Differential effects of cream, glucose, and orange juice on inflammation, endotoxin, and the expression of Toll-like receptor-4 and suppressor of cytokine signaling-3.
Identifieur interne : 000844 ( PubMed/Curation ); précédent : 000843; suivant : 000845Differential effects of cream, glucose, and orange juice on inflammation, endotoxin, and the expression of Toll-like receptor-4 and suppressor of cytokine signaling-3.
Auteurs : Rupali Deopurkar [États-Unis] ; Husam Ghanim ; Jay Friedman ; Sanaa Abuaysheh ; Chang Ling Sia ; Priya Mohanty ; Prabhakar Viswanathan ; Ajay Chaudhuri ; Paresh DandonaSource :
- Diabetes care [ 1935-5548 ] ; 2010.
English descriptors
- KwdEn :
- Acute-Phase Proteins, Adult, Animals, Blood Glucose (metabolism), Carrier Proteins (blood), Citrus sinensis, Cytokines (genetics), Cytokines (metabolism), Dietary Carbohydrates (administration & dosage), Dietary Carbohydrates (blood), Dietary Fats (administration & dosage), Dietary Fats (blood), Glucose (administration & dosage), Humans, Inflammation (blood), Inflammation (immunology), Insulin (blood), Lipopolysaccharides (blood), Membrane Glycoproteins (blood), Middle Aged, Milk, NF-kappa B (metabolism), Oxidative Stress (drug effects), Oxidative Stress (immunology), Postprandial Period (immunology), RNA, Messenger (metabolism), Reference Values, Signal Transduction (drug effects), Signal Transduction (immunology), Suppressor of Cytokine Signaling Proteins (genetics), Suppressor of Cytokine Signaling Proteins (metabolism), Toll-Like Receptor 4 (genetics), Toll-Like Receptor 4 (metabolism).
- MESH :
- chemical , administration & dosage : Dietary Carbohydrates, Dietary Fats, Glucose.
- chemical , blood : Carrier Proteins, Dietary Carbohydrates, Dietary Fats, Insulin, Lipopolysaccharides, Membrane Glycoproteins.
- chemical , genetics : Cytokines, Suppressor of Cytokine Signaling Proteins, Toll-Like Receptor 4.
- chemical , metabolism : Blood Glucose, Cytokines, NF-kappa B, RNA, Messenger, Suppressor of Cytokine Signaling Proteins, Toll-Like Receptor 4.
- chemical : Acute-Phase Proteins.
- blood : Inflammation.
- drug effects : Oxidative Stress, Signal Transduction.
- immunology : Inflammation, Oxidative Stress, Postprandial Period, Signal Transduction.
- Adult, Animals, Citrus sinensis, Humans, Middle Aged, Milk, Reference Values.
Abstract
We have recently shown that a high-fat high-carbohydrate (HFHC) meal induces an increase in plasma concentrations of endotoxin (lipopolysaccharide [LPS]) and the expression of Toll-like receptor-4 (TLR-4) and suppresser of cytokine signaling-3 (SOCS3) in mononuclear cells (MNCs) in addition to oxidative stress and cellular inflammation. Saturated fat and carbohydrates, components of the HFHC meal, known to induce oxidative stress and inflammation, also induce an increase in LPS, TLR-4, and SOCS3.
DOI: 10.2337/dc09-1630
PubMed: 20067961
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sort="Friedman, Jay" uniqKey="Friedman J" first="Jay" last="Friedman">Jay Friedman</name></author><author><name sortKey="Abuaysheh, Sanaa" sort="Abuaysheh, Sanaa" uniqKey="Abuaysheh S" first="Sanaa" last="Abuaysheh">Sanaa Abuaysheh</name></author><author><name sortKey="Sia, Chang Ling" sort="Sia, Chang Ling" uniqKey="Sia C" first="Chang Ling" last="Sia">Chang Ling Sia</name></author><author><name sortKey="Mohanty, Priya" sort="Mohanty, Priya" uniqKey="Mohanty P" first="Priya" last="Mohanty">Priya Mohanty</name></author><author><name sortKey="Viswanathan, Prabhakar" sort="Viswanathan, Prabhakar" uniqKey="Viswanathan P" first="Prabhakar" last="Viswanathan">Prabhakar Viswanathan</name></author><author><name sortKey="Chaudhuri, Ajay" sort="Chaudhuri, Ajay" uniqKey="Chaudhuri A" first="Ajay" last="Chaudhuri">Ajay Chaudhuri</name></author><author><name sortKey="Dandona, Paresh" sort="Dandona, Paresh" uniqKey="Dandona P" first="Paresh" last="Dandona">Paresh 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last="Viswanathan">Prabhakar Viswanathan</name></author><author><name sortKey="Chaudhuri, Ajay" sort="Chaudhuri, Ajay" uniqKey="Chaudhuri A" first="Ajay" last="Chaudhuri">Ajay Chaudhuri</name></author><author><name sortKey="Dandona, Paresh" sort="Dandona, Paresh" uniqKey="Dandona P" first="Paresh" last="Dandona">Paresh Dandona</name></author></analytic><series><title level="j">Diabetes care</title><idno type="eISSN">1935-5548</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acute-Phase Proteins</term><term>Adult</term><term>Animals</term><term>Blood Glucose (metabolism)</term><term>Carrier Proteins (blood)</term><term>Citrus sinensis</term><term>Cytokines (genetics)</term><term>Cytokines (metabolism)</term><term>Dietary Carbohydrates (administration & dosage)</term><term>Dietary Carbohydrates (blood)</term><term>Dietary Fats (administration & dosage)</term><term>Dietary Fats (blood)</term><term>Glucose (administration & dosage)</term><term>Humans</term><term>Inflammation (blood)</term><term>Inflammation (immunology)</term><term>Insulin (blood)</term><term>Lipopolysaccharides (blood)</term><term>Membrane Glycoproteins (blood)</term><term>Middle Aged</term><term>Milk</term><term>NF-kappa B (metabolism)</term><term>Oxidative Stress (drug effects)</term><term>Oxidative Stress (immunology)</term><term>Postprandial Period (immunology)</term><term>RNA, Messenger (metabolism)</term><term>Reference Values</term><term>Signal Transduction (drug effects)</term><term>Signal Transduction (immunology)</term><term>Suppressor of Cytokine Signaling Proteins (genetics)</term><term>Suppressor of Cytokine Signaling Proteins (metabolism)</term><term>Toll-Like Receptor 4 (genetics)</term><term>Toll-Like Receptor 4 (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Dietary Carbohydrates</term><term>Dietary Fats</term><term>Glucose</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Carrier Proteins</term><term>Dietary Carbohydrates</term><term>Dietary Fats</term><term>Insulin</term><term>Lipopolysaccharides</term><term>Membrane Glycoproteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Cytokines</term><term>Suppressor of Cytokine Signaling Proteins</term><term>Toll-Like Receptor 4</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Blood Glucose</term><term>Cytokines</term><term>NF-kappa B</term><term>RNA, Messenger</term><term>Suppressor of Cytokine Signaling Proteins</term><term>Toll-Like Receptor 4</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Acute-Phase Proteins</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Inflammation</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Oxidative Stress</term><term>Signal Transduction</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Inflammation</term><term>Oxidative Stress</term><term>Postprandial Period</term><term>Signal Transduction</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Animals</term><term>Citrus sinensis</term><term>Humans</term><term>Middle Aged</term><term>Milk</term><term>Reference Values</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We have recently shown that a high-fat high-carbohydrate (HFHC) meal induces an increase in plasma concentrations of endotoxin (lipopolysaccharide [LPS]) and the expression of Toll-like receptor-4 (TLR-4) and suppresser of cytokine signaling-3 (SOCS3) in mononuclear cells (MNCs) in addition to oxidative stress and cellular inflammation. Saturated fat and carbohydrates, components of the HFHC meal, known to induce oxidative stress and inflammation, also induce an increase in LPS, TLR-4, and SOCS3.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">20067961</PMID><DateCreated><Year>2010</Year><Month>4</Month><Day>29</Day></DateCreated><DateCompleted><Year>2010</Year><Month>07</Month><Day>21</Day></DateCompleted><DateRevised><Year>2016</Year><Month>10</Month><Day>19</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1935-5548</ISSN><JournalIssue CitedMedium="Internet"><Volume>33</Volume><Issue>5</Issue><PubDate><Year>2010</Year><Month>May</Month></PubDate></JournalIssue><Title>Diabetes care</Title><ISOAbbreviation>Diabetes Care</ISOAbbreviation></Journal><ArticleTitle>Differential effects of cream, glucose, and orange juice on inflammation, endotoxin, and the expression of Toll-like receptor-4 and suppressor of cytokine signaling-3.</ArticleTitle><Pagination><MedlinePgn>991-7</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.2337/dc09-1630</ELocationID><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">We have recently shown that a high-fat high-carbohydrate (HFHC) meal induces an increase in plasma concentrations of endotoxin (lipopolysaccharide [LPS]) and the expression of Toll-like receptor-4 (TLR-4) and suppresser of cytokine signaling-3 (SOCS3) in mononuclear cells (MNCs) in addition to oxidative stress and cellular inflammation. Saturated fat and carbohydrates, components of the HFHC meal, known to induce oxidative stress and inflammation, also induce an increase in LPS, TLR-4, and SOCS3.</AbstractText><AbstractText Label="RESEARCH DESIGN AND METHODS" NlmCategory="METHODS">Fasting normal subjects were given 300-calorie drinks of either glucose, saturated fat as cream, orange juice, or only water to ingest. Blood samples were obtained at 0, 1, 3, and 5 h for analysis.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Indexes of inflammation including nuclear factor-kappaB (NF-kappaB) binding, and the expression of SOCS3, tumor necrosis factor-alpha (TNF-alpha), and interleukin (IL)-1beta in MNCs, increased significantly after glucose and cream intake, but TLR-4 expression and plasma LPS concentrations increased only after cream intake. The intake of orange juice or water did not induce any change in any of the indexes measured.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Although both glucose and cream induce NF-kappaB binding and an increase in the expression of SOCS3, TNF-alpha, and IL-1beta in MNCs, only cream caused an increase in LPS concentration and TLR-4 expression. Equicaloric amounts of orange juice or water did not induce a change in any of these indexes. These changes are relevant to the pathogenesis of atherosclerosis and insulin resistance.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Deopurkar</LastName><ForeName>Rupali</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Division of Endocrinology, Diabetes, and Metabolism, State University of New York at Buffalo and Kaleida Health, Buffalo, New York, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ghanim</LastName><ForeName>Husam</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Friedman</LastName><ForeName>Jay</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Abuaysheh</LastName><ForeName>Sanaa</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Sia</LastName><ForeName>Chang Ling</ForeName><Initials>CL</Initials></Author><Author ValidYN="Y"><LastName>Mohanty</LastName><ForeName>Priya</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Viswanathan</LastName><ForeName>Prabhakar</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Chaudhuri</LastName><ForeName>Ajay</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Dandona</LastName><ForeName>Paresh</ForeName><Initials>P</Initials></Author></AuthorList><Language>ENG</Language><GrantList CompleteYN="Y"><Grant><GrantID>R01 DK069805</GrantID><Acronym>DK</Acronym><Agency>NIDDK NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 DK075877</GrantID><Acronym>DK</Acronym><Agency>NIDDK NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01-DK-069805</GrantID><Acronym>DK</Acronym><Agency>NIDDK NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01-DK-075877</GrantID><Acronym>DK</Acronym><Agency>NIDDK NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016430">Clinical Trial</PublicationType><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2010</Year><Month>Jan</Month><Day>12</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Diabetes Care</MedlineTA><NlmUniqueID>7805975</NlmUniqueID><ISSNLinking>0149-5992</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000209">Acute-Phase Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D001786">Blood Glucose</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D002352">Carrier Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016207">Cytokines</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004040">Dietary Carbohydrates</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004041">Dietary Fats</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007328">Insulin</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008070">Lipopolysaccharides</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008562">Membrane Glycoproteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016328">NF-kappa B</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D012333">RNA, Messenger</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C106644">SOCS3 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D050826">Suppressor of Cytokine Signaling Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C495345">TLR4 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D051197">Toll-Like Receptor 4</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C061257">lipopolysaccharide-binding protein</NameOfSubstance></Chemical><Chemical><RegistryNumber>IY9XDZ35W2</RegistryNumber><NameOfSubstance UI="D005947">Glucose</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>JAMA. 2000 May 3;283(17):2235; author reply 2236</RefSource><PMID 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