The phytochemical analysis and antioxidant activity assessment of orange peel (Citrus sinensis) cultivated in Greece-Crete indicates a new commercial source of hesperidin.
Identifieur interne : 000973 ( PubMed/Corpus ); précédent : 000972; suivant : 000974The phytochemical analysis and antioxidant activity assessment of orange peel (Citrus sinensis) cultivated in Greece-Crete indicates a new commercial source of hesperidin.
Auteurs : Firas I. Kanaze ; Aikaterini Termentzi ; Chrysi Gabrieli ; Ioannis Niopas ; Manolis Georgarakis ; Eugene KokkalouSource :
- Biomedical chromatography : BMC [ 1099-0801 ] ; 2009.
English descriptors
- KwdEn :
- Antioxidants (analysis), Antioxidants (chemistry), Antioxidants (metabolism), Biphenyl Compounds (chemistry), Chromatography, Liquid, Citrus sinensis (chemistry), Diosmin (analysis), Diosmin (chemistry), Diosmin (metabolism), Flavanones (analysis), Flavanones (chemistry), Flavanones (metabolism), Greece, Hesperidin (analysis), Hesperidin (chemistry), Hesperidin (metabolism), Luminescent Measurements, Luminol (chemistry), Methanol (chemistry), Models, Chemical, Picrates (chemistry), Plant Extracts (analysis), Plant Extracts (chemistry), Plant Extracts (metabolism), Reproducibility of Results, Spectrometry, Mass, Electrospray Ionization.
- MESH :
- chemical , analysis : Antioxidants, Diosmin, Flavanones, Hesperidin, Plant Extracts.
- chemical , chemistry : Antioxidants, Biphenyl Compounds, Diosmin, Flavanones, Hesperidin, Luminol, Methanol, Picrates, Plant Extracts.
- chemical , metabolism : Antioxidants, Diosmin, Flavanones, Hesperidin, Plant Extracts.
- geographic : Greece.
- chemistry : Citrus sinensis.
- Chromatography, Liquid, Luminescent Measurements, Models, Chemical, Reproducibility of Results, Spectrometry, Mass, Electrospray Ionization.
Abstract
The flavonoid content of several methanolic extract fractions of Navel orange peel (flavedo and albedo of Citrus sinensis) cultivated in Crete (Greece) was first analysed phytochemically and then assessed for its antioxidant activity in vitro. The chemical structures of the constituents fractionated were originally determined by comparing their retention times and the obtained UV spectral data with the available bibliographic data and further verified by detailed LC-DAD-MS (ESI+) analysis. The main flavonoid groups found within the fractions examined were polymethoxylated flavones, O-glycosylated flavones, C-glycosylated flavones, O-glycosylated flavonols, O-glycosylated flavanones and phenolic acids along with their ester derivatives. In addition, the quantitative HPLC analysis confirmed that hesperidin is the major flavonoid glycoside found in the orange peel. Interestingly enough, its quantity at 48 mg/g of dry peel permits the commercial use of orange peel as a source for the production of hesperidin. The antioxidant activity of the orange peel methanolic extract fractions was evaluated by applying two complementary methodologies, DPPH(*) assay and the Co(II)/EDTA-induced luminol chemiluminescence approach. Overall, the results have shown that orange peel methanolic extracts possess moderate antioxidant activity as compared with the activity seen in tests where the corresponding aglycones, diosmetin and hesperetin were assessed in different ratios.
DOI: 10.1002/bmc.1090
PubMed: 18823075
Links to Exploration step
pubmed:18823075Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The phytochemical analysis and antioxidant activity assessment of orange peel (Citrus sinensis) cultivated in Greece-Crete indicates a new commercial source of hesperidin.</title><author><name sortKey="Kanaze, Firas I" sort="Kanaze, Firas I" uniqKey="Kanaze F" first="Firas I" last="Kanaze">Firas I. Kanaze</name><affiliation><nlm:affiliation>Department of Pharmacognosy-Pharmacology, School of Pharmacy, Aristotle University of Thessaloniki, Greece.</nlm:affiliation></affiliation></author><author><name sortKey="Termentzi, Aikaterini" sort="Termentzi, Aikaterini" uniqKey="Termentzi A" first="Aikaterini" last="Termentzi">Aikaterini Termentzi</name></author><author><name sortKey="Gabrieli, Chrysi" sort="Gabrieli, Chrysi" uniqKey="Gabrieli C" first="Chrysi" last="Gabrieli">Chrysi Gabrieli</name></author><author><name sortKey="Niopas, Ioannis" sort="Niopas, Ioannis" uniqKey="Niopas I" first="Ioannis" last="Niopas">Ioannis Niopas</name></author><author><name sortKey="Georgarakis, Manolis" sort="Georgarakis, Manolis" uniqKey="Georgarakis M" first="Manolis" last="Georgarakis">Manolis Georgarakis</name></author><author><name sortKey="Kokkalou, Eugene" sort="Kokkalou, Eugene" uniqKey="Kokkalou E" first="Eugene" last="Kokkalou">Eugene Kokkalou</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2009">2009</date><idno type="RBID">pubmed:18823075</idno><idno type="pmid">18823075</idno><idno type="doi">10.1002/bmc.1090</idno><idno type="wicri:Area/PubMed/Corpus">000973</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The phytochemical analysis and antioxidant activity assessment of orange peel (Citrus sinensis) cultivated in Greece-Crete indicates a new commercial source of hesperidin.</title><author><name sortKey="Kanaze, Firas I" sort="Kanaze, Firas I" uniqKey="Kanaze F" first="Firas I" last="Kanaze">Firas I. Kanaze</name><affiliation><nlm:affiliation>Department of Pharmacognosy-Pharmacology, School of Pharmacy, Aristotle University of Thessaloniki, Greece.</nlm:affiliation></affiliation></author><author><name sortKey="Termentzi, Aikaterini" sort="Termentzi, Aikaterini" uniqKey="Termentzi A" first="Aikaterini" last="Termentzi">Aikaterini Termentzi</name></author><author><name sortKey="Gabrieli, Chrysi" sort="Gabrieli, Chrysi" uniqKey="Gabrieli C" first="Chrysi" last="Gabrieli">Chrysi Gabrieli</name></author><author><name sortKey="Niopas, Ioannis" sort="Niopas, Ioannis" uniqKey="Niopas I" first="Ioannis" last="Niopas">Ioannis Niopas</name></author><author><name sortKey="Georgarakis, Manolis" sort="Georgarakis, Manolis" uniqKey="Georgarakis M" first="Manolis" last="Georgarakis">Manolis Georgarakis</name></author><author><name sortKey="Kokkalou, Eugene" sort="Kokkalou, Eugene" uniqKey="Kokkalou E" first="Eugene" last="Kokkalou">Eugene Kokkalou</name></author></analytic><series><title level="j">Biomedical chromatography : BMC</title><idno type="eISSN">1099-0801</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antioxidants (analysis)</term><term>Antioxidants (chemistry)</term><term>Antioxidants (metabolism)</term><term>Biphenyl Compounds (chemistry)</term><term>Chromatography, Liquid</term><term>Citrus sinensis (chemistry)</term><term>Diosmin (analysis)</term><term>Diosmin (chemistry)</term><term>Diosmin (metabolism)</term><term>Flavanones (analysis)</term><term>Flavanones (chemistry)</term><term>Flavanones (metabolism)</term><term>Greece</term><term>Hesperidin (analysis)</term><term>Hesperidin (chemistry)</term><term>Hesperidin (metabolism)</term><term>Luminescent Measurements</term><term>Luminol (chemistry)</term><term>Methanol (chemistry)</term><term>Models, Chemical</term><term>Picrates (chemistry)</term><term>Plant Extracts (analysis)</term><term>Plant Extracts (chemistry)</term><term>Plant Extracts (metabolism)</term><term>Reproducibility of Results</term><term>Spectrometry, Mass, Electrospray Ionization</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Antioxidants</term><term>Diosmin</term><term>Flavanones</term><term>Hesperidin</term><term>Plant Extracts</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Antioxidants</term><term>Biphenyl Compounds</term><term>Diosmin</term><term>Flavanones</term><term>Hesperidin</term><term>Luminol</term><term>Methanol</term><term>Picrates</term><term>Plant Extracts</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Antioxidants</term><term>Diosmin</term><term>Flavanones</term><term>Hesperidin</term><term>Plant Extracts</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Greece</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Citrus sinensis</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Chromatography, Liquid</term><term>Luminescent Measurements</term><term>Models, Chemical</term><term>Reproducibility of Results</term><term>Spectrometry, Mass, Electrospray Ionization</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The flavonoid content of several methanolic extract fractions of Navel orange peel (flavedo and albedo of Citrus sinensis) cultivated in Crete (Greece) was first analysed phytochemically and then assessed for its antioxidant activity in vitro. The chemical structures of the constituents fractionated were originally determined by comparing their retention times and the obtained UV spectral data with the available bibliographic data and further verified by detailed LC-DAD-MS (ESI+) analysis. The main flavonoid groups found within the fractions examined were polymethoxylated flavones, O-glycosylated flavones, C-glycosylated flavones, O-glycosylated flavonols, O-glycosylated flavanones and phenolic acids along with their ester derivatives. In addition, the quantitative HPLC analysis confirmed that hesperidin is the major flavonoid glycoside found in the orange peel. Interestingly enough, its quantity at 48 mg/g of dry peel permits the commercial use of orange peel as a source for the production of hesperidin. The antioxidant activity of the orange peel methanolic extract fractions was evaluated by applying two complementary methodologies, DPPH(*) assay and the Co(II)/EDTA-induced luminol chemiluminescence approach. Overall, the results have shown that orange peel methanolic extracts possess moderate antioxidant activity as compared with the activity seen in tests where the corresponding aglycones, diosmetin and hesperetin were assessed in different ratios.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">18823075</PMID><DateCreated><Year>2009</Year><Month>2</Month><Day>16</Day></DateCreated><DateCompleted><Year>2009</Year><Month>08</Month><Day>12</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1099-0801</ISSN><JournalIssue CitedMedium="Internet"><Volume>23</Volume><Issue>3</Issue><PubDate><Year>2009</Year><Month>Mar</Month></PubDate></JournalIssue><Title>Biomedical chromatography : BMC</Title><ISOAbbreviation>Biomed. Chromatogr.</ISOAbbreviation></Journal><ArticleTitle>The phytochemical analysis and antioxidant activity assessment of orange peel (Citrus sinensis) cultivated in Greece-Crete indicates a new commercial source of hesperidin.</ArticleTitle><Pagination><MedlinePgn>239-49</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/bmc.1090</ELocationID><Abstract><AbstractText>The flavonoid content of several methanolic extract fractions of Navel orange peel (flavedo and albedo of Citrus sinensis) cultivated in Crete (Greece) was first analysed phytochemically and then assessed for its antioxidant activity in vitro. The chemical structures of the constituents fractionated were originally determined by comparing their retention times and the obtained UV spectral data with the available bibliographic data and further verified by detailed LC-DAD-MS (ESI+) analysis. The main flavonoid groups found within the fractions examined were polymethoxylated flavones, O-glycosylated flavones, C-glycosylated flavones, O-glycosylated flavonols, O-glycosylated flavanones and phenolic acids along with their ester derivatives. In addition, the quantitative HPLC analysis confirmed that hesperidin is the major flavonoid glycoside found in the orange peel. Interestingly enough, its quantity at 48 mg/g of dry peel permits the commercial use of orange peel as a source for the production of hesperidin. The antioxidant activity of the orange peel methanolic extract fractions was evaluated by applying two complementary methodologies, DPPH(*) assay and the Co(II)/EDTA-induced luminol chemiluminescence approach. Overall, the results have shown that orange peel methanolic extracts possess moderate antioxidant activity as compared with the activity seen in tests where the corresponding aglycones, diosmetin and hesperetin were assessed in different ratios.</AbstractText><CopyrightInformation>2008 John Wiley & Sons, Ltd.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kanaze</LastName><ForeName>Firas I</ForeName><Initials>FI</Initials><AffiliationInfo><Affiliation>Department of Pharmacognosy-Pharmacology, School of Pharmacy, Aristotle University of Thessaloniki, Greece.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Termentzi</LastName><ForeName>Aikaterini</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Gabrieli</LastName><ForeName>Chrysi</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Niopas</LastName><ForeName>Ioannis</ForeName><Initials>I</Initials></Author><Author ValidYN="Y"><LastName>Georgarakis</LastName><ForeName>Manolis</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Kokkalou</LastName><ForeName>Eugene</ForeName><Initials>E</Initials></Author></AuthorList><Language>ENG</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Biomed Chromatogr</MedlineTA><NlmUniqueID>8610241</NlmUniqueID><ISSNLinking>0269-3879</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000975">Antioxidants</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D001713">Biphenyl Compounds</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D044950">Flavanones</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010851">Picrates</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010936">Plant Extracts</NameOfSubstance></Chemical><Chemical><RegistryNumber>1898-66-4</RegistryNumber><NameOfSubstance UI="C004931">2,2-diphenyl-1-picrylhydrazyl</NameOfSubstance></Chemical><Chemical><RegistryNumber>5EXP385Q4F</RegistryNumber><NameOfSubstance UI="D008165">Luminol</NameOfSubstance></Chemical><Chemical><RegistryNumber>7QM776WJ5N</RegistryNumber><NameOfSubstance UI="D004145">Diosmin</NameOfSubstance></Chemical><Chemical><RegistryNumber>E750O06Y6O</RegistryNumber><NameOfSubstance UI="D006569">Hesperidin</NameOfSubstance></Chemical><Chemical><RegistryNumber>N7TD9J649B</RegistryNumber><NameOfSubstance UI="C005274">naringin</NameOfSubstance></Chemical><Chemical><RegistryNumber>Y4S76JWI15</RegistryNumber><NameOfSubstance UI="D000432">Methanol</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000975" MajorTopicYN="N">Antioxidants</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001713" MajorTopicYN="N">Biphenyl Compounds</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002853" MajorTopicYN="N">Chromatography, Liquid</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D032084" MajorTopicYN="N">Citrus sinensis</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004145" MajorTopicYN="N">Diosmin</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D044950" MajorTopicYN="N">Flavanones</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006115" MajorTopicYN="N" Type="Geographic">Greece</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006569" MajorTopicYN="N">Hesperidin</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008163" MajorTopicYN="N">Luminescent Measurements</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008165" MajorTopicYN="N">Luminol</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000432" MajorTopicYN="N">Methanol</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008956" MajorTopicYN="N">Models, Chemical</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010851" MajorTopicYN="N">Picrates</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010936" MajorTopicYN="N">Plant Extracts</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015203" MajorTopicYN="N">Reproducibility of Results</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D021241" MajorTopicYN="N">Spectrometry, Mass, Electrospray Ionization</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2008</Year><Month>10</Month><Day>1</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2009</Year><Month>8</Month><Day>13</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2008</Year><Month>10</Month><Day>1</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">18823075</ArticleId><ArticleId IdType="doi">10.1002/bmc.1090</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Bois/explor/OrangerV1/Data/PubMed/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000973 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 000973 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Bois
|area= OrangerV1
|flux= PubMed
|étape= Corpus
|type= RBID
|clé= pubmed:18823075
|texte= The phytochemical analysis and antioxidant activity assessment of orange peel (Citrus sinensis) cultivated in Greece-Crete indicates a new commercial source of hesperidin.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:18823075" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a OrangerV1
| This area was generated with Dilib version V0.6.25. |  |