Inhibition of TNF-α/IFN-γ induced RANTES expression in HaCaT cell by naringin.
Identifieur interne : 000718 ( PubMed/Corpus ); précédent : 000717; suivant : 000719Inhibition of TNF-α/IFN-γ induced RANTES expression in HaCaT cell by naringin.
Auteurs : Wang Si-Si ; Liu Liao ; Zhu Ling ; Yang Yun-XiaSource :
- Pharmaceutical biology [ 1744-5116 ] ; 2011.
English descriptors
- KwdEn :
- Anti-Inflammatory Agents (pharmacology), Cell Proliferation (drug effects), Chemokine CCL5 (genetics), Chemokine CCL5 (metabolism), Citrus, Epithelial Cells, Flavanones (pharmacology), Humans, Inflammation (drug therapy), Interferon-gamma (antagonists & inhibitors), Interferon-gamma (drug effects), Interferon-gamma (metabolism), Keratinocytes, NF-kappa B (genetics), NF-kappa B (metabolism), Phytotherapy, Plant Preparations (pharmacology), Tetrazolium Salts, Thiazoles, Tumor Necrosis Factor-alpha (antagonists & inhibitors), Tumor Necrosis Factor-alpha (drug effects), Tumor Necrosis Factor-alpha (metabolism).
- MESH :
- chemical , antagonists & inhibitors : Interferon-gamma, Tumor Necrosis Factor-alpha.
- chemical , drug effects : Interferon-gamma, Tumor Necrosis Factor-alpha.
- chemical , genetics : Chemokine CCL5, NF-kappa B.
- chemical , metabolism : Chemokine CCL5, Interferon-gamma, NF-kappa B, Tumor Necrosis Factor-alpha.
- chemical , pharmacology : Anti-Inflammatory Agents, Flavanones, Plant Preparations.
- drug effects : Cell Proliferation.
- drug therapy : Inflammation.
- Citrus, Epithelial Cells, Humans, Keratinocytes, Phytotherapy, Tetrazolium Salts, Thiazoles.
Abstract
Naringin is a bioflavonoid derivative and is predominantly found in Citrus paradisi Macf., Citrus sinensis (Linn.) Osbeck, Citrus unshiu Marc., Citrus reticulata Blanco cv. Nobilis, Citrus tachibana (Makino) Tanaka, Citrus junos Sieb. ex Tanaka (Rutaceae), and related citrus species. It has anti-inflammatory effects that have been well-documented, but the mechanism is poorly characterized.
DOI: 10.3109/13880209.2010.550054
PubMed: 21500970
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pubmed:21500970Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Inhibition of TNF-α/IFN-γ induced RANTES expression in HaCaT cell by naringin.</title><author><name sortKey="Si Si, Wang" sort="Si Si, Wang" uniqKey="Si Si W" first="Wang" last="Si-Si">Wang Si-Si</name><affiliation><nlm:affiliation>Department of Pharmacology, West-China Medical Center, Sichuan University, Chengdu, China.</nlm:affiliation></affiliation></author><author><name sortKey="Liao, Liu" sort="Liao, Liu" uniqKey="Liao L" first="Liu" last="Liao">Liu Liao</name></author><author><name sortKey="Ling, Zhu" sort="Ling, Zhu" uniqKey="Ling Z" first="Zhu" last="Ling">Zhu Ling</name></author><author><name sortKey="Yun Xia, Yang" sort="Yun Xia, Yang" uniqKey="Yun Xia Y" first="Yang" last="Yun-Xia">Yang Yun-Xia</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2011">2011</date><idno type="RBID">pubmed:21500970</idno><idno type="pmid">21500970</idno><idno type="doi">10.3109/13880209.2010.550054</idno><idno type="wicri:Area/PubMed/Corpus">000718</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Inhibition of TNF-α/IFN-γ induced RANTES expression in HaCaT cell by naringin.</title><author><name sortKey="Si Si, Wang" sort="Si Si, Wang" uniqKey="Si Si W" first="Wang" last="Si-Si">Wang Si-Si</name><affiliation><nlm:affiliation>Department of Pharmacology, West-China Medical Center, Sichuan University, Chengdu, China.</nlm:affiliation></affiliation></author><author><name sortKey="Liao, Liu" sort="Liao, Liu" uniqKey="Liao L" first="Liu" last="Liao">Liu Liao</name></author><author><name sortKey="Ling, Zhu" sort="Ling, Zhu" uniqKey="Ling Z" first="Zhu" last="Ling">Zhu Ling</name></author><author><name sortKey="Yun Xia, Yang" sort="Yun Xia, Yang" uniqKey="Yun Xia Y" first="Yang" last="Yun-Xia">Yang Yun-Xia</name></author></analytic><series><title level="j">Pharmaceutical biology</title><idno type="eISSN">1744-5116</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anti-Inflammatory Agents (pharmacology)</term><term>Cell Proliferation (drug effects)</term><term>Chemokine CCL5 (genetics)</term><term>Chemokine CCL5 (metabolism)</term><term>Citrus</term><term>Epithelial Cells</term><term>Flavanones (pharmacology)</term><term>Humans</term><term>Inflammation (drug therapy)</term><term>Interferon-gamma (antagonists & inhibitors)</term><term>Interferon-gamma (drug effects)</term><term>Interferon-gamma (metabolism)</term><term>Keratinocytes</term><term>NF-kappa B (genetics)</term><term>NF-kappa B (metabolism)</term><term>Phytotherapy</term><term>Plant Preparations (pharmacology)</term><term>Tetrazolium Salts</term><term>Thiazoles</term><term>Tumor Necrosis Factor-alpha (antagonists & inhibitors)</term><term>Tumor Necrosis Factor-alpha (drug effects)</term><term>Tumor Necrosis Factor-alpha (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Interferon-gamma</term><term>Tumor Necrosis Factor-alpha</term></keywords><keywords scheme="MESH" type="chemical" qualifier="drug effects" xml:lang="en"><term>Interferon-gamma</term><term>Tumor Necrosis Factor-alpha</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Chemokine CCL5</term><term>NF-kappa B</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Chemokine CCL5</term><term>Interferon-gamma</term><term>NF-kappa B</term><term>Tumor Necrosis Factor-alpha</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Anti-Inflammatory Agents</term><term>Flavanones</term><term>Plant Preparations</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cell Proliferation</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Inflammation</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Citrus</term><term>Epithelial Cells</term><term>Humans</term><term>Keratinocytes</term><term>Phytotherapy</term><term>Tetrazolium Salts</term><term>Thiazoles</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Naringin is a bioflavonoid derivative and is predominantly found in Citrus paradisi Macf., Citrus sinensis (Linn.) Osbeck, Citrus unshiu Marc., Citrus reticulata Blanco cv. Nobilis, Citrus tachibana (Makino) Tanaka, Citrus junos Sieb. ex Tanaka (Rutaceae), and related citrus species. It has anti-inflammatory effects that have been well-documented, but the mechanism is poorly characterized.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">21500970</PMID><DateCreated><Year>2011</Year><Month>6</Month><Day>23</Day></DateCreated><DateCompleted><Year>2012</Year><Month>01</Month><Day>19</Day></DateCompleted><DateRevised><Year>2012</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1744-5116</ISSN><JournalIssue CitedMedium="Internet"><Volume>49</Volume><Issue>8</Issue><PubDate><Year>2011</Year><Month>Aug</Month></PubDate></JournalIssue><Title>Pharmaceutical biology</Title><ISOAbbreviation>Pharm Biol</ISOAbbreviation></Journal><ArticleTitle>Inhibition of TNF-α/IFN-γ induced RANTES expression in HaCaT cell by naringin.</ArticleTitle><Pagination><MedlinePgn>810-4</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3109/13880209.2010.550054</ELocationID><Abstract><AbstractText Label="CONTEXT" NlmCategory="BACKGROUND">Naringin is a bioflavonoid derivative and is predominantly found in Citrus paradisi Macf., Citrus sinensis (Linn.) Osbeck, Citrus unshiu Marc., Citrus reticulata Blanco cv. Nobilis, Citrus tachibana (Makino) Tanaka, Citrus junos Sieb. ex Tanaka (Rutaceae), and related citrus species. It has anti-inflammatory effects that have been well-documented, but the mechanism is poorly characterized.</AbstractText><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">The effect of naringin on production of RANTES (regulated upon activation normal T-cell expressed and secreted) in human HaCaT cells was investigated here for the first time.</AbstractText><AbstractText Label="MATERIALS AND METHODS" NlmCategory="METHODS">The HaCaT cells were cultured in Dulbecco's modified Eagle's medium (DMEM) and the proliferation of cell was determined by 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT). The cells were divided into three groups including control group, tumor necrosis factor alpha (TNF-α)/interferon gamma (IFN-γ)-stimulated group, and naringin pretreatment group (first incubated in the presence of naringin and then exposed to TNF-α/IFN-γ). The concentration of RANTES in the supernatants was determined by enzyme-linked immunosorbent assay (ELISA). The expression of RANTES mRNA was analyzed by reverse transcription-polymerase chain reaction (RT-PCR). The expression of nuclear factor kappa B (NF-κB) P65 protein was detected with immunocytochemical method and western blot method.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Naringin hardly inhibits HaCaT cells growth at concentrations rising from 0.25 to 1 mmol/L. However, RANTES expression detected in supernatant stimulated with TNF-α/IFN-γ reduced 15 and 16%, respectively, when cultured with 0.25, 0.5 mmol/L naringin. Furthermore, 1 mmol/L naringin significantly decreased RANTES mRNA level. Finally, naringin decreased the expression of NF-κB P65 protein in nuclei.</AbstractText><AbstractText Label="DISCUSSION AND CONCLUSION" NlmCategory="CONCLUSIONS">Naringin can inhibit the increased production of RANTES, which is partially via NF-κB-dependent signal pathway.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Si-Si</LastName><ForeName>Wang</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Department of Pharmacology, West-China Medical Center, Sichuan University, Chengdu, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liao</LastName><ForeName>Liu</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Ling</LastName><ForeName>Zhu</ForeName><Initials>Z</Initials></Author><Author ValidYN="Y"><LastName>Yun-Xia</LastName><ForeName>Yang</ForeName><Initials>Y</Initials></Author></AuthorList><Language>ENG</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2011</Year><Month>Apr</Month><Day>18</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Pharm Biol</MedlineTA><NlmUniqueID>9812552</NlmUniqueID><ISSNLinking>1388-0209</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000893">Anti-Inflammatory Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018946">Chemokine CCL5</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D044950">Flavanones</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016328">NF-kappa B</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D028321">Plant Preparations</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D013778">Tetrazolium Salts</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D013844">Thiazoles</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014409">Tumor Necrosis Factor-alpha</NameOfSubstance></Chemical><Chemical><RegistryNumber>298-93-1</RegistryNumber><NameOfSubstance UI="C022616">thiazolyl blue</NameOfSubstance></Chemical><Chemical><RegistryNumber>82115-62-6</RegistryNumber><NameOfSubstance UI="D007371">Interferon-gamma</NameOfSubstance></Chemical><Chemical><RegistryNumber>N7TD9J649B</RegistryNumber><NameOfSubstance UI="C005274">naringin</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000893" MajorTopicYN="N">Anti-Inflammatory Agents</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D049109" MajorTopicYN="N">Cell Proliferation</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018946" MajorTopicYN="N">Chemokine CCL5</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002957" MajorTopicYN="N">Citrus</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004847" MajorTopicYN="N">Epithelial Cells</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D044950" MajorTopicYN="N">Flavanones</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007249" MajorTopicYN="N">Inflammation</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007371" MajorTopicYN="N">Interferon-gamma</DescriptorName><QualifierName UI="Q000037" MajorTopicYN="Y">antagonists & inhibitors</QualifierName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015603" MajorTopicYN="N">Keratinocytes</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016328" MajorTopicYN="N">NF-kappa B</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008517" MajorTopicYN="N">Phytotherapy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D028321" MajorTopicYN="N">Plant Preparations</DescriptorName><QualifierName UI="Q000494" 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