Ceramides as possible nutraceutical compounds: characterization of the ceramides of the Moro blood orange ( Citrus sinensis ).
Identifieur interne : 000559 ( PubMed/Curation ); précédent : 000558; suivant : 000560Ceramides as possible nutraceutical compounds: characterization of the ceramides of the Moro blood orange ( Citrus sinensis ).
Auteurs : Manuela Valsecchi [Italie] ; Laura Mauri ; Riccardo Casellato ; Maria Grazia Ciampa ; Luisa Rizza ; Andrea Bonina ; Francesco Bonina ; Sandro SonninoSource :
- Journal of agricultural and food chemistry [ 1520-5118 ] ; 2012.
English descriptors
- KwdEn :
- MESH :
- chemical , analysis : Ceramides.
- chemical , chemistry : Ceramides.
- geographic : Sicily.
- analysis : Dietary Supplements.
- chemistry : Citrus sinensis, Fruit.
- Chromatography, High Pressure Liquid, Mass Spectrometry, Spectrometry, Mass, Electrospray Ionization.
Abstract
Ceramides are presented as nutraceutical compounds for protection of colon carcinoma and as important cosmetic preparation components, increasing absorption through the skin. Therefore, the ceramide (Cer) content of Moro blood oranges was determined by mass spectrometry. A total of 114 Cer species were identified: ∼160 mg in the peels and ∼140 mg in the pulp per kilogram of oranges, expressed as "milligram equivalents of d18:1,17:0 Cer". The predominant ceramides contained 4-hydroxy-8-sphingenine (t18:1(Δ8)) and 4-hydroxysphinganine (t18:0) as long-chain bases (LCBs) and fatty acids (FAs) with different structures. In the pulp, t18:1(Δ8)- and t18:0-containing Cer species comprised 50.5 and 33.5% of the total, respectively, 11.5 and 3.5% non-hydroxylated FAs, respectively, 32.0 and 21.0% α-hydroxylated FAs, respectively, and 7.0 and 9.0% α,β-hydroxylated FAs, respectively. In the peels, t18:1(Δ8)- and t18:0-containing species comprised 49.5 and 34.5% of the total, respectively, 16.0 and 1.5% non-hydroxylated FAs, respectively, 31.5 and 29.0% α-hydroxylated FAs, respectively, and 2.0 and 4.0% α,β-hydroxylated FAs, respectively.
DOI: 10.1021/jf3027414
PubMed: 22985176
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<author><name sortKey="Valsecchi, Manuela" sort="Valsecchi, Manuela" uniqKey="Valsecchi M" first="Manuela" last="Valsecchi">Manuela Valsecchi</name>
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<author><name sortKey="Mauri, Laura" sort="Mauri, Laura" uniqKey="Mauri L" first="Laura" last="Mauri">Laura Mauri</name>
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<author><name sortKey="Ciampa, Maria Grazia" sort="Ciampa, Maria Grazia" uniqKey="Ciampa M" first="Maria Grazia" last="Ciampa">Maria Grazia Ciampa</name>
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<term>Dietary Supplements (analysis)</term>
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<term>Mass Spectrometry</term>
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<front><div type="abstract" xml:lang="en">Ceramides are presented as nutraceutical compounds for protection of colon carcinoma and as important cosmetic preparation components, increasing absorption through the skin. Therefore, the ceramide (Cer) content of Moro blood oranges was determined by mass spectrometry. A total of 114 Cer species were identified: ∼160 mg in the peels and ∼140 mg in the pulp per kilogram of oranges, expressed as "milligram equivalents of d18:1,17:0 Cer". The predominant ceramides contained 4-hydroxy-8-sphingenine (t18:1(Δ8)) and 4-hydroxysphinganine (t18:0) as long-chain bases (LCBs) and fatty acids (FAs) with different structures. In the pulp, t18:1(Δ8)- and t18:0-containing Cer species comprised 50.5 and 33.5% of the total, respectively, 11.5 and 3.5% non-hydroxylated FAs, respectively, 32.0 and 21.0% α-hydroxylated FAs, respectively, and 7.0 and 9.0% α,β-hydroxylated FAs, respectively. In the peels, t18:1(Δ8)- and t18:0-containing species comprised 49.5 and 34.5% of the total, respectively, 16.0 and 1.5% non-hydroxylated FAs, respectively, 31.5 and 29.0% α-hydroxylated FAs, respectively, and 2.0 and 4.0% α,β-hydroxylated FAs, respectively.</div>
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<Abstract><AbstractText>Ceramides are presented as nutraceutical compounds for protection of colon carcinoma and as important cosmetic preparation components, increasing absorption through the skin. Therefore, the ceramide (Cer) content of Moro blood oranges was determined by mass spectrometry. A total of 114 Cer species were identified: ∼160 mg in the peels and ∼140 mg in the pulp per kilogram of oranges, expressed as "milligram equivalents of d18:1,17:0 Cer". The predominant ceramides contained 4-hydroxy-8-sphingenine (t18:1(Δ8)) and 4-hydroxysphinganine (t18:0) as long-chain bases (LCBs) and fatty acids (FAs) with different structures. In the pulp, t18:1(Δ8)- and t18:0-containing Cer species comprised 50.5 and 33.5% of the total, respectively, 11.5 and 3.5% non-hydroxylated FAs, respectively, 32.0 and 21.0% α-hydroxylated FAs, respectively, and 7.0 and 9.0% α,β-hydroxylated FAs, respectively. In the peels, t18:1(Δ8)- and t18:0-containing species comprised 49.5 and 34.5% of the total, respectively, 16.0 and 1.5% non-hydroxylated FAs, respectively, 31.5 and 29.0% α-hydroxylated FAs, respectively, and 2.0 and 4.0% α,β-hydroxylated FAs, respectively.</AbstractText>
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