Sulfadiazine biodegradation by Phanerochaete chrysosporium: Mechanism and degradation product identification.
Identifieur interne : 000054 ( Main/Corpus ); précédent : 000053; suivant : 000055Sulfadiazine biodegradation by Phanerochaete chrysosporium: Mechanism and degradation product identification.
Auteurs : Ting Zhang ; Ling Cai ; Bentuo Xu ; Xicheng Li ; Wenhui Qiu ; Caixia Fu ; Chunmiao ZhengSource :
- Chemosphere [ 1879-1298 ] ; 2019.
English descriptors
- KwdEn :
- Anti-Bacterial Agents (metabolism), Biodegradation, Environmental (MeSH), Environmental Pollutants (metabolism), Environmental Restoration and Remediation (methods), Fungal Proteins (metabolism), Gene Expression Profiling (MeSH), Hydrogen-Ion Concentration (MeSH), Peroxidases (metabolism), Phanerochaete (genetics), Phanerochaete (metabolism), Sulfadiazine (metabolism), Tandem Mass Spectrometry (MeSH), Time Factors (MeSH).
- MESH :
- chemical , metabolism : Anti-Bacterial Agents, Environmental Pollutants, Fungal Proteins, Peroxidases, Sulfadiazine.
- genetics : Phanerochaete.
- metabolism : Phanerochaete.
- methods : Environmental Restoration and Remediation.
- Biodegradation, Environmental, Gene Expression Profiling, Hydrogen-Ion Concentration, Tandem Mass Spectrometry, Time Factors.
Abstract
Antibiotic contaminants have become a severe environmental problem in recent years and finding effective ways to deal with this issue is of great importance. In this study, Phanerochaete chrysosporium was used to degrade sulfadiazine (SDZ), which is frequently detected in the culture medium of isolates from soil and surface water systems. The results demonstrate that 10 mg L-1 SDZ can be completely degraded by P. chrysosporium under conditions of pH 5.7 and 30 °C within 6 days. The Q-Exactive-MS/MS analysis identified and confirmed several different SDZ degradation intermediates, and four proposed degradation pathways of SDZ were deduced. Moreover, enzyme activity tests revealed that manganese peroxidase and ligninolytic peroxidase played important roles in SDZ degradation. Moreover, a transcriptome analysis method was performed to explore the mechanism and pathways of SDZ degradation by P. chrysosporium in greater detail. The results of GO and KEGG analysis strongly suggest that the metabolism pathway is significantly activated and plays an important role in antibiotic degradation. Further, this is the first study to identify SDZ degradation intermediates and two main intermediates were found to be involved in possible SDZ degradation pathways. This study is also the first report results from RNA sequencing to evaluate genome-wide changes of P. chrysosporium to further explore SDZ degradation mechanism.
DOI: 10.1016/j.chemosphere.2019.124418
PubMed: 31369901
Links to Exploration step
pubmed:31369901Le document en format XML
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<series><title level="j">Chemosphere</title>
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<term>Environmental Restoration and Remediation (methods)</term>
<term>Fungal Proteins (metabolism)</term>
<term>Gene Expression Profiling (MeSH)</term>
<term>Hydrogen-Ion Concentration (MeSH)</term>
<term>Peroxidases (metabolism)</term>
<term>Phanerochaete (genetics)</term>
<term>Phanerochaete (metabolism)</term>
<term>Sulfadiazine (metabolism)</term>
<term>Tandem Mass Spectrometry (MeSH)</term>
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<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Anti-Bacterial Agents</term>
<term>Environmental Pollutants</term>
<term>Fungal Proteins</term>
<term>Peroxidases</term>
<term>Sulfadiazine</term>
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<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Phanerochaete</term>
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<front><div type="abstract" xml:lang="en">Antibiotic contaminants have become a severe environmental problem in recent years and finding effective ways to deal with this issue is of great importance. In this study, Phanerochaete chrysosporium was used to degrade sulfadiazine (SDZ), which is frequently detected in the culture medium of isolates from soil and surface water systems. The results demonstrate that 10 mg L<sup>-1</sup>
SDZ can be completely degraded by P. chrysosporium under conditions of pH 5.7 and 30 °C within 6 days. The Q-Exactive-MS/MS analysis identified and confirmed several different SDZ degradation intermediates, and four proposed degradation pathways of SDZ were deduced. Moreover, enzyme activity tests revealed that manganese peroxidase and ligninolytic peroxidase played important roles in SDZ degradation. Moreover, a transcriptome analysis method was performed to explore the mechanism and pathways of SDZ degradation by P. chrysosporium in greater detail. The results of GO and KEGG analysis strongly suggest that the metabolism pathway is significantly activated and plays an important role in antibiotic degradation. Further, this is the first study to identify SDZ degradation intermediates and two main intermediates were found to be involved in possible SDZ degradation pathways. This study is also the first report results from RNA sequencing to evaluate genome-wide changes of P. chrysosporium to further explore SDZ degradation mechanism.</div>
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<Abstract><AbstractText>Antibiotic contaminants have become a severe environmental problem in recent years and finding effective ways to deal with this issue is of great importance. In this study, Phanerochaete chrysosporium was used to degrade sulfadiazine (SDZ), which is frequently detected in the culture medium of isolates from soil and surface water systems. The results demonstrate that 10 mg L<sup>-1</sup>
SDZ can be completely degraded by P. chrysosporium under conditions of pH 5.7 and 30 °C within 6 days. The Q-Exactive-MS/MS analysis identified and confirmed several different SDZ degradation intermediates, and four proposed degradation pathways of SDZ were deduced. Moreover, enzyme activity tests revealed that manganese peroxidase and ligninolytic peroxidase played important roles in SDZ degradation. Moreover, a transcriptome analysis method was performed to explore the mechanism and pathways of SDZ degradation by P. chrysosporium in greater detail. The results of GO and KEGG analysis strongly suggest that the metabolism pathway is significantly activated and plays an important role in antibiotic degradation. Further, this is the first study to identify SDZ degradation intermediates and two main intermediates were found to be involved in possible SDZ degradation pathways. This study is also the first report results from RNA sequencing to evaluate genome-wide changes of P. chrysosporium to further explore SDZ degradation mechanism.</AbstractText>
<CopyrightInformation>Copyright © 2019. Published by Elsevier Ltd.</CopyrightInformation>
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