Concentration and solubility of flavanones in orange beverages affect their bioavailability in humans.
Identifieur interne : 000840 ( PubMed/Corpus ); précédent : 000839; suivant : 000841Concentration and solubility of flavanones in orange beverages affect their bioavailability in humans.
Auteurs : Fernando Vallejo ; Mar Larrosa ; Elisa Escudero ; María P. Zafrilla ; Bego A Cerdá ; Julio Boza ; María Teresa García-Conesa ; Juan Carlos Espín ; Francisco A. Tomás-BarberánSource :
- Journal of agricultural and food chemistry [ 1520-5118 ] ; 2010.
English descriptors
- KwdEn :
- Adult, Beverages (analysis), Biological Availability, Chromatography, High Pressure Liquid, Citrus sinensis, Cross-Over Studies, Female, Flavanones (analysis), Flavanones (blood), Flavanones (chemistry), Flavanones (pharmacokinetics), Flavanones (urine), Fruit (chemistry), Hesperidin (blood), Hesperidin (urine), Humans, Intestinal Absorption, Male, Solubility.
- MESH :
- chemical , analysis : Flavanones.
- analysis : Beverages.
- chemical , blood : Flavanones, Hesperidin.
- chemical , chemistry : Flavanones, Fruit.
- chemical , pharmacokinetics : Flavanones.
- chemical , urine : Flavanones, Hesperidin.
- Adult, Biological Availability, Chromatography, High Pressure Liquid, Citrus sinensis, Cross-Over Studies, Female, Humans, Intestinal Absorption, Male, Solubility.
Abstract
Orange juice is a very rich source of dietary flavanones. The effect of flavanone concentration and solubility of orange beverages on their bioavailability has been studied in a crossover study with 10 healthy volunteers. Five different beverages with different flavanone concentrations were evaluated. Commercial orange juices (29.2-70.3 mg of flavanones/100 mL) were compared with experimental orange beverages in which the flavanone concentration was enhanced (110.2 mg/100 mL). Hesperetin and naringenin glucuronides and sulfates were detected and quantified in plasma and urine. The study shows that the solubility of the flavanones, and particularly that of hesperidin, in the juice is a key factor for the bioavailability as flavanone excretion and the C(max) in plasma correlate well with the soluble flavanone concentration in the juice, whereas it has no correlation with the total flavanone intake. In addition, a large interindividual variation was observed, this being consistent for each individual after the intake of the different beverages, suggesting that flavanone bioavailability is also dependent on the occurrence of specific microbiota that is able to remove the rutinosides from the juice glycosides, which results in aglycones that are then absorbed from the gut.
DOI: 10.1021/jf100752j
PubMed: 20441150
Links to Exploration step
pubmed:20441150Le document en format XML
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Zafrilla</name></author><author><name sortKey="Cerda, Bego A" sort="Cerda, Bego A" uniqKey="Cerda B" first="Bego A" last="Cerdá">Bego A Cerdá</name></author><author><name sortKey="Boza, Julio" sort="Boza, Julio" uniqKey="Boza J" first="Julio" last="Boza">Julio Boza</name></author><author><name sortKey="Garcia Conesa, Maria Teresa" sort="Garcia Conesa, Maria Teresa" uniqKey="Garcia Conesa M" first="María Teresa" last="García-Conesa">María Teresa García-Conesa</name></author><author><name sortKey="Espin, Juan Carlos" sort="Espin, Juan Carlos" uniqKey="Espin J" first="Juan Carlos" last="Espín">Juan Carlos Espín</name></author><author><name sortKey="Tomas Barberan, Francisco A" sort="Tomas Barberan, Francisco A" uniqKey="Tomas Barberan F" first="Francisco A" last="Tomás-Barberán">Francisco A. Tomás-Barberán</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2010">2010</date><idno type="RBID">pubmed:20441150</idno><idno type="pmid">20441150</idno><idno type="doi">10.1021/jf100752j</idno><idno type="wicri:Area/PubMed/Corpus">000840</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Concentration and solubility of flavanones in orange beverages affect their bioavailability in humans.</title><author><name sortKey="Vallejo, Fernando" sort="Vallejo, Fernando" uniqKey="Vallejo F" first="Fernando" last="Vallejo">Fernando Vallejo</name><affiliation><nlm:affiliation>Research Group on Quality, Safety and Bioactivity of Plant Foods, Department of Food Science and Technology, CEBAS-CSIC, 30100 Campus de Espinardo, Murcia, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Larrosa, Mar" sort="Larrosa, Mar" uniqKey="Larrosa M" first="Mar" last="Larrosa">Mar Larrosa</name></author><author><name sortKey="Escudero, Elisa" sort="Escudero, Elisa" uniqKey="Escudero E" first="Elisa" last="Escudero">Elisa Escudero</name></author><author><name sortKey="Zafrilla, Maria P" sort="Zafrilla, Maria P" uniqKey="Zafrilla M" first="María P" last="Zafrilla">María P. Zafrilla</name></author><author><name sortKey="Cerda, Bego A" sort="Cerda, Bego A" uniqKey="Cerda B" first="Bego A" last="Cerdá">Bego A Cerdá</name></author><author><name sortKey="Boza, Julio" sort="Boza, Julio" uniqKey="Boza J" first="Julio" last="Boza">Julio Boza</name></author><author><name sortKey="Garcia Conesa, Maria Teresa" sort="Garcia Conesa, Maria Teresa" uniqKey="Garcia Conesa M" first="María Teresa" last="García-Conesa">María Teresa García-Conesa</name></author><author><name sortKey="Espin, Juan Carlos" sort="Espin, Juan Carlos" uniqKey="Espin J" first="Juan Carlos" last="Espín">Juan Carlos Espín</name></author><author><name sortKey="Tomas Barberan, Francisco A" sort="Tomas Barberan, Francisco A" uniqKey="Tomas Barberan F" first="Francisco A" last="Tomás-Barberán">Francisco A. Tomás-Barberán</name></author></analytic><series><title level="j">Journal of agricultural and food chemistry</title><idno type="eISSN">1520-5118</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Beverages (analysis)</term><term>Biological Availability</term><term>Chromatography, High Pressure Liquid</term><term>Citrus sinensis</term><term>Cross-Over Studies</term><term>Female</term><term>Flavanones (analysis)</term><term>Flavanones (blood)</term><term>Flavanones (chemistry)</term><term>Flavanones (pharmacokinetics)</term><term>Flavanones (urine)</term><term>Fruit (chemistry)</term><term>Hesperidin (blood)</term><term>Hesperidin (urine)</term><term>Humans</term><term>Intestinal Absorption</term><term>Male</term><term>Solubility</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Flavanones</term></keywords><keywords scheme="MESH" qualifier="analysis" xml:lang="en"><term>Beverages</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Flavanones</term><term>Hesperidin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Flavanones</term><term>Fruit</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Flavanones</term></keywords><keywords scheme="MESH" type="chemical" qualifier="urine" xml:lang="en"><term>Flavanones</term><term>Hesperidin</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Biological Availability</term><term>Chromatography, High Pressure Liquid</term><term>Citrus sinensis</term><term>Cross-Over Studies</term><term>Female</term><term>Humans</term><term>Intestinal Absorption</term><term>Male</term><term>Solubility</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Orange juice is a very rich source of dietary flavanones. The effect of flavanone concentration and solubility of orange beverages on their bioavailability has been studied in a crossover study with 10 healthy volunteers. Five different beverages with different flavanone concentrations were evaluated. Commercial orange juices (29.2-70.3 mg of flavanones/100 mL) were compared with experimental orange beverages in which the flavanone concentration was enhanced (110.2 mg/100 mL). Hesperetin and naringenin glucuronides and sulfates were detected and quantified in plasma and urine. The study shows that the solubility of the flavanones, and particularly that of hesperidin, in the juice is a key factor for the bioavailability as flavanone excretion and the C(max) in plasma correlate well with the soluble flavanone concentration in the juice, whereas it has no correlation with the total flavanone intake. In addition, a large interindividual variation was observed, this being consistent for each individual after the intake of the different beverages, suggesting that flavanone bioavailability is also dependent on the occurrence of specific microbiota that is able to remove the rutinosides from the juice glycosides, which results in aglycones that are then absorbed from the gut.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">20441150</PMID><DateCreated><Year>2010</Year><Month>5</Month><Day>20</Day></DateCreated><DateCompleted><Year>2010</Year><Month>10</Month><Day>18</Day></DateCompleted><DateRevised><Year>2015</Year><Month>11</Month><Day>19</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1520-5118</ISSN><JournalIssue CitedMedium="Internet"><Volume>58</Volume><Issue>10</Issue><PubDate><Year>2010</Year><Month>May</Month><Day>26</Day></PubDate></JournalIssue><Title>Journal of agricultural and food chemistry</Title><ISOAbbreviation>J. Agric. Food Chem.</ISOAbbreviation></Journal><ArticleTitle>Concentration and solubility of flavanones in orange beverages affect their bioavailability in humans.</ArticleTitle><Pagination><MedlinePgn>6516-24</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1021/jf100752j</ELocationID><Abstract><AbstractText>Orange juice is a very rich source of dietary flavanones. The effect of flavanone concentration and solubility of orange beverages on their bioavailability has been studied in a crossover study with 10 healthy volunteers. Five different beverages with different flavanone concentrations were evaluated. Commercial orange juices (29.2-70.3 mg of flavanones/100 mL) were compared with experimental orange beverages in which the flavanone concentration was enhanced (110.2 mg/100 mL). Hesperetin and naringenin glucuronides and sulfates were detected and quantified in plasma and urine. The study shows that the solubility of the flavanones, and particularly that of hesperidin, in the juice is a key factor for the bioavailability as flavanone excretion and the C(max) in plasma correlate well with the soluble flavanone concentration in the juice, whereas it has no correlation with the total flavanone intake. In addition, a large interindividual variation was observed, this being consistent for each individual after the intake of the different beverages, suggesting that flavanone bioavailability is also dependent on the occurrence of specific microbiota that is able to remove the rutinosides from the juice glycosides, which results in aglycones that are then absorbed from the gut.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Vallejo</LastName><ForeName>Fernando</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Research Group on Quality, Safety and Bioactivity of Plant Foods, Department of Food Science and Technology, CEBAS-CSIC, 30100 Campus de Espinardo, Murcia, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Larrosa</LastName><ForeName>Mar</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Escudero</LastName><ForeName>Elisa</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Zafrilla</LastName><ForeName>María P</ForeName><Initials>MP</Initials></Author><Author ValidYN="Y"><LastName>Cerdá</LastName><ForeName>Begoña</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Boza</LastName><ForeName>Julio</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>García-Conesa</LastName><ForeName>María Teresa</ForeName><Initials>MT</Initials></Author><Author ValidYN="Y"><LastName>Espín</LastName><ForeName>Juan Carlos</ForeName><Initials>JC</Initials></Author><Author ValidYN="Y"><LastName>Tomás-Barberán</LastName><ForeName>Francisco A</ForeName><Initials>FA</Initials></Author></AuthorList><Language>ENG</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Agric Food Chem</MedlineTA><NlmUniqueID>0374755</NlmUniqueID><ISSNLinking>0021-8561</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D044950">Flavanones</NameOfSubstance></Chemical><Chemical><RegistryNumber>E750O06Y6O</RegistryNumber><NameOfSubstance UI="D006569">Hesperidin</NameOfSubstance></Chemical><Chemical><RegistryNumber>HN5425SBF2</RegistryNumber><NameOfSubstance UI="C005273">naringenin</NameOfSubstance></Chemical><Chemical><RegistryNumber>Q9Q3D557F1</RegistryNumber><NameOfSubstance UI="C013015">hesperetin</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001628" MajorTopicYN="N">Beverages</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="Y">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001682" MajorTopicYN="N">Biological Availability</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002851" MajorTopicYN="N">Chromatography, High Pressure Liquid</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D032084" MajorTopicYN="Y">Citrus sinensis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018592" MajorTopicYN="N">Cross-Over Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D044950" MajorTopicYN="N">Flavanones</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="Y">analysis</QualifierName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000493" MajorTopicYN="Y">pharmacokinetics</QualifierName><QualifierName UI="Q000652" MajorTopicYN="N">urine</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005638" MajorTopicYN="N">Fruit</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006569" MajorTopicYN="N">Hesperidin</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000652" MajorTopicYN="N">urine</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007408" MajorTopicYN="N">Intestinal Absorption</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012995" MajorTopicYN="N">Solubility</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2010</Year><Month>5</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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