Determination of the toxicity of several aromatic carbonylic compounds and their reduced derivatives on Phanerochaete chrysosporium using a Pseudomonas putida test system.
Identifieur interne : 000A46 ( Main/Exploration ); précédent : 000A45; suivant : 000A47Determination of the toxicity of several aromatic carbonylic compounds and their reduced derivatives on Phanerochaete chrysosporium using a Pseudomonas putida test system.
Auteurs : A. Hage [Pays-Bas] ; H E Schoemaker ; R. Wever ; E. Zennaro ; H J HeipieperSource :
- Biotechnology and bioengineering [ 0006-3592 ] ; 2001.
Descripteurs français
- KwdFr :
- Acides gras (composition chimique), Alcools (composition chimique), Alcools (toxicité), Biotransformation (MeSH), Cétones (composition chimique), Cétones (toxicité), Division cellulaire (effets des médicaments et des substances chimiques), Facteurs temps (MeSH), Phanerochaete (effets des médicaments et des substances chimiques), Phanerochaete (physiologie), Pseudomonas putida (effets des médicaments et des substances chimiques), Pseudomonas putida (physiologie), Structure moléculaire (MeSH), Tests de toxicité (méthodes).
- MESH :
- composition chimique : Acides gras, Alcools, Cétones.
- effets des médicaments et des substances chimiques : Division cellulaire, Phanerochaete, Pseudomonas putida.
- méthodes : Tests de toxicité.
- physiologie : Phanerochaete, Pseudomonas putida.
- toxicité : Alcools, Cétones.
- Biotransformation, Facteurs temps, Structure moléculaire.
English descriptors
- KwdEn :
- Alcohols (chemistry), Alcohols (toxicity), Biotransformation (MeSH), Cell Division (drug effects), Fatty Acids (chemistry), Ketones (chemistry), Ketones (toxicity), Molecular Structure (MeSH), Phanerochaete (drug effects), Phanerochaete (physiology), Pseudomonas putida (drug effects), Pseudomonas putida (physiology), Time Factors (MeSH), Toxicity Tests (methods).
- MESH :
- chemical , chemistry : Alcohols, Fatty Acids, Ketones.
- chemical , toxicity : Alcohols, Ketones.
- drug effects : Cell Division, Phanerochaete, Pseudomonas putida.
- methods : Toxicity Tests.
- physiology : Phanerochaete, Pseudomonas putida.
- Biotransformation, Molecular Structure, Time Factors.
Abstract
We tested four aromatic carbonylic compounds and their corresponding reduced derivatives, possible substrates, and products of a biotransformation for toxicity against the white-rot fungus Phanerochaete chrysosporium. The bacterium Pseudomonas putida, which has been proven to be a good test organism for investigating toxic effects, was used as a primary screen. For both P. chrysosporium and P. putida, all ketones showed a higher toxicity than their corresponding alcohol derivatives. Within one chemical group a direct correlation between the hydrophobicity (logP values) of the compounds and their toxicity could be observed. Furthermore, all tested compounds also caused an isomerization of cis to trans unsaturated fatty acids in P. putida, a mechanism of this bacterium to adapt its membrane to toxic environmental influences. Toxicity of aromatic carbonylic compounds in an established biotransformation system with P. chrysosporium can be estimated by calculating the corresponding logP values of the substrates and potential products. P. putida can be used to test the toxicity of aromatic ketones to the basic diomycete P. chrysosporium.
DOI: 10.1002/1097-0290(20010405)73:1<69::aid-bit1037>3.0.co;2-w
PubMed: 11255153
Affiliations:
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Le document en format XML
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Zennaro</name></author><author><name sortKey="Heipieper, H J" sort="Heipieper, H J" uniqKey="Heipieper H" first="H J" last="Heipieper">H J Heipieper</name></author></analytic><series><title level="j">Biotechnology and bioengineering</title><idno type="ISSN">0006-3592</idno><imprint><date when="2001" type="published">2001</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alcohols (chemistry)</term><term>Alcohols (toxicity)</term><term>Biotransformation (MeSH)</term><term>Cell Division (drug effects)</term><term>Fatty Acids (chemistry)</term><term>Ketones (chemistry)</term><term>Ketones (toxicity)</term><term>Molecular Structure (MeSH)</term><term>Phanerochaete (drug effects)</term><term>Phanerochaete (physiology)</term><term>Pseudomonas putida (drug effects)</term><term>Pseudomonas putida (physiology)</term><term>Time Factors (MeSH)</term><term>Toxicity Tests (methods)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Acides gras (composition chimique)</term><term>Alcools (composition chimique)</term><term>Alcools (toxicité)</term><term>Biotransformation (MeSH)</term><term>Cétones (composition chimique)</term><term>Cétones (toxicité)</term><term>Division cellulaire (effets des médicaments et des substances chimiques)</term><term>Facteurs temps (MeSH)</term><term>Phanerochaete (effets des médicaments et des substances chimiques)</term><term>Phanerochaete (physiologie)</term><term>Pseudomonas putida (effets des médicaments et des substances chimiques)</term><term>Pseudomonas putida (physiologie)</term><term>Structure moléculaire (MeSH)</term><term>Tests de toxicité (méthodes)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Alcohols</term><term>Fatty Acids</term><term>Ketones</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Alcohols</term><term>Ketones</term></keywords><keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Acides gras</term><term>Alcools</term><term>Cétones</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cell Division</term><term>Phanerochaete</term><term>Pseudomonas putida</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Division cellulaire</term><term>Phanerochaete</term><term>Pseudomonas putida</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Toxicity Tests</term></keywords><keywords scheme="MESH" qualifier="méthodes" xml:lang="fr"><term>Tests de toxicité</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Phanerochaete</term><term>Pseudomonas putida</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Phanerochaete</term><term>Pseudomonas putida</term></keywords><keywords scheme="MESH" qualifier="toxicité" xml:lang="fr"><term>Alcools</term><term>Cétones</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Biotransformation</term><term>Molecular Structure</term><term>Time Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Biotransformation</term><term>Facteurs temps</term><term>Structure moléculaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We tested four aromatic carbonylic compounds and their corresponding reduced derivatives, possible substrates, and products of a biotransformation for toxicity against the white-rot fungus Phanerochaete chrysosporium. The bacterium Pseudomonas putida, which has been proven to be a good test organism for investigating toxic effects, was used as a primary screen. For both P. chrysosporium and P. putida, all ketones showed a higher toxicity than their corresponding alcohol derivatives. Within one chemical group a direct correlation between the hydrophobicity (logP values) of the compounds and their toxicity could be observed. Furthermore, all tested compounds also caused an isomerization of cis to trans unsaturated fatty acids in P. putida, a mechanism of this bacterium to adapt its membrane to toxic environmental influences. Toxicity of aromatic carbonylic compounds in an established biotransformation system with P. chrysosporium can be estimated by calculating the corresponding logP values of the substrates and potential products. P. putida can be used to test the toxicity of aromatic ketones to the basic diomycete P. chrysosporium.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">11255153</PMID><DateCompleted><Year>2001</Year><Month>06</Month><Day>28</Day></DateCompleted><DateRevised><Year>2019</Year><Month>09</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0006-3592</ISSN><JournalIssue CitedMedium="Print"><Volume>73</Volume><Issue>1</Issue><PubDate><Year>2001</Year><Month>Apr</Month><Day>05</Day></PubDate></JournalIssue><Title>Biotechnology and bioengineering</Title><ISOAbbreviation>Biotechnol Bioeng</ISOAbbreviation></Journal><ArticleTitle>Determination of the toxicity of several aromatic carbonylic compounds and their reduced derivatives on Phanerochaete chrysosporium using a Pseudomonas putida test system.</ArticleTitle><Pagination><MedlinePgn>69-73</MedlinePgn></Pagination><Abstract><AbstractText>We tested four aromatic carbonylic compounds and their corresponding reduced derivatives, possible substrates, and products of a biotransformation for toxicity against the white-rot fungus Phanerochaete chrysosporium. The bacterium Pseudomonas putida, which has been proven to be a good test organism for investigating toxic effects, was used as a primary screen. For both P. chrysosporium and P. putida, all ketones showed a higher toxicity than their corresponding alcohol derivatives. Within one chemical group a direct correlation between the hydrophobicity (logP values) of the compounds and their toxicity could be observed. Furthermore, all tested compounds also caused an isomerization of cis to trans unsaturated fatty acids in P. putida, a mechanism of this bacterium to adapt its membrane to toxic environmental influences. Toxicity of aromatic carbonylic compounds in an established biotransformation system with P. chrysosporium can be estimated by calculating the corresponding logP values of the substrates and potential products. 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Slater Institute, Department of Biochemistry, University of Amsterdam, Amsterdam, The Netherlands. annemarie.hage@imb.ftns.wau.nl</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schoemaker</LastName><ForeName>H E</ForeName><Initials>HE</Initials></Author><Author ValidYN="Y"><LastName>Wever</LastName><ForeName>R</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Zennaro</LastName><ForeName>E</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Heipieper</LastName><ForeName>H J</ForeName><Initials>HJ</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Biotechnol Bioeng</MedlineTA><NlmUniqueID>7502021</NlmUniqueID><ISSNLinking>0006-3592</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000438">Alcohols</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005227">Fatty Acids</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007659">Ketones</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000438" MajorTopicYN="N">Alcohols</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000633" MajorTopicYN="Y">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001711" MajorTopicYN="N">Biotransformation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002455" MajorTopicYN="N">Cell Division</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005227" MajorTopicYN="N">Fatty Acids</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007659" MajorTopicYN="N">Ketones</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000633" MajorTopicYN="Y">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015394" MajorTopicYN="N">Molecular Structure</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020075" MajorTopicYN="N">Phanerochaete</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016958" MajorTopicYN="N">Pseudomonas putida</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013997" MajorTopicYN="N">Time Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018675" MajorTopicYN="N">Toxicity Tests</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2001</Year><Month>3</Month><Day>20</Day><Hour>10</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2001</Year><Month>6</Month><Day>29</Day><Hour>10</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2001</Year><Month>3</Month><Day>20</Day><Hour>10</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">11255153</ArticleId><ArticleId IdType="pii">10.1002/1097-0290(20010405)73:1<69::AID-BIT1037>3.0.CO;2-W</ArticleId><ArticleId IdType="doi">10.1002/1097-0290(20010405)73:1<69::aid-bit1037>3.0.co;2-w</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Pays-Bas</li></country><region><li>Hollande-Septentrionale</li></region><settlement><li>Amsterdam</li></settlement><orgName><li>Université d'Amsterdam</li></orgName></list><tree><noCountry><name sortKey="Heipieper, H J" sort="Heipieper, H J" uniqKey="Heipieper H" first="H J" last="Heipieper">H J Heipieper</name><name sortKey="Schoemaker, H E" sort="Schoemaker, H E" uniqKey="Schoemaker H" first="H E" last="Schoemaker">H E Schoemaker</name><name sortKey="Wever, R" sort="Wever, R" uniqKey="Wever R" first="R" last="Wever">R. Wever</name><name sortKey="Zennaro, E" sort="Zennaro, E" uniqKey="Zennaro E" first="E" last="Zennaro">E. Zennaro</name></noCountry><country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Hage, A" sort="Hage, A" uniqKey="Hage A" first="A" last="Hage">A. Hage</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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