11</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Phytother Res</MedlineTA>
<NlmUniqueID>8904486</NlmUniqueID>
<ISSNLinking>0951-418X</ISSNLinking>
</MedlineJournalInfo>
<CitationSubset>IM</CitationSubset>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">functional foods</Keyword>
<Keyword MajorTopicYN="N">gut microbiome</Keyword>
<Keyword MajorTopicYN="N">menopause</Keyword>
<Keyword MajorTopicYN="N">osteoprotection</Keyword>
<Keyword MajorTopicYN="N">oxidative stress</Keyword>
<Keyword MajorTopicYN="N">phytoestrogen</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year>
<Month>01</Month>
<Day>21</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2020</Year>
<Month>06</Month>
<Day>01</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2020</Year>
<Month>07</Month>
<Day>02</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2020</Year>
<Month>8</Month>
<Day>12</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2020</Year>
<Month>8</Month>
<Day>12</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2020</Year>
<Month>8</Month>
<Day>12</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>aheadofprint</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">32780464</ArticleId>
<ArticleId IdType="doi">10.1002/ptr.6816</ArticleId>
</ArticleIdList>
<ReferenceList><Title>REFERENCE</Title>
<Reference><Citation>Adams, N. R. (1995). Detection of the effects of phytoestrogens on sheep and cattle. Journal of Animal Science, 73(5), 1509-1515. https://doi.org/10.2527/1995.7351509x</Citation>
</Reference>
<Reference><Citation>Adgent, M. A., Umbach, D. M., Zemel, B. S., Kelly, A., Schall, J. I., Ford, E. G., … Stallings, V. A. (2018). A longitudinal study of estrogen-responsive tissues and hormone concentrations in infants fed soy formula. Journal of Clinical Endocrinology and Metabolism, 103(5), 1899-1909. https://doi.org/10.1210/jc.2017-02249</Citation>
</Reference>
<Reference><Citation>Ali, S., & Coombes, R. C. (2000). Estrogen receptor alpha in human breast cancer: Occurrence and significance. Journal of Mammary Gland Biology and Neoplasia, 5(3), 271-281. https://doi.org/10.1023/A:1009594727358</Citation>
</Reference>
<Reference><Citation>Alwerdt, J., Valdés, E. G., Chanti-Ketterl, M., Small, B. J., & Edwards, J. D. (2016). The relationship between phytoestrogens and speed of processing. Menopause, 23(8), 911-918. https://doi.org/10.1097/GME.0000000000000632</Citation>
</Reference>
<Reference><Citation>Andres, S., Abraham, K., Appel, K. E., & Lampen, A. (2011). Risks and benefits of dietary isoflavones for cancer. Critical Reviews in Toxicology, 41(6), 463-506. https://doi.org/10.3109/10408444.2010.541900</Citation>
</Reference>
<Reference><Citation>Archer, D. F. (2010). Efficacy and tolerability of local estrogen therapy for urogenital atrophy. Menopause, 17(1), 194-203. https://doi.org/10.1097/gme.0b013e3181a95581</Citation>
</Reference>
<Reference><Citation>Ariyani, W., Miyazaki, W., & Koibuchi, N. (2019). A novel mechanism of s-equol action in neurons and astrocytes: The possible involvement of gpr30/gper1. International Journal of Molecular Sciences, 20(20), 1-14. https://doi.org/10.3390/ijms20205178</Citation>
</Reference>
<Reference><Citation>Aso, T., Uchiyama, S., Matsumura, Y., Taguchi, M., Nozaki, M., Takamatsu, K., … Ohta, H. (2012). A natural S -Equol supplement alleviates hot flushes and other menopausal symptoms in Equol nonproducing postmenopausal Japanese women. Journal of Women's Health, 21(1), 92-100. https://doi.org/10.1089/jwh.2011.2753</Citation>
</Reference>
<Reference><Citation>Baber, R. (2010). Phytoestrogens and post reproductive health. Maturitas, 66(4), 344-349. https://doi.org/10.1016/j.maturitas.2010.03.023</Citation>
</Reference>
<Reference><Citation>Bagheri, M., Roghani, M., Joghataei, M. T., & Mohseni, S. (2012). Genistein inhibits aggregation of exogenous amyloid-beta 1-40 and alleviates astrogliosis in the hippocampus of rats. Brain Research, 1429, 145-154. https://doi.org/10.1016/j.brainres.2011.10.020</Citation>
</Reference>
<Reference><Citation>Barker, D. (2019). Lignans. Molecules, 24(7), 2-5. https://doi.org/10.3390/molecules24071424</Citation>
</Reference>
<Reference><Citation>Barton, M., Filardo, E. J., Lolait, S. J., Thomas, P., Maggiolini, M., & Prossnitz, E. R. (2018). Historical and personal perspectives. Journal of Steroid Biochemistry and Molecular Biology, 176(2), 4-15. https://doi.org/10.1016/j.jsbmb.2017.03.021.Twenty</Citation>
</Reference>
<Reference><Citation>Bell, D. S. H., & Ovalle, F. (2001). Use of soy protein supplement and resultant need for increased dose of levothyroxine. Endocrine Practice, 7(3), 193-194. https://doi.org/10.4158/EP.7.3.193</Citation>
</Reference>
<Reference><Citation>Benassayag, C., Ferre, F., & Perrot-Applanat, M. (2002). Phytoestrogens as modulators of steroid action in target cells. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 777, 233-248. https://doi.org/10.1016/S1570-0232(02)00340-9</Citation>
</Reference>
<Reference><Citation>Bennetau-Pelissero, C. (2016). Risks and benefits of phytoestrogens: Where are we now. Current Opinion in Clinical Nutrition and Metabolic Care, 19(6), 477-483. https://doi.org/10.1097/MCO.0000000000000326</Citation>
</Reference>
<Reference><Citation>Berent-Spillson, A., Persad, C. C., Love, T., Sowers, M. F., Randolph, J. F., Zubieta, J. K., & Smith, Y. R. (2012). Hormonal environment affects cognition independent of age during the menopause transition. Journal of Clinical Endocrinology and Metabolism, 97(9), E1686-E1694. https://doi.org/10.1210/jc.2012-1365</Citation>
</Reference>
<Reference><Citation>Bhathena, S. J., & Velasquez, M. T. (2002). Beneficial role of dietary phytoestrogens in obesity and diabetes. American Journal of Clinical Nutrition, 76, 1191-1201. https://doi.org/10.1093/ajcn/76.6.1191</Citation>
</Reference>
<Reference><Citation>Boué, S. M., Burow, M. E., Wiese, T. E., Shih, B. Y., Elliott, S., Carter-Wientjes, C. H., … Bhatnagar, D. (2011). Estrogenic and antiestrogenic activities of phytoalexins from red kidney bean (Phaseolus vulgaris L.). Journal of Agricultural and Food Chemistry, 59(1), 112-120. https://doi.org/10.1021/jf102255u</Citation>
</Reference>
<Reference><Citation>Boulbaroud, S., Mesfioui, A., Arfaoui, A., Ouichou, A., & el Hessni, A. (2008). Preventive effects of flaxseed and sesame oil on bone loss in ovariectomized rats. Pakistan Journal of Biological Sciences, 11(13), 1696-1701. https://doi.org/10.3923/pjbs.2008.1696.1701</Citation>
</Reference>
<Reference><Citation>Branham, W. S., Dial, S. L., Moland, C. L., Hass, B. S., Blair, R. M., Fang, H., … Sheehan, D. M. (2002). Phytoestrogens and Mycoestrogens bind to the rat uterine estrogen receptor. The Journal of Nutrition, 132(4), 658-664. https://doi.org/10.1093/jn/132.4.658</Citation>
</Reference>
<Reference><Citation>Brinton, R. D. (2004). Impact of estrogen therapy on Alzheimer's disease: A fork in the road? CNS Drugs, 18(7), 405-422. https://doi.org/10.2165/00023210-200418070-00001</Citation>
</Reference>
<Reference><Citation>Butler, M. C., Long, C. N., Kinkade, J. A., Green, M. T., Martin, R. E., Marshall, B. L., … Rosenfeld, C. S. (2020). Endocrine disruption of gene expression and microRNA profiles in hippocampus and hypothalamus of California mice: Association of gene expression changes with behavioural outcomes. Journal of Neuroendocrinology, 32, 1-22. https://doi.org/10.1111/jne.12847</Citation>
</Reference>
<Reference><Citation>Çalışkan, G., Raza, S. A., Demiray, Y. E., Kul, E., Sandhu, K. V., & Stork, O. (2019). Depletion of dietary phytoestrogens reduces hippocampal plasticity and contextual fear memory stability in adult male mouse. Nutritional Neuroscience, 8305, 1-12. https://doi.org/10.1080/1028415X.2019.1698826</Citation>
</Reference>
<Reference><Citation>Cano, A., García-Pérez, M. Á., & Tarín, J. J. (2010). Isoflavones and cardiovascular disease. Maturitas, 67, 219-226. https://doi.org/10.1016/j.maturitas.2010.07.015</Citation>
</Reference>
<Reference><Citation>Carreau, C., Flouriot, G., Bennetau-Pelissero, C., & Potier, M. (2009). Respective contribution exerted by AF-1 and AF-2 transactivation functions in estrogen receptor α induced transcriptional activity by isoflavones and equol: Consequence on breast cancer cell proliferation. Molecular Nutrition and Food Research, 53(5), 652-658. https://doi.org/10.1002/mnfr.200800061</Citation>
</Reference>
<Reference><Citation>Castelló-Ruiz, M., Torregrosa, G., Burguete, M. C., Salom, J. B., Gil, J. V., Miranda, F. J., … Alborch, E. (2011). Soy-derived phytoestrogens as preventive and acute neuroprotectors in experimental ischemic stroke: Influence of rat strain. Phytomedicine, 18(6), 513-515. https://doi.org/10.1016/j.phymed.2011.02.001</Citation>
</Reference>
<Reference><Citation>Chen, F.-P., Chang, C. J., Chao, A-S., Huang, H.-Y., Huang, J-P., Wu, M-H., … Tsai, Y-C. (2016). Efficacy of Femarelle for the treatment of climacteric syndrome in postmenopausal women: An open label trial. Taiwanese Journal of Obstetrics and Gynecology, 55(3), 336-340. http://dx.doi.org/10.1016/j.tjog.2016.04.008.</Citation>
</Reference>
<Reference><Citation>Chen, M. N., Lin, C. C., & Liu, C. F. (2015). Efficacy of phytoestrogens for menopausal symptoms: A meta-analysis and systematic review. Climacteric, 18(2), 260-269. https://doi.org/10.3109/13697137.2014.966241</Citation>
</Reference>
<Reference><Citation>Chen, Y., Tang, Y-M., Yu, S.-L., Han, Y-W., Kou, J.-P., Liu B.-L., Yu, B.-Y. (2015). Advances in the pharmacological activities and mechanisms of diosgenin. Chinese Journal of Natural Medicines, 13(8), 578-587. http://dx.doi.org/10.1016/s1875-5364(15)30053-4.</Citation>
</Reference>
<Reference><Citation>Choi, E. J., & Lee, B. H. (2004). Evidence for genistein mediated cytotoxicity and apoptosis in rat brain. Life Sciences, 75(4), 499-509. https://doi.org/10.1016/j.lfs.2004.01.010</Citation>
</Reference>
<Reference><Citation>Choi, E. Y., Jin, J. Y., Lee, J. Y., Choi, J. I., Choi, I. S., & Kim, S. J. (2012). Anti-inflammatory effects and the underlying mechanisms of action of daidzein in murine macrophages stimulated with Prevotella intermedia lipopolysaccharide. Journal of Periodontal Research, 47(2), 204-211. https://doi.org/10.1111/j.1600-0765.2011.01422.x</Citation>
</Reference>
<Reference><Citation>Coldham, N. G., & Sauer, M. J. (2000). Pharmacokinetics of [14C]genistein in the rat: Gender-related differences, potential mechanisms of biological action, and implications for human health. Toxicology and Applied Pharmacology, 164(2), 206-215. https://doi.org/10.1006/taap.2000.8902</Citation>
</Reference>
<Reference><Citation>Conrad, S. C., Chiu, H., & Silverman, B. L. (2004). Soy formula complicates management of congenital hypothyroidism. Archives of Disease in Childhood, 89, 37-40. https://doi.org/10.1136/adc.2002.009365</Citation>
</Reference>
<Reference><Citation>Constantine, G., Millheiser, L. S., Kaunitz, A. M., Parish, S. J., Graham, S., Bernick, B., Mirkin, S. (2019). Early onset of action with a 17β-estradiol, softgel, vaginal insert for treating vulvar and vaginal atrophy and moderate to severe dyspareunia. Menopause, 26, (11), 1259-1264. http://dx.doi.org/10.1097/gme.0000000000001394.</Citation>
</Reference>
<Reference><Citation>Sotoca Covaleda, A. M., van den Berg, H., Vervoort, J., van der Saag, P., Ström, A., Gustafsson, J.-Å., …, Murk, A. J. (2008). Influence of Cellular ERα/ERβ Ratio on the ERα-Agonist Induced Proliferation of Human T47D Breast Cancer Cells. Toxicological Sciences, 105(2), 303-311. http://dx.doi.org/10.1093/toxsci/kfn141.</Citation>
</Reference>
<Reference><Citation>Cramer, H., Lauche, R., Langhorst, J., & Dobos, G. (2012). Effectiveness of yoga for menopausal symptoms: A systematic review and meta-analysis of randomized controlled trials. Evidence-Based Complementary and Alternative Medicine, 2012, 1-11. https://doi.org/10.1155/2012/863905</Citation>
</Reference>
<Reference><Citation>Csaba, G. (2018). Effect of endocrine disruptor phytoestrogens on the immune system: Present and future. Acta Microbiologica et Immunologica Hungarica, 65(1), 1-14. https://doi.org/10.1556/030.65.2018.018</Citation>
</Reference>
<Reference><Citation>Daniel, J. M. (2013). Estrogens, estrogen receptors, and female cognitive aging: The impact of timing. Hormones and Behavior, 63, 231-237. https://doi.org/10.1016/j.yhbeh.2012.05.003</Citation>
</Reference>
<Reference><Citation>Day, A. J., Cañada, F. J., Dı́az, J. C., Kroon, P. A., Mclauchlan, R., Faulds, C. B., … Williamson, G. (2000). Dietary flavonoid and isoflavone glycosides are hydrolysed by the lactase site of lactase phlorizin hydrolase. FEBS Letters, 468(2-3), 166-170. https://doi.org/10.1016/S0014-5793(00)01211-4</Citation>
</Reference>
<Reference><Citation>Dey, P., Barros, R. P. A., Warner, M., Ström, A., & Gustafsson, J. Å. (2013). Insight into the mechanisms of action of estrogen receptor β in the breast, prostate, colon, and CNS. Journal of Molecular Endocrinology, 51(3), T61-T74. https://doi.org/10.1530/JME-13-0150</Citation>
</Reference>
<Reference><Citation>Diel, P., Smolnikar, K., Schulz, T., Laudenbach-Leschowski, U., Michna, H., & Vollmer, G.̈. (2001). Phytoestrogens and carcinogensis - differential effects of genistein in experimental models of normal and malignant rat endometrium. Human Reproduction, 16(5), 997-1006. https://doi.org/10.1093/humrep/16.5.997</Citation>
</Reference>
<Reference><Citation>Dixon, R. A. (2004). PHYTOESTROGENS. Annual Review of Plant Biology, 55, 225-261. https://doi.org/10.1146/annurev.arplant.55.031903.141729</Citation>
</Reference>
<Reference><Citation>Djiogue, S., Halabalaki, M., Njamen, D., Kretzschmar, G., Lambrinidis, G., Hoepping, J., … Vollmer, G. (2014). Erythroidine alkaloids: A novel class of phytoestrogens. Planta Medica, 80(11), 861-869. https://doi.org/10.1055/s-0034-1382861</Citation>
</Reference>
<Reference><Citation>Do, S. H., Lee, J. W., Jeong, W. I., Chung, J. Y., Park, S. J., Hong, I. H., … Jeong, K. S. (2008). Bone-protecting effect of Rubus coreanus by dual regulation of osteoblasts and osteoclasts. Menopause, 15(4), 676-683. https://doi.org/10.1097/gme.0b013e31815bb687</Citation>
</Reference>
<Reference><Citation>Doerge, D. R., & Chang, H. C. (2002). Inactivation of thyroid peroxidase by soy isoflavones, in vitro and in vivo. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 777, 269-279. https://doi.org/10.1016/S1570-0232(02)00214-3</Citation>
</Reference>
<Reference><Citation>Du, M., Yang X., Hartman J. A., Cooke P. S., Doerge D. R., Ju Y. H., Helferich W. G. (2012). Low-dose dietary genistein negates the therapeutic effect of tamoxifen in athymic nude mice. Carcinogenesis, 33, (4), 895-901. http://dx.doi.org/10.1093/carcin/bgs017.</Citation>
</Reference>
<Reference><Citation>Elsenbrand, G. (2007). Isoflavones as phytoestrogens in food supplements and dietary foods for special medical purposes. Molecular Nutrition and Food Research, 51(10), 1305-1312. https://doi.org/10.1002/mnfr.200700217</Citation>
</Reference>
<Reference><Citation>Enmark, E., Pelto-Huikko, M., Grandien, K., Lagercrantz, S., Lagercrantz, J., Fried, G., … Gustafsson, J. Å. (1997). Human estrogen receptor β-gene structure, chromosomal localization, and expression pattern. Journal of Clinical Endocrinology and Metabolism, 82(12), 4258-4265. https://doi.org/10.1210/jcem.82.12.4470</Citation>
</Reference>
<Reference><Citation>Fang, K., Dong, H., Wang, D., Gong, J., Huang, W., & Lu, F. (2016). Soy isoflavones and glucose metabolism in menopausal women: A systematic review and meta-analysis of randomized controlled trials. Molecular Nutrition and Food Research, 60(7), 1602-1614. https://doi.org/10.1002/mnfr.201501024</Citation>
</Reference>
<Reference><Citation>Fritz, H., Seely, D., Flower, G., Skidmore, B., Fernandes, R., Vadeboncoeur, S., … Fergusson, D. (2013). Soy, red clover, and isoflavones and breast cancer: A systematic review. PLoS One, 8, e81968. https://doi.org/10.1371/journal.pone.0081968</Citation>
</Reference>
<Reference><Citation>Fruzza, A. G., Demeterco-Berggren, C., & Jones, K. L. (2012). Unawareness of the effects of soy intake on the Management of Congenital Hypothyroidism. Pediatrics, 130(3), e699-e702. https://doi.org/10.1542/peds.2011-3350</Citation>
</Reference>
<Reference><Citation>Galsworthy, T. D. (1994). Osteoporosis: Statistics, intervention, and prevention. Annals of the new York Academy of Sciences, 30(736), 158-164. https://doi.org/10.1111/j.1749-6632.1994.tb12828.x</Citation>
</Reference>
<Reference><Citation>Gao, M., Chen, L., Yu, H., Sun, Q., Kou, J., & Yu, B. (2013). Diosgenin down-regulates NF-κB p65/p50 and p38MAPK pathways and attenuates acute lung injury induced by lipopolysaccharide in mice. International Immunopharmacology, 15(2), 240-245. https://doi.org/10.1016/j.intimp.2012.11.019</Citation>
</Reference>
<Reference><Citation>Gass, M. L. S., Manson, J. E., Cosman, F., Grodstein, F., Craig, J. V., Karas, R. H., … Utian, W. H. (2012). The 2012 Hormone Therapy Position Statement of The North American Menopause Society. Menopause: The Journal of The North American Menopause Society, 19(3), 257-271. http://dx.doi.org/10.1097/gme.0b013e31824b970a.</Citation>
</Reference>
<Reference><Citation>González Cañete, N., & Durán Agüero, S. (2014). Soya isoflavones and evidences on cardiovascular protection. Nutricion Hospitalaria, 29(6), 1271-1282. https://doi.org/10.3305/nh.2014.29.6.7047</Citation>
</Reference>
<Reference><Citation>Gorodeski, G. I. (1994). Impact of the menopause on the epidemiology and risk factors of coronary artery heart disease in women. Experimental Gerontology, 29(3-4), 357-375. https://doi.org/10.1016/0531-5565(94)90017-5</Citation>
</Reference>
<Reference><Citation>Granado-Lorencio, F., & Hernández-Alvarez, E. (2016). Functional foods and health effects: A nutritional biochemistry perspective. Current Medicinal Chemistry, 23(26), 2929-2957. https://doi.org/10.2174/0929867323666160615105746</Citation>
</Reference>
<Reference><Citation>Greendale, G. A., Huang, M. H., Leung, K., Crawford, S. L., Gold, E. B., Wight, R., … Karlamangla, A. S. (2012). Dietary phytoestrogen intakes and cognitive function during the menopausal transition: Results from the study of Women's health across the nation phytoestrogen study. Menopause, 19(8), 894-903. https://doi.org/10.1097/gme.0b013e318242a654</Citation>
</Reference>
<Reference><Citation>Greendale, G. A., Tseng, C. H., Han, W., Huang, M. H., Leung, K., Crawford, S., … Karlamangla, A. S. (2015). Dietary isoflavones and bone mineral density during midlife and the menopausal transition: Cross-sectional and longitudinal results from the study of Women's health across the nation phytoestrogen study. Menopause, 22(3), 279-288. https://doi.org/10.1097/GME.0000000000000305</Citation>
</Reference>
<Reference><Citation>Harris, H. A. (2007). Estrogen receptor-β: Recent lessons from in vivo studies. Molecular Endocrinology, 21(1), 1-13. https://doi.org/10.1210/me.2005-0459</Citation>
</Reference>
<Reference><Citation>Hazim, S., Curtis, P. J., Schär, M. Y., Ostertag, L. M., Kay, C. D., Minihane, A. M., & Cassidy, A. (2016). Acute benefits of the microbial-derived isoflavone metabolite equol on arterial stiffness in men prospectively recruited according to equol producer phenotype: A double-blind randomized controlled trial. American Journal of Clinical Nutrition, 103(3), 694-702. https://doi.org/10.3945/ajcn.115.125690</Citation>
</Reference>
<Reference><Citation>He, Z., Tian, Y., Zhang, X., Bing, B., Zhang, L., Wang, H., & Zhao, W. (2012). Anti-tumour and immunomodulating activities of diosgenin, a naturally occurring steroidal saponin. Natural Product Research, 26(23), 2243-2246. https://doi.org/10.1080/14786419.2011.648192</Citation>
</Reference>
<Reference><Citation>Hmamouchi, I., Allali, F., Khazzani, H., Bennani, L., Mansouri, L. E. L., Ichchou, L., … Hajjaj-Hassouni, N. (2009). Low bone mineral density is related to atherosclerosis in postmenopausal Moroccan women. BMC Public Health, 9(388), 1-18. https://doi.org/10.1186/1471-2458-9-388</Citation>
</Reference>
<Reference><Citation>Hofmann, P. J., Schomburg, L., & Köhrle, J. (2009). Interference of endocrine disrupters with thyroid hormone receptor-dependent transactivation. Toxicological Sciences, 110(1), 125-137. https://doi.org/10.1093/toxsci/kfp086</Citation>
</Reference>
<Reference><Citation>Hollman, P. C. H., & Katan, M. B. (1997). Absorption, metabolism and health effects of dietary flavonoids in man. Biomedicine and Pharmacotherapy, 51(8), 305-310. https://doi.org/10.1016/S0753-3322(97)88045-6</Citation>
</Reference>
<Reference><Citation>Howes, L. G., Howes, J. B., & Knight, D. C. (2006). Isoflavone therapy for menopausal flushes: A systematic review and meta-analysis. Maturitas, 55, 203-211. https://doi.org/10.1016/j.maturitas.2006.03.008</Citation>
</Reference>
<Reference><Citation>Hwang, K. A., & Choi, K. C. (2015). Anticarcinogenic effects of dietary phytoestrogens and their Chemopreventive mechanisms. Nutrition and Cancer, 67, 796-803. https://doi.org/10.1080/01635581.2015.1040516</Citation>
</Reference>
<Reference><Citation>Isidoro, B., Lope, V., Whelan, D., Pedraz, C., Sánchez-Contador, C., Santamariña, C., … Pollán, M. (2016). Use of hormone therapy and isoflavones and mammographic density in Spain. Menopause, 23(5), 556-564. https://doi.org/10.1097/GME.0000000000000569</Citation>
</Reference>
<Reference><Citation>Jargin, S. V. (2014). Soy and phytoestrogens: Possible side effects. GMS German Medical Science, 12, 1-5. https://doi.org/10.3205/000203</Citation>
</Reference>
<Reference><Citation>Jeong, E. J., Lee, H. K., Lee, K. Y., Jeon, B. J., Kim, D. H., Park, J.-H., …, Sung, S. H. (2013). The effects of lignan-riched extract of Shisandra chinensis on amyloid-β-induced cognitive impairment and neurotoxicity in the cortex and hippocampus of mouse. Journal of Ethnopharmacology, 146(1), 347-354. http://dx.doi.org/10.1016/j.jep.2013.01.003.</Citation>
</Reference>
<Reference><Citation>Jin, X., Wang, S., Zhao, X., Jin, Q., Fan, C., Li, J., … Teng, W. (2016). Coumestrol inhibits autoantibody production through modulating Th1 response in experimental autoimmune thyroiditis. Oncotarget, 7(33), 52797-52809. https://doi.org/10.18632/oncotarget.10353</Citation>
</Reference>
<Reference><Citation>Johnson, A., Roberts, L., & Elkins, G. (2019). Complementary and alternative medicine for menopause. Journal of Evidence-Based Integrative Medicine, 24, 1-14. https://doi.org/10.1177/2515690X19829380</Citation>
</Reference>
<Reference><Citation>Jungbauer, A., & Medjakovic, S. (2014). Phytoestrogens and the metabolic syndrome. Journal of Steroid Biochemistry and Molecular Biology, 139, 277-289. https://doi.org/10.1016/j.jsbmb.2012.12.009</Citation>
</Reference>
<Reference><Citation>King, R. A., Broadbent, J. L., & Head, R. J. (1996). Absorption and excretion of the soy Isoflavone Genistein in rats. The Journal of Nutrition, 126(1), 176-182. https://doi.org/10.1093/jn/126.1.176</Citation>
</Reference>
<Reference><Citation>de Kleijn, M. J. J., van der Schouw, Y. T., Wilson, P. W. F., Grobbee, D. E., & Jacques, P. F. (2002). Dietary intake of phytoestrogens is associated with a favorable metabolic cardiovascular risk profile in postmenopausal U.S. women: The Framingham study. The Journal of Nutrition, 132(2), 276-282. https://doi.org/10.1093/jn/132.2.276</Citation>
</Reference>
<Reference><Citation>Kokubo, Y., Iso, H., Ishihara, J., Okada, K., Inoue, M., Tsugane, S., & JPHC Study Group. (2007). Association of dietary intake of soy, beans, and isoflavones with risk of cerebral and myocardial infarctions in Japanese populations: The Japan public health center-based (JPHC) study cohort I. Circulation, 116(22), 2553-2562. https://doi.org/10.1161/CIRCULATIONAHA.106.683755</Citation>
</Reference>
<Reference><Citation>Křížová, L., Dadáková, K., Kašparovská, J., & Kašparovský, T. (2019). Isoflavones. Molecules, 24(6), 1-62. https://doi.org/10.3390/molecules24061076</Citation>
</Reference>
<Reference><Citation>Ku, C. M., & Lin, J. Y. (2013). Anti-inflammatory effects of 27 selected terpenoid compounds tested through modulating Th1/Th2 cytokine secretion profiles using murine primary splenocytes. Food Chemistry, 141(2), 1104-1113. https://doi.org/10.1016/j.foodchem.2013.04.044</Citation>
</Reference>
<Reference><Citation>Kuiper, G. G., Enmark E., Pelto-Huikko M., Nilsson S., Gustafsson J. A. (1996). Cloning of a novel receptor expressed in rat prostate and ovary.. Proceedings of the National Academy of Sciences, 93(12), 5925-5930. http://dx.doi.org/10.1073/pnas.93.12.5925.</Citation>
</Reference>
<Reference><Citation>Kulkarni, J., Gavrilidis, E., Worsley, R., van Rheenen, T., & Hayes, E. (2013). The role of estrogen in the treatment of men with schizophrenia. International Journal of Endocrinology and Metabolism, 11(3), 129-136. https://doi.org/10.5812/ijem.6615</Citation>
</Reference>
<Reference><Citation>Landete, J. M., Arqués, J., Medina, M., Gaya, P., de Las Rivas, B., & Muñoz, R. (2016). Bioactivation of phytoestrogens: Intestinal Bacteria and health. Critical Reviews in Food Science and Nutrition, 56(11), 1826-1843. https://doi.org/10.1080/10408398.2013.789823</Citation>
</Reference>
<Reference><Citation>Langasco, R., Fancello, S., Rassu, G., Cossu, M., Cavalli, R., Galleri, G., … Gavini, E. (2019). Increasing protective activity of genistein by loading into transfersomes: A new potential adjuvant in the oxidative stress-related neurodegenerative diseases? Phytomedicine, 52, 23-31. https://doi.org/10.1016/j.phymed.2018.09.207</Citation>
</Reference>
<Reference><Citation>Lee, H.-R., Kim, T.-H., & Choi, K.-C. (2012). Functions and physiological roles of two types of estrogen receptors, ERα and ERβ, identified by estrogen receptor knockout mouse. Laboratory Animal Research, 28(2), 71-76. https://doi.org/10.5625/lar.2012.28.2.71</Citation>
</Reference>
<Reference><Citation>Lephart, E. D. (2016). Skin aging and oxidative stress: Equol's anti-aging effects via biochemical and molecular mechanisms. Ageing Research Reviews., 31, 36-54. https://doi.org/10.1016/j.arr.2016.08.001</Citation>
</Reference>
<Reference><Citation>Liang, H. W., Qiu, S. F., Shen, J., Sun, L. N., Wang, J. Y., Bruce, I. C., & Xia, Q. (2008). Genistein attenuates oxidative stress and neuronal damage following transient global cerebral ischemia in rat hippocampus. Neuroscience Letters, 438(1), 116-120. https://doi.org/10.1016/j.neulet.2008.04.058</Citation>
</Reference>
<Reference><Citation>Liu, B., Edgerton, S., Yang, X., Kim, A., Ordonez-Ercan, D., Mason, T., … Thor, A. (2005). Low-dose dietary phytoestrogen abrogates tamoxifen-associated mammary tumor prevention. Cancer Research, 65(3), 879-886.</Citation>
</Reference>
<Reference><Citation>Liu, X., Nam, J. W., Song, Y. S., Viswanath, A. N. I., Pae, A. N., Kil, Y. S., … Chang, M. (2014). Psoralidin, a coumestan analogue, as a novel potent estrogen receptor signaling molecule isolated from Psoralea corylifolia. Bioorganic and Medicinal Chemistry Letters, 24(5), 1403-1406. https://doi.org/10.1016/j.bmcl.2014.01.029</Citation>
</Reference>
<Reference><Citation>Lucas, E. A., Wild, R. D., Hammond, L. J., Khalil, D. A., Juma, S., Daggy, B. P., … Arjmandi, B. H. (2002). Flaxseed improves lipid profile without altering biomarkers of bone metabolism in postmenopausal women. Journal of Clinical Endocrinology and Metabolism, 87(4), 1527-1532. https://doi.org/10.1210/jcem.87.4.8374</Citation>
</Reference>
<Reference><Citation>Mali, A. V., Padhye, S. B., Anant, S., Hegde, M. V., & Kadam, S. S. (2019). Anticancer and antimetastatic potential of enterolactone: Clinical, preclinical and mechanistic perspectives. European Journal of Pharmacology, 852(December 2018), 107-124. https://doi.org/10.1016/j.ejphar.2019.02.022</Citation>
</Reference>
<Reference><Citation>The North American Menopause Society. (2013). Management of symptomatic vulvovaginal atrophy: 2013 position statement of the North American Menopause Society. Menopause, 20(9), 888-902. https://doi.org/10.1097/GME.0b013e3182a122c2</Citation>
</Reference>
<Reference><Citation>Manonai, J., Chittacharoen, A., Theppisai, U., & Theppisai, H. (2007). Effect of Pueraria mirifica on vaginal health. Menopause, 14(5), 919-924. https://doi.org/10.1097/gme.0b013e3180399486</Citation>
</Reference>
<Reference><Citation>Mao, X., Liao, Z., Guo, L., Xu, X., Wu, B., Xu, M., … Jia, Y. (2015). Schisandrin C ameliorates learning and memory deficits by Aβ1-42-induced oxidative stress and neurotoxicity in mice. Phytotherapy Research, 29(9), 1373-1380. https://doi.org/10.1002/ptr.5390</Citation>
</Reference>
<Reference><Citation>Marchesi, J. R., Adams, D. H., Fava, F., Hermes, G. D. A., Hirschfield, G. M., Hold, G., … Hart, A. (2016). The gut microbiota and host health: A new clinical frontier. Gut, 65(2), 330-339. https://doi.org/10.1136/gutjnl-2015-309990</Citation>
</Reference>
<Reference><Citation>Marín, L., Miguélez, E. M., Villar, C. J., & Lombó, F. (2015). Bioavailability of dietary polyphenols and gut microbiota metabolism: Antimicrobial properties. BioMed Research International, 2015, 1-18. https://doi.org/10.1155/2015/905215</Citation>
</Reference>
<Reference><Citation>Marraudino, M., Farinetti, A., Arevalo, M. A., Gotti, S., Panzica, G. C., & Garcia-Segura, L. M. (2019). Sexually dimorphic effect of Genistein on hypothalamic neuronal differentiation in vitro. International Journal of Molecular Sciences, 20(10), 1-9. https://doi.org/10.3390/ijms20102465</Citation>
</Reference>
<Reference><Citation>Meng, H., Fu, G., Shen, J., Shen, K., Xu, Z., Wang, Y., …, Pan, H. (2017). Ameliorative Effect of Daidzein on Cisplatin-Induced Nephrotoxicity in Mice via Modulation of Inflammation, Oxidative Stress, and Cell Death. Oxidative Medicine and Cellular Longevity, 2017, 1-10. http://dx.doi.org/10.1155/2017/3140680.</Citation>
</Reference>
<Reference><Citation>Mense, S. M., Hei, T. K., Ganju, R. K., & Bhat, H. K. (2008). Phytoestrogens and breast cancer prevention: Possible mechanisms of action. Environmental Health Perspectives, 116(4), 426-433. https://doi.org/10.1289/ehp.10538</Citation>
</Reference>
<Reference><Citation>Messina, M. (2016). Soy and health update: Evaluation of the clinical and epidemiologic literature. Nutrients, 8(12), 1-42. https://doi.org/10.3390/nu8120754</Citation>
</Reference>
<Reference><Citation>Miao, Z.-Y., Xia, X., Che, L., Song, Y.-T. (2018). Genistein attenuates brain damage induced by transient cerebral ischemia through up-regulation of Nrf2 expression in ovariectomized rats. Neurological Research, 40(8), 1-7. http://dx.doi.org/10.1080/01616412.2018.1462879.</Citation>
</Reference>
<Reference><Citation>Miyauchi, Y., Sato, Y., Kobayashi, T., Yoshida, S., Mori, T., Kanagawa, H., … Miyamoto, T. (2013). HIF1 is required for osteoclast activation by estrogen deficiency in postmenopausal osteoporosis. Proceedings of the National Academy of Sciences, 110(41), 16568-16573. https://doi.org/10.1073/pnas.1308755110</Citation>
</Reference>
<Reference><Citation>Molina, L., Bustamante, F. A., Bhoola, K. D., Figueroa, C. D., & Ehrenfeld, P. (2018). Possible role of phytoestrogens in breast cancer via GPER-1/GPR30 signaling. Clinical Science, 132(24), 2583-2598. https://doi.org/10.1042/CS20180885</Citation>
</Reference>
<Reference><Citation>Monteleone, P., Mascagni, G., Giannini, A., Genazzani, A. R., & Simoncini, T. (2018). Symptoms of menopause - global prevalence, physiology and implications. Nature Reviews Endocrinology., 14(4), 199-215. https://doi.org/10.1038/nrendo.2017.180</Citation>
</Reference>
<Reference><Citation>Morán, J., Garrido, P., Alonso, A., Cabello, E., & González, C. (2013). 17β-estradiol and genistein acute treatments improve some cerebral cortex homeostasis aspects deteriorated by aging in female rats. Experimental Gerontology, 48(4), 414-421. https://doi.org/10.1016/j.exger.2013.02.010</Citation>
</Reference>
<Reference><Citation>Morrison, J. H., Brinton, R. D., Schmidt, P. J., & Gore, A. C. (2006). Estrogen, menopause, and the aging brain: How basic neuroscience can inform hormone therapy in women. Journal of Neuroscience, 26(41), 10332-10348. https://doi.org/10.1523/jneurosci.3369-06.2006</Citation>
</Reference>
<Reference><Citation>Mukhopadhyay, P., Pan, H., Rajesh, M., Bátkai, S., Patel, V., Harvey-White, J., … Pacher, P. (2010). CB 1 cannabinoid receptors promote oxidative/nitrosative stress, inflammation and cell death in a murine nephropathy model. British Journal of Pharmacology, 160(3), 657-668. https://doi.org/10.1111/j.1476-5381.2010.00769.x</Citation>
</Reference>
<Reference><Citation>Murota, K., Nakamura, Y., & Uehara, M. (2018). Flavonoid metabolism: The interaction of metabolites and gut microbiota. Bioscience, Biotechnology and Biochemistry, 82(4), 600-610. https://doi.org/10.1080/09168451.2018.1444467</Citation>
</Reference>
<Reference><Citation>Nagata, C. (2000). Ecological study of the association between soy product intake and mortality from cancer and heart disease in Japan. International Journal of Epidemiology, 29(5), 832-836. https://doi.org/10.1093/ije/29.5.832</Citation>
</Reference>
<Reference><Citation>Najaf Najafi, M., & Ghazanfarpour, M. (2018). Effect of phytoestrogens on sexual function in menopausal women: A systematic review and meta-analysis. Climacteric, 21(5), 437-445. https://doi.org/10.1080/13697137.2018.1472566</Citation>
</Reference>
<Reference><Citation>Narukawa, M. (2018). Physiological responses to taste signals of functional food components. Bioscience, Biotechnology and Biochemistry, 82(2), 200-206. https://doi.org/10.1080/09168451.2017.1422385</Citation>
</Reference>
<Reference><Citation>National Toxicology Program| (Ed.). (2008). Toxicology and carcinogenesis studies of genistein (Cas no. 446-72-0) in Sprague-Dawley rats (feed study). National Toxicology Program Technical Report Series, 545, 1-240.</Citation>
</Reference>
<Reference><Citation>Ndebele, K., Graham, B., & Tchounwou, P. B. (2010). Estrogenic activity of coumestrol, DDT, and TCDD in human cervical cancer cells. International Journal of Environmental Research and Public Health, 7(5), 2045-2056. https://doi.org/10.3390/ijerph7052045</Citation>
</Reference>
<Reference><Citation>Neese, S. L., Korol, D. L., Katzenellenbogen, J. A., & Schantz, S. L. (2010). Impact of estrogen receptor alpha and beta agonists on delayed alternation in middle-aged rats. Hormones and Behavior, 58(5), 878-890. https://doi.org/10.1016/j.yhbeh.2010.08.017</Citation>
</Reference>
<Reference><Citation>Nooyens, A. C. J., Milder, I. E. J., van Gelder, B. M., Bueno-de-Mesquita, H. B., van Boxtel, M. P. J., & Verschuren, W. M. M. (2015). Diet and cognitive decline at middle age: The role of antioxidants. British Journal of Nutrition, 113(9), 1410-1417. https://doi.org/10.1017/S0007114515000720</Citation>
</Reference>
<Reference><Citation>Ogawara, H., Akiyama, T., & Ishida, J. (1986). A specific inhibitor for tyrosine protein kinase from pseudomonas. The Journal of Antibiotics, 39, 606-608. https://doi.org/10.7164/antibiotics.39.606</Citation>
</Reference>
<Reference><Citation>Oliveira, J. S., Silva, A. A. N., & Silva Junior, V. A. (2016). Phytotherapy in reducing glycemic index and testicular oxidative stress resulting from induced diabetes: A review. Brazilian Journal of Biology, 77(1), 68-78. https://doi.org/10.1590/1519-6984.09915</Citation>
</Reference>
<Reference><Citation>Oyama, A., Ueno, T., Uchiyama, S., Aihara, T., Miyake, A., Kondo, S., & Matsunaga, K. (2012). The effects of natural S-equol supplementation on skin aging in postmenopausal women: A pilot randomized placebo-controlled trial. Menopause, 19(2), 202-210. https://doi.org/10.1097/gme.0b013e318227427b</Citation>
</Reference>
<Reference><Citation>Park, J.-W., Kim, D.-H., Ahn, H.-N., Song, Y.-S., Lee, Y.-J., Ryu, J.-H. (2012). Activation of Estrogen Receptor by Bavachin from Psoralea corylifolia. Biomolecules and Therapeutics, 20(2), 183-188. http://dx.doi.org/10.4062/biomolther.2012.20.2.183.</Citation>
</Reference>
<Reference><Citation>Patade, A., Devareddy, L., Lucas, E. A., Korlagunta, K., Daggy, B. P., & Arjmandi, B. H. (2008). Flaxseed reduces Total and LDL cholesterol concentrations in native American postmenopausal women. Journal of Women's Health, 17(3), 356-366. https://doi.org/10.1089/jwh.2007.0359</Citation>
</Reference>
<Reference><Citation>Pearce, S. T., & Jordan, V. C. (2004). The biological role of estrogen receptors alpha and beta in cancer. Critical Reviews in Oncology/Hematology, 50(1), 3-22. https://doi.org/10.1016/j.critrevonc.2003.09.003</Citation>
</Reference>
<Reference><Citation>Pérez-Jiménez, J., & Saura-Calixto, F. (2015). Macromolecular antioxidants or non-extractable polyphenols in fruit and vegetables: Intake in four European countries. Food Research International, 74, 315-323. https://doi.org/10.1016/j.foodres.2015.05.007</Citation>
</Reference>
<Reference><Citation>Petersmann, A., Müller-Wieland, D., Müller, U. A., Landgraf, R., Nauck, M., Freckmann, G., … Schleicher, E. (2019). Definition, classification and diagnosis of diabetes mellitus. Experimental and Clinical Endocrinology & Diabetes, 127(Suppl 1), S1-S7. https://doi.org/10.1055/a-1018-9078</Citation>
</Reference>
<Reference><Citation>Peterson, T. G., Coward, L., Kirk, M., Falany, C. N., & Barnes, S. (1996). The role of metabolism in mammary epithelial cell growth inhibition by the isoflavones genistein and biochanin a. Carcinogenesis, 17(9), 1861-1869. https://doi.org/10.1093/carcin/17.9.1861</Citation>
</Reference>
<Reference><Citation>Peterson, T. G., Ji, G. P., Kirk, M., Coward, L., Falany, C. N., & Barnes, S. (1998). Metabolism of the isoflavones genistein and biochanin a in human breast cancer cell lines. American Journal of Clinical Nutrition, 68, 1505S-1511S. https://doi.org/10.1093/ajcn/68.6.1505S</Citation>
</Reference>
<Reference><Citation>Pitkin, J. (2012). Alternative and complementary therapies for the menopause. Menopause International, 18(1), 20-27. https://doi.org/10.1258/mi.2012.012001</Citation>
</Reference>
<Reference><Citation>Plessow, D., Waldschläger, J., Richter, D. U., Jeschke, U., Bruer, G., Briese, V., & Friese, K. (2003). Effects of phytoestrogens on the trophoblast tumour cell lines BeWo and Jeg3. Anticancer Research, 23(2A), 1081-1086.</Citation>
</Reference>
<Reference><Citation>Poluzzi, E., Piccinni, C., Raschi, E., Rampa, A., Recanatini, M., & Ponti, F. (2014). Phytoestrogens in Postmenopause: The state of the art from a chemical, pharmacological and regulatory perspective. Current Medicinal Chemistry, 21(4), 417-436. https://doi.org/10.2174/09298673113206660297</Citation>
</Reference>
<Reference><Citation>Ponti, G., Rodriguez-Gomez, A., Farinetti, A., Marraudino, M., Filice, F., Foglio, B., … Gotti, S. (2017). Early postnatal genistein administration permanently affects nitrergic and vasopressinergic systems in a sex-specific way. Neuroscience, 346, 203-215. https://doi.org/10.1016/j.neuroscience.2017.01.024</Citation>
</Reference>
<Reference><Citation>Ponti, G., Farinetti, A., Marraudino, M., Panzica, G. C., & Gotti, S. (2019). Postnatal genistein administration selectively abolishes sexual dimorphism in specific hypothalamic dopaminergic system in mice. Brain Research, 1724, 1-10. https://doi.org/10.1016/j.brainres.2019.146434</Citation>
</Reference>
<Reference><Citation>Potter, B., Schrager, S., Dalby, J., Torell, E., & Hampton, A. (2018). Primary care-Clinics in office practice. Menopause, 45(4), 625-641. https://doi.org/10.1016/j.pop.2018.08.001</Citation>
</Reference>
<Reference><Citation>Qin, H., Lin, Z., Vásquez, E., Luan, X., Guo, F., & Xu, L. (2019). High soy isoflavone or soy-based foods intake during infancy and in adulthood is associated with an increased risk of uterine fibroids in premenopausal women: A meta-analysis. Nutrition Research, 71, 30-42. https://doi.org/10.1016/j.nutres.2019.06.002</Citation>
</Reference>
<Reference><Citation>Quartieri, A., García-Villalba, R., Amaretti, A., Raimondi, S., Leonardi, A., Rossi, M., & Tomàs-Barberàn, F. (2016). Detection of novel metabolites of flaxseed lignans in vitro and in vivo. Molecular Nutrition and Food Research, 60(7), 1590-1601. https://doi.org/10.1002/mnfr.201500773</Citation>
</Reference>
<Reference><Citation>Renko, K., Schäche, S., Hoefig, C. S., Welsink, T., Schwiebert, C., Braun, D., … Schomburg, L. (2015). An improved nonradioactive screening method identifies Genistein and Xanthohumol as potent inhibitors of iodothyronine deiodinases. Thyroid, 25(8), 962-968. https://doi.org/10.1089/thy.2015.0058</Citation>
</Reference>
<Reference><Citation>Riccardi, G., Aggett, P., Brighenti, F., Delzenne, N., Frayn, K., Nieuwenhuizen, A., … Vessby, B. (2004). PASSCLAIM1?Body weight regulation, insulin sensitivity and diabetes risk. European Journal of Nutrition, 43, II/7-II/46. https://doi.org/10.1007/s00394-004-1202-7</Citation>
</Reference>
<Reference><Citation>Ricci, E., Cipriani, S., Chiaffarino, F., Malvezzi, M., & Parazzini, F. (2010). Effects of soy isoflavones and genistein on glucose metabolism in perimenopausal and postmenopausal non-Asian women: A meta-analysis of randomized controlled trials. Menopause, 17(5), 1080-1086. https://doi.org/10.1097/gme.0b013e3181dd05a9</Citation>
</Reference>
<Reference><Citation>Rietjens, I. M. C. M., Sotoca, A. M., Vervoort, J., & Louisse, J. (2013). Mechanisms underlying the dualistic mode of action of major soy isoflavones in relation to cell proliferation and cancer risks. Molecular Nutrition and Food Research, 57(1), 100-113. https://doi.org/10.1002/mnfr.201200439</Citation>
</Reference>
<Reference><Citation>Rietjens, I. M. C. M., Louisse, J., & Beekmann, K. (2017). The potential health effects of dietary phytoestrogens. British Journal of Pharmacology, 174(11), 1263-1280. https://doi.org/10.1111/bph.13622</Citation>
</Reference>
<Reference><Citation>Rodriguez-Gomez, A., Filice, F., Gotti, S., & Panzica, G. C. (2014). Perinatal exposure to genistein affects the normal development of anxiety and aggressive behaviors and nitric oxide system in CD1 male mice. Physiology & Behavior, 133, 107-114. https://doi.org/10.1016/j.physbeh.2014.05.020</Citation>
</Reference>
<Reference><Citation>Rosen, C. J., & Bouxsein, M. L. (2006). Mechanisms of disease: Is osteoporosis the obesity of bone? Nature Clinical Practice Rheumatology, 2, 35-43. https://doi.org/10.1038/ncprheum0070</Citation>
</Reference>
<Reference><Citation>Rossouw, J. E., Prentice, R. L., Manson, J. A. E., Wu, L. L., Barad, D., Barnabei, V. M., … Stefanick, M. L. (2007). Postmenopausal hormone therapy and risk of cardiovascular disease by age and years since menopause. Journal of the American Medical Association, 297(13), 1465-1477. https://doi.org/10.1001/jama.297.13.1465</Citation>
</Reference>
<Reference><Citation>Russo, G. I., di Mauro, M., Regis, F., Reale, G., Campisi, D., Marranzano, M., … Morgia, G. (2018). Association between dietary phytoestrogens intakes and prostate cancer risk in Sicily. The Aging Male, 21(1), 48-54. https://doi.org/10.1080/13685538.2017.1365834</Citation>
</Reference>
<Reference><Citation>Sacco, S. M., Jiang, J. M. Y., Reza-López, S., Ma, D. W. L., Thompson, L. U., & Ward, W. E. (2009). Flaxseed combined with low-dose estrogen therapy preserves bone tissue in ovariectomized rats. Menopause, 16(3), 545-554. https://doi.org/10.1097/gme.0b013e31818fc00a</Citation>
</Reference>
<Reference><Citation>Sahu, B. D., Kumar, J. M., & Sistla, R. (2015). Baicalein, a bioflavonoid, prevents cisplatin- induced acute kidney injury by up- regulating antioxidant defenses and down- regulating the MAPKs and NF-κB pathways. PLoS One, 10(7), 1-19. https://doi.org/10.1371/journal.pone.0134139</Citation>
</Reference>
<Reference><Citation>Sandhu, K. V., Demiray, Y. E., Yanagawa, Y., & Stork, O. (2020). Dietary phytoestrogens modulate aggression and activity in social behavior circuits of male mice. Hormones and Behavior, 119, 1-9. https://doi.org/10.1016/j.yhbeh.2019.104637</Citation>
</Reference>
<Reference><Citation>Santoro, N., & Komi, J. (2009). Prevalence and impact of vaginal symptoms among postmenopausal women. Journal of Sexual Medicine, 6(8), 2133-2142. https://doi.org/10.1111/j.1743-6109.2009.01335.x</Citation>
</Reference>
<Reference><Citation>Savoia, P., Raina, G., Camillo, L., Farruggio, S., Mary, D., Veronese, F., … Grossini, E. (2018). Anti-oxidative effects of 17 β-estradiol and genistein in human skin fibroblasts and keratinocytes. Journal of Dermatological Science, 92(1), 62-77. https://doi.org/10.1016/j.jdermsci.2018.07.007</Citation>
</Reference>
<Reference><Citation>Scherr, F. F., Sarmah, A. K., di, H. J., & Cameron, K. C. (2009). Degradation and metabolite formation of 17β-estradiol-3-sulphate in New Zealand pasture soils. Environment International, 35(2), 291-297. https://doi.org/10.1016/j.envint.2008.07.002</Citation>
</Reference>
<Reference><Citation>Schreihofer, D. A., & Ma, Y. (2013). Estrogen receptors and ischemic neuroprotection: Who, what, where, and when? Brain Research, 1514, 107-122. https://doi.org/10.1016/j.brainres.2013.02.051</Citation>
</Reference>
<Reference><Citation>Sen, T., & Samanta, S. K. (2014). Medicinal Plants, Human Health and Biodiversity: A Broad Review. Advances in Biochemical Engineering/Biotechnology, 147, 59-110. https://doi.org/10.1007/10_2014_273</Citation>
</Reference>
<Reference><Citation>Setchell, K. D. R. (1998). Phytoestrogens: The biochemistry, physiology, and implications for human health of soy isoflavones. American Journal of Clinical Nutrition, 68, 1333S-1346S. https://doi.org/10.1093/ajcn/68.6.1333S</Citation>
</Reference>
<Reference><Citation>Sfakianos, J., Coward, L., Kirk, M., & Barnes, S. (1997). Biochemical and molecular roles of nutrients intestinal uptake and biliary excretion of the Isoflavone Genistein in rats. The Journal of Nutrition, 127(7), 1260-1268. https://doi.org/10.1093/jn/127.7.1260</Citation>
</Reference>
<Reference><Citation>Shale, T. L., Stirk, W. A., & van Staden, J. (2005). Variation in antibacterial and anti-inflammatory activity of different growth forms of Malva parviflora and evidence for synergism of the anti-inflammatory compounds. Journal of Ethnopharmacology, 96(1-2), 325-330. https://doi.org/10.1016/j.jep.2004.09.032</Citation>
</Reference>
<Reference><Citation>Shike, M., Doane, A. S., Russo, L., Cabal, R., Reis-Filo, J., Gerald, W., … Norton, L. (2014). The effects of soy supplementation on gene expression in breast cancer: A randomized placebo-controlled study. Journal of the National Cancer Institute, 106(9), 1-12. https://doi.org/10.1093/jnci/dju189</Citation>
</Reference>
<Reference><Citation>Sierens, J., Hartley, J. A., Campbell, M. J., Leathem, A. J. C., & Woodside, J. V. (2001). Effect of phytoestrogen and antioxidant supplementation on oxidative DNA damage assessed using the comet assay. Mutation Research - DNA Repair, 485(2), 169-176. https://doi.org/10.1016/S0921-8777(00)00069-0</Citation>
</Reference>
<Reference><Citation>Simon, J. A., Kokot-Kierepa, M., Goldstein, J., & Nappi, R. E. (2013). Vaginal health in the United States: Results from the vaginal health: Insights, views & attitudes survey. Menopause, 20(10), 1043-1048. https://doi.org/10.1097/GME.0b013e318287342d</Citation>
</Reference>
<Reference><Citation>Sirotkin, A. V. H. A. H. (2014). Phytoestrogens and their effects. European Journal of Pharmacology, 741, 230-236. https://doi.org/10.1016/j.ejphar.2014.07.057</Citation>
</Reference>
<Reference><Citation>Sirtori, C. R., Arnoldi, A., & Johnson, S. K. (2005). Phytoestrogens: End of a tale? Annals of Medicine, 37(6), 423-438. https://doi.org/10.1080/07853890510044586</Citation>
</Reference>
<Reference><Citation>Small, B. J., Dixon, R. A., & McArdle, J. J. (2011). Tracking cognition-health changes from 55 to 95 years of age. The Journals of Gerontology Series B: Psychological Sciences and Social Sciences, 66B(S1), iI53-iI61. https://doi.org/10.1093/geronb/gbq093</Citation>
</Reference>
<Reference><Citation>Soni, M., Rahardjo, T. B. W., Soekardi, R., Sulistyowati, Y., Lestariningsih, , Y.-U., A., …, Hogervorst, E. (2014). Phytoestrogens and cognitive function: a review. Maturitas, 77(3), 209-220. http://dx.doi.org/10.1016/j.maturitas.2013.12.010.</Citation>
</Reference>
<Reference><Citation>Srivastava, M., & Deal, C. (2002). Osteoporosis in elderly: Prevention and treatment. Clinics in Geriatric Medicine, 18(3), 529-555. https://doi.org/10.1016/s0749-0690(02)00022-8</Citation>
</Reference>
<Reference><Citation>Strom, A., Hartman, J., Foster, J. S., Kietz, S., Wimalasena, J., & Gustafsson, J. A. (2004). Estrogen receptor inhibits 17 -estradiol-stimulated proliferation of the breast cancer cell line T47D. Proceedings of the National Academy of Sciences, 101(6), 1566-1571. https://doi.org/10.1073/pnas.0308319100</Citation>
</Reference>
<Reference><Citation>Stuenkel, C. A., Gass, M. L. S., Manson, J. A. E., Lobo, R. A., Pal, L., Rebar, R. W., & Hall, J. E. (2012). A decade after the Women's health initiative-The experts Do agree. The Journal of Clinical Endocrinology & Metabolism, 97(8), 2617-2618. https://doi.org/10.1210/jc.2012-2403</Citation>
</Reference>
<Reference><Citation>Sturdee, D. W., & Panay, N. (2010). Recommendations for the management of postmenopausal vaginal atrophy. Climacteric, 13(6), 509-522. https://doi.org/10.3109/13697137.2010.522875</Citation>
</Reference>
<Reference><Citation>Tadaishi, M., Nishide, Y., Tousen, Y., Kruger, M. C., & Ishimi, Y. (2014). Cooperative effects of soy isoflavones and carotenoids on osteoclast formation. Journal of Clinical Biochemistry and Nutrition, 54(2), 109-115. https://doi.org/10.3164/jcbn.13-94</Citation>
</Reference>
<Reference><Citation>Takeuchi, S., Takahashi, T., Sawada, Y., Iida, M., Matsuda, T., & Kojima, H. (2009). Comparative study on the nuclear hormone receptor activity of various phytochemicals and their metabolites by reporter gene assays using Chinese hamster ovary cells. Biological & Pharmaceutical Bulletin, 32(2), 195-202. https://doi.org/10.1248/bpb.32.195</Citation>
</Reference>
<Reference><Citation>Talia, M., de Francesco, E., Rigiracciolo, D., Muoio, M., Muglia, L., Belfiore, A., … Lappano, R. (2020). The G protein-coupled estrogen receptor (GPER) expression correlates with pro-metastatic pathways in ER-negative breast Cancer: A bioinformatics analysis. Cell, 9(3), 1-13. https://doi.org/10.3390/cells9030622</Citation>
</Reference>
<Reference><Citation>Thomas, C., & Gustafsson, J. Å. (2011). The different roles of ER subtypes in cancer biology and therapy’, Nature Reviews Cancer. Nature Publishing Group, 11(8), 597-608. https://doi.org/10.1038/nrc3093</Citation>
</Reference>
<Reference><Citation>Thomas, P., & Dong, J. (2006). Binding and activation of the seven-transmembrane estrogen receptor GPR30 by environmental estrogens: A potential novel mechanism of endocrine disruption. Journal of Steroid Biochemistry and Molecular Biology, 102(1-5 SPEC. ISS), 175-179. https://doi.org/10.1016/j.jsbmb.2006.09.017</Citation>
</Reference>
<Reference><Citation>Thornton, M. J. (2013). Estrogens and aging skin. Dermato-Endocrinology, 5(2), 264-270. https://doi.org/10.4161/derm.23872</Citation>
</Reference>
<Reference><Citation>Tokede, O. A., Onabanjo, T. A., Yansane, A., Gaziano, J. M., & Djoussé, L. (2015). Soya products and serum lipids: A meta-analysis of randomised controlled trials. British Journal of Nutrition, 114(6), 831-843. https://doi.org/10.1017/S0007114515002603</Citation>
</Reference>
<Reference><Citation>Tomás-Barberán, F. A., Selma, M. V., & Espín, J. C. (2016). Interactions of gut microbiota with dietary polyphenols and consequences to human health. Current Opinion in Clinical Nutrition and Metabolic Care, 19(6), 471-476. https://doi.org/10.1097/MCO.0000000000000314</Citation>
</Reference>
<Reference><Citation>Uesugi, T., Toda, T., Okuhira, T., & Chen, J. T. (2003). Evidence of estrogenic effect by the three-month-intervention of Isoflavone on vaginal maturation and bone metabolism in early postmenopausal women. Endocrine Journal, 50(5), 613-619. https://doi.org/10.1507/endocrj.50.613</Citation>
</Reference>
<Reference><Citation>Upson, K., Harmon, Q. E., Laughlin-Tommaso, S. K., Umbach, D. M., & Baird, D. D. (2016). Soy-based infant formula feeding and heavy menstrual bleeding among young African American women. Epidemiology, 27(5), 716-725. https://doi.org/10.1097/EDE.0000000000000508</Citation>
</Reference>
<Reference><Citation>Urpi-Sarda, M., Morand, C., Besson, C., Kraft, G., Viala, D., Scalbert, A., … Manach, C. (2008). Tissue distribution of isoflavones in ewes after consumption of red clover silage. Archives of Biochemistry and Biophysics, 476(2), 205-210. https://doi.org/10.1016/j.abb.2008.05.002</Citation>
</Reference>
<Reference><Citation>Valsta, L. M., Kilkkinen, A., Mazur, W., Nurmi, T., Lampi, A. M., Ovaskainen, M. L., … Pietinen, P. (2003). Phyto-oestrogen database of foods and average intake in Finland. British Journal of Nutrition, 89(S1), S31-S38. https://doi.org/10.1079/bjn2002794</Citation>
</Reference>
<Reference><Citation>Verma, R., Samanta, R., & Krishna, A. (2019). Comparative effects of estrogen and phytoestrogen, Genistein on testicular activities of Streptozotocin-induced type 2 diabetic mice. Reproductive Sciences, 26(9), 1294-1306. https://doi.org/10.1177/1933719118815576</Citation>
</Reference>
<Reference><Citation>Wang, C. C., Prasain, J. K., & Barnes, S. (2002). Review of the methods used in the determination of phytoestrogens. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 777, 3-28. https://doi.org/10.1016/S1570-0232(02)00341-0</Citation>
</Reference>
<Reference><Citation>Wang, S., Aarts, J. M.M.J.G., Evers, N. M., Peijnenburg, A. A.C.M., Rietjens, I. M.C.M., Bovee, T. F.H. (2012). Proliferation assays for estrogenicity testing with high predictive value for the in vivo uterotrophic effect. The Journal of Steroid Biochemistry and Molecular Biology, 128(3-5), 98-106. http://dx.doi.org/10.1016/j.jsbmb.2011.11.009.</Citation>
</Reference>
<Reference><Citation>Wang, S., Wei, H., Cai, M., Lu, Y., Hou, W., Yang, Q., … Xiong, L. (2014). Genistein attenuates brain damage induced by transient cerebral ischemia through up-regulation of ERK activity in ovariectomized mice. International Journal of Biological Sciences, 10(4), 457-465. https://doi.org/10.7150/ijbs.7562</Citation>
</Reference>
<Reference><Citation>Wang, T., Liu, Y., Li, X., Xu, Q., Feng, Y., & Yang, S. (2018). Isoflavones from green vegetable soya beans and their antimicrobial and antioxidant activities. Journal of the Science of Food and Agriculture, 98(5), 2043-2047. https://doi.org/10.1002/jsfa.8663</Citation>
</Reference>
<Reference><Citation>Whitten, P. L., Lewis, C., Russell, E., & Naftolin, F. (1995). Potential adverse effects of phytoestrogens. Journal of Nutrition, 125, 771S-776S. https://doi.org/10.1093/jn/125.3_Suppl.771S</Citation>
</Reference>
<Reference><Citation>Wilcox, G., Wahlqvist, M. L., Burger, H. G., & Medley, G. (1990). Oestrogenic effects of plant foods in postmenopausal women. BMJ, 301(6757), 905-906. https://doi.org/10.1136/bmj.301.6757.905-a</Citation>
</Reference>
<Reference><Citation>Williams, C., Edvardsson, K., Lewandowski, S. A., Ström, A., & Gustafsson, J. Å. (2008). A genome-wide study of the repressive effects of estrogen receptor beta on estrogen receptor alpha signaling in breast cancer cells. Oncogene, 27(7), 1019-1032. https://doi.org/10.1038/sj.onc.1210712</Citation>
</Reference>
<Reference><Citation>Wuttke, W., Jarry, H., & Seidlová-Wuttke, D. (2007). Isoflavones-safe food additives or dangerous drugs? Ageing Research Reviews, 6, 150-188. https://doi.org/10.1016/j.arr.2007.05.001</Citation>
</Reference>
<Reference><Citation>Yamaguchi, M., & Gao, Y. H. (1998). Inhibitory effect of genistein on bone resorption in tissue culture. Biochemical Pharmacology, 55(1), 71-76. https://doi.org/10.1016/S0006-2952(97)00402-4</Citation>
</Reference>
<Reference><Citation>Yao, J., Zhao, L., Mao, Z., Chen, S., Wong, K. C., To, J., & Brinton, R. D. (2013). Potentiation of brain mitochondrial function by S-equol and R/S-equol estrogen receptor β-selective phytoSERM treatments. Brain Research, 1514, 128-141. https://doi.org/10.1016/j.brainres.2013.02.021</Citation>
</Reference>
<Reference><Citation>Zhang, F. F., Haslam, D. E., Terry, M. B., Knight, J. A., Andrulis, I. L., Daly, M. B., … John, E. M. (2017). Dietary isoflavone intake and all-cause mortality in breast cancer survivors: The breast Cancer family registry. Cancer, 123(11), 2070-2079. https://doi.org/10.1002/cncr.30615</Citation>
</Reference>
<Reference><Citation>Zhang, X., Shu, X. O., Gao, Y. T., Yang, G., Li, Q., Li, H., … Zheng, W. (2003). Soy food consumption is associated with lower risk of coronary heart disease in Chinese women. The Journal of Nutrition, 133(9), 2874-2878. https://doi.org/10.1093/jn/133.9.2874</Citation>
</Reference>
<Reference><Citation>Zhang, Y. B., Chen, W. H., Guo, J. J., Fu, Z. H., Yi, C., Zhang, M., & Na, X. L. (2013). Soy isoflavone supplementation could reduce body weight and improve glucose metabolism in non-Asian postmenopausal women-a meta-analysis. Nutrition, 29(1), 8-14. https://doi.org/10.1016/j.nut.2012.03.019</Citation>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Bois/explor/PlantImRecepV1/Data/Main/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000073 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Corpus/biblio.hfd -nk 000073 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Bois |area= PlantImRecepV1 |flux= Main |étape= Corpus |type= RBID |clé= pubmed:32780464 |texte= The influence of phytoestrogens on different physiological and pathological processes: An overview. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Corpus/RBID.i -Sk "pubmed:32780464" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Corpus/biblio.hfd \ | NlmPubMed2Wicri -a PlantImRecepV1
![]() | This area was generated with Dilib version V0.6.38. | ![]() |