Elucidation of antifungal metabolites produced by Pseudomonas aurantiaca IB5-10 with broad-spectrum antifungal activity.
Identifieur interne : 001545 ( Main/Exploration ); précédent : 001544; suivant : 001546Elucidation of antifungal metabolites produced by Pseudomonas aurantiaca IB5-10 with broad-spectrum antifungal activity.
Auteurs : Gwee Kyo Park [Corée du Sud] ; Jong-Hui Lim ; Sang-Dal Kim ; Sang Hee ShimSource :
- Journal of microbiology and biotechnology [ 1738-8872 ] ; 2012.
Descripteurs français
- KwdFr :
- Antifongiques (composition chimique), Antifongiques (métabolisme), Antifongiques (pharmacologie), Champignons (effets des médicaments et des substances chimiques), Champignons (physiologie), Maladies des plantes (microbiologie), Phénazines (composition chimique), Phénazines (métabolisme), Phénazines (pharmacologie), Pseudomonas (composition chimique), Pseudomonas (métabolisme), Tests de sensibilité microbienne (MeSH).
- MESH :
- composition chimique : Antifongiques, Phénazines, Pseudomonas.
- effets des médicaments et des substances chimiques : Champignons.
- microbiologie : Maladies des plantes.
- métabolisme : Antifongiques, Phénazines, Pseudomonas.
- pharmacologie : Antifongiques, Phénazines.
- physiologie : Champignons.
- Tests de sensibilité microbienne.
English descriptors
- KwdEn :
- Antifungal Agents (chemistry), Antifungal Agents (metabolism), Antifungal Agents (pharmacology), Fungi (drug effects), Fungi (physiology), Microbial Sensitivity Tests (MeSH), Phenazines (chemistry), Phenazines (metabolism), Phenazines (pharmacology), Plant Diseases (microbiology), Pseudomonas (chemistry), Pseudomonas (metabolism).
- MESH :
- chemical , chemistry : Antifungal Agents, Phenazines.
- chemical , metabolism : Antifungal Agents, Phenazines.
- chemical , pharmacology : Antifungal Agents, Phenazines.
- chemistry : Pseudomonas.
- drug effects : Fungi.
- metabolism : Pseudomonas.
- microbiology : Plant Diseases.
- physiology : Fungi.
- Microbial Sensitivity Tests.
Abstract
Antifungal metabolites were isolated from a culture of Pseudomonas aurantiaca IB5-10. Chemical structures of the metabolites were elucidated as phenazine-1-carboxylic acid (PCA; 1), 2-hydroxyphenazine (2-OH-PHZ; 2), and cyclo-(L-Pro-L-Val; 3), respectively, based on spectroscopic methods. Among them, 3 was isolated for the first time from this strain. The antifungal activities of 1-3 were evaluated against a variety of plant pathogens. To the best of our knowledge, the antifungal activities of 3 against plant fungal pathogens have been evaluated for the first time in this work. PCA (1) showed the most potent antifungal activities against Phytophthora capsici, Rhizoctonia solani AG-1(IA), and Pythium ultimum with MICs (microgram/ml) of less than 1.0, 1.3, and 2.0, respectively. On the other hand, 2-OH-PHZ (2) showed potent antifungal activity against R. solani AG-1(IA) with the MIC (microgram/ml) of 2.0, whereas it showed moderate antifungal activity against P. ultimum with the MIC (microgram/ml) of 50.0. In addition, 3 showed antifungal activity against only R. solani AG- 1(IA).
DOI: 10.4014/jmb.1106.06042
PubMed: 22450787
Affiliations:
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Sensitivity Tests</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Tests de sensibilité microbienne</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Antifungal metabolites were isolated from a culture of Pseudomonas aurantiaca IB5-10. Chemical structures of the metabolites were elucidated as phenazine-1-carboxylic acid (PCA; 1), 2-hydroxyphenazine (2-OH-PHZ; 2), and cyclo-(L-Pro-L-Val; 3), respectively, based on spectroscopic methods. Among them, 3 was isolated for the first time from this strain. The antifungal activities of 1-3 were evaluated against a variety of plant pathogens. To the best of our knowledge, the antifungal activities of 3 against plant fungal pathogens have been evaluated for the first time in this work. PCA (1) showed the most potent antifungal activities against Phytophthora capsici, Rhizoctonia solani AG-1(IA), and Pythium ultimum with MICs (microgram/ml) of less than 1.0, 1.3, and 2.0, respectively. On the other hand, 2-OH-PHZ (2) showed potent antifungal activity against R. solani AG-1(IA) with the MIC (microgram/ml) of 2.0, whereas it showed moderate antifungal activity against P. ultimum with the MIC (microgram/ml) of 50.0. In addition, 3 showed antifungal activity against only R. solani AG- 1(IA).</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">22450787</PMID><DateCompleted><Year>2012</Year><Month>07</Month><Day>16</Day></DateCompleted><DateRevised><Year>2019</Year><Month>09</Month><Day>23</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1738-8872</ISSN><JournalIssue CitedMedium="Internet"><Volume>22</Volume><Issue>3</Issue><PubDate><Year>2012</Year><Month>Mar</Month></PubDate></JournalIssue><Title>Journal of microbiology and biotechnology</Title><ISOAbbreviation>J Microbiol Biotechnol</ISOAbbreviation></Journal><ArticleTitle>Elucidation of antifungal metabolites produced by Pseudomonas aurantiaca IB5-10 with broad-spectrum antifungal activity.</ArticleTitle><Pagination><MedlinePgn>326-30</MedlinePgn></Pagination><Abstract><AbstractText>Antifungal metabolites were isolated from a culture of Pseudomonas aurantiaca IB5-10. Chemical structures of the metabolites were elucidated as phenazine-1-carboxylic acid (PCA; 1), 2-hydroxyphenazine (2-OH-PHZ; 2), and cyclo-(L-Pro-L-Val; 3), respectively, based on spectroscopic methods. Among them, 3 was isolated for the first time from this strain. The antifungal activities of 1-3 were evaluated against a variety of plant pathogens. To the best of our knowledge, the antifungal activities of 3 against plant fungal pathogens have been evaluated for the first time in this work. PCA (1) showed the most potent antifungal activities against Phytophthora capsici, Rhizoctonia solani AG-1(IA), and Pythium ultimum with MICs (microgram/ml) of less than 1.0, 1.3, and 2.0, respectively. On the other hand, 2-OH-PHZ (2) showed potent antifungal activity against R. solani AG-1(IA) with the MIC (microgram/ml) of 2.0, whereas it showed moderate antifungal activity against P. ultimum with the MIC (microgram/ml) of 50.0. 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