Inhibitory effects of various beverages on human recombinant sulfotransferase isoforms SULT1A1 and SULT1A3.
Identifieur interne : 000A86 ( PubMed/Corpus ); précédent : 000A85; suivant : 000A87Inhibitory effects of various beverages on human recombinant sulfotransferase isoforms SULT1A1 and SULT1A3.
Auteurs : Haruka Nishimuta ; Hisakazu Ohtani ; Masayuki Tsujimoto ; Kenichiro Ogura ; Akira Hiratsuka ; Yasufumi SawadaSource :
- Biopharmaceutics & drug disposition [ 0142-2782 ] ; 2007.
English descriptors
- KwdEn :
- Adrenergic beta-Agonists (metabolism), Arylsulfotransferase (drug effects), Arylsulfotransferase (metabolism), Beverages, Biflavonoids (pharmacology), Biological Availability, Catechin (analogs & derivatives), Catechin (pharmacology), Citrus paradisi (chemistry), Citrus sinensis (chemistry), Flavanones (pharmacology), Flavones (pharmacology), Herb-Drug Interactions, Humans, In Vitro Techniques, Phenols (pharmacology), Polyphenols, Quercetin (pharmacology), Sulfotransferases (drug effects), Sulfotransferases (metabolism), Tea (chemistry).
- MESH :
- chemical , analogs & derivatives : Catechin.
- chemical , chemistry : Tea.
- chemical , drug effects : Arylsulfotransferase, Sulfotransferases.
- chemical , metabolism : Adrenergic beta-Agonists, Arylsulfotransferase, Sulfotransferases.
- chemical , pharmacology : Biflavonoids, Catechin, Flavanones, Flavones, Phenols, Quercetin.
- chemistry : Citrus paradisi, Citrus sinensis.
- Beverages, Biological Availability, Herb-Drug Interactions, Humans, In Vitro Techniques, Polyphenols.
Abstract
Sulfotransferase (SULT) 1A1 and SULT1A3 play important roles in the presystemic inactivation of beta(2) agonists in the liver and intestine, respectively. The study aimed to investigate the inhibitory effects of grapefruit juice, orange juice, green tea, black tea and oolong tea and their constituents on the activities of SULT1A1 and SULT1A3. The activities of both SULT1A1 and SULT1A3 were significantly inhibited by all the beverages investigated at a concentration of 10%. The beverage constituents were tested in concentration ranges considered to be physiologically relevant. The grapefruit constituent, quercetin, completely inhibited SULT1A1, while quercetin and naringin both partially inhibited SULT1A3. The orange constituents, tangeretin and nobiletin, also completely inhibited SULT1A1. The tea constituents, (-)-epicatechin gallate and (-)-epigallocatechin gallate, both almost completely inhibited SULT1A1 and SULT1A3. Moreover, the theaflavin and thearubigin fractions of black tea both completely inhibited SULT1A1 and strongly inhibited SULT1A3. The inhibitory action of green tea on SULT1A3 was competitive, while that of black tea and oolong tea was mixed competitive/non-competitive. Mechanism-based inhibition was not observed with any beverage. In conclusion, various beverages, especially teas, inhibit the function of SULT1A3, and therefore may have the potential to increase the bioavailability of orally administered substrates of SULT1A3, such as beta(2) agonists.
DOI: 10.1002/bdd.579
PubMed: 17876860
Links to Exploration step
pubmed:17876860Le document en format XML
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Ogura</name></author><author><name sortKey="Hiratsuka, Akira" sort="Hiratsuka, Akira" uniqKey="Hiratsuka A" first="Akira" last="Hiratsuka">Akira Hiratsuka</name></author><author><name sortKey="Sawada, Yasufumi" sort="Sawada, Yasufumi" uniqKey="Sawada Y" first="Yasufumi" last="Sawada">Yasufumi Sawada</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2007">2007</date><idno type="RBID">pubmed:17876860</idno><idno type="pmid">17876860</idno><idno type="doi">10.1002/bdd.579</idno><idno type="wicri:Area/PubMed/Corpus">000A86</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Inhibitory effects of various beverages on human recombinant sulfotransferase isoforms SULT1A1 and SULT1A3.</title><author><name sortKey="Nishimuta, Haruka" sort="Nishimuta, Haruka" uniqKey="Nishimuta H" first="Haruka" last="Nishimuta">Haruka Nishimuta</name><affiliation><nlm:affiliation>Department of Medico-Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka-shi, Fukuoka 812-8582, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Ohtani, Hisakazu" sort="Ohtani, Hisakazu" uniqKey="Ohtani H" first="Hisakazu" last="Ohtani">Hisakazu Ohtani</name></author><author><name sortKey="Tsujimoto, Masayuki" sort="Tsujimoto, Masayuki" uniqKey="Tsujimoto M" first="Masayuki" last="Tsujimoto">Masayuki Tsujimoto</name></author><author><name sortKey="Ogura, Kenichiro" sort="Ogura, Kenichiro" uniqKey="Ogura K" first="Kenichiro" last="Ogura">Kenichiro Ogura</name></author><author><name sortKey="Hiratsuka, Akira" sort="Hiratsuka, Akira" uniqKey="Hiratsuka A" first="Akira" last="Hiratsuka">Akira Hiratsuka</name></author><author><name sortKey="Sawada, Yasufumi" sort="Sawada, Yasufumi" uniqKey="Sawada Y" first="Yasufumi" last="Sawada">Yasufumi Sawada</name></author></analytic><series><title level="j">Biopharmaceutics & drug disposition</title><idno type="ISSN">0142-2782</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adrenergic beta-Agonists (metabolism)</term><term>Arylsulfotransferase (drug effects)</term><term>Arylsulfotransferase (metabolism)</term><term>Beverages</term><term>Biflavonoids (pharmacology)</term><term>Biological Availability</term><term>Catechin (analogs & derivatives)</term><term>Catechin (pharmacology)</term><term>Citrus paradisi (chemistry)</term><term>Citrus sinensis (chemistry)</term><term>Flavanones (pharmacology)</term><term>Flavones (pharmacology)</term><term>Herb-Drug Interactions</term><term>Humans</term><term>In Vitro Techniques</term><term>Phenols (pharmacology)</term><term>Polyphenols</term><term>Quercetin (pharmacology)</term><term>Sulfotransferases (drug effects)</term><term>Sulfotransferases (metabolism)</term><term>Tea (chemistry)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Catechin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Tea</term></keywords><keywords scheme="MESH" type="chemical" qualifier="drug effects" xml:lang="en"><term>Arylsulfotransferase</term><term>Sulfotransferases</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Adrenergic beta-Agonists</term><term>Arylsulfotransferase</term><term>Sulfotransferases</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Biflavonoids</term><term>Catechin</term><term>Flavanones</term><term>Flavones</term><term>Phenols</term><term>Quercetin</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Citrus paradisi</term><term>Citrus sinensis</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Beverages</term><term>Biological Availability</term><term>Herb-Drug Interactions</term><term>Humans</term><term>In Vitro Techniques</term><term>Polyphenols</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Sulfotransferase (SULT) 1A1 and SULT1A3 play important roles in the presystemic inactivation of beta(2) agonists in the liver and intestine, respectively. The study aimed to investigate the inhibitory effects of grapefruit juice, orange juice, green tea, black tea and oolong tea and their constituents on the activities of SULT1A1 and SULT1A3. The activities of both SULT1A1 and SULT1A3 were significantly inhibited by all the beverages investigated at a concentration of 10%. The beverage constituents were tested in concentration ranges considered to be physiologically relevant. The grapefruit constituent, quercetin, completely inhibited SULT1A1, while quercetin and naringin both partially inhibited SULT1A3. The orange constituents, tangeretin and nobiletin, also completely inhibited SULT1A1. The tea constituents, (-)-epicatechin gallate and (-)-epigallocatechin gallate, both almost completely inhibited SULT1A1 and SULT1A3. Moreover, the theaflavin and thearubigin fractions of black tea both completely inhibited SULT1A1 and strongly inhibited SULT1A3. The inhibitory action of green tea on SULT1A3 was competitive, while that of black tea and oolong tea was mixed competitive/non-competitive. Mechanism-based inhibition was not observed with any beverage. In conclusion, various beverages, especially teas, inhibit the function of SULT1A3, and therefore may have the potential to increase the bioavailability of orally administered substrates of SULT1A3, such as beta(2) agonists.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">17876860</PMID><DateCreated><Year>2007</Year><Month>12</Month><Day>6</Day></DateCreated><DateCompleted><Year>2008</Year><Month>04</Month><Day>14</Day></DateCompleted><DateRevised><Year>2015</Year><Month>11</Month><Day>19</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0142-2782</ISSN><JournalIssue CitedMedium="Print"><Volume>28</Volume><Issue>9</Issue><PubDate><Year>2007</Year><Month>Dec</Month></PubDate></JournalIssue><Title>Biopharmaceutics & drug disposition</Title><ISOAbbreviation>Biopharm Drug Dispos</ISOAbbreviation></Journal><ArticleTitle>Inhibitory effects of various beverages on human recombinant sulfotransferase isoforms SULT1A1 and SULT1A3.</ArticleTitle><Pagination><MedlinePgn>491-500</MedlinePgn></Pagination><Abstract><AbstractText>Sulfotransferase (SULT) 1A1 and SULT1A3 play important roles in the presystemic inactivation of beta(2) agonists in the liver and intestine, respectively. The study aimed to investigate the inhibitory effects of grapefruit juice, orange juice, green tea, black tea and oolong tea and their constituents on the activities of SULT1A1 and SULT1A3. The activities of both SULT1A1 and SULT1A3 were significantly inhibited by all the beverages investigated at a concentration of 10%. The beverage constituents were tested in concentration ranges considered to be physiologically relevant. The grapefruit constituent, quercetin, completely inhibited SULT1A1, while quercetin and naringin both partially inhibited SULT1A3. The orange constituents, tangeretin and nobiletin, also completely inhibited SULT1A1. The tea constituents, (-)-epicatechin gallate and (-)-epigallocatechin gallate, both almost completely inhibited SULT1A1 and SULT1A3. Moreover, the theaflavin and thearubigin fractions of black tea both completely inhibited SULT1A1 and strongly inhibited SULT1A3. The inhibitory action of green tea on SULT1A3 was competitive, while that of black tea and oolong tea was mixed competitive/non-competitive. Mechanism-based inhibition was not observed with any beverage. In conclusion, various beverages, especially teas, inhibit the function of SULT1A3, and therefore may have the potential to increase the bioavailability of orally administered substrates of SULT1A3, such as beta(2) agonists.</AbstractText><CopyrightInformation>Copyright (c) 2007 John Wiley & Sons, Ltd.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Nishimuta</LastName><ForeName>Haruka</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Medico-Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka-shi, Fukuoka 812-8582, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ohtani</LastName><ForeName>Hisakazu</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Tsujimoto</LastName><ForeName>Masayuki</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Ogura</LastName><ForeName>Kenichiro</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Hiratsuka</LastName><ForeName>Akira</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Sawada</LastName><ForeName>Yasufumi</ForeName><Initials>Y</Initials></Author></AuthorList><Language>ENG</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Biopharm Drug Dispos</MedlineTA><NlmUniqueID>7911226</NlmUniqueID><ISSNLinking>0142-2782</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000318">Adrenergic beta-Agonists</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D044946">Biflavonoids</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D044950">Flavanones</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D047309">Flavones</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010636">Phenols</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D059808">Polyphenols</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D013662">Tea</NameOfSubstance></Chemical><Chemical><RegistryNumber>12698-96-3</RegistryNumber><NameOfSubstance UI="C086701">thearubigin</NameOfSubstance></Chemical><Chemical><RegistryNumber>1IA46M0D13</RegistryNumber><NameOfSubstance UI="C056068">theaflavin</NameOfSubstance></Chemical><Chemical><RegistryNumber>8R1V1STN48</RegistryNumber><NameOfSubstance UI="D002392">Catechin</NameOfSubstance></Chemical><Chemical><RegistryNumber>92587OVD8Z</RegistryNumber><NameOfSubstance UI="C062669">epicatechin gallate</NameOfSubstance></Chemical><Chemical><RegistryNumber>9IKM0I5T1E</RegistryNumber><NameOfSubstance UI="D011794">Quercetin</NameOfSubstance></Chemical><Chemical><RegistryNumber>BQM438CTEL</RegistryNumber><NameOfSubstance UI="C045651">epigallocatechin gallate</NameOfSubstance></Chemical><Chemical><RegistryNumber>D65ILJ7WLY</RegistryNumber><NameOfSubstance UI="C008661">nobiletin</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.8.2.-</RegistryNumber><NameOfSubstance UI="D015238">Sulfotransferases</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.8.2.1</RegistryNumber><NameOfSubstance UI="D015239">Arylsulfotransferase</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.8.2.1</RegistryNumber><NameOfSubstance UI="C117544">SULT1A1 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.8.2.1</RegistryNumber><NameOfSubstance UI="C403170">monoamine-sulfating phenol sulfotransferase</NameOfSubstance></Chemical><Chemical><RegistryNumber>I4TLA1DLX6</RegistryNumber><NameOfSubstance UI="C059006">tangeretin</NameOfSubstance></Chemical><Chemical><RegistryNumber>N7TD9J649B</RegistryNumber><NameOfSubstance UI="C005274">naringin</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000318" MajorTopicYN="N">Adrenergic beta-Agonists</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015239" MajorTopicYN="N">Arylsulfotransferase</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001628" MajorTopicYN="Y">Beverages</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D044946" MajorTopicYN="N">Biflavonoids</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001682" MajorTopicYN="N">Biological Availability</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002392" MajorTopicYN="N">Catechin</DescriptorName><QualifierName UI="Q000031" MajorTopicYN="N">analogs & derivatives</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D032083" MajorTopicYN="N">Citrus paradisi</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D032084" MajorTopicYN="N">Citrus sinensis</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D044950" MajorTopicYN="N">Flavanones</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D047309" MajorTopicYN="N">Flavones</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D041743" MajorTopicYN="N">Herb-Drug Interactions</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D066298" MajorTopicYN="N">In Vitro Techniques</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010636" MajorTopicYN="N">Phenols</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D059808" MajorTopicYN="N">Polyphenols</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011794" MajorTopicYN="N">Quercetin</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015238" MajorTopicYN="N">Sulfotransferases</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013662" MajorTopicYN="N">Tea</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2007</Year><Month>9</Month><Day>19</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2008</Year><Month>4</Month><Day>15</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2007</Year><Month>9</Month><Day>19</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">17876860</ArticleId><ArticleId 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