Nematicidal activity of 5-iodoindole against root-knot nematodes.
Identifieur interne : 000088 ( Main/Exploration ); précédent : 000087; suivant : 000089Nematicidal activity of 5-iodoindole against root-knot nematodes.
Auteurs : Satish Kumar Rajasekharan [Corée du Sud] ; Seulbi Kim [Corée du Sud] ; Jin-Cheol Kim [Corée du Sud] ; Jintae Lee [Corée du Sud]Source :
- Pesticide biochemistry and physiology [ 1095-9939 ] ; 2020.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical : Antinematodal Agents.
- Animals, Lycopersicon esculentum, Tylenchoidea.
Abstract
Multi-drug resistance in nematodes is a serious problem as lately several resistant phenotypes have emerged following the intermittent usage of synthetic nematicides. Contemporary research continues to focus on developing and/or repurposing small molecule inhibitors that are eco-friendly. Here, we describe the repurposing of the indole derivative, 5-iodoindole, as a nematicide for the root-knot nematode, Meloidogyne incognita. 5-Iodoindole effectively killed juveniles and freshly hatched juveniles by inducing multiple vacuole formation. Notably, at higher dosage (50 μg/mL), 5-iodoindole induced rapid juvenile death within 6 h. Microscopic analysis confirmed that the rapid death was due to the generation of reactive oxygen species (ROS). Computational docking attributed this ROS production to the antagonistic effect of 5-iodoindole on glutathione S-transferase (GST), which is known to play a critical role in the suppression of ROS in nematode models. Furthermore, 5-iodoindole also effectively reduced the gall formations and eggs masses of M. incognita on Solanum lycopersicum roots in pot experiments, and importantly it did not harm the physiological properties of the plant. Overall, the study provides valuable insights on the use of 5-iodoindole as an alternate measure to control root-knot nematodes. Overall, our findings suggest the efficacy of 5-iodoindole should be studied under field conditions.
DOI: 10.1016/j.pestbp.2019.10.012
PubMed: 31973872
Affiliations:
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Electronic address: jtlee@ynu.ac.kr.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>School of Chemical Engineering, Yeungnam University, Gyeongsan 38541</wicri:regionArea><wicri:noRegion>Gyeongsan 38541</wicri:noRegion></affiliation></author></analytic><series><title level="j">Pesticide biochemistry and physiology</title><idno type="eISSN">1095-9939</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term><term>Antinematodal Agents (MeSH)</term><term>Lycopersicon esculentum (MeSH)</term><term>Tylenchoidea (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term><term>Antihelminthiques antinématodes (MeSH)</term><term>Lycopersicon esculentum (MeSH)</term><term>Tylenchoidea (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Antinematodal Agents</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Lycopersicon esculentum</term><term>Tylenchoidea</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Antihelminthiques antinématodes</term><term>Lycopersicon esculentum</term><term>Tylenchoidea</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Multi-drug resistance in nematodes is a serious problem as lately several resistant phenotypes have emerged following the intermittent usage of synthetic nematicides. Contemporary research continues to focus on developing and/or repurposing small molecule inhibitors that are eco-friendly. Here, we describe the repurposing of the indole derivative, 5-iodoindole, as a nematicide for the root-knot nematode, Meloidogyne incognita. 5-Iodoindole effectively killed juveniles and freshly hatched juveniles by inducing multiple vacuole formation. Notably, at higher dosage (50 μg/mL), 5-iodoindole induced rapid juvenile death within 6 h. Microscopic analysis confirmed that the rapid death was due to the generation of reactive oxygen species (ROS). Computational docking attributed this ROS production to the antagonistic effect of 5-iodoindole on glutathione S-transferase (GST), which is known to play a critical role in the suppression of ROS in nematode models. Furthermore, 5-iodoindole also effectively reduced the gall formations and eggs masses of M. incognita on Solanum lycopersicum roots in pot experiments, and importantly it did not harm the physiological properties of the plant. Overall, the study provides valuable insights on the use of 5-iodoindole as an alternate measure to control root-knot nematodes. Overall, our findings suggest the efficacy of 5-iodoindole should be studied under field conditions.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" IndexingMethod="Automated" Owner="NLM"><PMID Version="1">31973872</PMID><DateCompleted><Year>2020</Year><Month>02</Month><Day>21</Day></DateCompleted><DateRevised><Year>2020</Year><Month>02</Month><Day>21</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1095-9939</ISSN><JournalIssue CitedMedium="Internet"><Volume>163</Volume><PubDate><Year>2020</Year><Month>Feb</Month></PubDate></JournalIssue><Title>Pesticide biochemistry and physiology</Title><ISOAbbreviation>Pestic Biochem Physiol</ISOAbbreviation></Journal><ArticleTitle>Nematicidal activity of 5-iodoindole against root-knot nematodes.</ArticleTitle><Pagination><MedlinePgn>76-83</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0048-3575(19)30472-9</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.pestbp.2019.10.012</ELocationID><Abstract><AbstractText>Multi-drug resistance in nematodes is a serious problem as lately several resistant phenotypes have emerged following the intermittent usage of synthetic nematicides. Contemporary research continues to focus on developing and/or repurposing small molecule inhibitors that are eco-friendly. Here, we describe the repurposing of the indole derivative, 5-iodoindole, as a nematicide for the root-knot nematode, Meloidogyne incognita. 5-Iodoindole effectively killed juveniles and freshly hatched juveniles by inducing multiple vacuole formation. Notably, at higher dosage (50 μg/mL), 5-iodoindole induced rapid juvenile death within 6 h. Microscopic analysis confirmed that the rapid death was due to the generation of reactive oxygen species (ROS). Computational docking attributed this ROS production to the antagonistic effect of 5-iodoindole on glutathione S-transferase (GST), which is known to play a critical role in the suppression of ROS in nematode models. Furthermore, 5-iodoindole also effectively reduced the gall formations and eggs masses of M. incognita on Solanum lycopersicum roots in pot experiments, and importantly it did not harm the physiological properties of the plant. Overall, the study provides valuable insights on the use of 5-iodoindole as an alternate measure to control root-knot nematodes. Overall, our findings suggest the efficacy of 5-iodoindole should be studied under field conditions.</AbstractText><CopyrightInformation>Copyright © 2019 Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Rajasekharan</LastName><ForeName>Satish Kumar</ForeName><Initials>SK</Initials><AffiliationInfo><Affiliation>School of Chemical Engineering, Yeungnam University, Gyeongsan 38541, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Seulbi</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Agricultural Chemistry, Institute of Environmentally Friendly Agriculture, College of Agriculture and Life Sciences, Chonnam National University, Gwangju 61186, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Jin-Cheol</ForeName><Initials>JC</Initials><AffiliationInfo><Affiliation>Department of Agricultural Chemistry, Institute of Environmentally Friendly Agriculture, College of Agriculture and Life Sciences, Chonnam National University, Gwangju 61186, Republic of Korea. Electronic address: kjinc@jnu.ac.kr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Jintae</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>School of Chemical Engineering, Yeungnam University, Gyeongsan 38541, Republic of Korea. Electronic address: jtlee@ynu.ac.kr.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2019</Year><Month>11</Month><Day>01</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Pestic Biochem Physiol</MedlineTA><NlmUniqueID>1301573</NlmUniqueID><ISSNLinking>0048-3575</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000969">Antinematodal Agents</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000969" MajorTopicYN="N">Antinematodal Agents</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018551" MajorTopicYN="Y">Lycopersicon esculentum</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014431" MajorTopicYN="Y">Tylenchoidea</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">5-Iodoindole</Keyword><Keyword MajorTopicYN="N">GST</Keyword><Keyword MajorTopicYN="N">Juveniles</Keyword><Keyword MajorTopicYN="N">M. incognita</Keyword><Keyword MajorTopicYN="N">ROS</Keyword><Keyword MajorTopicYN="N">Root-knot nematode</Keyword></KeywordList><CoiStatement>Declaration of Competing Interest The authors have no conflict of interest to declare.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2019</Year><Month>07</Month><Day>16</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2019</Year><Month>10</Month><Day>04</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2019</Year><Month>10</Month><Day>29</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>1</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>1</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>2</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">31973872</ArticleId><ArticleId IdType="pii">S0048-3575(19)30472-9</ArticleId><ArticleId IdType="doi">10.1016/j.pestbp.2019.10.012</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Corée du Sud</li></country></list><tree><country name="Corée du Sud"><noRegion><name sortKey="Rajasekharan, Satish Kumar" sort="Rajasekharan, Satish Kumar" uniqKey="Rajasekharan S" first="Satish Kumar" last="Rajasekharan">Satish Kumar Rajasekharan</name></noRegion><name sortKey="Kim, Jin Cheol" sort="Kim, Jin Cheol" uniqKey="Kim J" first="Jin-Cheol" last="Kim">Jin-Cheol Kim</name><name sortKey="Kim, Seulbi" sort="Kim, Seulbi" uniqKey="Kim S" first="Seulbi" last="Kim">Seulbi Kim</name><name sortKey="Lee, Jintae" sort="Lee, Jintae" uniqKey="Lee J" first="Jintae" last="Lee">Jintae Lee</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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