Inhibitory effect of glyceollin isolated from soybean against melanogenesis in B16 melanoma cells.
Identifieur interne : 001869 ( Main/Corpus ); précédent : 001868; suivant : 001870Inhibitory effect of glyceollin isolated from soybean against melanogenesis in B16 melanoma cells.
Auteurs : Young-Sang Lee ; Hyun-Kyoung Kim ; Kyung Ju Lee ; Hye Won Jeon ; Song Cui ; You Mie Lee ; Byung Jo Moon ; Yong-Hoon Kim ; Young-Sup LeeSource :
- BMB reports [ 1976-670X ] ; 2010.
English descriptors
- KwdEn :
- Animals (MeSH), Cell Line, Tumor (MeSH), Cosmetics (chemistry), Cosmetics (pharmacology), Cyclic AMP (metabolism), Intramolecular Oxidoreductases (antagonists & inhibitors), Intramolecular Oxidoreductases (metabolism), Melanins (biosynthesis), Melanoma, Experimental (enzymology), Melanoma, Experimental (metabolism), Monophenol Monooxygenase (antagonists & inhibitors), Monophenol Monooxygenase (metabolism), Oxidoreductases (antagonists & inhibitors), Oxidoreductases (metabolism), Pterocarpans (chemistry), Pterocarpans (pharmacology), Signal Transduction (MeSH), Soybeans (chemistry), alpha-MSH (metabolism).
- MESH :
- chemical , antagonists & inhibitors : Intramolecular Oxidoreductases, Monophenol Monooxygenase, Oxidoreductases.
- chemical , biosynthesis : Melanins.
- chemical , chemistry : Cosmetics, Pterocarpans.
- chemical , metabolism : Cyclic AMP, Intramolecular Oxidoreductases, Monophenol Monooxygenase, Oxidoreductases, alpha-MSH.
- chemical , pharmacology : Cosmetics, Pterocarpans.
- chemistry : Soybeans.
- enzymology : Melanoma, Experimental.
- metabolism : Melanoma, Experimental.
- Animals, Cell Line, Tumor, Signal Transduction.
Abstract
Natural products with non-toxic and environmentally friendly properties are good resources for skin-whitening cosmetic agents when compared to artificial synthetic chemicals. Here, we investigated the effect of glyceollin produced to induce disease resistance responses of soybean to specific races of an incompatible pathogen, phytophthora sojae, on melanogenesis and discussed their mechanisms in melanin biosynthesis. We found that glyceollin inhibits melanin synthesis and tyrosinase activity in B16 melanoma cells without cytotoxicity. To elucidate the mechanism of the effect of glyceollin on melanogenesis, we conducted western blot analysis for melanogenic enzymes such as tyrosinase, tyrosinase-related protein-1 (TRP-1), and TRP-2. Glyceollin inhibited tyrosinase and TRP-1 protein expression. Additionally, glyceollin effectively inhibited intracellular cAMP levels in B16 melanoma cells stimulated by alpha-melanocyte stimulating hormone (alpha-MSH). These results suggest that the whitening activity of glyceollin may be due to the inhibition of cAMP involved in the signal pathway of alpha-MSH in B16 melanoma cells.
DOI: 10.5483/bmbrep.2010.43.7.461
PubMed: 20663406
Links to Exploration step
pubmed:20663406Le document en format XML
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uniqKey="Lee Y" first="You Mie" last="Lee">You Mie Lee</name></author><author><name sortKey="Moon, Byung Jo" sort="Moon, Byung Jo" uniqKey="Moon B" first="Byung Jo" last="Moon">Byung Jo Moon</name></author><author><name sortKey="Kim, Yong Hoon" sort="Kim, Yong Hoon" uniqKey="Kim Y" first="Yong-Hoon" last="Kim">Yong-Hoon Kim</name></author><author><name sortKey="Lee, Young Sup" sort="Lee, Young Sup" uniqKey="Lee Y" first="Young-Sup" last="Lee">Young-Sup Lee</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2010">2010</date><idno type="RBID">pubmed:20663406</idno><idno type="pmid">20663406</idno><idno type="doi">10.5483/bmbrep.2010.43.7.461</idno><idno type="wicri:Area/Main/Corpus">001869</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">001869</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Inhibitory effect of glyceollin isolated from soybean against melanogenesis in B16 melanoma cells.</title><author><name sortKey="Lee, Young Sang" sort="Lee, Young Sang" uniqKey="Lee Y" first="Young-Sang" last="Lee">Young-Sang Lee</name><affiliation><nlm:affiliation>Kyungpook National University, Daegu, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Kim, Hyun Kyoung" sort="Kim, Hyun Kyoung" uniqKey="Kim H" first="Hyun-Kyoung" last="Kim">Hyun-Kyoung Kim</name></author><author><name sortKey="Lee, Kyung Ju" sort="Lee, Kyung Ju" uniqKey="Lee K" first="Kyung Ju" last="Lee">Kyung Ju Lee</name></author><author><name sortKey="Jeon, Hye Won" sort="Jeon, Hye Won" uniqKey="Jeon H" first="Hye Won" last="Jeon">Hye Won Jeon</name></author><author><name sortKey="Cui, Song" sort="Cui, Song" uniqKey="Cui S" first="Song" last="Cui">Song Cui</name></author><author><name sortKey="Lee, You Mie" sort="Lee, You Mie" uniqKey="Lee Y" first="You Mie" last="Lee">You Mie Lee</name></author><author><name sortKey="Moon, Byung Jo" sort="Moon, Byung Jo" uniqKey="Moon B" first="Byung Jo" last="Moon">Byung Jo Moon</name></author><author><name sortKey="Kim, Yong Hoon" sort="Kim, Yong Hoon" uniqKey="Kim Y" first="Yong-Hoon" last="Kim">Yong-Hoon Kim</name></author><author><name sortKey="Lee, Young Sup" sort="Lee, Young Sup" uniqKey="Lee Y" first="Young-Sup" last="Lee">Young-Sup Lee</name></author></analytic><series><title level="j">BMB reports</title><idno type="eISSN">1976-670X</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term><term>Cell Line, Tumor (MeSH)</term><term>Cosmetics (chemistry)</term><term>Cosmetics (pharmacology)</term><term>Cyclic AMP (metabolism)</term><term>Intramolecular Oxidoreductases (antagonists & inhibitors)</term><term>Intramolecular Oxidoreductases (metabolism)</term><term>Melanins (biosynthesis)</term><term>Melanoma, Experimental (enzymology)</term><term>Melanoma, Experimental (metabolism)</term><term>Monophenol Monooxygenase (antagonists & inhibitors)</term><term>Monophenol Monooxygenase (metabolism)</term><term>Oxidoreductases (antagonists & inhibitors)</term><term>Oxidoreductases (metabolism)</term><term>Pterocarpans (chemistry)</term><term>Pterocarpans (pharmacology)</term><term>Signal Transduction (MeSH)</term><term>Soybeans (chemistry)</term><term>alpha-MSH (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Intramolecular Oxidoreductases</term><term>Monophenol Monooxygenase</term><term>Oxidoreductases</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Melanins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Cosmetics</term><term>Pterocarpans</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cyclic AMP</term><term>Intramolecular Oxidoreductases</term><term>Monophenol Monooxygenase</term><term>Oxidoreductases</term><term>alpha-MSH</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Cosmetics</term><term>Pterocarpans</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Soybeans</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Melanoma, Experimental</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Melanoma, Experimental</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Line, Tumor</term><term>Signal Transduction</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Natural products with non-toxic and environmentally friendly properties are good resources for skin-whitening cosmetic agents when compared to artificial synthetic chemicals. Here, we investigated the effect of glyceollin produced to induce disease resistance responses of soybean to specific races of an incompatible pathogen, phytophthora sojae, on melanogenesis and discussed their mechanisms in melanin biosynthesis. We found that glyceollin inhibits melanin synthesis and tyrosinase activity in B16 melanoma cells without cytotoxicity. To elucidate the mechanism of the effect of glyceollin on melanogenesis, we conducted western blot analysis for melanogenic enzymes such as tyrosinase, tyrosinase-related protein-1 (TRP-1), and TRP-2. Glyceollin inhibited tyrosinase and TRP-1 protein expression. Additionally, glyceollin effectively inhibited intracellular cAMP levels in B16 melanoma cells stimulated by alpha-melanocyte stimulating hormone (alpha-MSH). These results suggest that the whitening activity of glyceollin may be due to the inhibition of cAMP involved in the signal pathway of alpha-MSH in B16 melanoma cells.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">20663406</PMID><DateCompleted><Year>2010</Year><Month>11</Month><Day>15</Day></DateCompleted><DateRevised><Year>2019</Year><Month>06</Month><Day>08</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1976-670X</ISSN><JournalIssue CitedMedium="Internet"><Volume>43</Volume><Issue>7</Issue><PubDate><Year>2010</Year><Month>Jul</Month></PubDate></JournalIssue><Title>BMB reports</Title><ISOAbbreviation>BMB Rep</ISOAbbreviation></Journal><ArticleTitle>Inhibitory effect of glyceollin isolated from soybean against melanogenesis in B16 melanoma cells.</ArticleTitle><Pagination><MedlinePgn>461-7</MedlinePgn></Pagination><Abstract><AbstractText>Natural products with non-toxic and environmentally friendly properties are good resources for skin-whitening cosmetic agents when compared to artificial synthetic chemicals. Here, we investigated the effect of glyceollin produced to induce disease resistance responses of soybean to specific races of an incompatible pathogen, phytophthora sojae, on melanogenesis and discussed their mechanisms in melanin biosynthesis. We found that glyceollin inhibits melanin synthesis and tyrosinase activity in B16 melanoma cells without cytotoxicity. To elucidate the mechanism of the effect of glyceollin on melanogenesis, we conducted western blot analysis for melanogenic enzymes such as tyrosinase, tyrosinase-related protein-1 (TRP-1), and TRP-2. Glyceollin inhibited tyrosinase and TRP-1 protein expression. Additionally, glyceollin effectively inhibited intracellular cAMP levels in B16 melanoma cells stimulated by alpha-melanocyte stimulating hormone (alpha-MSH). These results suggest that the whitening activity of glyceollin may be due to the inhibition of cAMP involved in the signal pathway of alpha-MSH in B16 melanoma cells.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Young-Sang</ForeName><Initials>YS</Initials><AffiliationInfo><Affiliation>Kyungpook National University, Daegu, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Hyun-Kyoung</ForeName><Initials>HK</Initials></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Kyung Ju</ForeName><Initials>KJ</Initials></Author><Author ValidYN="Y"><LastName>Jeon</LastName><ForeName>Hye Won</ForeName><Initials>HW</Initials></Author><Author ValidYN="Y"><LastName>Cui</LastName><ForeName>Song</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>You Mie</ForeName><Initials>YM</Initials></Author><Author ValidYN="Y"><LastName>Moon</LastName><ForeName>Byung Jo</ForeName><Initials>BJ</Initials></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Yong-Hoon</ForeName><Initials>YH</Initials></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Young-Sup</ForeName><Initials>YS</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Korea (South)</Country><MedlineTA>BMB Rep</MedlineTA><NlmUniqueID>101465334</NlmUniqueID><ISSNLinking>1976-6696</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D003358">Cosmetics</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008543">Melanins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D036343">Pterocarpans</NameOfSubstance></Chemical><Chemical><RegistryNumber>581-05-5</RegistryNumber><NameOfSubstance UI="D000521">alpha-MSH</NameOfSubstance></Chemical><Chemical><RegistryNumber>6461TV6UCH</RegistryNumber><NameOfSubstance UI="C017343">glyceollin</NameOfSubstance></Chemical><Chemical><RegistryNumber>E0399OZS9N</RegistryNumber><NameOfSubstance UI="D000242">Cyclic AMP</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.-</RegistryNumber><NameOfSubstance UI="D010088">Oxidoreductases</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.14.18.-</RegistryNumber><NameOfSubstance UI="C064056">tyrosinase-related protein-1</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.14.18.1</RegistryNumber><NameOfSubstance UI="D014442">Monophenol Monooxygenase</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 5.3.-</RegistryNumber><NameOfSubstance UI="D019746">Intramolecular Oxidoreductases</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 5.3.3.12</RegistryNumber><NameOfSubstance UI="C042501">dopachrome isomerase</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D045744" MajorTopicYN="N">Cell Line, Tumor</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003358" MajorTopicYN="N">Cosmetics</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000242" MajorTopicYN="N">Cyclic AMP</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019746" MajorTopicYN="N">Intramolecular Oxidoreductases</DescriptorName><QualifierName UI="Q000037" MajorTopicYN="N">antagonists & inhibitors</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008543" MajorTopicYN="N">Melanins</DescriptorName><QualifierName UI="Q000096" MajorTopicYN="Y">biosynthesis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008546" MajorTopicYN="N">Melanoma, Experimental</DescriptorName><QualifierName UI="Q000201" MajorTopicYN="N">enzymology</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014442" MajorTopicYN="N">Monophenol Monooxygenase</DescriptorName><QualifierName UI="Q000037" MajorTopicYN="N">antagonists & inhibitors</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010088" MajorTopicYN="N">Oxidoreductases</DescriptorName><QualifierName UI="Q000037" MajorTopicYN="N">antagonists & inhibitors</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D036343" MajorTopicYN="N">Pterocarpans</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013025" MajorTopicYN="N">Soybeans</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000521" MajorTopicYN="N">alpha-MSH</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate 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