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Antiproliferative activity of Citrus juices and HPLC evaluation of their flavonoid composition.

Identifieur interne : 000B11 ( PubMed/Corpus ); précédent : 000B10; suivant : 000B12

Antiproliferative activity of Citrus juices and HPLC evaluation of their flavonoid composition.

Auteurs : Lorenzo Camarda ; Vita Di Stefano ; Sergio Fatta Del Bosco ; Domenico Schillaci

Source :

Fitoterapia [ 0367-326X ] ; 2007.

RBID : pubmed:17628348

English descriptors

KwdEn :
- Antineoplastic Agents, Phytogenic (administration & dosage), Antineoplastic Agents, Phytogenic (pharmacology), Antineoplastic Agents, Phytogenic (therapeutic use), Cell Line, Tumor (drug effects), Cell Proliferation (drug effects), Chromatography, High Pressure Liquid, Citrus, Flavanones (administration & dosage), Flavanones (chemistry), Flavanones (pharmacology), Flavanones (therapeutic use), Fruit, HL-60 Cells (drug effects), Humans, K562 Cells (drug effects), Phytotherapy.
MESH :
- chemical , administration & dosage : Antineoplastic Agents, Phytogenic, Flavanones.
- chemical , chemistry : Flavanones.
- chemical , pharmacology : Antineoplastic Agents, Phytogenic, Flavanones.
- chemical , therapeutic use : Antineoplastic Agents, Phytogenic, Flavanones.
- drug effects : Cell Line, Tumor, Cell Proliferation, HL-60 Cells, K562 Cells.
- Chromatography, High Pressure Liquid, Citrus, Fruit, Humans, Phytotherapy.

Abstract

The antiproliferative activity of fresh fruit juices extracted from Citrus sinensis (cv. Washington Navel and cv. Sanguinello), C. deliciosa cv. Avana, C. clementina cv. Nules, C. aurantium subsp. myrtifolia , was evaluated against K562 (human chronic myelogenous leukemia), HL-60 (human leukemia) and MCF-7 (human breast adenocarcinoma) cell lines. All the juices tested showed antiproliferative activity. Moreover, the pattern of the main flavanone compounds in the juices has been determined by HPLC analysis.

DOI: 10.1016/j.fitote.2007.02.020
PubMed: 17628348

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pubmed:17628348

Le document en format XML

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<author><name sortKey="Camarda, Lorenzo" sort="Camarda, Lorenzo" uniqKey="Camarda L" first="Lorenzo" last="Camarda">Lorenzo Camarda</name>
<affiliation><nlm:affiliation>Dipartimento di Chimica e Tecnologie Farmaceutiche, Università degli Studi di Palermo, via Archirafi 32, 90123, Palermo, Italy. camarnat@unipa.it</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Di Stefano, Vita" sort="Di Stefano, Vita" uniqKey="Di Stefano V" first="Vita" last="Di Stefano">Vita Di Stefano</name>
</author>
<author><name sortKey="Del Bosco, Sergio Fatta" sort="Del Bosco, Sergio Fatta" uniqKey="Del Bosco S" first="Sergio Fatta" last="Del Bosco">Sergio Fatta Del Bosco</name>
</author>
<author><name sortKey="Schillaci, Domenico" sort="Schillaci, Domenico" uniqKey="Schillaci D" first="Domenico" last="Schillaci">Domenico Schillaci</name>
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<affiliation><nlm:affiliation>Dipartimento di Chimica e Tecnologie Farmaceutiche, Università degli Studi di Palermo, via Archirafi 32, 90123, Palermo, Italy. camarnat@unipa.it</nlm:affiliation>
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<author><name sortKey="Di Stefano, Vita" sort="Di Stefano, Vita" uniqKey="Di Stefano V" first="Vita" last="Di Stefano">Vita Di Stefano</name>
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<author><name sortKey="Del Bosco, Sergio Fatta" sort="Del Bosco, Sergio Fatta" uniqKey="Del Bosco S" first="Sergio Fatta" last="Del Bosco">Sergio Fatta Del Bosco</name>
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<author><name sortKey="Schillaci, Domenico" sort="Schillaci, Domenico" uniqKey="Schillaci D" first="Domenico" last="Schillaci">Domenico Schillaci</name>
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<series><title level="j">Fitoterapia</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antineoplastic Agents, Phytogenic (administration & dosage)</term>
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<term>Antineoplastic Agents, Phytogenic (therapeutic use)</term>
<term>Cell Line, Tumor (drug effects)</term>
<term>Cell Proliferation (drug effects)</term>
<term>Chromatography, High Pressure Liquid</term>
<term>Citrus</term>
<term>Flavanones (administration & dosage)</term>
<term>Flavanones (chemistry)</term>
<term>Flavanones (pharmacology)</term>
<term>Flavanones (therapeutic use)</term>
<term>Fruit</term>
<term>HL-60 Cells (drug effects)</term>
<term>Humans</term>
<term>K562 Cells (drug effects)</term>
<term>Phytotherapy</term>
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<term>Flavanones</term>
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<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cell Line, Tumor</term>
<term>Cell Proliferation</term>
<term>HL-60 Cells</term>
<term>K562 Cells</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Chromatography, High Pressure Liquid</term>
<term>Citrus</term>
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<term>Humans</term>
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<front><div type="abstract" xml:lang="en">The antiproliferative activity of fresh fruit juices extracted from Citrus sinensis (cv. Washington Navel and cv. Sanguinello), C. deliciosa cv. Avana, C. clementina cv. Nules, C. aurantium subsp. myrtifolia , was evaluated against K562 (human chronic myelogenous leukemia), HL-60 (human leukemia) and MCF-7 (human breast adenocarcinoma) cell lines. All the juices tested showed antiproliferative activity. Moreover, the pattern of the main flavanone compounds in the juices has been determined by HPLC analysis.</div>
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<Day>27</Day>
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<DateRevised><Year>2007</Year>
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<JournalIssue CitedMedium="Print"><Volume>78</Volume>
<Issue>6</Issue>
<PubDate><Year>2007</Year>
<Month>Sep</Month>
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</JournalIssue>
<Title>Fitoterapia</Title>
<ISOAbbreviation>Fitoterapia</ISOAbbreviation>
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<ArticleTitle>Antiproliferative activity of Citrus juices and HPLC evaluation of their flavonoid composition.</ArticleTitle>
<Pagination><MedlinePgn>426-9</MedlinePgn>
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<Abstract><AbstractText>The antiproliferative activity of fresh fruit juices extracted from Citrus sinensis (cv. Washington Navel and cv. Sanguinello), C. deliciosa cv. Avana, C. clementina cv. Nules, C. aurantium subsp. myrtifolia , was evaluated against K562 (human chronic myelogenous leukemia), HL-60 (human leukemia) and MCF-7 (human breast adenocarcinoma) cell lines. All the juices tested showed antiproliferative activity. Moreover, the pattern of the main flavanone compounds in the juices has been determined by HPLC analysis.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Camarda</LastName>
<ForeName>Lorenzo</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Dipartimento di Chimica e Tecnologie Farmaceutiche, Università degli Studi di Palermo, via Archirafi 32, 90123, Palermo, Italy. camarnat@unipa.it</Affiliation>
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<Author ValidYN="Y"><LastName>Del Bosco</LastName>
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<Author ValidYN="Y"><LastName>Schillaci</LastName>
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</MeshHeading>
<MeshHeading><DescriptorName UI="D005638" MajorTopicYN="N">Fruit</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018922" MajorTopicYN="N">HL-60 Cells</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
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<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
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<MeshHeading><DescriptorName UI="D020014" MajorTopicYN="N">K562 Cells</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008517" MajorTopicYN="Y">Phytotherapy</DescriptorName>
</MeshHeading>
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Antiproliferative activity of Citrus juices and HPLC evaluation of their flavonoid composition.

Antiproliferative activity of Citrus juices and HPLC evaluation of their flavonoid composition.

Source :

English descriptors

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

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