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Quantitative analysis of hydroxylated polymethoxyflavones by high-performance liquid chromatography.

Identifieur interne : 000813 ( PubMed/Curation ); précédent : 000812; suivant : 000814

Quantitative analysis of hydroxylated polymethoxyflavones by high-performance liquid chromatography.

Auteurs : Shiming Li [États-Unis] ; Yu Wang ; Zhenyu Wang ; Hang Xiao ; Chih-Yu Lo ; Nancy Rawson ; Chi-Tang Ho

Source :

Biomedical chromatography : BMC [ 1099-0801 ] ; 2010.

RBID : pubmed:20033889

English descriptors

KwdEn :
- Chromatography, High Pressure Liquid (methods), Citrus sinensis (chemistry), Flavonoids (chemistry), Hydroxylation, Plant Extracts (chemistry).
MESH :
- chemical , chemistry : Flavonoids, Plant Extracts.
- chemistry : Citrus sinensis.
- methods : Chromatography, High Pressure Liquid.
- Hydroxylation.

Abstract

Since the hydroxylated polymethoxyflavones were isolated from orange and other citrus peels, they have been found to exhibit potent anti-cancer and anti-inflammatory activities. Hydroxylated polymethoxyflavones, especially 5-demethylnobiletin and 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone, exert more potent activities than their counterpart polymethoxyflavones (PMFs). These findings have led to a new era of exploration of hydroxylated polymethoxyflavones and PMFs from the citrus genus for their potential application in nutraceutical, pharmaceuticals and functional foods. A practical and efficient analytical method for quantitatively characterizing the composition of PMFs has only recently been developed, and has applications both in academic research laboratories and quality controls. However, chemical analyses of the hydroxylated polymethoxyflavones have not been previously described. This paper reports the quantitative analysis of six 5-demethylated PMFs in various commercial orange peel extracts, using high-performance liquid chromatography with UV detection.

DOI: 10.1002/bmc.1372
PubMed: 20033889

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Le document en format XML

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<author><name sortKey="Li, Shiming" sort="Li, Shiming" uniqKey="Li S" first="Shiming" last="Li">Shiming Li</name>
<affiliation wicri:level="1"><nlm:affiliation>Analytical and Natural Product Chemistry, WellGen Inc., 675 US Highway One, North Brunswick, NJ 08902, USA. shiming3702@yahoo.com</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Analytical and Natural Product Chemistry, WellGen Inc., 675 US Highway One, North Brunswick, NJ 08902</wicri:regionArea>
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<author><name sortKey="Wang, Yu" sort="Wang, Yu" uniqKey="Wang Y" first="Yu" last="Wang">Yu Wang</name>
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<author><name sortKey="Wang, Zhenyu" sort="Wang, Zhenyu" uniqKey="Wang Z" first="Zhenyu" last="Wang">Zhenyu Wang</name>
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<author><name sortKey="Xiao, Hang" sort="Xiao, Hang" uniqKey="Xiao H" first="Hang" last="Xiao">Hang Xiao</name>
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<author><name sortKey="Lo, Chih Yu" sort="Lo, Chih Yu" uniqKey="Lo C" first="Chih-Yu" last="Lo">Chih-Yu Lo</name>
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<author><name sortKey="Rawson, Nancy" sort="Rawson, Nancy" uniqKey="Rawson N" first="Nancy" last="Rawson">Nancy Rawson</name>
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<front><div type="abstract" xml:lang="en">Since the hydroxylated polymethoxyflavones were isolated from orange and other citrus peels, they have been found to exhibit potent anti-cancer and anti-inflammatory activities. Hydroxylated polymethoxyflavones, especially 5-demethylnobiletin and 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone, exert more potent activities than their counterpart polymethoxyflavones (PMFs). These findings have led to a new era of exploration of hydroxylated polymethoxyflavones and PMFs from the citrus genus for their potential application in nutraceutical, pharmaceuticals and functional foods. A practical and efficient analytical method for quantitatively characterizing the composition of PMFs has only recently been developed, and has applications both in academic research laboratories and quality controls. However, chemical analyses of the hydroxylated polymethoxyflavones have not been previously described. This paper reports the quantitative analysis of six 5-demethylated PMFs in various commercial orange peel extracts, using high-performance liquid chromatography with UV detection.</div>
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Quantitative analysis of hydroxylated polymethoxyflavones by high-performance liquid chromatography.

Quantitative analysis of hydroxylated polymethoxyflavones by high-performance liquid chromatography.

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki