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Amelioration of diabetic nephropathy by orange peel extract in rats.

Identifieur interne : 000399 ( PubMed/Curation ); précédent : 000398; suivant : 000400

Amelioration of diabetic nephropathy by orange peel extract in rats.

Auteurs : Nishad Parkar [Inde] ; Veeranjaneyulu Addepalli

Source :

Natural product research [ 1478-6427 ] ; 2014.

RBID : pubmed:25103218

English descriptors

KwdEn :
- Animals, Citrus sinensis (chemistry), Creatinine (blood), Diabetes Mellitus, Experimental (pathology), Diabetic Nephropathies (drug therapy), Flavonoids (analysis), Flavonoids (isolation & purification), Flavonoids (pharmacology), Kidney (drug effects), Male, Nitrogen (blood), Phenols (analysis), Phenols (isolation & purification), Phenols (pharmacology), Rats, Urea (blood).
MESH :
- chemical , analysis : Flavonoids, Phenols.
- chemical , blood : Creatinine, Nitrogen, Urea.
- chemistry : Citrus sinensis.
- drug effects : Kidney.
- drug therapy : Diabetic Nephropathies.
- chemical , isolation & purification : Flavonoids, Phenols.
- pathology : Diabetes Mellitus, Experimental.
- chemical , pharmacology : Flavonoids, Phenols.
- Animals, Male, Rats.

Abstract

This study was aimed to evaluate the effect of alcoholic orange peel extract (OPE) on streptozotocin-induced diabetic nephropathy. Four weeks after the induction of diabetes, treatment with OPE (100 and 200 mg/kg) was further given for 4 weeks. Treatment with OPE 200 improved renal functions and significantly prevented the increase in creatinine, urea and blood urea nitrogen levels. Histological analysis of the kidneys revealed that tubulointerstitial fibrosis index was significantly decreased in OPE 200-treated group. The results indicated the prevention of diabetic nephropathy in rats by OPE treatment and suggest OPE as a potential treatment option.

DOI: 10.1080/14786419.2014.925894
PubMed: 25103218

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Le document en format XML

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<author><name sortKey="Parkar, Nishad" sort="Parkar, Nishad" uniqKey="Parkar N" first="Nishad" last="Parkar">Nishad Parkar</name>
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<country xml:lang="fr">Inde</country>
<wicri:regionArea>a Dr. Bhanuben Nanavati College of Pharmacy , Vile Parle West, Mumbai 400056 </wicri:regionArea>
</affiliation>
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<author><name sortKey="Addepalli, Veeranjaneyulu" sort="Addepalli, Veeranjaneyulu" uniqKey="Addepalli V" first="Veeranjaneyulu" last="Addepalli">Veeranjaneyulu Addepalli</name>
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<affiliation wicri:level="1"><nlm:affiliation>a Dr. Bhanuben Nanavati College of Pharmacy , Vile Parle West, Mumbai 400056 , India.</nlm:affiliation>
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<author><name sortKey="Addepalli, Veeranjaneyulu" sort="Addepalli, Veeranjaneyulu" uniqKey="Addepalli V" first="Veeranjaneyulu" last="Addepalli">Veeranjaneyulu Addepalli</name>
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<series><title level="j">Natural product research</title>
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<term>Citrus sinensis (chemistry)</term>
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<term>Diabetic Nephropathies (drug therapy)</term>
<term>Flavonoids (analysis)</term>
<term>Flavonoids (isolation & purification)</term>
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<term>Nitrogen (blood)</term>
<term>Phenols (analysis)</term>
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<keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Flavonoids</term>
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<front><div type="abstract" xml:lang="en">This study was aimed to evaluate the effect of alcoholic orange peel extract (OPE) on streptozotocin-induced diabetic nephropathy. Four weeks after the induction of diabetes, treatment with OPE (100 and 200 mg/kg) was further given for 4 weeks. Treatment with OPE 200 improved renal functions and significantly prevented the increase in creatinine, urea and blood urea nitrogen levels. Histological analysis of the kidneys revealed that tubulointerstitial fibrosis index was significantly decreased in OPE 200-treated group. The results indicated the prevention of diabetic nephropathy in rats by OPE treatment and suggest OPE as a potential treatment option.</div>
</front>
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<Month>9</Month>
<Day>29</Day>
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<DateCompleted><Year>2015</Year>
<Month>02</Month>
<Day>26</Day>
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<DateRevised><Year>2014</Year>
<Month>9</Month>
<Day>29</Day>
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<Issue>23</Issue>
<PubDate><Year>2014</Year>
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<Title>Natural product research</Title>
<ISOAbbreviation>Nat. Prod. Res.</ISOAbbreviation>
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<ArticleTitle>Amelioration of diabetic nephropathy by orange peel extract in rats.</ArticleTitle>
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<Abstract><AbstractText>This study was aimed to evaluate the effect of alcoholic orange peel extract (OPE) on streptozotocin-induced diabetic nephropathy. Four weeks after the induction of diabetes, treatment with OPE (100 and 200 mg/kg) was further given for 4 weeks. Treatment with OPE 200 improved renal functions and significantly prevented the increase in creatinine, urea and blood urea nitrogen levels. Histological analysis of the kidneys revealed that tubulointerstitial fibrosis index was significantly decreased in OPE 200-treated group. The results indicated the prevention of diabetic nephropathy in rats by OPE treatment and suggest OPE as a potential treatment option.</AbstractText>
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<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
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<QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
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<QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName>
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<MeshHeading><DescriptorName UI="D014508" MajorTopicYN="N">Urea</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">diabetic nephropathy</Keyword>
<Keyword MajorTopicYN="N">extracellular matrix</Keyword>
<Keyword MajorTopicYN="N">orange peel extract</Keyword>
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</MedlineCitation>
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Amelioration of diabetic nephropathy by orange peel extract in rats.

Amelioration of diabetic nephropathy by orange peel extract in rats.

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

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