The cytotoxicities in prokaryote and eukaryote varied for CdSe and CdSe/ZnS quantum dots and differed from cadmium ions.
Identifieur interne : 000063 ( Main/Corpus ); précédent : 000062; suivant : 000064The cytotoxicities in prokaryote and eukaryote varied for CdSe and CdSe/ZnS quantum dots and differed from cadmium ions.
Auteurs : Liang Hu ; Hui Zhong ; Zhiguo HeSource :
- Ecotoxicology and environmental safety [ 1090-2414 ] ; 2019.
English descriptors
- KwdEn :
- Cadmium (toxicity), Cadmium Compounds (toxicity), Cytotoxins (metabolism), Cytotoxins (toxicity), Escherichia coli (drug effects), Escherichia coli (metabolism), Escherichia coli (ultrastructure), Ions (MeSH), Membrane Fluidity (drug effects), Microbial Viability (drug effects), Phanerochaete (drug effects), Phanerochaete (ultrastructure), Quantum Dots (metabolism), Quantum Dots (toxicity), Reactive Oxygen Species (metabolism), Selenium Compounds (toxicity), Sulfides (metabolism), Sulfides (toxicity), Zinc Compounds (metabolism), Zinc Compounds (toxicity).
- MESH :
- chemical , metabolism : Cytotoxins, Reactive Oxygen Species, Sulfides, Zinc Compounds.
- chemical , toxicity : Cadmium, Cadmium Compounds, Cytotoxins, Selenium Compounds, Sulfides, Zinc Compounds.
- drug effects : Escherichia coli, Membrane Fluidity, Microbial Viability, Phanerochaete.
- metabolism : Escherichia coli, Quantum Dots.
- toxicity : Quantum Dots.
- ultrastructure : Escherichia coli, Phanerochaete.
- chemical : Ions.
Abstract
The present study focused on the bioaccumulation and cytotoxicities of Cd2+, CdSe quantum dots (QDs) and CdSe/ZnS QDs in Escherichia coli (E. coli, represents prokaryotic system) and Phanerochaete chrysosporium (P. chrysosporium, represents eukaryotic system), respectively. Two types of QDs were characterized by transmission electron microscopy (TEM) and dynamic light scattering. The inductively coupled plasma optical emission spectrometer results showed that the bioaccumulation amounts of CdSe QDs by E. coli and P. chrysosporium were larger than those of CdSe/ZnS QDs due to the smaller particle size and less negative surface charges of CdSe QDs. Confocal microscopy and TEM results showed that there was an interaction between QDs and cells, and QDs have entered into the cells eventually, leading to the change of cell morphology. Plasma membrane fluidities and membrane H+-ATPase activities of E. coli and P. chrysosporium decreased gradually with the increasing concentrations of Cd2+, CdSe and CdSe/ZnS QDs. Results of the cell viabilities and intracellular reactive oxygen species levels indicated that the induced cytotoxicities were decreased as follows: CdSe QDs > CdSe/ZnS QDs > Cd2+. These findings suggested that the cytotoxicity of QDs was not only attributed to their heavy metal components, but also related to their nanosize effects which could induce particle-specific toxicity. The above results offer valuable information for exploring the cytotoxicity mechanism of QDs in prokaryote and eukaryote.
DOI: 10.1016/j.ecoenv.2019.06.027
PubMed: 31202934
Links to Exploration step
pubmed:31202934Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The cytotoxicities in prokaryote and eukaryote varied for CdSe and CdSe/ZnS quantum dots and differed from cadmium ions.</title><author><name sortKey="Hu, Liang" sort="Hu, Liang" uniqKey="Hu L" first="Liang" last="Hu">Liang Hu</name><affiliation><nlm:affiliation>School of Minerals Processing and Bioengineering, Key Laboratory of Biohydrometallurgy of Ministry of Education, Central South University, Changsha, 410083, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhong, Hui" sort="Zhong, Hui" uniqKey="Zhong H" first="Hui" last="Zhong">Hui Zhong</name><affiliation><nlm:affiliation>School of Life Science, Central South University, Changsha, 410012, China. Electronic address: 35406719@qq.com.</nlm:affiliation></affiliation></author><author><name sortKey="He, Zhiguo" sort="He, Zhiguo" uniqKey="He Z" first="Zhiguo" last="He">Zhiguo He</name><affiliation><nlm:affiliation>School of Minerals Processing and Bioengineering, Key Laboratory of Biohydrometallurgy of Ministry of Education, Central South University, Changsha, 410083, China. Electronic address: zghe@csu.edu.cn.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2019">2019</date><idno type="RBID">pubmed:31202934</idno><idno type="pmid">31202934</idno><idno type="doi">10.1016/j.ecoenv.2019.06.027</idno><idno type="wicri:Area/Main/Corpus">000063</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000063</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The cytotoxicities in prokaryote and eukaryote varied for CdSe and CdSe/ZnS quantum dots and differed from cadmium ions.</title><author><name sortKey="Hu, Liang" sort="Hu, Liang" uniqKey="Hu L" first="Liang" last="Hu">Liang Hu</name><affiliation><nlm:affiliation>School of Minerals Processing and Bioengineering, Key Laboratory of Biohydrometallurgy of Ministry of Education, Central South University, Changsha, 410083, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhong, Hui" sort="Zhong, Hui" uniqKey="Zhong H" first="Hui" last="Zhong">Hui Zhong</name><affiliation><nlm:affiliation>School of Life Science, Central South University, Changsha, 410012, China. Electronic address: 35406719@qq.com.</nlm:affiliation></affiliation></author><author><name sortKey="He, Zhiguo" sort="He, Zhiguo" uniqKey="He Z" first="Zhiguo" last="He">Zhiguo He</name><affiliation><nlm:affiliation>School of Minerals Processing and Bioengineering, Key Laboratory of Biohydrometallurgy of Ministry of Education, Central South University, Changsha, 410083, China. Electronic address: zghe@csu.edu.cn.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Ecotoxicology and environmental safety</title><idno type="eISSN">1090-2414</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cadmium (toxicity)</term><term>Cadmium Compounds (toxicity)</term><term>Cytotoxins (metabolism)</term><term>Cytotoxins (toxicity)</term><term>Escherichia coli (drug effects)</term><term>Escherichia coli (metabolism)</term><term>Escherichia coli (ultrastructure)</term><term>Ions (MeSH)</term><term>Membrane Fluidity (drug effects)</term><term>Microbial Viability (drug effects)</term><term>Phanerochaete (drug effects)</term><term>Phanerochaete (ultrastructure)</term><term>Quantum Dots (metabolism)</term><term>Quantum Dots (toxicity)</term><term>Reactive Oxygen Species (metabolism)</term><term>Selenium Compounds (toxicity)</term><term>Sulfides (metabolism)</term><term>Sulfides (toxicity)</term><term>Zinc Compounds (metabolism)</term><term>Zinc Compounds (toxicity)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cytotoxins</term><term>Reactive Oxygen Species</term><term>Sulfides</term><term>Zinc Compounds</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Cadmium</term><term>Cadmium Compounds</term><term>Cytotoxins</term><term>Selenium Compounds</term><term>Sulfides</term><term>Zinc Compounds</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Escherichia coli</term><term>Membrane Fluidity</term><term>Microbial Viability</term><term>Phanerochaete</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Escherichia coli</term><term>Quantum Dots</term></keywords><keywords scheme="MESH" qualifier="toxicity" xml:lang="en"><term>Quantum Dots</term></keywords><keywords scheme="MESH" qualifier="ultrastructure" xml:lang="en"><term>Escherichia coli</term><term>Phanerochaete</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Ions</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The present study focused on the bioaccumulation and cytotoxicities of Cd<sup>2+</sup>, CdSe quantum dots (QDs) and CdSe/ZnS QDs in Escherichia coli (E. coli, represents prokaryotic system) and Phanerochaete chrysosporium (P. chrysosporium, represents eukaryotic system), respectively. Two types of QDs were characterized by transmission electron microscopy (TEM) and dynamic light scattering. The inductively coupled plasma optical emission spectrometer results showed that the bioaccumulation amounts of CdSe QDs by E. coli and P. chrysosporium were larger than those of CdSe/ZnS QDs due to the smaller particle size and less negative surface charges of CdSe QDs. Confocal microscopy and TEM results showed that there was an interaction between QDs and cells, and QDs have entered into the cells eventually, leading to the change of cell morphology. Plasma membrane fluidities and membrane H<sup>+</sup>-ATPase activities of E. coli and P. chrysosporium decreased gradually with the increasing concentrations of Cd<sup>2+</sup>, CdSe and CdSe/ZnS QDs. Results of the cell viabilities and intracellular reactive oxygen species levels indicated that the induced cytotoxicities were decreased as follows: CdSe QDs > CdSe/ZnS QDs > Cd<sup>2+</sup>. These findings suggested that the cytotoxicity of QDs was not only attributed to their heavy metal components, but also related to their nanosize effects which could induce particle-specific toxicity. The above results offer valuable information for exploring the cytotoxicity mechanism of QDs in prokaryote and eukaryote.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" IndexingMethod="Curated" Owner="NLM"><PMID Version="1">31202934</PMID><DateCompleted><Year>2019</Year><Month>08</Month><Day>27</Day></DateCompleted><DateRevised><Year>2019</Year><Month>08</Month><Day>27</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1090-2414</ISSN><JournalIssue CitedMedium="Internet"><Volume>181</Volume><PubDate><Year>2019</Year><Month>Oct</Month><Day>15</Day></PubDate></JournalIssue><Title>Ecotoxicology and environmental safety</Title><ISOAbbreviation>Ecotoxicol Environ Saf</ISOAbbreviation></Journal><ArticleTitle>The cytotoxicities in prokaryote and eukaryote varied for CdSe and CdSe/ZnS quantum dots and differed from cadmium ions.</ArticleTitle><Pagination><MedlinePgn>336-344</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0147-6513(19)30665-7</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.ecoenv.2019.06.027</ELocationID><Abstract><AbstractText>The present study focused on the bioaccumulation and cytotoxicities of Cd<sup>2+</sup>, CdSe quantum dots (QDs) and CdSe/ZnS QDs in Escherichia coli (E. coli, represents prokaryotic system) and Phanerochaete chrysosporium (P. chrysosporium, represents eukaryotic system), respectively. Two types of QDs were characterized by transmission electron microscopy (TEM) and dynamic light scattering. The inductively coupled plasma optical emission spectrometer results showed that the bioaccumulation amounts of CdSe QDs by E. coli and P. chrysosporium were larger than those of CdSe/ZnS QDs due to the smaller particle size and less negative surface charges of CdSe QDs. Confocal microscopy and TEM results showed that there was an interaction between QDs and cells, and QDs have entered into the cells eventually, leading to the change of cell morphology. Plasma membrane fluidities and membrane H<sup>+</sup>-ATPase activities of E. coli and P. chrysosporium decreased gradually with the increasing concentrations of Cd<sup>2+</sup>, CdSe and CdSe/ZnS QDs. Results of the cell viabilities and intracellular reactive oxygen species levels indicated that the induced cytotoxicities were decreased as follows: CdSe QDs > CdSe/ZnS QDs > Cd<sup>2+</sup>. These findings suggested that the cytotoxicity of QDs was not only attributed to their heavy metal components, but also related to their nanosize effects which could induce particle-specific toxicity. The above results offer valuable information for exploring the cytotoxicity mechanism of QDs in prokaryote and eukaryote.</AbstractText><CopyrightInformation>Copyright © 2019 Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Hu</LastName><ForeName>Liang</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>School of Minerals Processing and Bioengineering, Key Laboratory of Biohydrometallurgy of Ministry of Education, Central South University, Changsha, 410083, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhong</LastName><ForeName>Hui</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>School of Life Science, Central South University, Changsha, 410012, China. Electronic address: 35406719@qq.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>He</LastName><ForeName>Zhiguo</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>School of Minerals Processing and Bioengineering, Key Laboratory of Biohydrometallurgy of Ministry of Education, Central South University, Changsha, 410083, China. Electronic address: zghe@csu.edu.cn.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2019</Year><Month>06</Month><Day>13</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Ecotoxicol Environ Saf</MedlineTA><NlmUniqueID>7805381</NlmUniqueID><ISSNLinking>0147-6513</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D019187">Cadmium Compounds</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D003603">Cytotoxins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007477">Ions</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D017382">Reactive Oxygen Species</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018036">Selenium Compounds</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D013440">Sulfides</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D017967">Zinc Compounds</NameOfSubstance></Chemical><Chemical><RegistryNumber>00BH33GNGH</RegistryNumber><NameOfSubstance UI="D002104">Cadmium</NameOfSubstance></Chemical><Chemical><RegistryNumber>KPS085631O</RegistryNumber><NameOfSubstance UI="C031238">zinc sulfide</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D002104" MajorTopicYN="N">Cadmium</DescriptorName><QualifierName UI="Q000633" MajorTopicYN="Y">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019187" MajorTopicYN="N">Cadmium Compounds</DescriptorName><QualifierName UI="Q000633" MajorTopicYN="Y">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003603" MajorTopicYN="N">Cytotoxins</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000633" MajorTopicYN="N">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004926" MajorTopicYN="N">Escherichia coli</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000648" MajorTopicYN="N">ultrastructure</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007477" MajorTopicYN="N">Ions</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008560" MajorTopicYN="N">Membrane Fluidity</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D050296" MajorTopicYN="N">Microbial Viability</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020075" MajorTopicYN="N">Phanerochaete</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000648" MajorTopicYN="N">ultrastructure</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D045663" MajorTopicYN="N">Quantum Dots</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000633" MajorTopicYN="Y">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017382" MajorTopicYN="N">Reactive Oxygen Species</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018036" MajorTopicYN="N">Selenium Compounds</DescriptorName><QualifierName UI="Q000633" MajorTopicYN="Y">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013440" MajorTopicYN="N">Sulfides</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000633" MajorTopicYN="Y">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017967" MajorTopicYN="N">Zinc Compounds</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000633" MajorTopicYN="Y">toxicity</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Cadmium ions</Keyword><Keyword MajorTopicYN="N">Cellular uptake</Keyword><Keyword MajorTopicYN="N">Eukaryote</Keyword><Keyword MajorTopicYN="N">Particle-specific toxicity</Keyword><Keyword MajorTopicYN="N">Prokaryote</Keyword><Keyword MajorTopicYN="N">Quantum dots</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year><Month>12</Month><Day>10</Day></PubMedPubDate><PubMedPubDate 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