CJ-12,954 and its congeners, new anti-Helicobacter pylori compounds produced by Phanerochaete velutina: fermentation, isolation, structural elucidation and biological activities.
Identifieur interne : 000B96 ( Main/Corpus ); précédent : 000B95; suivant : 000B97CJ-12,954 and its congeners, new anti-Helicobacter pylori compounds produced by Phanerochaete velutina: fermentation, isolation, structural elucidation and biological activities.
Auteurs : K A Dekker ; T. Inagaki ; T D Gootz ; K. Kaneda ; E. Nomura ; T. Sakakibara ; S. Sakemi ; Y. Sugie ; Y. Yamauchi ; N. Yoshikawa ; N. KojimaSource :
- The Journal of antibiotics [ 0021-8820 ] ; 1997.
English descriptors
- KwdEn :
- Anti-Bacterial Agents (MeSH), Anti-Infective Agents (chemistry), Anti-Infective Agents (metabolism), Anti-Infective Agents (pharmacology), Basidiomycota (chemistry), Basidiomycota (metabolism), Benzofurans (chemistry), Benzofurans (metabolism), Benzofurans (pharmacology), Fermentation (MeSH), Helicobacter pylori (drug effects), Microbial Sensitivity Tests (MeSH), Molecular Structure (MeSH), Spiro Compounds (chemistry), Spiro Compounds (metabolism), Spiro Compounds (pharmacology), Structure-Activity Relationship (MeSH).
- MESH :
- chemical , chemistry : Anti-Infective Agents, Benzofurans, Spiro Compounds.
- chemical , metabolism : Anti-Infective Agents, Benzofurans, Spiro Compounds.
- chemical , pharmacology : Anti-Infective Agents, Benzofurans, Spiro Compounds.
- chemical : Anti-Bacterial Agents.
- chemistry : Basidiomycota.
- drug effects : Helicobacter pylori.
- metabolism : Basidiomycota.
- Fermentation, Microbial Sensitivity Tests, Molecular Structure, Structure-Activity Relationship.
Abstract
Seven new phthalide compounds with anti-Helicobacter pylori activities were isolated from the basidiomycete Phanerochaete velutina CL6387. The two most potent phthalide compounds, CJ-12,954 and CJ-13,014, have MICs of 5 ng/ml. The structure-activity relationship shows that the presence of a spiroketal part in addition to the phthalide part, greatly enhances the activity. The phthalide compounds appear to be specific for H. pylori, since they did not show antibacterial activities when tested against a panel of other microorganisms.
DOI: 10.7164/antibiotics.50.833
PubMed: 9402988
Links to Exploration step
pubmed:9402988Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">CJ-12,954 and its congeners, new anti-Helicobacter pylori compounds produced by Phanerochaete velutina: fermentation, isolation, structural elucidation and biological activities.</title><author><name sortKey="Dekker, K A" sort="Dekker, K A" uniqKey="Dekker K" first="K A" last="Dekker">K A Dekker</name><affiliation><nlm:affiliation>Central Research Division, Pfizer Pharmaceuticals, Inc., Aichi, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Inagaki, T" sort="Inagaki, T" uniqKey="Inagaki T" first="T" last="Inagaki">T. Inagaki</name></author><author><name sortKey="Gootz, T D" sort="Gootz, T D" uniqKey="Gootz T" first="T D" last="Gootz">T D Gootz</name></author><author><name sortKey="Kaneda, K" sort="Kaneda, K" uniqKey="Kaneda K" first="K" last="Kaneda">K. Kaneda</name></author><author><name sortKey="Nomura, E" sort="Nomura, E" uniqKey="Nomura E" first="E" last="Nomura">E. Nomura</name></author><author><name sortKey="Sakakibara, T" sort="Sakakibara, T" uniqKey="Sakakibara T" first="T" last="Sakakibara">T. Sakakibara</name></author><author><name sortKey="Sakemi, S" sort="Sakemi, S" uniqKey="Sakemi S" first="S" last="Sakemi">S. Sakemi</name></author><author><name sortKey="Sugie, Y" sort="Sugie, Y" uniqKey="Sugie Y" first="Y" last="Sugie">Y. Sugie</name></author><author><name sortKey="Yamauchi, Y" sort="Yamauchi, Y" uniqKey="Yamauchi Y" first="Y" last="Yamauchi">Y. Yamauchi</name></author><author><name sortKey="Yoshikawa, N" sort="Yoshikawa, N" uniqKey="Yoshikawa N" first="N" last="Yoshikawa">N. Yoshikawa</name></author><author><name sortKey="Kojima, N" sort="Kojima, N" uniqKey="Kojima N" first="N" last="Kojima">N. Kojima</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1997">1997</date><idno type="RBID">pubmed:9402988</idno><idno type="pmid">9402988</idno><idno type="doi">10.7164/antibiotics.50.833</idno><idno type="wicri:Area/Main/Corpus">000B96</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000B96</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">CJ-12,954 and its congeners, new anti-Helicobacter pylori compounds produced by Phanerochaete velutina: fermentation, isolation, structural elucidation and biological activities.</title><author><name sortKey="Dekker, K A" sort="Dekker, K A" uniqKey="Dekker K" first="K A" last="Dekker">K A Dekker</name><affiliation><nlm:affiliation>Central Research Division, Pfizer Pharmaceuticals, Inc., Aichi, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Inagaki, T" sort="Inagaki, T" uniqKey="Inagaki T" first="T" last="Inagaki">T. Inagaki</name></author><author><name sortKey="Gootz, T D" sort="Gootz, T D" uniqKey="Gootz T" first="T D" last="Gootz">T D Gootz</name></author><author><name sortKey="Kaneda, K" sort="Kaneda, K" uniqKey="Kaneda K" first="K" last="Kaneda">K. Kaneda</name></author><author><name sortKey="Nomura, E" sort="Nomura, E" uniqKey="Nomura E" first="E" last="Nomura">E. Nomura</name></author><author><name sortKey="Sakakibara, T" sort="Sakakibara, T" uniqKey="Sakakibara T" first="T" last="Sakakibara">T. Sakakibara</name></author><author><name sortKey="Sakemi, S" sort="Sakemi, S" uniqKey="Sakemi S" first="S" last="Sakemi">S. Sakemi</name></author><author><name sortKey="Sugie, Y" sort="Sugie, Y" uniqKey="Sugie Y" first="Y" last="Sugie">Y. Sugie</name></author><author><name sortKey="Yamauchi, Y" sort="Yamauchi, Y" uniqKey="Yamauchi Y" first="Y" last="Yamauchi">Y. Yamauchi</name></author><author><name sortKey="Yoshikawa, N" sort="Yoshikawa, N" uniqKey="Yoshikawa N" first="N" last="Yoshikawa">N. Yoshikawa</name></author><author><name sortKey="Kojima, N" sort="Kojima, N" uniqKey="Kojima N" first="N" last="Kojima">N. Kojima</name></author></analytic><series><title level="j">The Journal of antibiotics</title><idno type="ISSN">0021-8820</idno><imprint><date when="1997" type="published">1997</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anti-Bacterial Agents (MeSH)</term><term>Anti-Infective Agents (chemistry)</term><term>Anti-Infective Agents (metabolism)</term><term>Anti-Infective Agents (pharmacology)</term><term>Basidiomycota (chemistry)</term><term>Basidiomycota (metabolism)</term><term>Benzofurans (chemistry)</term><term>Benzofurans (metabolism)</term><term>Benzofurans (pharmacology)</term><term>Fermentation (MeSH)</term><term>Helicobacter pylori (drug effects)</term><term>Microbial Sensitivity Tests (MeSH)</term><term>Molecular Structure (MeSH)</term><term>Spiro Compounds (chemistry)</term><term>Spiro Compounds (metabolism)</term><term>Spiro Compounds (pharmacology)</term><term>Structure-Activity Relationship (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Anti-Infective Agents</term><term>Benzofurans</term><term>Spiro Compounds</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Anti-Infective Agents</term><term>Benzofurans</term><term>Spiro Compounds</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Anti-Infective Agents</term><term>Benzofurans</term><term>Spiro Compounds</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Anti-Bacterial Agents</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Basidiomycota</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Helicobacter pylori</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Basidiomycota</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Fermentation</term><term>Microbial Sensitivity Tests</term><term>Molecular Structure</term><term>Structure-Activity Relationship</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Seven new phthalide compounds with anti-Helicobacter pylori activities were isolated from the basidiomycete Phanerochaete velutina CL6387. The two most potent phthalide compounds, CJ-12,954 and CJ-13,014, have MICs of 5 ng/ml. The structure-activity relationship shows that the presence of a spiroketal part in addition to the phthalide part, greatly enhances the activity. The phthalide compounds appear to be specific for H. pylori, since they did not show antibacterial activities when tested against a panel of other microorganisms.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">9402988</PMID><DateCompleted><Year>1998</Year><Month>01</Month><Day>20</Day></DateCompleted><DateRevised><Year>2019</Year><Month>07</Month><Day>23</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0021-8820</ISSN><JournalIssue CitedMedium="Print"><Volume>50</Volume><Issue>10</Issue><PubDate><Year>1997</Year><Month>Oct</Month></PubDate></JournalIssue><Title>The Journal of antibiotics</Title><ISOAbbreviation>J Antibiot (Tokyo)</ISOAbbreviation></Journal><ArticleTitle>CJ-12,954 and its congeners, new anti-Helicobacter pylori compounds produced by Phanerochaete velutina: fermentation, isolation, structural elucidation and biological activities.</ArticleTitle><Pagination><MedlinePgn>833-9</MedlinePgn></Pagination><Abstract><AbstractText>Seven new phthalide compounds with anti-Helicobacter pylori activities were isolated from the basidiomycete Phanerochaete velutina CL6387. The two most potent phthalide compounds, CJ-12,954 and CJ-13,014, have MICs of 5 ng/ml. The structure-activity relationship shows that the presence of a spiroketal part in addition to the phthalide part, greatly enhances the activity. The phthalide compounds appear to be specific for H. pylori, since they did not show antibacterial activities when tested against a panel of other microorganisms.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Dekker</LastName><ForeName>K A</ForeName><Initials>KA</Initials><AffiliationInfo><Affiliation>Central Research Division, Pfizer Pharmaceuticals, Inc., Aichi, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Inagaki</LastName><ForeName>T</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Gootz</LastName><ForeName>T D</ForeName><Initials>TD</Initials></Author><Author ValidYN="Y"><LastName>Kaneda</LastName><ForeName>K</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Nomura</LastName><ForeName>E</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Sakakibara</LastName><ForeName>T</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Sakemi</LastName><ForeName>S</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Sugie</LastName><ForeName>Y</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Yamauchi</LastName><ForeName>Y</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Yoshikawa</LastName><ForeName>N</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Kojima</LastName><ForeName>N</ForeName><Initials>N</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Japan</Country><MedlineTA>J Antibiot (Tokyo)</MedlineTA><NlmUniqueID>0151115</NlmUniqueID><ISSNLinking>0021-8820</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000900">Anti-Bacterial Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000890">Anti-Infective Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D001572">Benzofurans</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C109706">CJ 12954</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C109705">CJ 13014</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D013141">Spiro Compounds</NameOfSubstance></Chemical><Chemical><RegistryNumber>8VV922U86J</RegistryNumber><NameOfSubstance UI="C082022">phthalide</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000900" MajorTopicYN="N">Anti-Bacterial Agents</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000890" MajorTopicYN="N">Anti-Infective Agents</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001487" MajorTopicYN="N">Basidiomycota</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001572" MajorTopicYN="N">Benzofurans</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005285" MajorTopicYN="N">Fermentation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016480" MajorTopicYN="N">Helicobacter pylori</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008826" MajorTopicYN="N">Microbial Sensitivity Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015394" MajorTopicYN="N">Molecular Structure</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013141" MajorTopicYN="N">Spiro Compounds</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013329" MajorTopicYN="N">Structure-Activity Relationship</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1997</Year><Month>12</Month><Day>24</Day></PubMedPubDate><PubMedPubDate 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