OrangerV1, PubMed, Corpus, bibRecord, 000850

[Effect and mechanism of total flavonoids of orange peel on rat adjuvant arthritis].

Identifieur interne : 000850 ( PubMed/Corpus ); précédent : 000849; suivant : 000851

[Effect and mechanism of total flavonoids of orange peel on rat adjuvant arthritis].

Auteurs : Gang Chen ; Zhongyi Yin ; Xuxu Zheng

Source :

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica [ 1001-5302 ] ; 2010.

RBID : pubmed:20707201

English descriptors

KwdEn :
- Animals, Arthritis, Experimental (chemically induced), Arthritis, Experimental (drug therapy), Arthritis, Experimental (immunology), Citrus sinensis (chemistry), Disease Models, Animal, Flavonoids (administration & dosage), Freund's Adjuvant (adverse effects), Humans, Interleukin-1 (immunology), Male, Plant Extracts (administration & dosage), Random Allocation, Rats, Rats, Wistar, Tumor Necrosis Factor-alpha (immunology).
MESH :
- chemical , administration & dosage : Flavonoids, Plant Extracts.
- chemical , adverse effects : Freund's Adjuvant.
- chemically induced : Arthritis, Experimental.
- chemistry : Citrus sinensis.
- drug therapy : Arthritis, Experimental.
- immunology : Arthritis, Experimental, Interleukin-1, Tumor Necrosis Factor-alpha.
- Animals, Disease Models, Animal, Humans, Male, Random Allocation, Rats, Rats, Wistar.

Abstract

To investigate the effect of the total flavonoids of orange peel (TFO) against adjuvant arthritis (AA) and the underlying mechanism.

PubMed: 20707201

Links to Exploration step

pubmed:20707201

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">[Effect and mechanism of total flavonoids of orange peel on rat adjuvant arthritis].</title>
<author><name sortKey="Chen, Gang" sort="Chen, Gang" uniqKey="Chen G" first="Gang" last="Chen">Gang Chen</name>
<affiliation><nlm:affiliation>Research Center of Medical Chemistry and Chemical Biology, Chongqing Technology and Business University, Chongqing 400067, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Yin, Zhongyi" sort="Yin, Zhongyi" uniqKey="Yin Z" first="Zhongyi" last="Yin">Zhongyi Yin</name>
</author>
<author><name sortKey="Zheng, Xuxu" sort="Zheng, Xuxu" uniqKey="Zheng X" first="Xuxu" last="Zheng">Xuxu Zheng</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2010">2010</date>
<idno type="RBID">pubmed:20707201</idno>
<idno type="pmid">20707201</idno>
<idno type="wicri:Area/PubMed/Corpus">000850</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">[Effect and mechanism of total flavonoids of orange peel on rat adjuvant arthritis].</title>
<author><name sortKey="Chen, Gang" sort="Chen, Gang" uniqKey="Chen G" first="Gang" last="Chen">Gang Chen</name>
<affiliation><nlm:affiliation>Research Center of Medical Chemistry and Chemical Biology, Chongqing Technology and Business University, Chongqing 400067, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Yin, Zhongyi" sort="Yin, Zhongyi" uniqKey="Yin Z" first="Zhongyi" last="Yin">Zhongyi Yin</name>
</author>
<author><name sortKey="Zheng, Xuxu" sort="Zheng, Xuxu" uniqKey="Zheng X" first="Xuxu" last="Zheng">Xuxu Zheng</name>
</author>
</analytic>
<series><title level="j">Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica</title>
<idno type="ISSN">1001-5302</idno>
<imprint><date when="2010" type="published">2010</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Arthritis, Experimental (chemically induced)</term>
<term>Arthritis, Experimental (drug therapy)</term>
<term>Arthritis, Experimental (immunology)</term>
<term>Citrus sinensis (chemistry)</term>
<term>Disease Models, Animal</term>
<term>Flavonoids (administration & dosage)</term>
<term>Freund's Adjuvant (adverse effects)</term>
<term>Humans</term>
<term>Interleukin-1 (immunology)</term>
<term>Male</term>
<term>Plant Extracts (administration & dosage)</term>
<term>Random Allocation</term>
<term>Rats</term>
<term>Rats, Wistar</term>
<term>Tumor Necrosis Factor-alpha (immunology)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Flavonoids</term>
<term>Plant Extracts</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Freund's Adjuvant</term>
</keywords>
<keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Arthritis, Experimental</term>
</keywords>
<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Citrus sinensis</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Arthritis, Experimental</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Arthritis, Experimental</term>
<term>Interleukin-1</term>
<term>Tumor Necrosis Factor-alpha</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Disease Models, Animal</term>
<term>Humans</term>
<term>Male</term>
<term>Random Allocation</term>
<term>Rats</term>
<term>Rats, Wistar</term>
</keywords>
</textClass>
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</teiHeader>
<front><div type="abstract" xml:lang="en">To investigate the effect of the total flavonoids of orange peel (TFO) against adjuvant arthritis (AA) and the underlying mechanism.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">20707201</PMID>
<DateCreated><Year>2010</Year>
<Month>8</Month>
<Day>16</Day>
</DateCreated>
<DateCompleted><Year>2010</Year>
<Month>09</Month>
<Day>09</Day>
</DateCompleted>
<DateRevised><Year>2010</Year>
<Month>8</Month>
<Day>16</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Print">1001-5302</ISSN>
<JournalIssue CitedMedium="Print"><Volume>35</Volume>
<Issue>10</Issue>
<PubDate><Year>2010</Year>
<Month>May</Month>
</PubDate>
</JournalIssue>
<Title>Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica</Title>
<ISOAbbreviation>Zhongguo Zhong Yao Za Zhi</ISOAbbreviation>
</Journal>
<ArticleTitle>[Effect and mechanism of total flavonoids of orange peel on rat adjuvant arthritis].</ArticleTitle>
<Pagination><MedlinePgn>1298-301</MedlinePgn>
</Pagination>
<Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To investigate the effect of the total flavonoids of orange peel (TFO) against adjuvant arthritis (AA) and the underlying mechanism.</AbstractText>
<AbstractText Label="METHOD" NlmCategory="METHODS">AA model was induced in male Wistar (correction of SD) rats by immunization with Freund's complete adjuvant Pad thickness was assayed by caliper. Pathological impairment of ankle joint was analysised by hematoxylin and eosin (H&E) staining. Levels of tumor necrosis factor (TNF)-alpha, Interleukin (IL)-1beta and prostaglandin (PG) E2 in serum was detected by radioimmunoassay method. Cyclooxygenase (COX)-2 expression in synovium tissues was measured by Western blot assay.</AbstractText>
<AbstractText Label="RESULT" NlmCategory="RESULTS">The 75 mg x kg(-1) and 150 mg x kg(-1) TFO treatment obviously decreased the pad thickness and improve the pathological impairment of ankle joint of AA rats. In addition, abnormal elevation of TNF-alpha, IL-1beta and PGE2 in serum and COX-2 expression in synovium tissues of AA rats were markedly repressed by TFO treatment.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">TFO can inhibit the development of AA in rats, and the mechanism were likely due to depressing inflammatory mediators production.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Chen</LastName>
<ForeName>Gang</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Research Center of Medical Chemistry and Chemical Biology, Chongqing Technology and Business University, Chongqing 400067, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yin</LastName>
<ForeName>Zhongyi</ForeName>
<Initials>Z</Initials>
</Author>
<Author ValidYN="Y"><LastName>Zheng</LastName>
<ForeName>Xuxu</ForeName>
<Initials>X</Initials>
</Author>
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<Language>CHI</Language>
<PublicationTypeList><PublicationType UI="D004740">English Abstract</PublicationType>
<PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>China</Country>
<MedlineTA>Zhongguo Zhong Yao Za Zhi</MedlineTA>
<NlmUniqueID>8913656</NlmUniqueID>
<ISSNLinking>1001-5302</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D005419">Flavonoids</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D007375">Interleukin-1</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D010936">Plant Extracts</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D014409">Tumor Necrosis Factor-alpha</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>9007-81-2</RegistryNumber>
<NameOfSubstance UI="D005620">Freund's Adjuvant</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001169" MajorTopicYN="N">Arthritis, Experimental</DescriptorName>
<QualifierName UI="Q000139" MajorTopicYN="N">chemically induced</QualifierName>
<QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D032084" MajorTopicYN="N">Citrus sinensis</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004195" MajorTopicYN="N">Disease Models, Animal</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005419" MajorTopicYN="N">Flavonoids</DescriptorName>
<QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005620" MajorTopicYN="N">Freund's Adjuvant</DescriptorName>
<QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007375" MajorTopicYN="N">Interleukin-1</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010936" MajorTopicYN="N">Plant Extracts</DescriptorName>
<QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011897" MajorTopicYN="N">Random Allocation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017208" MajorTopicYN="N">Rats, Wistar</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014409" MajorTopicYN="N">Tumor Necrosis Factor-alpha</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2010</Year>
<Month>8</Month>
<Day>17</Day>
<Hour>6</Hour>
<Minute>0</Minute>
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<Month>8</Month>
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<PubMedPubDate PubStatus="medline"><Year>2010</Year>
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<Minute>0</Minute>
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<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">20707201</ArticleId>
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</record>

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[Effect and mechanism of total flavonoids of orange peel on rat adjuvant arthritis].

[Effect and mechanism of total flavonoids of orange peel on rat adjuvant arthritis].

Source :

English descriptors

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki