Pharmacokinetics-based elucidation on disparity in clinical effectiveness between varieties of Zhi Zhu Wan, a Traditional Chinese Medical formula.
Identifieur interne : 000852 ( PubMed/Curation ); précédent : 000851; suivant : 000853Pharmacokinetics-based elucidation on disparity in clinical effectiveness between varieties of Zhi Zhu Wan, a Traditional Chinese Medical formula.
Auteurs : Hongxin Cao [République populaire de Chine] ; Xi Chen ; Hui Sun ; Tetsuro Sakurai ; Jue Zhou ; Wenjun Sun ; Haitao Lv ; Xijun WangSource :
- Journal of ethnopharmacology [ 1872-7573 ] ; 2010.
English descriptors
- KwdEn :
- Administration, Oral, Adult, Animals, Area Under Curve, Asian Continental Ancestry Group, Chromatography, High Pressure Liquid (methods), Citrus (chemistry), Citrus sinensis (chemistry), Cricetinae, Cricetulus, Flavanones, Hesperidin, Humans, Male, Wiskott-Aldrich Syndrome, Wiskott-Aldrich Syndrome Protein.
- MESH :
- chemical : Flavanones, Hesperidin, Wiskott-Aldrich Syndrome Protein.
- chemistry : Citrus, Citrus sinensis.
- methods : Chromatography, High Pressure Liquid.
- Administration, Oral, Adult, Animals, Area Under Curve, Asian Continental Ancestry Group, Cricetinae, Cricetulus, Humans, Male, Wiskott-Aldrich Syndrome.
Abstract
Zhi Zhu Wan (ZZW) is a classical Chinese medical formulation used for the treatment of functional dyspepsia that attributed to Spleen-deficiency Syndrome. ZZW contains Atractylodes Rhizome and Fructus Citrus Immaturus, the later originates from both Citrus aurantium L. (BZZW) and Citrus sinensis Osbeck (RZZW). The present study is designed to elucidate disparities in the clinical efficacy of two ZZW varieties based on the pharmacokinetics of naringenin and hesperetin. MEHTOD: After oral administration of ZZWs, blood sample was collected from healthy volunteers at designed time points. Naringenin and hesperetin were detected in plasma by RP-HPLC, pharmacokinetic parameters were processed using mode-independent methods with WINNONLIN.
DOI: 10.1016/j.jep.2010.02.005
PubMed: 20184950
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Pharmacokinetics-based elucidation on disparity in clinical effectiveness between varieties of Zhi Zhu Wan, a Traditional Chinese Medical formula.</title><author><name sortKey="Cao, Hongxin" sort="Cao, Hongxin" uniqKey="Cao H" first="Hongxin" last="Cao">Hongxin Cao</name><affiliation wicri:level="1"><nlm:affiliation>National TCM Key Laboratory of Serum Pharmacochemistry, Heilongjiang University of Chinese Medicine, No. 24 Heping Road, Harbin 150040, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>National TCM Key Laboratory of Serum Pharmacochemistry, Heilongjiang University of Chinese Medicine, No. 24 Heping Road, Harbin 150040</wicri:regionArea></affiliation></author><author><name sortKey="Chen, Xi" sort="Chen, Xi" uniqKey="Chen X" first="Xi" last="Chen">Xi Chen</name></author><author><name sortKey="Sun, Hui" sort="Sun, Hui" uniqKey="Sun H" first="Hui" last="Sun">Hui Sun</name></author><author><name sortKey="Sakurai, Tetsuro" sort="Sakurai, Tetsuro" uniqKey="Sakurai T" first="Tetsuro" last="Sakurai">Tetsuro Sakurai</name></author><author><name sortKey="Zhou, Jue" sort="Zhou, Jue" uniqKey="Zhou J" first="Jue" last="Zhou">Jue Zhou</name></author><author><name sortKey="Sun, Wenjun" sort="Sun, Wenjun" uniqKey="Sun W" first="Wenjun" last="Sun">Wenjun Sun</name></author><author><name sortKey="Lv, Haitao" sort="Lv, Haitao" uniqKey="Lv H" first="Haitao" last="Lv">Haitao Lv</name></author><author><name sortKey="Wang, Xijun" sort="Wang, Xijun" uniqKey="Wang X" first="Xijun" last="Wang">Xijun Wang</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2010">2010</date><idno type="RBID">pubmed:20184950</idno><idno type="pmid">20184950</idno><idno type="doi">10.1016/j.jep.2010.02.005</idno><idno type="wicri:Area/PubMed/Corpus">000852</idno><idno 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sort="Sun, Hui" uniqKey="Sun H" first="Hui" last="Sun">Hui Sun</name></author><author><name sortKey="Sakurai, Tetsuro" sort="Sakurai, Tetsuro" uniqKey="Sakurai T" first="Tetsuro" last="Sakurai">Tetsuro Sakurai</name></author><author><name sortKey="Zhou, Jue" sort="Zhou, Jue" uniqKey="Zhou J" first="Jue" last="Zhou">Jue Zhou</name></author><author><name sortKey="Sun, Wenjun" sort="Sun, Wenjun" uniqKey="Sun W" first="Wenjun" last="Sun">Wenjun Sun</name></author><author><name sortKey="Lv, Haitao" sort="Lv, Haitao" uniqKey="Lv H" first="Haitao" last="Lv">Haitao Lv</name></author><author><name sortKey="Wang, Xijun" sort="Wang, Xijun" uniqKey="Wang X" first="Xijun" last="Wang">Xijun Wang</name></author></analytic><series><title level="j">Journal of ethnopharmacology</title><idno type="eISSN">1872-7573</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Administration, Oral</term><term>Adult</term><term>Animals</term><term>Area Under Curve</term><term>Asian Continental Ancestry Group</term><term>Chromatography, High Pressure Liquid (methods)</term><term>Citrus (chemistry)</term><term>Citrus sinensis (chemistry)</term><term>Cricetinae</term><term>Cricetulus</term><term>Flavanones</term><term>Hesperidin</term><term>Humans</term><term>Male</term><term>Wiskott-Aldrich Syndrome</term><term>Wiskott-Aldrich Syndrome Protein</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Flavanones</term><term>Hesperidin</term><term>Wiskott-Aldrich Syndrome Protein</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Citrus</term><term>Citrus sinensis</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Chromatography, High Pressure Liquid</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Administration, Oral</term><term>Adult</term><term>Animals</term><term>Area Under Curve</term><term>Asian Continental Ancestry Group</term><term>Cricetinae</term><term>Cricetulus</term><term>Humans</term><term>Male</term><term>Wiskott-Aldrich Syndrome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Zhi Zhu Wan (ZZW) is a classical Chinese medical formulation used for the treatment of functional dyspepsia that attributed to Spleen-deficiency Syndrome. ZZW contains Atractylodes Rhizome and Fructus Citrus Immaturus, the later originates from both Citrus aurantium L. (BZZW) and Citrus sinensis Osbeck (RZZW). The present study is designed to elucidate disparities in the clinical efficacy of two ZZW varieties based on the pharmacokinetics of naringenin and hesperetin. MEHTOD: After oral administration of ZZWs, blood sample was collected from healthy volunteers at designed time points. Naringenin and hesperetin were detected in plasma by RP-HPLC, pharmacokinetic parameters were processed using mode-independent methods with WINNONLIN.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">20184950</PMID><DateCreated><Year>2010</Year><Month>4</Month><Day>12</Day></DateCreated><DateCompleted><Year>2010</Year><Month>07</Month><Day>13</Day></DateCompleted><DateRevised><Year>2015</Year><Month>11</Month><Day>19</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1872-7573</ISSN><JournalIssue CitedMedium="Internet"><Volume>128</Volume><Issue>3</Issue><PubDate><Year>2010</Year><Month>Apr</Month><Day>21</Day></PubDate></JournalIssue><Title>Journal of ethnopharmacology</Title><ISOAbbreviation>J Ethnopharmacol</ISOAbbreviation></Journal><ArticleTitle>Pharmacokinetics-based elucidation on disparity in clinical effectiveness between varieties of Zhi Zhu Wan, a Traditional Chinese Medical formula.</ArticleTitle><Pagination><MedlinePgn>606-10</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jep.2010.02.005</ELocationID><Abstract><AbstractText Label="AIM" NlmCategory="OBJECTIVE">Zhi Zhu Wan (ZZW) is a classical Chinese medical formulation used for the treatment of functional dyspepsia that attributed to Spleen-deficiency Syndrome. ZZW contains Atractylodes Rhizome and Fructus Citrus Immaturus, the later originates from both Citrus aurantium L. (BZZW) and Citrus sinensis Osbeck (RZZW). The present study is designed to elucidate disparities in the clinical efficacy of two ZZW varieties based on the pharmacokinetics of naringenin and hesperetin. MEHTOD: After oral administration of ZZWs, blood sample was collected from healthy volunteers at designed time points. Naringenin and hesperetin were detected in plasma by RP-HPLC, pharmacokinetic parameters were processed using mode-independent methods with WINNONLIN.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">After oral administration of BZZW, both naringenin and hesperetin were detected in plasma, and demonstrated similar pharmacokinetic parameters. Ka was 0.384+/-0.165 and 0.401+/-0.159, T(1/2(ke))(h) was 5.491+/-3.926 and 5.824+/-3.067, the AUC (mg/Lh) was 34.886+/-22.199 and 39.407+/-19.535 for naringenin and hesperetin, respectively. However, in the case of RZZW, only hesperetin was found in plasma, but the pharmacokinetic properties for hesperetin in RZZW was different from that in BZZW. T(max) for hesperetin in RZZW is about 8.515h, and its C(max) is much larger than that of BZZW. Moreover, it was eliminated slowly as it possessed a much larger AUC value.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">The distinct therapeutic orientations of the Chinese medical formula ZZWs with different Fructus Citrus Immaturus could be elucidated based on the pharmacokinetic parameters of constituents after oral administration.</AbstractText><CopyrightInformation>Copyright 2010 Elsevier Ireland Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Cao</LastName><ForeName>Hongxin</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>National TCM Key Laboratory of Serum Pharmacochemistry, Heilongjiang University of Chinese Medicine, No. 24 Heping Road, Harbin 150040, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Xi</ForeName><Initials>X</Initials></Author><Author ValidYN="Y"><LastName>Sun</LastName><ForeName>Hui</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Sakurai</LastName><ForeName>Tetsuro</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Zhou</LastName><ForeName>Jue</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Sun</LastName><ForeName>Wenjun</ForeName><Initials>W</Initials></Author><Author ValidYN="Y"><LastName>Lv</LastName><ForeName>Haitao</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Xijun</ForeName><Initials>X</Initials></Author></AuthorList><Language>ENG</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2010</Year><Month>Feb</Month><Day>23</Day></ArticleDate></Article><MedlineJournalInfo><Country>Ireland</Country><MedlineTA>J Ethnopharmacol</MedlineTA><NlmUniqueID>7903310</NlmUniqueID><ISSNLinking>0378-8741</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D044950">Flavanones</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D051316">Wiskott-Aldrich Syndrome Protein</NameOfSubstance></Chemical><Chemical><RegistryNumber>E750O06Y6O</RegistryNumber><NameOfSubstance UI="D006569">Hesperidin</NameOfSubstance></Chemical><Chemical><RegistryNumber>HN5425SBF2</RegistryNumber><NameOfSubstance UI="C005273">naringenin</NameOfSubstance></Chemical><Chemical><RegistryNumber>Q9Q3D557F1</RegistryNumber><NameOfSubstance UI="C013015">hesperetin</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000284" MajorTopicYN="N">Administration, Oral</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019540" MajorTopicYN="N">Area Under Curve</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D044466" MajorTopicYN="N">Asian Continental Ancestry Group</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002851" MajorTopicYN="N">Chromatography, High Pressure Liquid</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002957" MajorTopicYN="N">Citrus</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D032084" MajorTopicYN="N">Citrus sinensis</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006224" MajorTopicYN="N">Cricetinae</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003412" MajorTopicYN="N">Cricetulus</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D044950" MajorTopicYN="N">Flavanones</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006569" MajorTopicYN="N">Hesperidin</DescriptorName></MeshHeading><MeshHeading><DescriptorName 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