Regulatory mechanism of food factors in bone metabolism and prevention of osteoporosis.
Identifieur interne : 000B95 ( PubMed/Curation ); précédent : 000B94; suivant : 000B96Regulatory mechanism of food factors in bone metabolism and prevention of osteoporosis.
Auteurs : Masayoshi Yamaguchi [Japon]Source :
- Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan [ 0031-6903 ] ; 2006.
English descriptors
- KwdEn :
- Animals, Bone Density (drug effects), Bone Resorption (prevention & control), Bone and Bones (metabolism), Citrus sinensis, Coumaric Acids (pharmacology), Cryptoxanthins, Food, Food Analysis, Humans, Isoflavones (pharmacology), Metabolism (drug effects), Osteogenesis (drug effects), Osteoporosis (etiology), Osteoporosis (prevention & control), Rats, Soybeans, Stimulation, Chemical, Vitamin K 2 (analogs & derivatives), Vitamin K 2 (pharmacology), Xanthophylls (pharmacology).
- MESH :
- chemical , analogs & derivatives : Vitamin K 2.
- chemical , pharmacology : Coumaric Acids, Isoflavones, Vitamin K 2, Xanthophylls.
- drug effects : Bone Density, Metabolism, Osteogenesis.
- etiology : Osteoporosis.
- metabolism : Bone and Bones.
- prevention & control : Bone Resorption, Osteoporosis.
- Animals, Citrus sinensis, Cryptoxanthins, Food, Food Analysis, Humans, Rats, Soybeans, Stimulation, Chemical.
Abstract
Aging induces a decrease in bone mass, and osteoporosis with its accompanying decrease in bone mass is widely recognized as a major public health problem. Bone loss with increasing age may be due to decreased bone formation and increased bone resorption. Pharmacologic and nutritional factors may prevent bone loss with aging, although chemical compounds in food and plants which act on bone metabolism are poorly understood. We have found that isoflavones (including genistein and daidzein), which are contained in soybeans, have a stimulatory effect on osteoblastic bone formation and an inhibitory effect on osteoclastic bone resorption, thereby increasing bone mass. Menaquinone-7, an analogue of vitamin K(2) which is abundant in fermented soybeans, has been demonstrated to stimulate osteoblastic bone formation and to inhibit osteoclastic bone resorption. Of various carotenoids, beta-cryptoxanthin, which is abundant in Satsuma mandarin (Citrus unchiu MARC), has a stimulatory effect on osteoblastic bone formation and an inhibitory effect on osteoclastic bone resorption. The supplementation of these factors has a preventive effect on bone loss induced by ovariectomy in rats, which are an animal model of osteoporosis, and their intake has been shown to have a stimulatory effect on bone mass in humans. Factors with an anabolic effect on bone metabolism were found in extracts obtained from wasabi leafstalk (Wasabi japonica MATSUM), the marine alga Sargassum horneri, and bee pollen Cistus ladaniferus. Phytocomponent p-hydroxycinnamic acid was also found to have an anabolic effect on bone metabolism. Food chemical factors thus play a role in bone health and may be important in the prevention of bone loss with increasing age.
PubMed: 17077614
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Regulatory mechanism of food factors in bone metabolism and prevention of osteoporosis.</title><author><name sortKey="Yamaguchi, Masayoshi" sort="Yamaguchi, Masayoshi" uniqKey="Yamaguchi M" first="Masayoshi" last="Yamaguchi">Masayoshi Yamaguchi</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka City 422-8526, Japan. yamaguch@u-shizuoka-ken.ac.jp</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka City 422-8526</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2006">2006</date><idno type="RBID">pubmed:17077614</idno><idno type="pmid">17077614</idno><idno type="wicri:Area/PubMed/Corpus">000B95</idno><idno type="wicri:Area/PubMed/Curation">000B95</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Regulatory mechanism of food factors in bone metabolism and prevention of osteoporosis.</title><author><name sortKey="Yamaguchi, Masayoshi" sort="Yamaguchi, Masayoshi" uniqKey="Yamaguchi M" first="Masayoshi" last="Yamaguchi">Masayoshi Yamaguchi</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka City 422-8526, Japan. yamaguch@u-shizuoka-ken.ac.jp</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka City 422-8526</wicri:regionArea></affiliation></author></analytic><series><title level="j">Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan</title><idno type="ISSN">0031-6903</idno><imprint><date when="2006" type="published">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Bone Density (drug effects)</term><term>Bone Resorption (prevention & control)</term><term>Bone and Bones (metabolism)</term><term>Citrus sinensis</term><term>Coumaric Acids (pharmacology)</term><term>Cryptoxanthins</term><term>Food</term><term>Food Analysis</term><term>Humans</term><term>Isoflavones (pharmacology)</term><term>Metabolism (drug effects)</term><term>Osteogenesis (drug effects)</term><term>Osteoporosis (etiology)</term><term>Osteoporosis (prevention & control)</term><term>Rats</term><term>Soybeans</term><term>Stimulation, Chemical</term><term>Vitamin K 2 (analogs & derivatives)</term><term>Vitamin K 2 (pharmacology)</term><term>Xanthophylls (pharmacology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Vitamin K 2</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Coumaric Acids</term><term>Isoflavones</term><term>Vitamin K 2</term><term>Xanthophylls</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Bone Density</term><term>Metabolism</term><term>Osteogenesis</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Osteoporosis</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Bone and Bones</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Bone Resorption</term><term>Osteoporosis</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Citrus sinensis</term><term>Cryptoxanthins</term><term>Food</term><term>Food Analysis</term><term>Humans</term><term>Rats</term><term>Soybeans</term><term>Stimulation, Chemical</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Aging induces a decrease in bone mass, and osteoporosis with its accompanying decrease in bone mass is widely recognized as a major public health problem. Bone loss with increasing age may be due to decreased bone formation and increased bone resorption. Pharmacologic and nutritional factors may prevent bone loss with aging, although chemical compounds in food and plants which act on bone metabolism are poorly understood. We have found that isoflavones (including genistein and daidzein), which are contained in soybeans, have a stimulatory effect on osteoblastic bone formation and an inhibitory effect on osteoclastic bone resorption, thereby increasing bone mass. Menaquinone-7, an analogue of vitamin K(2) which is abundant in fermented soybeans, has been demonstrated to stimulate osteoblastic bone formation and to inhibit osteoclastic bone resorption. Of various carotenoids, beta-cryptoxanthin, which is abundant in Satsuma mandarin (Citrus unchiu MARC), has a stimulatory effect on osteoblastic bone formation and an inhibitory effect on osteoclastic bone resorption. The supplementation of these factors has a preventive effect on bone loss induced by ovariectomy in rats, which are an animal model of osteoporosis, and their intake has been shown to have a stimulatory effect on bone mass in humans. Factors with an anabolic effect on bone metabolism were found in extracts obtained from wasabi leafstalk (Wasabi japonica MATSUM), the marine alga Sargassum horneri, and bee pollen Cistus ladaniferus. Phytocomponent p-hydroxycinnamic acid was also found to have an anabolic effect on bone metabolism. Food chemical factors thus play a role in bone health and may be important in the prevention of bone loss with increasing age.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">17077614</PMID><DateCreated><Year>2006</Year><Month>11</Month><Day>1</Day></DateCreated><DateCompleted><Year>2007</Year><Month>01</Month><Day>26</Day></DateCompleted><DateRevised><Year>2014</Year><Month>11</Month><Day>20</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0031-6903</ISSN><JournalIssue CitedMedium="Print"><Volume>126</Volume><Issue>11</Issue><PubDate><Year>2006</Year><Month>Nov</Month></PubDate></JournalIssue><Title>Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan</Title><ISOAbbreviation>Yakugaku Zasshi</ISOAbbreviation></Journal><ArticleTitle>Regulatory mechanism of food factors in bone metabolism and prevention of osteoporosis.</ArticleTitle><Pagination><MedlinePgn>1117-37</MedlinePgn></Pagination><Abstract><AbstractText>Aging induces a decrease in bone mass, and osteoporosis with its accompanying decrease in bone mass is widely recognized as a major public health problem. Bone loss with increasing age may be due to decreased bone formation and increased bone resorption. Pharmacologic and nutritional factors may prevent bone loss with aging, although chemical compounds in food and plants which act on bone metabolism are poorly understood. We have found that isoflavones (including genistein and daidzein), which are contained in soybeans, have a stimulatory effect on osteoblastic bone formation and an inhibitory effect on osteoclastic bone resorption, thereby increasing bone mass. Menaquinone-7, an analogue of vitamin K(2) which is abundant in fermented soybeans, has been demonstrated to stimulate osteoblastic bone formation and to inhibit osteoclastic bone resorption. Of various carotenoids, beta-cryptoxanthin, which is abundant in Satsuma mandarin (Citrus unchiu MARC), has a stimulatory effect on osteoblastic bone formation and an inhibitory effect on osteoclastic bone resorption. The supplementation of these factors has a preventive effect on bone loss induced by ovariectomy in rats, which are an animal model of osteoporosis, and their intake has been shown to have a stimulatory effect on bone mass in humans. Factors with an anabolic effect on bone metabolism were found in extracts obtained from wasabi leafstalk (Wasabi japonica MATSUM), the marine alga Sargassum horneri, and bee pollen Cistus ladaniferus. Phytocomponent p-hydroxycinnamic acid was also found to have an anabolic effect on bone metabolism. Food chemical factors thus play a role in bone health and may be important in the prevention of bone loss with increasing age.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Yamaguchi</LastName><ForeName>Masayoshi</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka City 422-8526, Japan. yamaguch@u-shizuoka-ken.ac.jp</Affiliation></AffiliationInfo></Author></AuthorList><Language>ENG</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Japan</Country><MedlineTA>Yakugaku Zasshi</MedlineTA><NlmUniqueID>0413613</NlmUniqueID><ISSNLinking>0031-6903</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D003373">Coumaric Acids</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D065366">Cryptoxanthins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007529">Isoflavones</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D024341">Xanthophylls</NameOfSubstance></Chemical><Chemical><RegistryNumber>11032-49-8</RegistryNumber><NameOfSubstance UI="D024482">Vitamin K 2</NameOfSubstance></Chemical><Chemical><RegistryNumber>8427BML8NY</RegistryNumber><NameOfSubstance UI="C062629">vitamin MK 7</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015519" MajorTopicYN="N">Bone Density</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001862" MajorTopicYN="N">Bone Resorption</DescriptorName><QualifierName UI="Q000517" MajorTopicYN="N">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001842" MajorTopicYN="N">Bone and Bones</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D032084" MajorTopicYN="N">Citrus sinensis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003373" MajorTopicYN="N">Coumaric Acids</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D065366" MajorTopicYN="N">Cryptoxanthins</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005502" MajorTopicYN="Y">Food</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005504" MajorTopicYN="N">Food Analysis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007529" MajorTopicYN="Y">Isoflavones</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008660" MajorTopicYN="N">Metabolism</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010012" MajorTopicYN="N">Osteogenesis</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010024" MajorTopicYN="N">Osteoporosis</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName><QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013025" MajorTopicYN="N">Soybeans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013268" MajorTopicYN="N">Stimulation, Chemical</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D024482" MajorTopicYN="N">Vitamin K 2</DescriptorName><QualifierName UI="Q000031" MajorTopicYN="Y">analogs & derivatives</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D024341" MajorTopicYN="Y">Xanthophylls</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading></MeshHeadingList><NumberOfReferences>124</NumberOfReferences></MedlineCitation><PubmedData><History><PubMedPubDate 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