Transcriptional response of Fusarium oxysporum and Neocosmospora solani challenged with amphotericin B or posaconazole.
Identifieur interne : 000101 ( Main/Corpus ); précédent : 000100; suivant : 000102Transcriptional response of Fusarium oxysporum and Neocosmospora solani challenged with amphotericin B or posaconazole.
Auteurs : A. Castillo-Casta Eda ; S J Ca As-Duarte ; M. Guevara-Suarez ; J. Guarro ; S. Restrepo ; A M Celis RamírezSource :
- Microbiology (Reading, England) [ 1465-2080 ] ; 2020.
Abstract
Some species of fusaria are well-known pathogens of humans, animals and plants. Fusarium oxysporum and Neocosmospora solani (formerly Fusarium solani) cause human infections that range from onychomycosis or keratitis to severe disseminated infections. In general, these infections are difficult to treat due to poor therapeutic responses in immunocompromised patients. Despite that, little is known about the molecular mechanisms and transcriptional changes responsible for the antifungal resistance in fusaria. To shed light on the transcriptional response to antifungals, we carried out the first reported high-throughput RNA-seq analysis for F. oxysporum and N. solani that had been exposed to amphotericin B (AMB) and posaconazole (PSC). We detected significant differences between the transcriptional profiles of the two species and we found that some oxidation-reduction, metabolic, cellular and transport processes were regulated differentially by both fungi. The same was found with several genes from the ergosterol synthesis, efflux pumps, oxidative stress response and membrane biosynthesis pathways. A significant up-regulation of the C-22 sterol desaturase (ERG5), the sterol 24-C-methyltransferase (ERG6) gene, the glutathione S-transferase (GST) gene and of several members of the major facilitator superfamily (MSF) was demonstrated in this study after treating F. oxysporum with AMB. These results offer a good overview of transcriptional changes after exposure to commonly used antifungals, highlights the genes that are related to resistance mechanisms of these fungi, which will be a valuable tool for identifying causes of failure of treatments.
DOI: 10.1099/mic.0.000927
PubMed: 32644917
PubMed Central: PMC7660915
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Castillo-Casta Eda</name><affiliation><nlm:affiliation>Laboratorio de Micología y Fitopatología (LAMFU), Facultad de Ingeniería, Universidad de Los Andes, Bogotá, Colombia.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Grupo de Investigación Celular y Molecular de Microorganismos Patógenos (CeMoP), Departamento de Ciencias Biológicas, Universidad de Los Andes, Bogotá, Colombia.</nlm:affiliation></affiliation></author><author><name sortKey="Ca As Duarte, S J" sort="Ca As Duarte, S J" uniqKey="Ca As Duarte S" first="S J" last="Ca As-Duarte">S J Ca As-Duarte</name><affiliation><nlm:affiliation>Department of Systems Biology, Blavatnik Institute at Harvard Medical School, Harvard University, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Guevara Suarez, M" sort="Guevara Suarez, M" uniqKey="Guevara Suarez M" first="M" last="Guevara-Suarez">M. Guevara-Suarez</name><affiliation><nlm:affiliation>Laboratorio de Micología y Fitopatología (LAMFU), Facultad de Ingeniería, Universidad de Los Andes, Bogotá, Colombia.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Grupo de Investigación Celular y Molecular de Microorganismos Patógenos (CeMoP), Departamento de Ciencias Biológicas, Universidad de Los Andes, Bogotá, Colombia.</nlm:affiliation></affiliation></author><author><name sortKey="Guarro, J" sort="Guarro, J" uniqKey="Guarro J" first="J" last="Guarro">J. Guarro</name><affiliation><nlm:affiliation>Facultat de Medicina I Ciéncies de la Salut, Departament de Ciéncies Médiques Básiques, Unitat de Microbiología. Universitat de Rovira I Virgili, Reus, España.</nlm:affiliation></affiliation></author><author><name sortKey="Restrepo, S" sort="Restrepo, S" uniqKey="Restrepo S" first="S" last="Restrepo">S. Restrepo</name><affiliation><nlm:affiliation>Laboratorio de Micología y Fitopatología (LAMFU), Facultad de Ingeniería, Universidad de Los Andes, Bogotá, Colombia.</nlm:affiliation></affiliation></author><author><name sortKey="Celis Ramirez, A M" sort="Celis Ramirez, A M" uniqKey="Celis Ramirez A" first="A M" last="Celis Ramírez">A M Celis Ramírez</name><affiliation><nlm:affiliation>Grupo de Investigación Celular y Molecular de Microorganismos Patógenos (CeMoP), Departamento de Ciencias Biológicas, Universidad de Los Andes, Bogotá, Colombia.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32644917</idno><idno type="pmid">32644917</idno><idno type="doi">10.1099/mic.0.000927</idno><idno type="pmc">PMC7660915</idno><idno type="wicri:Area/Main/Corpus">000101</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000101</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Transcriptional response of <i>Fusarium oxysporum</i> and <i>Neocosmospora solani</i> challenged with amphotericin B or posaconazole.</title><author><name sortKey="Castillo Casta Eda, A" sort="Castillo Casta Eda, A" uniqKey="Castillo Casta Eda A" first="A" last="Castillo-Casta Eda">A. Castillo-Casta Eda</name><affiliation><nlm:affiliation>Laboratorio de Micología y Fitopatología (LAMFU), Facultad de Ingeniería, Universidad de Los Andes, Bogotá, Colombia.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Grupo de Investigación Celular y Molecular de Microorganismos Patógenos (CeMoP), Departamento de Ciencias Biológicas, Universidad de Los Andes, Bogotá, Colombia.</nlm:affiliation></affiliation></author><author><name sortKey="Ca As Duarte, S J" sort="Ca As Duarte, S J" uniqKey="Ca As Duarte S" first="S J" last="Ca As-Duarte">S J Ca As-Duarte</name><affiliation><nlm:affiliation>Department of Systems Biology, Blavatnik Institute at Harvard Medical School, Harvard University, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Guevara Suarez, M" sort="Guevara Suarez, M" uniqKey="Guevara Suarez M" first="M" last="Guevara-Suarez">M. Guevara-Suarez</name><affiliation><nlm:affiliation>Laboratorio de Micología y Fitopatología (LAMFU), Facultad de Ingeniería, Universidad de Los Andes, Bogotá, Colombia.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Grupo de Investigación Celular y Molecular de Microorganismos Patógenos (CeMoP), Departamento de Ciencias Biológicas, Universidad de Los Andes, Bogotá, Colombia.</nlm:affiliation></affiliation></author><author><name sortKey="Guarro, J" sort="Guarro, J" uniqKey="Guarro J" first="J" last="Guarro">J. Guarro</name><affiliation><nlm:affiliation>Facultat de Medicina I Ciéncies de la Salut, Departament de Ciéncies Médiques Básiques, Unitat de Microbiología. Universitat de Rovira I Virgili, Reus, España.</nlm:affiliation></affiliation></author><author><name sortKey="Restrepo, S" sort="Restrepo, S" uniqKey="Restrepo S" first="S" last="Restrepo">S. Restrepo</name><affiliation><nlm:affiliation>Laboratorio de Micología y Fitopatología (LAMFU), Facultad de Ingeniería, Universidad de Los Andes, Bogotá, Colombia.</nlm:affiliation></affiliation></author><author><name sortKey="Celis Ramirez, A M" sort="Celis Ramirez, A M" uniqKey="Celis Ramirez A" first="A M" last="Celis Ramírez">A M Celis Ramírez</name><affiliation><nlm:affiliation>Grupo de Investigación Celular y Molecular de Microorganismos Patógenos (CeMoP), Departamento de Ciencias Biológicas, Universidad de Los Andes, Bogotá, Colombia.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Microbiology (Reading, England)</title><idno type="eISSN">1465-2080</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Some species of fusaria are well-known pathogens of humans, animals and plants. <i>Fusarium oxysporum</i> and <i>Neocosmospora solani</i> (formerly <i>Fusarium solani</i>) cause human infections that range from onychomycosis or keratitis to severe disseminated infections. In general, these infections are difficult to treat due to poor therapeutic responses in immunocompromised patients. Despite that, little is known about the molecular mechanisms and transcriptional changes responsible for the antifungal resistance in fusaria. To shed light on the transcriptional response to antifungals, we carried out the first reported high-throughput RNA-seq analysis for <i>F. oxysporum</i> and <i>N. solani</i> that had been exposed to amphotericin B (AMB) and posaconazole (PSC). We detected significant differences between the transcriptional profiles of the two species and we found that some oxidation-reduction, metabolic, cellular and transport processes were regulated differentially by both fungi. The same was found with several genes from the ergosterol synthesis, efflux pumps, oxidative stress response and membrane biosynthesis pathways. A significant up-regulation of the C-22 sterol desaturase (<i>ERG5</i>), the sterol 24-C-methyltransferase (<i>ERG6</i>) gene, the glutathione S-transferase (<i>GST</i>) gene and of several members of the major facilitator superfamily (<i>MSF</i>) was demonstrated in this study after treating <i>F. oxysporum</i> with AMB. These results offer a good overview of transcriptional changes after exposure to commonly used antifungals, highlights the genes that are related to resistance mechanisms of these fungi, which will be a valuable tool for identifying causes of failure of treatments.</div></front></TEI><pubmed><MedlineCitation Status="In-Data-Review" Owner="NLM"><PMID Version="1">32644917</PMID><DateRevised><Year>2020</Year><Month>11</Month><Day>17</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1465-2080</ISSN><JournalIssue CitedMedium="Internet"><Volume>166</Volume><Issue>10</Issue><PubDate><Year>2020</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Microbiology (Reading, England)</Title><ISOAbbreviation>Microbiology (Reading)</ISOAbbreviation></Journal><ArticleTitle>Transcriptional response of <i>Fusarium oxysporum</i> and <i>Neocosmospora solani</i> challenged with amphotericin B or posaconazole.</ArticleTitle><Pagination><MedlinePgn>936-946</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1099/mic.0.000927</ELocationID><Abstract><AbstractText>Some species of fusaria are well-known pathogens of humans, animals and plants. <i>Fusarium oxysporum</i> and <i>Neocosmospora solani</i> (formerly <i>Fusarium solani</i>) cause human infections that range from onychomycosis or keratitis to severe disseminated infections. In general, these infections are difficult to treat due to poor therapeutic responses in immunocompromised patients. Despite that, little is known about the molecular mechanisms and transcriptional changes responsible for the antifungal resistance in fusaria. To shed light on the transcriptional response to antifungals, we carried out the first reported high-throughput RNA-seq analysis for <i>F. oxysporum</i> and <i>N. solani</i> that had been exposed to amphotericin B (AMB) and posaconazole (PSC). We detected significant differences between the transcriptional profiles of the two species and we found that some oxidation-reduction, metabolic, cellular and transport processes were regulated differentially by both fungi. The same was found with several genes from the ergosterol synthesis, efflux pumps, oxidative stress response and membrane biosynthesis pathways. A significant up-regulation of the C-22 sterol desaturase (<i>ERG5</i>), the sterol 24-C-methyltransferase (<i>ERG6</i>) gene, the glutathione S-transferase (<i>GST</i>) gene and of several members of the major facilitator superfamily (<i>MSF</i>) was demonstrated in this study after treating <i>F. oxysporum</i> with AMB. These results offer a good overview of transcriptional changes after exposure to commonly used antifungals, highlights the genes that are related to resistance mechanisms of these fungi, which will be a valuable tool for identifying causes of failure of treatments.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Castillo-Castañeda</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Laboratorio de Micología y Fitopatología (LAMFU), Facultad de Ingeniería, Universidad de Los Andes, Bogotá, Colombia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Grupo de Investigación Celular y Molecular de Microorganismos Patógenos (CeMoP), Departamento de Ciencias Biológicas, Universidad de Los Andes, Bogotá, Colombia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cañas-Duarte</LastName><ForeName>S J</ForeName><Initials>SJ</Initials><AffiliationInfo><Affiliation>Department of Systems Biology, Blavatnik Institute at Harvard Medical School, Harvard University, Boston, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guevara-Suarez</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Laboratorio de Micología y Fitopatología (LAMFU), Facultad de Ingeniería, Universidad de Los Andes, Bogotá, Colombia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Grupo de Investigación Celular y Molecular de Microorganismos Patógenos (CeMoP), Departamento de Ciencias Biológicas, Universidad de Los Andes, Bogotá, Colombia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guarro</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Facultat de Medicina I Ciéncies de la Salut, Departament de Ciéncies Médiques Básiques, Unitat de Microbiología. Universitat de Rovira I Virgili, Reus, España.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Restrepo</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Laboratorio de Micología y Fitopatología (LAMFU), Facultad de Ingeniería, Universidad de Los Andes, Bogotá, Colombia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Celis Ramírez</LastName><ForeName>A M</ForeName><Initials>AM</Initials><AffiliationInfo><Affiliation>Grupo de Investigación Celular y Molecular de Microorganismos Patógenos (CeMoP), Departamento de Ciencias Biológicas, Universidad de Los Andes, Bogotá, Colombia.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Microbiology 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|étape= Corpus
|type= RBID
|clé= pubmed:32644917
|texte= Transcriptional response of Fusarium oxysporum and Neocosmospora solani challenged with amphotericin B or posaconazole.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Corpus/RBID.i -Sk "pubmed:32644917" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a PlantGlutaTransV1
| This area was generated with Dilib version V0.6.38. |  |