Hesperidin contributes to the vascular protective effects of orange juice: a randomized crossover study in healthy volunteers.
Identifieur interne : 000769 ( PubMed/Curation ); précédent : 000768; suivant : 000770Hesperidin contributes to the vascular protective effects of orange juice: a randomized crossover study in healthy volunteers.
Auteurs : Christine Morand [France] ; Claude Dubray ; Dragan Milenkovic ; Delphine Lioger ; Jean François Martin ; Augustin Scalbert ; Andrzej MazurSource :
- The American journal of clinical nutrition [ 1938-3207 ] ; 2011.
English descriptors
- KwdEn :
- Aged, Antioxidants (metabolism), Beverages, C-Reactive Protein (analysis), Citrus sinensis, Cross-Over Studies, Diastole (drug effects), Endothelium, Vascular (drug effects), Endothelium, Vascular (physiology), Hesperidin (pharmacology), Humans, Male, Middle Aged, Oxidative Stress, Vasodilation (drug effects).
- MESH :
- chemical , analysis : C-Reactive Protein.
- chemical , metabolism : Antioxidants.
- drug effects : Diastole, Endothelium, Vascular, Vasodilation.
- chemical , pharmacology : Hesperidin.
- physiology : Endothelium, Vascular.
- Aged, Beverages, Citrus sinensis, Cross-Over Studies, Humans, Male, Middle Aged, Oxidative Stress.
Abstract
Although numerous human studies have shown consistent effects of some polyphenol-rich foods on several intermediate markers for cardiovascular diseases, it is still unknown whether their action could be specifically related to polyphenols.
DOI: 10.3945/ajcn.110.004945
PubMed: 21068346
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Hesperidin contributes to the vascular protective effects of orange juice: a randomized crossover study in healthy volunteers.</title><author><name sortKey="Morand, Christine" sort="Morand, Christine" uniqKey="Morand C" first="Christine" last="Morand">Christine Morand</name><affiliation wicri:level="1"><nlm:affiliation>INRA, UMR 1019, UNH, CRNH Auvergne, Clermont-Ferrand, France. christine.morand@clermont.inra.fr</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INRA, UMR 1019, UNH, CRNH Auvergne, Clermont-Ferrand</wicri:regionArea></affiliation></author><author><name sortKey="Dubray, Claude" sort="Dubray, Claude" uniqKey="Dubray C" first="Claude" last="Dubray">Claude Dubray</name></author><author><name sortKey="Milenkovic, Dragan" sort="Milenkovic, Dragan" uniqKey="Milenkovic D" first="Dragan" last="Milenkovic">Dragan Milenkovic</name></author><author><name sortKey="Lioger, Delphine" sort="Lioger, Delphine" uniqKey="Lioger D" first="Delphine" last="Lioger">Delphine Lioger</name></author><author><name sortKey="Martin, Jean Francois" sort="Martin, Jean Francois" uniqKey="Martin J" first="Jean François" last="Martin">Jean François Martin</name></author><author><name sortKey="Scalbert, Augustin" sort="Scalbert, Augustin" uniqKey="Scalbert A" first="Augustin" last="Scalbert">Augustin Scalbert</name></author><author><name sortKey="Mazur, Andrzej" sort="Mazur, Andrzej" uniqKey="Mazur A" first="Andrzej" last="Mazur">Andrzej Mazur</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2011">2011</date><idno type="RBID">pubmed:21068346</idno><idno type="pmid">21068346</idno><idno type="doi">10.3945/ajcn.110.004945</idno><idno type="wicri:Area/PubMed/Corpus">000769</idno><idno type="wicri:Area/PubMed/Curation">000769</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Hesperidin contributes to the vascular protective effects of orange juice: a randomized crossover study in healthy volunteers.</title><author><name sortKey="Morand, Christine" sort="Morand, Christine" uniqKey="Morand C" first="Christine" last="Morand">Christine Morand</name><affiliation wicri:level="1"><nlm:affiliation>INRA, UMR 1019, UNH, CRNH Auvergne, Clermont-Ferrand, France. christine.morand@clermont.inra.fr</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INRA, UMR 1019, UNH, CRNH Auvergne, Clermont-Ferrand</wicri:regionArea></affiliation></author><author><name sortKey="Dubray, Claude" sort="Dubray, Claude" uniqKey="Dubray C" first="Claude" last="Dubray">Claude Dubray</name></author><author><name sortKey="Milenkovic, Dragan" sort="Milenkovic, Dragan" uniqKey="Milenkovic D" first="Dragan" last="Milenkovic">Dragan Milenkovic</name></author><author><name sortKey="Lioger, Delphine" sort="Lioger, Delphine" uniqKey="Lioger D" first="Delphine" last="Lioger">Delphine Lioger</name></author><author><name sortKey="Martin, Jean Francois" sort="Martin, Jean Francois" uniqKey="Martin J" first="Jean François" last="Martin">Jean François Martin</name></author><author><name sortKey="Scalbert, Augustin" sort="Scalbert, Augustin" uniqKey="Scalbert A" first="Augustin" last="Scalbert">Augustin Scalbert</name></author><author><name sortKey="Mazur, Andrzej" sort="Mazur, Andrzej" uniqKey="Mazur A" first="Andrzej" last="Mazur">Andrzej Mazur</name></author></analytic><series><title level="j">The American journal of clinical nutrition</title><idno type="eISSN">1938-3207</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Antioxidants (metabolism)</term><term>Beverages</term><term>C-Reactive Protein (analysis)</term><term>Citrus sinensis</term><term>Cross-Over Studies</term><term>Diastole (drug effects)</term><term>Endothelium, Vascular (drug effects)</term><term>Endothelium, Vascular (physiology)</term><term>Hesperidin (pharmacology)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Oxidative Stress</term><term>Vasodilation (drug effects)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>C-Reactive Protein</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Antioxidants</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Diastole</term><term>Endothelium, Vascular</term><term>Vasodilation</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Hesperidin</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Endothelium, Vascular</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Beverages</term><term>Citrus sinensis</term><term>Cross-Over Studies</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Oxidative Stress</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Although numerous human studies have shown consistent effects of some polyphenol-rich foods on several intermediate markers for cardiovascular diseases, it is still unknown whether their action could be specifically related to polyphenols.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">21068346</PMID><DateCreated><Year>2010</Year><Month>12</Month><Day>21</Day></DateCreated><DateCompleted><Year>2011</Year><Month>01</Month><Day>27</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1938-3207</ISSN><JournalIssue CitedMedium="Internet"><Volume>93</Volume><Issue>1</Issue><PubDate><Year>2011</Year><Month>Jan</Month></PubDate></JournalIssue><Title>The American journal of clinical nutrition</Title><ISOAbbreviation>Am. J. Clin. Nutr.</ISOAbbreviation></Journal><ArticleTitle>Hesperidin contributes to the vascular protective effects of orange juice: a randomized crossover study in healthy volunteers.</ArticleTitle><Pagination><MedlinePgn>73-80</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3945/ajcn.110.004945</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Although numerous human studies have shown consistent effects of some polyphenol-rich foods on several intermediate markers for cardiovascular diseases, it is still unknown whether their action could be specifically related to polyphenols.</AbstractText><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">We investigated the effect of orange juice and its major flavonoid, hesperidin, on microvascular reactivity, blood pressure, and cardiovascular risk biomarkers through both postprandial and chronic intervention studies.</AbstractText><AbstractText Label="DESIGN" NlmCategory="METHODS">Twenty-four healthy, overweight men (age 50-65 y) were included in a randomized, controlled, crossover study. Throughout the three 4-wk periods, volunteers daily consumed 500 mL orange juice, 500 mL control drink plus hesperidin (CDH), or 500 mL control drink plus placebo (CDP). All measurements and blood collections were performed in overnight-fasted subjects before and after the 4-wk treatment periods. The postprandial study was conducted at the beginning of each experimental period.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Diastolic blood pressure (DBP) was significantly lower after 4 wk consumption of orange juice or CDH than after consumption of CDP (P = 0.02), whereas microvascular endothelium-related reactivity was not significantly affected when measured after an overnight fast. However, both orange juice and CDH ingestion significantly improved postprandial microvascular endothelial reactivity compared with CDP (P < 0.05) when measured at the peak of plasma hesperetin concentration.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">In healthy, middle-aged, moderately overweight men, orange juice decreases DBP when regularly consumed and postprandially increases endothelium-dependent microvascular reactivity. Our study suggests that hesperidin could be causally linked to the beneficial effect of orange juice. This trial is registered at clinicaltrials.gov as NCT00983086.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Morand</LastName><ForeName>Christine</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>INRA, UMR 1019, UNH, CRNH Auvergne, Clermont-Ferrand, France. christine.morand@clermont.inra.fr</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dubray</LastName><ForeName>Claude</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Milenkovic</LastName><ForeName>Dragan</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Lioger</LastName><ForeName>Delphine</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Martin</LastName><ForeName>Jean François</ForeName><Initials>JF</Initials></Author><Author ValidYN="Y"><LastName>Scalbert</LastName><ForeName>Augustin</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Mazur</LastName><ForeName>Andrzej</ForeName><Initials>A</Initials></Author></AuthorList><Language>ENG</Language><DataBankList CompleteYN="Y"><DataBank><DataBankName>ClinicalTrials.gov</DataBankName><AccessionNumberList><AccessionNumber>NCT00983086</AccessionNumber></AccessionNumberList></DataBank></DataBankList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016449">Randomized Controlled Trial</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2010</Year><Month>Nov</Month><Day>10</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Am J Clin Nutr</MedlineTA><NlmUniqueID>0376027</NlmUniqueID><ISSNLinking>0002-9165</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000975">Antioxidants</NameOfSubstance></Chemical><Chemical><RegistryNumber>9007-41-4</RegistryNumber><NameOfSubstance UI="D002097">C-Reactive Protein</NameOfSubstance></Chemical><Chemical><RegistryNumber>E750O06Y6O</RegistryNumber><NameOfSubstance UI="D006569">Hesperidin</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000975" MajorTopicYN="N">Antioxidants</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001628" MajorTopicYN="Y">Beverages</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002097" MajorTopicYN="N">C-Reactive Protein</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D032084" MajorTopicYN="Y">Citrus sinensis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018592" MajorTopicYN="N">Cross-Over Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003971" MajorTopicYN="N">Diastole</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004730" MajorTopicYN="N">Endothelium, Vascular</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006569" MajorTopicYN="N">Hesperidin</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018384" MajorTopicYN="N">Oxidative Stress</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014664" MajorTopicYN="N">Vasodilation</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2010</Year><Month>11</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2010</Year><Month>11</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2011</Year><Month>1</Month><Day>29</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">21068346</ArticleId><ArticleId IdType="pii">ajcn.110.004945</ArticleId><ArticleId IdType="doi">10.3945/ajcn.110.004945</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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