Potential risks resulting from fruit/vegetable-drug interactions: effects on drug-metabolizing enzymes and drug transporters.
Identifieur interne : 000744 ( PubMed/Curation ); précédent : 000743; suivant : 000745Potential risks resulting from fruit/vegetable-drug interactions: effects on drug-metabolizing enzymes and drug transporters.
Auteurs : Lourdes Rodríguez-Fragoso [Mexique] ; José Luis Martínez-Arismendi ; Danae Orozco-Bustos ; Jorge Reyes-Esparza ; Eliseo Torres ; Scott W. BurchielSource :
- Journal of food science [ 1750-3841 ] ; 2011.
English descriptors
- KwdEn :
- Biological Availability, Biological Transport, Citrus (metabolism), Citrus paradisi (metabolism), Citrus sinensis (metabolism), Food-Drug Interactions, Fruit (metabolism), Humans, Inactivation, Metabolic, Malus (metabolism), Medicine, Traditional, Morus (metabolism), Nutritive Value, Plant Extracts (pharmacokinetics), Punicaceae (metabolism), Risk Factors, Vegetables (metabolism), Vitis (metabolism).
- MESH :
- chemical , pharmacokinetics : Plant Extracts.
- metabolism : Citrus, Citrus paradisi, Citrus sinensis, Fruit, Malus, Morus, Punicaceae, Vegetables, Vitis.
- Biological Availability, Biological Transport, Food-Drug Interactions, Humans, Inactivation, Metabolic, Medicine, Traditional, Nutritive Value, Risk Factors.
Abstract
It has been well established that complex mixtures of phytochemicals in fruits and vegetables can be beneficial for human health. Moreover, it is becoming increasingly apparent that phytochemicals can influence the pharmacological activity of drugs by modifying their absorption characteristics through interactions with drug transporters as well as drug-metabolizing enzyme systems. Such effects are more likely to occur in the intestine and liver, where high concentrations of phytochemicals may occur. Alterations in cytochrome P450 and other enzyme activities may influence the fate of drugs subject to extensive first-pass metabolism. Although numerous studies of nutrient-drug interactions have been published and systematic reviews and meta-analyses of these studies are available, no generalizations on the effect of nutrient-drug interactions on drug bioavailability are currently available. Several publications have highlighted the unintended consequences of the combined use of nutrients and drugs. Many phytochemicals have been shown to have pharmacokinetic interactions with drugs. The present review is limited to commonly consumed fruits and vegetables with significant beneficial effects as nutrients and components in folk medicine. Here, we discuss the phytochemistry and pharmacokinetic interactions of the following fruit and vegetables: grapefruit, orange, tangerine, grapes, cranberry, pomegranate, mango, guava, black raspberry, black mulberry, apple, broccoli, cauliflower, watercress, spinach, tomato, carrot, and avocado. We conclude that our knowledge of the potential risk of nutrient-drug interactions is still limited. Therefore, efforts to elucidate potential risks resulting from food-drug interactions should be intensified in order to prevent undesired and harmful clinical consequences.
DOI: 10.1111/j.1750-3841.2011.02155.x
PubMed: 22417366
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Potential risks resulting from fruit/vegetable-drug interactions: effects on drug-metabolizing enzymes and drug transporters.</title><author><name sortKey="Rodriguez Fragoso, Lourdes" sort="Rodriguez Fragoso, Lourdes" uniqKey="Rodriguez Fragoso L" first="Lourdes" last="Rodríguez-Fragoso">Lourdes Rodríguez-Fragoso</name><affiliation wicri:level="1"><nlm:affiliation>Facultad de Farmacia, Univ. Autónoma del Estado de Morelos, Cuernavaca, México. mrodriguezf@uaem.mx</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Mexique</country><wicri:regionArea>Facultad de Farmacia, Univ. Autónoma del Estado de Morelos, Cuernavaca</wicri:regionArea></affiliation></author><author><name sortKey="Martinez Arismendi, Jose Luis" sort="Martinez Arismendi, Jose Luis" uniqKey="Martinez Arismendi J" first="José Luis" last="Martínez-Arismendi">José Luis Martínez-Arismendi</name></author><author><name sortKey="Orozco Bustos, Danae" sort="Orozco Bustos, Danae" uniqKey="Orozco Bustos D" first="Danae" last="Orozco-Bustos">Danae Orozco-Bustos</name></author><author><name sortKey="Reyes Esparza, Jorge" sort="Reyes Esparza, Jorge" uniqKey="Reyes Esparza J" first="Jorge" last="Reyes-Esparza">Jorge Reyes-Esparza</name></author><author><name sortKey="Torres, Eliseo" sort="Torres, Eliseo" uniqKey="Torres E" first="Eliseo" last="Torres">Eliseo Torres</name></author><author><name sortKey="Burchiel, Scott W" sort="Burchiel, Scott W" uniqKey="Burchiel S" first="Scott W" last="Burchiel">Scott W. 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Autónoma del Estado de Morelos, Cuernavaca, México. mrodriguezf@uaem.mx</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Mexique</country><wicri:regionArea>Facultad de Farmacia, Univ. Autónoma del Estado de Morelos, Cuernavaca</wicri:regionArea></affiliation></author><author><name sortKey="Martinez Arismendi, Jose Luis" sort="Martinez Arismendi, Jose Luis" uniqKey="Martinez Arismendi J" first="José Luis" last="Martínez-Arismendi">José Luis Martínez-Arismendi</name></author><author><name sortKey="Orozco Bustos, Danae" sort="Orozco Bustos, Danae" uniqKey="Orozco Bustos D" first="Danae" last="Orozco-Bustos">Danae Orozco-Bustos</name></author><author><name sortKey="Reyes Esparza, Jorge" sort="Reyes Esparza, Jorge" uniqKey="Reyes Esparza J" first="Jorge" last="Reyes-Esparza">Jorge Reyes-Esparza</name></author><author><name sortKey="Torres, Eliseo" sort="Torres, Eliseo" uniqKey="Torres E" first="Eliseo" last="Torres">Eliseo Torres</name></author><author><name sortKey="Burchiel, Scott W" sort="Burchiel, Scott W" uniqKey="Burchiel S" first="Scott W" last="Burchiel">Scott W. Burchiel</name></author></analytic><series><title level="j">Journal of food science</title><idno type="eISSN">1750-3841</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Biological Availability</term><term>Biological Transport</term><term>Citrus (metabolism)</term><term>Citrus paradisi (metabolism)</term><term>Citrus sinensis (metabolism)</term><term>Food-Drug Interactions</term><term>Fruit (metabolism)</term><term>Humans</term><term>Inactivation, Metabolic</term><term>Malus (metabolism)</term><term>Medicine, Traditional</term><term>Morus (metabolism)</term><term>Nutritive Value</term><term>Plant Extracts (pharmacokinetics)</term><term>Punicaceae (metabolism)</term><term>Risk Factors</term><term>Vegetables (metabolism)</term><term>Vitis (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Plant Extracts</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Citrus</term><term>Citrus paradisi</term><term>Citrus sinensis</term><term>Fruit</term><term>Malus</term><term>Morus</term><term>Punicaceae</term><term>Vegetables</term><term>Vitis</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Biological Availability</term><term>Biological Transport</term><term>Food-Drug Interactions</term><term>Humans</term><term>Inactivation, Metabolic</term><term>Medicine, Traditional</term><term>Nutritive Value</term><term>Risk Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">It has been well established that complex mixtures of phytochemicals in fruits and vegetables can be beneficial for human health. Moreover, it is becoming increasingly apparent that phytochemicals can influence the pharmacological activity of drugs by modifying their absorption characteristics through interactions with drug transporters as well as drug-metabolizing enzyme systems. Such effects are more likely to occur in the intestine and liver, where high concentrations of phytochemicals may occur. Alterations in cytochrome P450 and other enzyme activities may influence the fate of drugs subject to extensive first-pass metabolism. Although numerous studies of nutrient-drug interactions have been published and systematic reviews and meta-analyses of these studies are available, no generalizations on the effect of nutrient-drug interactions on drug bioavailability are currently available. Several publications have highlighted the unintended consequences of the combined use of nutrients and drugs. Many phytochemicals have been shown to have pharmacokinetic interactions with drugs. The present review is limited to commonly consumed fruits and vegetables with significant beneficial effects as nutrients and components in folk medicine. Here, we discuss the phytochemistry and pharmacokinetic interactions of the following fruit and vegetables: grapefruit, orange, tangerine, grapes, cranberry, pomegranate, mango, guava, black raspberry, black mulberry, apple, broccoli, cauliflower, watercress, spinach, tomato, carrot, and avocado. We conclude that our knowledge of the potential risk of nutrient-drug interactions is still limited. Therefore, efforts to elucidate potential risks resulting from food-drug interactions should be intensified in order to prevent undesired and harmful clinical consequences.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">22417366</PMID><DateCreated><Year>2012</Year><Month>3</Month><Day>15</Day></DateCreated><DateCompleted><Year>2012</Year><Month>07</Month><Day>25</Day></DateCompleted><DateRevised><Year>2014</Year><Month>11</Month><Day>20</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1750-3841</ISSN><JournalIssue CitedMedium="Internet"><Volume>76</Volume><Issue>4</Issue><PubDate><Year>2011</Year><Month>May</Month></PubDate></JournalIssue><Title>Journal of food science</Title><ISOAbbreviation>J. Food Sci.</ISOAbbreviation></Journal><ArticleTitle>Potential risks resulting from fruit/vegetable-drug interactions: effects on drug-metabolizing enzymes and drug transporters.</ArticleTitle><Pagination><MedlinePgn>R112-24</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/j.1750-3841.2011.02155.x</ELocationID><Abstract><AbstractText>It has been well established that complex mixtures of phytochemicals in fruits and vegetables can be beneficial for human health. Moreover, it is becoming increasingly apparent that phytochemicals can influence the pharmacological activity of drugs by modifying their absorption characteristics through interactions with drug transporters as well as drug-metabolizing enzyme systems. Such effects are more likely to occur in the intestine and liver, where high concentrations of phytochemicals may occur. Alterations in cytochrome P450 and other enzyme activities may influence the fate of drugs subject to extensive first-pass metabolism. Although numerous studies of nutrient-drug interactions have been published and systematic reviews and meta-analyses of these studies are available, no generalizations on the effect of nutrient-drug interactions on drug bioavailability are currently available. Several publications have highlighted the unintended consequences of the combined use of nutrients and drugs. Many phytochemicals have been shown to have pharmacokinetic interactions with drugs. The present review is limited to commonly consumed fruits and vegetables with significant beneficial effects as nutrients and components in folk medicine. Here, we discuss the phytochemistry and pharmacokinetic interactions of the following fruit and vegetables: grapefruit, orange, tangerine, grapes, cranberry, pomegranate, mango, guava, black raspberry, black mulberry, apple, broccoli, cauliflower, watercress, spinach, tomato, carrot, and avocado. We conclude that our knowledge of the potential risk of nutrient-drug interactions is still limited. Therefore, efforts to elucidate potential risks resulting from food-drug interactions should be intensified in order to prevent undesired and harmful clinical consequences.</AbstractText><CopyrightInformation>© 2011 Institute of Food Technologists®</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Rodríguez-Fragoso</LastName><ForeName>Lourdes</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Facultad de Farmacia, Univ. Autónoma del Estado de Morelos, Cuernavaca, México. mrodriguezf@uaem.mx</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Martínez-Arismendi</LastName><ForeName>José Luis</ForeName><Initials>JL</Initials></Author><Author ValidYN="Y"><LastName>Orozco-Bustos</LastName><ForeName>Danae</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Reyes-Esparza</LastName><ForeName>Jorge</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Torres</LastName><ForeName>Eliseo</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Burchiel</LastName><ForeName>Scott W</ForeName><Initials>SW</Initials></Author></AuthorList><Language>ENG</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Food Sci</MedlineTA><NlmUniqueID>0014052</NlmUniqueID><ISSNLinking>0022-1147</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010936">Plant Extracts</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D001682" MajorTopicYN="N">Biological Availability</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001692" MajorTopicYN="Y">Biological Transport</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002957" MajorTopicYN="N">Citrus</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D032083" MajorTopicYN="N">Citrus paradisi</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D032084" MajorTopicYN="N">Citrus sinensis</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018565" MajorTopicYN="Y">Food-Drug Interactions</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005638" MajorTopicYN="N">Fruit</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008658" MajorTopicYN="Y">Inactivation, Metabolic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D027845" MajorTopicYN="N">Malus</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008519" MajorTopicYN="N">Medicine, Traditional</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D031625" MajorTopicYN="N">Morus</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009753" MajorTopicYN="N">Nutritive Value</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010936" MajorTopicYN="N">Plant Extracts</DescriptorName><QualifierName UI="Q000493" MajorTopicYN="Y">pharmacokinetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D031826" MajorTopicYN="N">Punicaceae</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014675" MajorTopicYN="N">Vegetables</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D027843" MajorTopicYN="N">Vitis</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2012</Year><Month>3</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2012</Year><Month>3</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2012</Year><Month>7</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">22417366</ArticleId><ArticleId IdType="doi">10.1111/j.1750-3841.2011.02155.x</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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